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TDMS Study 96017-06 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  DATE: 05/19/04       
EXPERIMENT: 96017 TEST: 06                                                                                     TIME: 09:30:16       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96017       
PATHOLOGIST: HEATH, JAMES                                                                                      CAS: 631-64-1        
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                                                            FINAL#1 MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                  DATE: 05/19/04       
EXPERIMENT: 96017 TEST: 06                                                                                     TIME: 09:30:16       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96017       
PATHOLOGIST: HEATH, JAMES                                                                                      CAS: 631-64-1        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF   WATER DISINFECTION BYPRODUCTS (DIBROMOAC                                                                       
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex: Capsule                Hyperplasia                                                                                  
Bone Marrow                            Hyperplasia                                                                                  
Eye                                    Cataract                                                                                     
Harderian Gland                        Hyperplasia Focal                                                                            
Islets, Pancreatic                     Hyperplasia                                                                                  
Kidney                                 Nephropathy                                                                                  
Kidney: Renal Tubule                   Pigmentation                                                                                 
Liver                                  Clear Cell Focus                                                                             
Lung                                   Hemorrhage                                                                                   
                                       Hyperplasia Lymphoid                                                                         
Lymph Node, Mandibular                 Hyperplasia Lymphoid                                                                         
                                       Pigmentation                                                                                 
Lymph Node, Mesenteric                 Atrophy                                                                                      
Parathyroid Gland                      Cyst                                                                                         
Preputial Gland                        Cyst                                                                                         
Seminal Vesicle                        Degeneration                                                                                 
Spleen                                 Hematopoietic Cell Proliferation                                                             
Stomach, Forestomach                   Inflammation Chronic                                                                         
Thyroid Gland: Follicular Cell         Hyperplasia                                                                                  
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Liver                                  Hepatodiaphragmatic Nodule                                                                   
Liver: Centrilobular                   Necrosis                                                                                     
Lymph Node, Mesenteric                 Hemorrhage                                                                                   
Ovary                                  Cyst                                                                                         
Pancreas                               Atrophy                                                                                      
                                       Cyst                                                                                         
Spleen                                 Hematopoietic Cell Proliferation                                                             
Thyroid Gland                          Degeneration Cystic                                                                          
Thyroid Gland: Follicular Cell         Hyperplasia                                                                                  
Urinary Bladder                        Edema                                                                                        
===============================================================                                                                     
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/49 (14%)   5/50 (10%)   4/50 (8%)    6/50 (12%)  |9/50 (18%)   11/50 (22%)  6/50 (12%)   9/49 (18%)   | 
|POLY-3 RATE (b)    |     7/42.70      5/45.99      4/43.74      6/43.93     |9/46.04      11/45.88     6/44.64      9/45.17      | 
|POLY-3 PERCENT (g) |     16.4%        10.9%        9.2%         13.7%       |19.6%        24.0%        13.4%        19.9%        | 
|TERMINAL (d)       |     6/31 (19%)   5/38 (13%)   4/34 (12%)   5/31 (16%)  |7/38 (18%)   10/35 (29%)  5/32 (16%)   7/32 (22%)   | 
|FIRST INCIDENCE    |     601          729 (T)      729 (T)      623         |710          601          634          715          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.552      P=0.252N     P=0.212N     P=0.496N    |P=0.503N     P=0.331      P=0.415N     P=0.452      | 
