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TDMS Study 96017-06 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  DATE: 05/19/04       
EXPERIMENT: 96017 TEST: 06                                                                                     TIME: 09:19:53       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96017       
PATHOLOGIST: HEATH, JAMES                                                                                      CAS: 631-64-1        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#1 MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  DATE: 05/19/04       
EXPERIMENT: 96017 TEST: 06                                                                                     TIME: 09:19:53       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96017       
PATHOLOGIST: HEATH, JAMES                                                                                      CAS: 631-64-1        
Mice(B6C3F1)                                                                                                                        
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Bone Marrow                                                                        
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Pancreas                                                                           
                                                 Pituitary Gland                                                                    
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thyroid Gland                                                                      
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  DATE: 05/19/04       
EXPERIMENT: 96017 TEST: 06                                                                                     TIME: 09:19:53       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96017       
PATHOLOGIST: HEATH, JAMES                                                                                      CAS: 631-64-1        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF   WATER DISINFECTION BYPRODUCTS (DIBROMOAC                                                                       
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Adenoma                                                                                      
Intestine Small: Jejunum               Carcinoma                                                                                    
Intestine Small: Site Unspecified      Carcinoma                                                                                    
Liver                                  Hepatoblastoma                                                                               
                                       Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma                                                                     
                                       Hepatocellular Carcinoma or Hepatoblastoma                                                   
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
Spleen                                 Hemangiosarcoma                                                                              
All Organs                             Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type      
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Liver                                  Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma                                                                     
                                       Hepatocellular Carcinoma or Hepatoblastoma                                                   
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
Skin                                   Fibrous Histiocytoma                                                                         
Thyroid Gland: Follicular Cell         Adenoma                                                                                      
Tongue                                 Squamous Cell Carcinoma or Papilloma Squamous                                                
All Organs                             Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type      
                                       Benign Tumors                                                                                
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    4/50 (8%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     3/42.26      4/46.25      2/43.74      0/43.55     |0/45.94      0/45.44      1/44.30      0/45.07      | 
|POLY-3 PERCENT (g) |     7.1%         8.7%         4.6%         0.0%        |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     3/31 (10%)   3/38 (8%)    2/34 (6%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    1/32 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      659          729 (T)      ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.050N     P=0.607      P=0.458N     P=0.120N    |P=0.611      (e)          P=0.466      (e)          | 
|POLY 3             |     P=0.042N*    P=0.549      P=0.484N     P=0.113N    |P=0.637      (e)          P=0.493      (e)          | 
|POLY 1.5           |     P=0.041N*    P=0.533      P=0.487N     P=0.113N    |P=0.636      (e)          P=0.496      (e)          | 
|POLY 6             |     P=0.045N*    P=0.569      P=0.482N     P=0.114N    |P=0.637      (e)          P=0.487      (e)          | 
|LOGISTIC REGRESSION|     P=0.046N*    P=0.564      P=0.458N     (e)         |(e)          (e)          P=0.466      (e)          | 
|COCH-ARM / FISHERS |     P=0.041N*    P=0.511      P=0.490N     P=0.117N    |P=0.631      (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.075N     (e)          (e)          (e)         |P=0.374      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   5/50 (10%)   7/50 (14%)  |9/50 (18%)   4/50 (8%)    8/50 (16%)   8/50 (16%)   | 
|POLY-3 RATE (b)    |     3/42.29      5/46.02      5/43.80      7/43.64     |9/46.71      4/46.54      8/45.08      8/45.43      | 
|POLY-3 PERCENT (g) |     7.1%         10.9%        11.4%        16.0%       |19.3%        8.6%         17.8%        17.6%        | 
|TERMINAL (d)       |     3/31 (10%)   4/38 (11%)   4/34 (12%)   6/31 (19%)  |6/38 (16%)   2/35 (6%)    5/32 (16%)   5/32 (16%)   | 
|FIRST INCIDENCE    |     729 (T)      721          714          706         |591          487          622          688          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.109      P=0.474      P=0.405      P=0.154     |P=0.278      P=0.149N     P=0.584      P=0.586      | 
|POLY 3             |     P=0.151      P=0.404      P=0.375      P=0.169     |P=0.334      P=0.116N     P=0.532N     P=0.525N     | 
|POLY 1.5           |     P=0.156      P=0.387      P=0.371      P=0.168     |P=0.344      P=0.117N     P=0.517N     P=0.517N     | 
|POLY 6             |     P=0.141      P=0.423      P=0.379      P=0.166     |P=0.318      P=0.117N     P=0.558N     P=0.540N     | 
|LOGISTIC REGRESSION|     P=0.109      P=0.457      P=0.383      P=0.147     |P=0.361      P=0.108N     P=0.509N     P=0.513N     | 
|COCH-ARM / FISHERS |     P=0.153      P=0.357      P=0.357      P=0.159     |P=0.362      P=0.117N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.152      (e)          (e)          (e)         |P=0.426N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/42.29      0/45.99      0/43.74      0/43.55     |1/45.94      2/45.98      2/44.44      1/45.39      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         4.4%         4.5%         2.2%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |1/38 (3%)    0/35 (0%)    1/32 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      615          692          659          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.543N     P=0.491      P=0.446      P=0.747      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.517N     P=0.500      P=0.488      P=0.758      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.515N     P=0.499      P=0.494      P=0.758      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.522N     P=0.502      P=0.479      P=0.757      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.503N     P=0.511      P=0.480      P=0.761N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.510N     P=0.500      P=0.500      P=0.753N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.540      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   5/50 (10%)   7/50 (14%)  |10/50 (20%)  5/50 (10%)   10/50 (20%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |     3/42.29      5/46.02      5/43.80      7/43.64     |10/46.71     5/46.68      10/45.22     9/45.69      | 
|POLY-3 PERCENT (g) |     7.1%         10.9%        11.4%        16.0%       |21.4%        10.7%        22.1%        19.7%        | 
|TERMINAL (d)       |     3/31 (10%)   4/38 (11%)   4/34 (12%)   6/31 (19%)  |7/38 (18%)   2/35 (6%)    6/32 (19%)   5/32 (16%)   | 
|FIRST INCIDENCE    |     729 (T)      721          714          706         |591          487          622          659          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.109      P=0.474      P=0.405      P=0.154     |P=0.263      P=0.168N     P=0.462      P=0.576      | 
|POLY 3             |     P=0.151      P=0.404      P=0.375      P=0.169     |P=0.324      P=0.129N     P=0.568      P=0.521N     | 
|POLY 1.5           |     P=0.156      P=0.387      P=0.371      P=0.168     |P=0.333      P=0.130N     P=0.582      P=0.515N     | 
|POLY 6             |     P=0.141      P=0.423      P=0.379      P=0.166     |P=0.309      P=0.129N     P=0.543      P=0.532N     | 
|LOGISTIC REGRESSION|     P=0.109      P=0.457      P=0.383      P=0.147     |P=0.350      P=0.123N     P=0.584      P=0.512N     | 
|COCH-ARM / FISHERS |     P=0.153      P=0.357      P=0.357      P=0.159     |P=0.350      P=0.131N     P=0.598N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.152      (e)          (e)          (e)         |P=0.434      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Duodenum                                                                                                        | 
|     Polyp Adenomatous                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.29      1/45.99      2/43.74      1/44.25     |0/45.94      2/45.70      0/44.30      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         4.6%         2.3%        |0.0%         4.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    1/38 (3%)    2/34 (6%)    0/31 (0%)   |0/38 (0%)    1/35 (3%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      489         |---          659          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.357      P=0.541      P=0.259      P=0.513     |P=0.241N     P=0.236      (e)          (e)          | 
|POLY 3             |     P=0.387      P=0.517      P=0.245      P=0.509     |P=0.230N     P=0.236      (e)          (e)          | 
|POLY 1.5           |     P=0.387      P=0.511      P=0.243      P=0.507     |P=0.229N     P=0.236      (e)          (e)          | 
|POLY 6             |     P=0.382      P=0.523      P=0.246      P=0.509     |P=0.233N     P=0.236      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.372      P=0.541      P=0.259      P=0.346     |P=0.226N     P=0.239      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.377      P=0.500      P=0.247      P=0.500     |P=0.227N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.233      (e)          (e)          (e)         |P=0.250N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Jejunum                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/42.29      2/45.99      0/43.74      3/43.55     |0/45.94      0/45.44      0/44.30      1/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         0.0%         6.9%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/31 (0%)    2/38 (5%)    0/34 (0%)    3/31 (10%)  |0/38 (0%)    0/35 (0%)    0/32 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.129      P=0.284      (e)          P=0.120     |P=0.167      (e)          (e)          P=0.466      | 
|POLY 3             |     P=0.157      P=0.256      (e)          P=0.124     |P=0.183      (e)          (e)          P=0.496      | 
|POLY 1.5           |     P=0.157      P=0.249      (e)          P=0.123     |P=0.183      (e)          (e)          P=0.497      | 
|POLY 6             |     P=0.156      P=0.264      (e)          P=0.122     |P=0.181      (e)          (e)          P=0.494      | 
|LOGISTIC REGRESSION|     (e)          P=0.284      (e)          P=0.120     |(e)          (e)          (e)          P=0.466      | 
|COCH-ARM / FISHERS |     P=0.153      P=0.247      (e)          P=0.121     |P=0.184      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.039 *    (e)          (e)          (e)         |P=0.116      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/42.29      2/45.99      0/43.74      4/43.55     |0/45.94      0/45.44      0/44.30      1/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         0.0%         9.2%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/31 (0%)    2/38 (5%)    0/34 (0%)    4/31 (13%)  |0/38 (0%)    0/35 (0%)    0/32 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.045 *    P=0.284      (e)          P=0.062     |P=0.167      (e)          (e)          P=0.466      | 
|POLY 3             |     P=0.059      P=0.256      (e)          P=0.064     |P=0.183      (e)          (e)          P=0.496      | 
|POLY 1.5           |     P=0.059      P=0.249      (e)          P=0.063     |P=0.183      (e)          (e)          P=0.497      | 
|POLY 6             |     P=0.058      P=0.264      (e)          P=0.062     |P=0.181      (e)          (e)          P=0.494      | 
|LOGISTIC REGRESSION|     (e)          P=0.284      (e)          P=0.062     |(e)          (e)          (e)          P=0.466      | 
|COCH-ARM / FISHERS |     P=0.059      P=0.247      (e)          P=0.059     |P=0.184      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.012 *    (e)          (e)          (e)         |P=0.116      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Polyp Adenomatous                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.29      3/45.99      2/43.74      1/44.25     |0/45.94      2/45.70      0/44.30      0/45.13      | 
|POLY-3 PERCENT (g) |     2.4%         6.5%         4.6%         2.3%        |0.0%         4.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    3/38 (8%)    2/34 (6%)    0/31 (0%)   |0/38 (0%)    1/35 (3%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      489         |---          659          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.413N     P=0.380      P=0.532      P=0.753N    |P=0.241N     P=0.236      (e)          (e)          | 
|POLY 3             |     P=0.371N     P=0.336      P=0.512      P=0.751N    |P=0.230N     P=0.236      (e)          (e)          | 
|POLY 1.5           |     P=0.373N     P=0.325      P=0.509      P=0.753N    |P=0.229N     P=0.236      (e)          (e)          | 
|POLY 6             |     P=0.374N     P=0.348      P=0.514      P=0.751N    |P=0.233N     P=0.236      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.383N     P=0.380      P=0.532      P=0.724     |P=0.226N     P=0.239      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.383N     P=0.309      P=0.500      P=0.753N    |P=0.227N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.467N     (e)          (e)          (e)         |P=0.250N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/46 (0%)    3/50 (6%)    4/50 (8%)    3/49 (6%)   |1/49 (2%)    0/49 (0%)    2/49 (4%)    2/46 (4%)    | 
|POLY-3 RATE (b)    |     0/40.18      3/46.02      4/44.19      3/43.10     |1/45.58      0/44.88      2/44.58      2/42.85      | 
|POLY-3 PERCENT (g) |     0.0%         6.5%         9.1%         7.0%        |2.2%         0.0%         4.5%         4.7%         | 
|TERMINAL (d)       |     0/31 (0%)    2/38 (5%)    3/34 (9%)    3/31 (10%)  |1/38 (3%)    0/35 (0%)    1/32 (3%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          721          596          729 (T)     |729 (T)      ---          553          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.172      P=0.163      P=0.074      P=0.120     |P=0.154      P=0.516N     P=0.460      P=0.440      | 
|POLY 3             |     P=0.211      P=0.144      P=0.073      P=0.131     |P=0.169      P=0.503N     P=0.492      P=0.478      | 
|POLY 1.5           |     P=0.215      P=0.140      P=0.072      P=0.132     |P=0.168      P=0.502N     P=0.496      P=0.478      | 
|POLY 6             |     P=0.201      P=0.148      P=0.072      P=0.128     |P=0.168      P=0.504N     P=0.484      P=0.477      | 
|LOGISTIC REGRESSION|     P=0.201      P=0.151      P=0.074      P=0.120     |P=0.161      (e)          P=0.517      P=0.440      | 
|COCH-ARM / FISHERS |     P=0.215      P=0.137      P=0.069      P=0.133     |P=0.165      P=0.500N     P=0.500      P=0.476      | 