|POLY 3             |     P=0.505N     P=0.327N     P=0.246N     P=0.478N    |P=0.385N     P=0.397      P=0.309N     P=0.586      | 
|POLY 1.5           |     P=0.494N     P=0.343N     P=0.247N     P=0.478N    |P=0.381N     P=0.397      P=0.299N     P=0.586      | 
|POLY 6             |     P=0.523N     P=0.310N     P=0.246N     P=0.483N    |P=0.399N     P=0.397      P=0.328N     P=0.578      | 
|LOGISTIC REGRESSION|     P=0.525N     P=0.301N     P=0.237N     P=0.479N    |P=0.402N     P=0.386      P=0.346N     P=0.529      | 
|COCH-ARM / FISHERS |     P=0.485N     P=0.365N     P=0.251N     P=0.484N    |P=0.381N     P=0.402      P=0.288N     P=0.584      | 
|ORDER RESTRICTED   |     P=0.374N     (e)          (e)          (e)         |P=0.427N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    7/50 (14%)   5/50 (10%)   1/50 (2%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     4/42.54      7/46.02      5/43.74      1/43.55     |0/45.94      2/45.70      0/44.30      1/45.07      | 
|POLY-3 PERCENT (g) |     9.4%         15.2%        11.4%        2.3%        |0.0%         4.4%         0.0%         2.2%         | 
|TERMINAL (d)       |     3/31 (10%)   6/38 (16%)   5/34 (15%)   1/31 (3%)   |0/38 (0%)    1/35 (3%)    0/32 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     655          721          729 (T)      729 (T)     |---          659          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.076N     P=0.387      P=0.550      P=0.179N    |P=0.632N     P=0.236      (e)          P=0.466      | 
|POLY 3             |     P=0.058N     P=0.307      P=0.517      P=0.171N    |P=0.617N     P=0.236      (e)          P=0.496      | 
|POLY 1.5           |     P=0.056N     P=0.293      P=0.516      P=0.171N    |P=0.615N     P=0.236      (e)          P=0.496      | 
|POLY 6             |     P=0.063N     P=0.324      P=0.517      P=0.174N    |P=0.622N     P=0.236      (e)          P=0.494      | 
|LOGISTIC REGRESSION|     P=0.070N     P=0.338      P=0.526      P=0.171N    |P=0.611N     P=0.239      (e)          P=0.466      | 
|COCH-ARM / FISHERS |     P=0.057N     P=0.274      P=0.513      P=0.175N    |P=0.612N     P=0.247      (e)          P=0.495      | 
|ORDER RESTRICTED   |     P=0.086N     (e)          (e)          (e)         |P=0.321      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/49 (24%)  11/50 (22%)  13/50 (26%)  6/50 (12%)  |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     12/42.26     11/46.48     13/43.88     6/43.55     |0/45.94      1/45.44      0/44.30      0/45.07      | 
|POLY-3 PERCENT (g) |     28.4%        23.7%        29.6%        13.8%       |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     12/31 (39%)  10/38 (26%)  12/34 (35%)  6/31 (19%)  |0/38 (0%)    1/35 (3%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      582          691          729 (T)     |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.139N     P=0.286N     P=0.585N     P=0.083N    |P=0.437N     P=0.484      (e)          (e)          | 
|POLY 3             |     P=0.106N     P=0.396N     P=0.545      P=0.078N    |P=0.422N     P=0.498      (e)          (e)          | 
|POLY 1.5           |     P=0.098N     P=0.431N     P=0.535      P=0.081N    |P=0.420N     P=0.498      (e)          (e)          | 
|POLY 6             |     P=0.121N     P=0.354N     P=0.555      P=0.078N    |P=0.426N     P=0.497      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.130N     P=0.353N     P=0.565      P=0.083N    |(e)          P=0.484      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.094N     P=0.478N     P=0.523      P=0.088N    |P=0.417N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.086N     (e)          (e)          (e)         |P=0.382N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex: Capsule                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/49 (14%)   4/50 (8%)    1/50 (2%)    5/50 (10%)  |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     7/43.02      4/45.99      1/43.74      5/43.55     |0/45.94      1/45.44      0/44.30      1/45.07      | 
|POLY-3 PERCENT (g) |     16.3%        8.7%         2.3%         11.5%       |0.0%         2.2%         0.0%         2.2%         | 
|TERMINAL (d)       |     6/31 (19%)   4/38 (11%)   1/34 (3%)    5/31 (16%)  |0/38 (0%)    1/35 (3%)    0/32 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     458          729 (T)      729 (T)      729 (T)     |---          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.397N     P=0.163N     P=0.024N*    P=0.373N    |P=0.448      P=0.484      (e)          P=0.466      | 
|POLY 3             |     P=0.357N     P=0.223N     P=0.028N*    P=0.369N    |P=0.477      P=0.498      (e)          P=0.496      | 
|POLY 1.5           |     P=0.347N     P=0.235N     P=0.028N*    P=0.366N    |P=0.478      P=0.498      (e)          P=0.496      | 
|POLY 6             |     P=0.372N     P=0.208N     P=0.027N*    P=0.377N    |P=0.474      P=0.497      (e)          P=0.494      | 
|LOGISTIC REGRESSION|     P=0.357N     P=0.229N     P=0.030N*    P=0.359N    |(e)          P=0.484      (e)          P=0.466      | 
|COCH-ARM / FISHERS |     P=0.337N     P=0.251N     P=0.028N*    P=0.365N    |P=0.478      P=0.500      (e)          P=0.495      | 
|ORDER RESTRICTED   |     P=0.106N     (e)          (e)          (e)         |P=0.247      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     1/42.26      1/45.99      0/43.74      1/43.55     |0/45.94      2/45.44      1/44.30      1/45.07      | 
|POLY-3 PERCENT (g) |     2.4%         2.2%         0.0%         2.3%        |0.0%         4.4%         2.3%         2.2%         | 
|TERMINAL (d)       |     1/31 (3%)    1/38 (3%)    0/34 (0%)    1/31 (3%)   |0/38 (0%)    2/35 (6%)    1/32 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.606N     P=0.716N     P=0.482N     P=0.762     |P=0.551      P=0.220      P=0.466      P=0.466      | 