|ORDER RESTRICTED   |     P=0.094      (e)          (e)          (e)         |P=0.249      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/46 (0%)    3/50 (6%)    4/50 (8%)    3/49 (6%)   |1/49 (2%)    0/49 (0%)    3/49 (6%)    2/46 (4%)    | 
|POLY-3 RATE (b)    |     0/40.18      3/46.02      4/44.19      3/43.10     |1/45.58      0/44.88      3/44.92      2/42.85      | 
|POLY-3 PERCENT (g) |     0.0%         6.5%         9.1%         7.0%        |2.2%         0.0%         6.7%         4.7%         | 
|TERMINAL (d)       |     0/31 (0%)    2/38 (5%)    3/34 (9%)    3/31 (10%)  |1/38 (3%)    0/35 (0%)    1/32 (3%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          721          596          729 (T)     |729 (T)      ---          553          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.172      P=0.163      P=0.074      P=0.120     |P=0.149      P=0.516N     P=0.274      P=0.440      | 
|POLY 3             |     P=0.211      P=0.144      P=0.073      P=0.131     |P=0.158      P=0.503N     P=0.300      P=0.478      | 
|POLY 1.5           |     P=0.215      P=0.140      P=0.072      P=0.132     |P=0.157      P=0.502N     P=0.303      P=0.478      | 
|POLY 6             |     P=0.201      P=0.148      P=0.072      P=0.128     |P=0.157      P=0.504N     P=0.293      P=0.477      | 
|LOGISTIC REGRESSION|     P=0.201      P=0.151      P=0.074      P=0.120     |P=0.146      (e)          P=0.321      P=0.440      | 
|COCH-ARM / FISHERS |     P=0.215      P=0.137      P=0.069      P=0.133     |P=0.154      P=0.500N     P=0.309      P=0.476      | 
|ORDER RESTRICTED   |     P=0.094      (e)          (e)          (e)         |P=0.182      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |1/49 (2%)    1/50 (2%)    2/50 (4%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/42.26      2/45.99      0/43.74      2/43.55     |1/45.87      1/45.44      2/44.76      0/45.07      | 
|POLY-3 PERCENT (g) |     2.4%         4.4%         0.0%         4.6%        |2.2%         2.2%         4.5%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    2/38 (5%)    0/34 (0%)    2/31 (7%)   |0/38 (0%)    1/35 (3%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |653          729 (T)      617          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.505      P=0.571      P=0.482N     P=0.500     |P=0.395N     P=0.751      P=0.473      P=0.500N     | 
|POLY 3             |     P=0.541      P=0.529      P=0.493N     P=0.510     |P=0.382N     P=0.758      P=0.491      P=0.503N     | 
|POLY 1.5           |     P=0.543      P=0.520      P=0.494N     P=0.510     |P=0.380N     P=0.760N     P=0.499      P=0.502N     | 
|POLY 6             |     P=0.536      P=0.541      P=0.492N     P=0.508     |P=0.387N     P=0.756      P=0.480      P=0.507N     | 
|LOGISTIC REGRESSION|     P=0.505      P=0.571      (e)          P=0.500     |P=0.382N     P=0.753N     P=0.548      P=0.493N     | 
|COCH-ARM / FISHERS |     P=0.543      P=0.508      P=0.495N     P=0.508     |P=0.379N     P=0.747N     P=0.508      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.415      (e)          (e)          (e)         |P=0.271N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatoblastoma                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    4/50 (8%)    6/50 (12%)   18/50 (36%) |1/49 (2%)    0/50 (0%)    1/50 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/42.26      4/46.04      6/45.11      18/46.03    |1/45.58      0/45.44      1/44.48      1/45.07      | 
|POLY-3 PERCENT (g) |     0.0%         8.7%         13.3%        39.1%       |2.2%         0.0%         2.3%         2.2%         | 
|TERMINAL (d)       |     0/31 (0%)    3/38 (8%)    3/34 (9%)    9/31 (29%)  |1/38 (3%)    0/35 (0%)    0/32 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          717          573          469         |729 (T)      ---          680          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.094      P=0.024 *    P<0.001 **  |P=0.418      P=0.516N     P=0.730      P=0.723      | 
|POLY 3             |     P<0.001 **   P=0.072      P=0.019 *    P<0.001 **  |P=0.450      P=0.501N     P=0.755      P=0.758      | 
|POLY 1.5           |     P<0.001 **   P=0.068      P=0.018 *    P<0.001 **  |P=0.450      P=0.499N     P=0.760      P=0.759      | 
|POLY 6             |     P<0.001 **   P=0.077      P=0.020 *    P<0.001 **  |P=0.447      P=0.502N     P=0.748      P=0.755      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.083      P=0.018 *    P<0.001 **  |P=0.446      (e)          P=0.762N     P=0.723      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.061      P=0.014 *    P<0.001 **  |P=0.448      P=0.495N     P=0.747N     P=0.753N     | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.530      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/49 (37%)  37/50 (74%)  37/50 (74%)  42/50 (84%) |19/49 (39%)  26/50 (52%)  32/50 (64%)  35/49 (71%)  | 
|POLY-3 RATE (b)    |     18/43.32     37/47.46     37/46.19     42/47.33    |19/45.87     26/45.74     32/45.91     35/46.13     | 
|POLY-3 PERCENT (g) |     41.6%        78.0%        80.1%        88.7%       |41.4%        56.8%        69.7%        75.9%        | 
|TERMINAL (d)       |     14/31 (45%)  31/38 (82%)  29/34 (85%)  29/31 (94%) |18/38 (47%)  22/35 (63%)  26/32 (81%)  28/32 (88%)  | 
|FIRST INCIDENCE    |     596          573          573          469         |653          694          573          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.055      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.098      P=0.004 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.109      P=0.006 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.089      P=0.002 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.083      P=0.002 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.131      P=0.010 *    P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/49 (29%)  9/50 (18%)   19/50 (38%)  26/50 (52%) |3/49 (6%)    3/50 (6%)    12/50 (24%)  8/49 (16%)   | 
|POLY-3 RATE (b)    |     14/44.73     9/46.45      19/46.69     26/47.37    |3/45.93      3/45.58      12/44.94     8/45.29      | 
|POLY-3 PERCENT (g) |     31.3%        19.4%        40.7%        54.9%       |6.5%         6.6%         26.7%        17.7%        | 
|TERMINAL (d)       |     6/31 (19%)   6/38 (16%)   10/34 (29%)  14/31 (45%) |1/38 (3%)    2/35 (6%)    9/32 (28%)   7/32 (22%)   | 
|FIRST INCIDENCE    |     451          659          573          476         |658          694          617          671          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.097N     P=0.284      P=0.031 *   |P=0.013 *    P=0.637      P=0.007 **   P=0.069      | 
|POLY 3             |     P<0.001 **   P=0.141N     P=0.236      P=0.016 *   |P=0.019 *    P=0.659      P=0.009 **   P=0.094      | 
|POLY 1.5           |     P<0.001 **   P=0.147N     P=0.227      P=0.015 *   |P=0.020 *    P=0.661N     P=0.010 *    P=0.096      | 
|POLY 6             |     P<0.001 **   P=0.137N     P=0.249      P=0.018 *   |P=0.017 *    P=0.654      P=0.007 **   P=0.088      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.160N     P=0.213      P=0.014 *   |P=0.021 *    P=0.658N     P=0.011 *    P=0.096      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.157N     P=0.217      P=0.015 *   |P=0.022 *    P=0.651N     P=0.013 *    P=0.100      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.019 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/49 (29%)  11/50 (22%)  23/50 (46%)  37/50 (74%) |4/49 (8%)    3/50 (6%)    13/50 (26%)  9/49 (18%)   | 
|POLY-3 RATE (b)    |     14/44.73     11/46.45     23/47.04     37/49.04    |4/45.93      3/45.58      13/45.13     9/45.29      | 
|POLY-3 PERCENT (g) |     31.3%        23.7%        48.9%        75.5%       |8.7%         6.6%         28.8%        19.9%        | 
|TERMINAL (d)       |     6/31 (19%)   8/38 (21%)   13/34 (38%)  20/31 (65%) |2/38 (5%)    2/35 (6%)    9/32 (28%)   8/32 (25%)   | 
|FIRST INCIDENCE    |     451          659          573          469         |658          694          617          671          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.189N     P=0.108      P<0.001 **  |P=0.010 *    P=0.529N     P=0.009 **   P=0.075      | 
|POLY 3             |     P<0.001 **   P=0.281N     P=0.063      P<0.001 **  |P=0.015 *    P=0.504N     P=0.012 *    P=0.109      | 
|POLY 1.5           |     P<0.001 **   P=0.289N     P=0.059      P<0.001 **  |P=0.016 *    P=0.499N     P=0.014 *    P=0.113      | 
|POLY 6             |     P<0.001 **   P=0.275N     P=0.072      P<0.001 **  |P=0.014 *    P=0.510N     P=0.010 *    P=0.102      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.298N     P=0.055      P<0.001 **  |P=0.017 *    P=0.497N     P=0.014 *    P=0.110      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.301N     P=0.056      P<0.001 **  |P=0.018 *    P=0.489N     P=0.017 *    P=0.116      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.017 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     28/49 (57%)  41/50 (82%)  42/50 (84%)  47/50 (94%) |22/49 (45%)  28/50 (56%)  37/50 (74%)  37/49 (76%)  | 
|POLY-3 RATE (b)    |     28/45.72     41/47.77     42/47.58     47/48.97    |22/46.21     28/45.74     37/46.56     37/46.35     | 
|POLY-3 PERCENT (g) |     61.2%        85.8%        88.3%        96.0%       |47.6%        61.2%        79.5%        79.8%        | 
|TERMINAL (d)       |     17/31 (55%)  33/38 (87%)  30/34 (88%)  30/31 (97%) |19/38 (50%)  24/35 (69%)  28/32 (88%)  29/32 (91%)  | 
|FIRST INCIDENCE    |     451          573          573          469         |653          694          573          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.157      P=0.039 *    P=0.002 **  |P<0.001 **   P=0.084      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.131      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.004 **   P=0.002 **   P<0.001 **  |P<0.001 **   P=0.149      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.005 **   P=0.002 **   P<0.001 **  |P<0.001 **   P=0.112      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.012 *    P=0.003 **   P<0.001 **  |P<0.001 **   P=0.127      P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.006 **   P=0.003 **   P<0.001 **  |P<0.001 **   P=0.183      P=0.003 **   P=0.002 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     28/49 (57%)  41/50 (82%)  43/50 (86%)  48/50 (96%) |22/49 (45%)  28/50 (56%)  37/50 (74%)  37/49 (76%)  | 
|POLY-3 RATE (b)    |     28/45.72     41/47.77     43/47.58     48/49.30    |22/46.21     28/45.74     37/46.56     37/46.35     | 
|POLY-3 PERCENT (g) |     61.2%        85.8%        90.4%        97.4%       |47.6%        61.2%        79.5%        79.8%        | 
|TERMINAL (d)       |     17/31 (55%)  33/38 (87%)  31/34 (91%)  30/31 (97%) |19/38 (50%)  24/35 (69%)  28/32 (88%)  29/32 (91%)  | 
|FIRST INCIDENCE    |     451          573          573          469         |653          694          573          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.157      P=0.026 *    P=0.002 **  |P<0.001 **   P=0.084      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.131      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.149      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.005 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.112      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.012 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.127      P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.183      P=0.003 **   P=0.002 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/49 (14%)   5/50 (10%)   17/50 (34%)  12/50 (24%) |1/50 (2%)    3/50 (6%)    3/50 (6%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     7/43.05      5/46.44      17/44.31     12/45.15    |1/45.94      3/46.14      3/44.93      6/45.51      | 
|POLY-3 PERCENT (g) |     16.3%        10.8%        38.4%        26.6%       |2.2%         6.5%         6.7%         13.2%        | 
|TERMINAL (d)       |     5/31 (16%)   4/38 (11%)   15/34 (44%)  8/31 (26%)  |1/38 (3%)    2/35 (6%)    1/32 (3%)    4/32 (13%)   | 
|FIRST INCIDENCE    |     482          596          604          489         |729 (T)      490          553          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.013 *    P=0.269N     P=0.030 *    P=0.162     |P=0.035 *    P=0.283      P=0.265      P=0.042 *    | 
|POLY 3             |     P=0.019 *    P=0.326N     P=0.016 *    P=0.178     |P=0.044 *    P=0.307      P=0.297      P=0.054      | 
|POLY 1.5           |     P=0.021 *    P=0.344N     P=0.017 *    P=0.174     |P=0.044 *    P=0.306      P=0.302      P=0.055      | 
|POLY 6             |     P=0.016 *    P=0.306N     P=0.016 *    P=0.179     |P=0.042 *    P=0.307      P=0.289      P=0.053      | 
|LOGISTIC REGRESSION|     P=0.022 *    P=0.360N     P=0.021 *    P=0.166     |P=0.049 *    P=0.321      P=0.317      P=0.055      | 
|COCH-ARM / FISHERS |     P=0.025 *    P=0.365N     P=0.019 *    P=0.166     |P=0.047 *    P=0.309      P=0.309      P=0.056      | 
|ORDER RESTRICTED   |     P=0.020 *    (e)          (e)          (e)         |P=0.027 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/49 (10%)   8/50 (16%)   8/50 (16%)   7/50 (14%)  |1/50 (2%)    2/50 (4%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     5/42.59      8/46.17      8/43.94      7/43.93     |1/45.94      2/45.58      2/44.68      2/45.13      | 
|POLY-3 PERCENT (g) |     11.7%        17.3%        18.2%        15.9%       |2.2%         4.4%         4.5%         4.4%         | 
|TERMINAL (d)       |     3/31 (10%)   6/38 (16%)   6/34 (18%)   5/31 (16%)  |1/38 (3%)    1/35 (3%)    1/32 (3%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     662          691          699          652         |729 (T)      694          622          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.356      P=0.410      P=0.326      P=0.374     |P=0.398      P=0.481      P=0.460      P=0.440      | 
|POLY 3             |     P=0.436      P=0.329      P=0.294      P=0.400     |P=0.440      P=0.497      P=0.490      P=0.494      | 
|POLY 1.5           |     P=0.446      P=0.312      P=0.293      P=0.400     |P=0.443      P=0.498      P=0.495      P=0.496      | 
|POLY 6             |     P=0.417      P=0.349      P=0.295      P=0.396     |P=0.433      P=0.497      P=0.482      P=0.490      | 
|LOGISTIC REGRESSION|     P=0.403      P=0.353      P=0.299      P=0.396     |P=0.443      P=0.496      P=0.505      P=0.440      | 
|COCH-ARM / FISHERS |     P=0.451      P=0.290      P=0.290      P=0.394     |P=0.448      P=0.500      P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.394      (e)          (e)          (e)         |P=0.455      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/49 (24%)  12/50 (24%)  22/50 (44%)  17/50 (34%) |2/50 (4%)    5/50 (10%)   5/50 (10%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     12/43.38     12/46.62     22/44.52     17/45.53    |2/45.94      5/46.27      5/45.31      7/45.51      | 
|POLY-3 PERCENT (g) |     27.7%        25.7%        49.4%        37.3%       |4.4%         10.8%        11.0%        15.4%        | 
|TERMINAL (d)       |     8/31 (26%)   9/38 (24%)   18/34 (53%)  11/31 (36%) |2/38 (5%)    3/35 (9%)    2/32 (6%)    5/32 (16%)   | 
|FIRST INCIDENCE    |     482          596          604          489         |729 (T)      490          553          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.039 *    P=0.398N     P=0.057      P=0.200     |P=0.074      P=0.196      P=0.176      P=0.054      | 
|POLY 3             |     P=0.066      P=0.513N     P=0.027 *    P=0.226     |P=0.095      P=0.219      P=0.210      P=0.076      | 
|POLY 1.5           |     P=0.071      P=0.538N     P=0.028 *    P=0.220     |P=0.097      P=0.218      P=0.214      P=0.077      | 
|POLY 6             |     P=0.058      P=0.482N     P=0.025 *    P=0.229     |P=0.092      P=0.221      P=0.204      P=0.075      | 
|LOGISTIC REGRESSION|     P=0.063      P=0.523N     P=0.034 *    P=0.211     |P=0.103      P=0.222      P=0.227      P=0.075      | 
|COCH-ARM / FISHERS |     P=0.075      P=0.570N     P=0.033 *    P=0.207     |P=0.101      P=0.218      P=0.218      P=0.080      | 
|ORDER RESTRICTED   |     P=0.071      (e)          (e)          (e)         |P=0.061      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.29      0/45.99      0/43.74      0/43.55     |0/45.94      2/45.50      1/44.30      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.4%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    1/35 (3%)    1/32 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          715          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.359N     P=0.225      P=0.466      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.333N     P=0.235      P=0.493      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.331N     P=0.236      P=0.496      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.337N     P=0.234      P=0.487      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.343N     P=0.234      P=0.466      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.326N     P=0.247      P=0.500      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.320      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.29      0/45.99      0/43.74      0/43.55     |2/46.48      1/45.44      0/44.30      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.3%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |1/38 (3%)    1/35 (3%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |563          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.120N     P=0.519N     P=0.259N     P=0.256N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.109N     P=0.508N     P=0.248N     P=0.244N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.108N     P=0.505N     P=0.243N     P=0.242N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.111N     P=0.511N     P=0.256N     P=0.248N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.101N     P=0.486N     P=0.220N     P=0.205N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.107N     P=0.500N     P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.078N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/49 (0%)    2/47 (4%)    1/47 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |                                                        |0/44.94      2/42.71      1/41.30      0/45.07      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         4.7%         2.4%         0.0%         | 
|TERMINAL (d)       |                                                        |0/37 (0%)    2/34 (6%)    1/29 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.362N     P=0.220      P=0.451      (e)          | 
|POLY 3             |                                                        |P=0.325N     P=0.226      P=0.483      (e)          | 
|POLY 1.5           |                                                        |P=0.324N     P=0.226      P=0.487      (e)          | 
|POLY 6             |                                                        |P=0.329N     P=0.226      P=0.476      (e)          | 
|LOGISTIC REGRESSION|                                                        |(e)          P=0.220      P=0.451      (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.324N     P=0.237      P=0.490      (e)          | 
|ORDER RESTRICTED   |                                                        |P=0.307N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/45 (0%)    0/50 (0%)    0/48 (0%)    0/48 (0%)   |2/47 (4%)    4/49 (8%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/39.54      0/45.99      0/42.09      0/42.44     |2/43.62      4/44.58      0/43.30      1/44.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.6%         9.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/30 (0%)    0/38 (0%)    0/33 (0%)    0/31 (0%)   |1/36 (3%)    3/34 (9%)    0/31 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |720          694          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.146N     P=0.316      P=0.278N     P=0.553N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.114N     P=0.347      P=0.239N     P=0.496N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.112N     P=0.350      P=0.234N     P=0.493N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.118N     P=0.344      P=0.247N     P=0.502N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.122N     P=0.341      P=0.256N     P=0.520N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.109N     P=0.359      P=0.237N     P=0.484N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.135N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/45 (0%)    0/50 (0%)    0/48 (0%)    0/48 (0%)   |1/47 (2%)    0/49 (0%)    2/49 (4%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/39.54      0/45.99      0/42.09      0/42.44     |1/43.58      0/44.44      2/43.69      0/44.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         0.0%         4.6%         0.0%         | 
|TERMINAL (d)       |     0/30 (0%)    0/38 (0%)    0/33 (0%)    0/31 (0%)   |1/36 (3%)    0/34 (0%)    1/31 (3%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          618          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.572N     P=0.511N     P=0.465      P=0.530N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.548N     P=0.496N     P=0.501      P=0.498N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.547N     P=0.495N     P=0.507      P=0.496N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.552N     P=0.498N     P=0.491      P=0.501N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.540N     (e)          P=0.525      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.543N     P=0.490N     P=0.516      P=0.490N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.322N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skeletal Muscle                                                                                                                  | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/42.29      1/46.44      0/43.74      0/43.55     |1/45.94      1/45.44      0/44.30      2/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |2.2%         2.2%         0.0%         4.4%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |1/38 (3%)    1/35 (3%)    0/32 (0%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          596          ---          ---         |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.414N     P=0.509      (e)          (e)         |P=0.331      P=0.743      P=0.534N     P=0.440      | 
|POLY 3             |     P=0.399N     P=0.519      (e)          (e)         |P=0.372      P=0.758      P=0.507N     P=0.494      | 
|POLY 1.5           |     P=0.404N     P=0.512      (e)          (e)         |P=0.375      P=0.759      P=0.504N     P=0.496      | 
|POLY 6             |     P=0.393N     P=0.526      (e)          (e)         |P=0.368      P=0.758      P=0.513N     P=0.490      | 
|LOGISTIC REGRESSION|     P=0.443N     P=0.447      (e)          (e)         |P=0.331      P=0.743      (e)          P=0.440      | 
|COCH-ARM / FISHERS |     P=0.414N     P=0.500      (e)          (e)         |P=0.377      P=0.753N     P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.392N     (e)          (e)          (e)         |P=0.268      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |4/50 (8%)    3/50 (6%)    3/50 (6%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     1/42.73      1/45.99      0/43.74      1/43.81     |4/46.02      3/46.30      3/45.07      6/45.44      | 
|POLY-3 PERCENT (g) |     2.3%         2.2%         0.0%         2.3%        |8.7%         6.5%         6.7%         13.2%        | 
|TERMINAL (d)       |     0/31 (0%)    1/38 (3%)    0/34 (0%)    0/31 (0%)   |3/38 (8%)    0/35 (0%)    1/32 (3%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     601          729 (T)      ---          659         |710          490          573          682          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.591N     P=0.733N     P=0.495N     P=0.752N    |P=0.181      P=0.535N     P=0.568N     P=0.295      | 
|POLY 3             |     P=0.580N     P=0.744N     P=0.495N     P=0.755N    |P=0.210      P=0.497N     P=0.511N     P=0.361      | 
|POLY 1.5           |     P=0.579N     P=0.750N     P=0.496N     P=0.755N    |P=0.214      P=0.499N     P=0.506N     P=0.363      | 
|POLY 6             |     P=0.584N     P=0.738N     P=0.496N     P=0.757N    |P=0.204      P=0.494N     P=0.522N     P=0.357      | 
|LOGISTIC REGRESSION|     P=0.586N     P=0.750      P=0.536N     P=0.738     |P=0.224      P=0.489N     P=0.493N     P=0.351      | 
|COCH-ARM / FISHERS |     P=0.579N     P=0.753N     P=0.500N     P=0.753N    |P=0.219      P=0.500N     P=0.500N     P=0.370      | 
|ORDER RESTRICTED   |     P=0.527N     (e)          (e)          (e)         |P=0.252      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/42.29      1/45.99      0/43.74      0/43.55     |1/46.02      2/46.23      2/44.81      2/45.17      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |2.2%         4.3%         4.5%         4.4%         | 
|TERMINAL (d)       |     0/31 (0%)    1/38 (3%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    1/32 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |710          490          573          719          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.427N     P=0.541      (e)          (e)         |P=0.411      P=0.483      P=0.462      P=0.450      | 
|POLY 3             |     P=0.400N     P=0.517      (e)          (e)         |P=0.437      P=0.502      P=0.491      P=0.494      | 
|POLY 1.5           |     P=0.405N     P=0.511      (e)          (e)         |P=0.441      P=0.501      P=0.495      P=0.495      | 
|POLY 6             |     P=0.395N     P=0.523      (e)          (e)         |P=0.430      P=0.502      P=0.482      P=0.490      | 
|LOGISTIC REGRESSION|     (e)          P=0.541      (e)          (e)         |P=0.474      P=0.544      P=0.517      P=0.490      | 
|COCH-ARM / FISHERS |     P=0.414N     P=0.500      (e)          (e)         |P=0.448      P=0.500      P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.391N     (e)          (e)          (e)         |P=0.455      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 15      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |4/50 (8%)    3/50 (6%)    3/50 (6%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     0/42.29      1/45.99      0/43.74      1/43.81     |4/46.02      3/46.30      3/45.07      6/45.44      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         2.3%        |8.7%         6.5%         6.7%         13.2%        | 
|TERMINAL (d)       |     0/31 (0%)    1/38 (3%)    0/34 (0%)    0/31 (0%)   |3/38 (8%)    0/35 (0%)    1/32 (3%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          659         |710          490          573          682          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.467      P=0.541      (e)          P=0.510     |P=0.181      P=0.535N     P=0.568N     P=0.295      | 
|POLY 3             |     P=0.491      P=0.517      (e)          P=0.507     |P=0.210      P=0.497N     P=0.511N     P=0.361      | 
|POLY 1.5           |     P=0.490      P=0.511      (e)          P=0.506     |P=0.214      P=0.499N     P=0.506N     P=0.363      | 
|POLY 6             |     P=0.491      P=0.523      (e)          P=0.507     |P=0.204      P=0.494N     P=0.522N     P=0.357      | 
|LOGISTIC REGRESSION|     P=0.483      P=0.541      (e)          P=0.489     |P=0.224      P=0.489N     P=0.493N     P=0.351      | 
|COCH-ARM / FISHERS |     P=0.482      P=0.500      (e)          P=0.500     |P=0.219      P=0.500N     P=0.500N     P=0.370      | 
|ORDER RESTRICTED   |     P=0.258      (e)          (e)          (e)         |P=0.252      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrous Histiocytoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |3/50 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.29      0/45.99      0/43.74      1/43.81     |3/45.94      0/45.44      0/44.30      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.3%        |6.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |3/38 (8%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          659         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.180      (e)          (e)          P=0.510     |P=0.112N     P=0.136N     P=0.153N     P=0.153N     | 
|POLY 3             |     P=0.183      (e)          (e)          P=0.507     |P=0.092N     P=0.121N     P=0.125N     P=0.122N     | 
|POLY 1.5           |     P=0.185      (e)          (e)          P=0.506     |P=0.091N     P=0.120N     P=0.122N     P=0.121N     | 
|POLY 6             |     P=0.181      (e)          (e)          P=0.507     |P=0.093N     P=0.121N     P=0.131N     P=0.124N     | 
|LOGISTIC REGRESSION|     P=0.179      (e)          (e)          P=0.489     |P=0.112N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.184      (e)          (e)          P=0.500     |P=0.094N     P=0.121N     P=0.121N     P=0.121N     | 
|ORDER RESTRICTED   |     P=0.127      (e)          (e)          (e)         |P=0.009N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 16      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Neurofibrosarcoma or Schwannoma (malignant or NOS)                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/42.29      0/45.99      0/43.74      0/43.55     |0/45.94      2/46.42      0/44.30      1/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.3%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          383          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.631N     P=0.237      (e)          P=0.466      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.611N     P=0.240      (e)          P=0.496      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.609N     P=0.239      (e)          P=0.497      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.616N     P=0.240      (e)          P=0.494      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.536N     P=0.321      (e)          P=0.466      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.606N     P=0.247      (e)          P=0.500      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.322      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Neurofibrosarcoma, Neurofibroma, or Schwannoma (benign,                                                                     | 
|     malignant or NOS)                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/42.29      0/45.99      0/43.74      0/43.55     |0/45.94      2/46.42      0/44.30      2/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.3%         0.0%         4.4%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          383          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.323      P=0.237      (e)          P=0.201      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.347      P=0.240      (e)          P=0.233      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.349      P=0.239      (e)          P=0.234      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.342      P=0.240      (e)          P=0.231      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.398      P=0.321      (e)          P=0.201      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.354      P=0.247      (e)          P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.113      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 17      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/42.29      0/45.99      0/43.74      0/43.55     |1/45.94      1/45.52      1/44.56      4/45.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         2.2%         2.2%         8.8%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |1/38 (3%)    0/35 (0%)    0/32 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      710          659          682          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.056      P=0.743      P=0.736      P=0.152      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.063      P=0.759      P=0.754      P=0.175      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.064      P=0.759      P=0.757      P=0.176      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.062      P=0.758      P=0.748      P=0.173      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.064      P=0.760      P=0.760N     P=0.173      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.065      P=0.753N     P=0.753N     P=0.181      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.073      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/47 (4%)    3/50 (6%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     2/40.70      3/45.99      0/43.74      0/43.55     |0/45.94      0/45.44      0/44.30      0/44.12      | 
|POLY-3 PERCENT (g) |     4.9%         6.5%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/30 (7%)    3/38 (8%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.045N*    P=0.608      P=0.211N     P=0.231N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.039N*    P=0.555      P=0.221N     P=0.222N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.039N*    P=0.544      P=0.222N     P=0.222N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.040N*    P=0.568      P=0.221N     P=0.224N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.045N*    P=0.608      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.039N*    P=0.530      P=0.232N     P=0.232N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.089N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 18      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/42.56      1/45.99      0/43.74      1/43.55     |1/45.94      1/45.44      3/44.34      1/45.13      | 
|POLY-3 PERCENT (g) |     2.4%         2.2%         0.0%         2.3%        |2.2%         2.2%         6.8%         2.2%         | 
|TERMINAL (d)       |     0/31 (0%)    1/38 (3%)    0/34 (0%)    1/31 (3%)   |1/38 (3%)    1/35 (3%)    2/32 (6%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     655          729 (T)      ---          729 (T)     |729 (T)      729 (T)      718          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.601N     P=0.721N     P=0.505N     P=0.757N    |P=0.453      P=0.743      P=0.249      P=0.723      | 
|POLY 3             |     P=0.580N     P=0.743N     P=0.495N     P=0.756N    |P=0.503      P=0.758      P=0.293      P=0.757      | 
|POLY 1.5           |     P=0.579N     P=0.749N     P=0.496N     P=0.756N    |P=0.505      P=0.759      P=0.299      P=0.758      | 
|POLY 6             |     P=0.584N     P=0.737N     P=0.495N     P=0.758N    |P=0.498      P=0.758      P=0.282      P=0.754      | 
|LOGISTIC REGRESSION|     P=0.580N     P=0.763N     P=0.510N     P=0.760N    |P=0.470      P=0.743      P=0.258      P=0.723      | 
|COCH-ARM / FISHERS |     P=0.579N     P=0.753N     P=0.500N     P=0.753N    |P=0.510      P=0.753N     P=0.309      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.527N     (e)          (e)          (e)         |P=0.428      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.29      0/45.99      0/43.74      1/43.55     |1/45.94      1/45.44      2/44.34      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.3%        |2.2%         2.2%         4.5%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    1/31 (3%)   |1/38 (3%)    1/35 (3%)    1/32 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |729 (T)      729 (T)      718          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.170      (e)          (e)          P=0.500     |P=0.421N     P=0.743      P=0.442      P=0.534N     | 
|POLY 3             |     P=0.183      (e)          (e)          P=0.506     |P=0.383N     P=0.758      P=0.488      P=0.504N     | 
|POLY 1.5           |     P=0.184      (e)          (e)          P=0.505     |P=0.381N     P=0.759      P=0.494      P=0.503N     | 
|POLY 6             |     P=0.179      (e)          (e)          P=0.505     |P=0.387N     P=0.758      P=0.478      P=0.506N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.500     |P=0.404N     P=0.743      P=0.458      (e)          | 
|COCH-ARM / FISHERS |     P=0.184      (e)          (e)          P=0.500     |P=0.377N     P=0.753N     P=0.500      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.126      (e)          (e)          (e)         |P=0.269N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 19      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     0/42.26      2/45.99      0/43.74      1/43.55     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         0.0%         2.3%        |                                                    | 
|TERMINAL (d)       |     0/31 (0%)    2/38 (5%)    0/34 (0%)    1/31 (3%)   |                                                    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.634N     P=0.284      (e)          P=0.500     |                                                    | 
|POLY 3             |     P=0.594N     P=0.256      (e)          P=0.506     |                                                    | 
|POLY 1.5           |     P=0.598N     P=0.250      (e)          P=0.506     |                                                    | 
|POLY 6             |     P=0.591N     P=0.264      (e)          P=0.505     |                                                    | 
|LOGISTIC REGRESSION|     (e)          P=0.284      (e)          P=0.500     |                                                    | 
|COCH-ARM / FISHERS |     P=0.603N     P=0.253      (e)          P=0.505     |                                                    | 
|ORDER RESTRICTED   |     P=0.330      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |3/50 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.70      0/45.99      1/43.74      1/43.55     |3/46.00      0/45.44      0/44.30      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         2.3%        |6.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    1/34 (3%)    1/31 (3%)   |2/38 (5%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |714          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.183      (e)          P=0.518      P=0.500     |P=0.111N     P=0.138N     P=0.156N     P=0.151N     | 
|POLY 3             |     P=0.199      (e)          P=0.509      P=0.509     |P=0.091N     P=0.121N     P=0.126N     P=0.122N     | 
|POLY 1.5           |     P=0.203      (e)          P=0.509      P=0.509     |P=0.091N     P=0.120N     P=0.122N     P=0.121N     | 
|POLY 6             |     P=0.193      (e)          P=0.509      P=0.506     |P=0.093N     P=0.122N     P=0.131N     P=0.124N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.518      P=0.500     |P=0.102N     P=0.123N     P=0.138N     P=0.129N     | 
|COCH-ARM / FISHERS |     P=0.205      (e)          P=0.510      P=0.510     |P=0.094N     P=0.121N     P=0.121N     P=0.121N     | 
|ORDER RESTRICTED   |     P=0.259      (e)          (e)          (e)         |P=0.009N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 20      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tongue                                                                                                                           | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.29      0/45.99      0/43.74      0/43.55     |2/46.48      0/45.44      0/44.30      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |1/38 (3%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |563          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.188N     P=0.249N     P=0.259N     P=0.256N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.176N     P=0.242N     P=0.248N     P=0.244N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.175N     P=0.241N     P=0.243N     P=0.242N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.177N     P=0.244N     P=0.256N     P=0.248N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.160N     P=0.212N     P=0.220N     P=0.205N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.178N     P=0.247N     P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.032N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |3/50 (6%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/42.29      1/45.99      2/43.85      0/43.55     |3/45.94      1/45.44      2/44.56      1/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         4.6%         0.0%        |6.5%         2.2%         4.5%         2.2%         | 
|TERMINAL (d)       |     0/31 (0%)    1/38 (3%)    1/34 (3%)    0/31 (0%)   |3/38 (8%)    1/35 (3%)    1/32 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      699          ---         |729 (T)      729 (T)      659          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.606N     P=0.541      P=0.253      (e)         |P=0.399N     P=0.335N     P=0.567N     P=0.368N     | 
|POLY 3             |     P=0.575N     P=0.517      P=0.245      (e)         |P=0.353N     P=0.309N     P=0.514N     P=0.312N     | 
|POLY 1.5           |     P=0.573N     P=0.511      P=0.243      (e)         |P=0.351N     P=0.308N     P=0.507N     P=0.310N     | 
|POLY 6             |     P=0.580N     P=0.523      P=0.247      (e)         |P=0.357N     P=0.310N     P=0.525N     P=0.315N     | 
|LOGISTIC REGRESSION|     P=0.591N     P=0.541      P=0.245      (e)         |P=0.361N     P=0.335N     P=0.523N     P=0.368N     | 
|COCH-ARM / FISHERS |     P=0.579N     P=0.500      P=0.247      (e)         |P=0.347N     P=0.309N     P=0.500N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.331      (e)          (e)          (e)         |P=0.226N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 21      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    2/50 (4%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/42.29      4/45.99      0/43.74      2/43.55     |1/46.22      2/45.44      2/44.76      1/45.49      | 
|POLY-3 PERCENT (g) |     9.5%         8.7%         0.0%         4.6%        |2.2%         4.4%         4.5%         2.2%         | 
|TERMINAL (d)       |     4/31 (13%)   4/38 (11%)   0/34 (0%)    2/31 (7%)   |0/38 (0%)    2/35 (6%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |653          729 (T)      617          629          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.146N     P=0.528N     P=0.051N     P=0.335N    |P=0.531N     P=0.481      P=0.473      P=0.755N     | 
|POLY 3             |     P=0.127N     P=0.597N     P=0.056N     P=0.323N    |P=0.516N     P=0.494      P=0.489      P=0.757      | 
|POLY 1.5           |     P=0.125N     P=0.613N     P=0.057N     P=0.325N    |P=0.514N     P=0.496      P=0.494      P=0.758      | 
|POLY 6             |     P=0.130N     P=0.578N     P=0.055N     P=0.325N    |P=0.521N     P=0.491      P=0.479      P=0.755      | 
|LOGISTIC REGRESSION|     P=0.146N     P=0.528N     (e)          P=0.335N    |P=0.497N     P=0.499      P=0.521      P=0.737N     | 
|COCH-ARM / FISHERS |     P=0.126N     P=0.643N     P=0.059N     P=0.339N    |P=0.510N     P=0.500      P=0.500      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.118N     (e)          (e)          (e)         |P=0.536      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   2/50 (4%)    2/50 (4%)   |4/50 (8%)    3/50 (6%)    4/50 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     4/42.29      5/45.99      2/43.85      2/43.55     |4/46.22      3/45.44      4/45.02      2/45.49      | 
|POLY-3 PERCENT (g) |     9.5%         10.9%        4.6%         4.6%        |8.7%         6.6%         8.9%         4.4%         | 
|TERMINAL (d)       |     4/31 (13%)   5/38 (13%)   1/34 (3%)    2/31 (7%)   |3/38 (8%)    3/35 (9%)    1/32 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      699          729 (T)     |653          729 (T)      617          629          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.165N     P=0.628      P=0.301N     P=0.335N    |P=0.379N     P=0.538N     P=0.574      P=0.389N     | 
|POLY 3             |     P=0.138N     P=0.552      P=0.320N     P=0.323N    |P=0.331N     P=0.509N     P=0.629      P=0.345N     | 
|POLY 1.5           |     P=0.136N     P=0.534      P=0.325N     P=0.325N    |P=0.330N     P=0.506N     P=0.636      P=0.343N     | 
|POLY 6             |     P=0.143N     P=0.573      P=0.316N     P=0.325N    |P=0.335N     P=0.514N     P=0.617      P=0.349N     | 
|LOGISTIC REGRESSION|     P=0.162N     P=0.628      P=0.315N     P=0.335N    |P=0.326N     P=0.507N     P=0.638N     P=0.336N     | 
|COCH-ARM / FISHERS |     P=0.137N     P=0.500      P=0.339N     P=0.339N    |P=0.325N     P=0.500N     P=0.643N     P=0.339N     | 
|ORDER RESTRICTED   |     P=0.259N     (e)          (e)          (e)         |P=0.341N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 22      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    5/50 (10%)   3/50 (6%)    2/50 (4%)   |27/50 (54%)  24/50 (48%)  17/50 (34%)  14/50 (28%)  | 
|POLY-3 RATE (b)    |     0/42.29      5/45.99      3/45.77      2/43.55     |27/46.69     24/46.42     17/45.30     14/46.14     | 
|POLY-3 PERCENT (g) |     0.0%         10.9%        6.6%         4.6%        |57.8%        51.7%        37.5%        30.3%        | 
|TERMINAL (d)       |     0/31 (0%)    5/38 (13%)   0/34 (0%)    2/31 (7%)   |25/38 (66%)  21/35 (60%)  12/32 (38%)  11/32 (34%)  | 
|FIRST INCIDENCE    |     ---          729 (T)      367          729 (T)     |474          490          618          430          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.572N     P=0.053      P=0.127      P=0.238     |P=0.015N*    P=0.496N     P=0.133N     P=0.034N*    | 
|POLY 3             |     P=0.518N     P=0.038 *    P=0.133      P=0.244     |P=0.002N**   P=0.348N     P=0.036N*    P=0.005N**   | 
|POLY 1.5           |     P=0.522N     P=0.035 *    P=0.129      P=0.243     |P=0.002N**   P=0.351N     P=0.035N*    P=0.006N**   | 
|POLY 6             |     P=0.520N     P=0.041 *    P=0.137      P=0.242     |P=0.002N**   P=0.341N     P=0.040N*    P=0.005N**   | 
|LOGISTIC REGRESSION|     P=0.562N     P=0.053      P=0.034 *    P=0.238     |P=0.003N**   P=0.360N     P=0.050N     P=0.008N**   | 
|COCH-ARM / FISHERS |     P=0.540N     P=0.028 *    P=0.121      P=0.247     |P=0.003N**   P=0.345N     P=0.035N*    P=0.007N**   | 
|ORDER RESTRICTED   |     P=0.108      (e)          (e)          (e)         |P=0.003N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     25/50 (50%)  38/50 (76%)  42/50 (84%)  46/50 (92%) |29/50 (58%)  33/50 (66%)  41/50 (82%)  38/50 (76%)  | 
|POLY-3 RATE (b)    |     25/44.13     38/47.73     42/46.46     46/48.58    |29/47.59     33/47.80     41/47.98     38/46.23     | 
|POLY-3 PERCENT (g) |     56.7%        79.6%        90.4%        94.7%       |60.9%        69.0%        85.5%        82.2%        | 
|TERMINAL (d)       |     19/31 (61%)  31/38 (82%)  32/34 (94%)  31/31 (100%)|23/38 (61%)  25/35 (71%)  28/32 (88%)  30/32 (94%)  | 
|FIRST INCIDENCE    |     482          573          573          469         |563          487          553          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.118      P=0.005 **   P<0.001 **  |P=0.005 **   P=0.178      P=0.003 **   P=0.006 **   | 
|POLY 3             |     P<0.001 **   P=0.012 *    P<0.001 **   P<0.001 **  |P=0.005 **   P=0.267      P=0.004 **   P=0.015 *    | 
|POLY 1.5           |     P<0.001 **   P=0.008 **   P<0.001 **   P<0.001 **  |P=0.008 **   P=0.266      P=0.005 **   P=0.022 *    | 
|POLY 6             |     P<0.001 **   P=0.018 *    P<0.001 **   P<0.001 **  |P=0.002 **   P=0.264      P=0.004 **   P=0.009 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.019 *    P<0.001 **   P<0.001 **  |P=0.014 *    P=0.251      P=0.005 **   P=0.028 *    | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **  |P=0.022 *    P=0.268      P=0.008 **   P=0.044 *    | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.005 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 23      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/50 (46%)  28/50 (56%)  32/50 (64%)  43/50 (86%) |36/50 (72%)  37/50 (74%)  34/50 (68%)  32/50 (64%)  | 
|POLY-3 RATE (b)    |     23/45.18     28/47.09     32/49.55     43/49.30    |36/48.25     37/48.14     34/48.06     32/48.45     | 
|POLY-3 PERCENT (g) |     50.9%        59.5%        64.6%        87.2%       |74.6%        76.9%        70.8%        66.0%        | 
|TERMINAL (d)       |     12/31 (39%)  22/38 (58%)  17/34 (50%)  25/31 (81%) |29/38 (76%)  27/35 (77%)  19/32 (59%)  18/32 (56%)  | 
|FIRST INCIDENCE    |     451          596          367          469         |474          383          573          430          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.538      P=0.162      P=0.002 **  |P=0.481N     P=0.324      P=0.376      P=0.539      | 
|POLY 3             |     P<0.001 **   P=0.267      P=0.125      P<0.001 **  |P=0.124N     P=0.491      P=0.421N     P=0.240N     | 
|POLY 1.5           |     P<0.001 **   P=0.250      P=0.096      P<0.001 **  |P=0.139N     P=0.495      P=0.422N     P=0.256N     | 
|POLY 6             |     P<0.001 **   P=0.274      P=0.156      P<0.001 **  |P=0.106N     P=0.484      P=0.410N     P=0.220N     | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.305      P=0.051      P<0.001 **  |P=0.155N     P=0.482      P=0.443N     P=0.271N     | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.212      P=0.054      P<0.001 **  |P=0.147N     P=0.500      P=0.414N     P=0.260N     | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.221N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     37/50 (74%)  44/50 (88%)  49/50 (98%)  50/50 (100%)|42/50 (84%)  43/50 (86%)  46/50 (92%)  48/50 (96%)  | 
|POLY-3 RATE (b)    |     37/46.78     44/48.04     49/50.00     50/50.00    |42/49.36     43/48.89     46/48.62     48/49.06     | 
|POLY-3 PERCENT (g) |     79.1%        91.6%        98.0%        100.0%      |85.1%        88.0%        94.6%        97.9%        | 
|TERMINAL (d)       |     23/31 (74%)  35/38 (92%)  33/34 (97%)  31/31 (100%)|31/38 (82%)  31/35 (89%)  30/32 (94%)  31/32 (97%)  | 
|FIRST INCIDENCE    |     451          573          367          469         |474          383          553          430          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.004 **   P=0.550N     P=0.094      P=0.031 *   |P=0.019 *    P=0.308      P=0.059      P=0.033 *    | 
|POLY 3             |     P<0.001 **   P=0.067      P=0.002 **   P<0.001 **  |P=0.008 **   P=0.452      P=0.103      P=0.025 *    | 
|POLY 1.5           |     P<0.001 **   P=0.065      P<0.001 **   P<0.001 **  |P=0.009 **   P=0.477      P=0.126      P=0.025 *    | 
|POLY 6             |     P<0.001 **   P=0.066      P=0.004 **   P<0.001 **  |P=0.010 *    P=0.406      P=0.089      P=0.028 *    | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.140      P<0.001 **   P<0.001 **  |P=0.015 *    P=0.492      P=0.151      P=0.035 *    | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.062      P<0.001 **   P<0.001 **  |P=0.022 *    P=0.500      P=0.178      P=0.046 *    | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.012 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.