|POLY 3             |     P=0.578N     P=0.742N     P=0.493N     P=0.754N    |P=0.593      P=0.235      P=0.493      P=0.496      | 
|POLY 1.5           |     P=0.576N     P=0.748N     P=0.494N     P=0.754N    |P=0.593      P=0.235      P=0.496      P=0.496      | 
|POLY 6             |     P=0.581N     P=0.734N     P=0.492N     P=0.756N    |P=0.588      P=0.234      P=0.487      P=0.494      | 
|LOGISTIC REGRESSION|     P=0.606N     P=0.716N     (e)          P=0.762     |(e)          P=0.220      P=0.466      P=0.466      | 
|COCH-ARM / FISHERS |     P=0.575N     P=0.747N     P=0.495N     P=0.747N    |P=0.593      P=0.247      P=0.500      P=0.495      | 
|ORDER RESTRICTED   |     P=0.525N     (e)          (e)          (e)         |P=0.267      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Myelofibrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/42.26      0/45.99      0/43.74      0/43.55     |1/45.94      2/45.70      1/44.41      2/45.59      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         4.4%         2.3%         4.4%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |1/38 (3%)    1/35 (3%)    0/32 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      659          701          593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.458      P=0.486      P=0.724      P=0.468      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.485      P=0.498      P=0.753      P=0.497      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.487      P=0.498      P=0.757      P=0.498      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.482      P=0.499      P=0.747      P=0.496      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.495      P=0.499      P=0.752      P=0.510      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.490      P=0.500      P=0.753N     P=0.500      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.440      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/47 (47%)  22/50 (44%)  28/50 (56%)  32/50 (64%) |20/50 (40%)  26/50 (52%)  24/50 (48%)  20/50 (40%)  | 
|POLY-3 RATE (b)    |     22/44.87     22/48.70     28/49.55     32/48.17    |20/47.88     26/48.05     24/49.09     20/48.79     | 
|POLY-3 PERCENT (g) |     49.0%        45.2%        56.5%        66.4%       |41.8%        54.1%        48.9%        41.0%        | 
|TERMINAL (d)       |     12/31 (39%)  14/38 (37%)  13/34 (38%)  18/31 (58%) |12/38 (32%)  16/35 (46%)  8/32 (25%)   5/32 (16%)   | 
|FIRST INCIDENCE    |     435          297          367          469         |555          383          479          430          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.016 *    P=0.326N     P=0.288      P=0.081     |P=0.503N     P=0.139      P=0.181      P=0.439      | 
|POLY 3             |     P=0.016 *    P=0.434N     P=0.301      P=0.064     |P=0.280N     P=0.156      P=0.309      P=0.551N     | 
|POLY 1.5           |     P=0.017 *    P=0.447N     P=0.277      P=0.065     |P=0.302N     P=0.157      P=0.296      P=0.568N     | 
|POLY 6             |     P=0.016 *    P=0.422N     P=0.330      P=0.062     |P=0.254N     P=0.152      P=0.322      P=0.530N     | 
|LOGISTIC REGRESSION|     P=0.023 *    P=0.549N     P=0.231      P=0.064     |P=0.291N     P=0.162      P=0.331      P=0.555N     | 
|COCH-ARM / FISHERS |     P=0.018 *    P=0.471N     P=0.241      P=0.067     |P=0.320N     P=0.158      P=0.273      P=0.581N     | 
|ORDER RESTRICTED   |     P=0.042 *    (e)          (e)          (e)         |P=0.376N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/49 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.26      0/45.99      0/43.74      0/43.55     |0/45.94      2/44.62      0/44.30      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          721          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.252N     P=0.228      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.229N     P=0.231      (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.227N     P=0.231      (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.232N     P=0.230      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.235N     P=0.230      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.226N     P=0.242      (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.245N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Atypia Cellular                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/49 (10%)   4/50 (8%)    2/50 (4%)    6/50 (12%)  |                                                    | 
|POLY-3 RATE (b)    |     5/43.07      4/46.30      2/44.19      6/44.20     |                                                    | 
|POLY-3 PERCENT (g) |     11.6%        8.6%         4.5%         13.6%       |                                                    | 
|TERMINAL (d)       |     3/31 (10%)   2/38 (5%)    1/34 (3%)    4/31 (13%)  |                                                    | 
|FIRST INCIDENCE    |     596          659          596          563         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.363      P=0.396N     P=0.198N     P=0.502     |                                                    | 
|POLY 3             |     P=0.402      P=0.455N     P=0.205N     P=0.518     |                                                    | 
|POLY 1.5           |     P=0.411      P=0.469N     P=0.206N     P=0.519     |                                                    | 
|POLY 6             |     P=0.387      P=0.439N     P=0.205N     P=0.511     |                                                    | 
|LOGISTIC REGRESSION|     P=0.418      P=0.487N     P=0.211N     P=0.516     |                                                    | 
|COCH-ARM / FISHERS |     P=0.418      P=0.487N     P=0.210N     P=0.514     |                                                    | 
|ORDER RESTRICTED   |     P=0.318      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Granuloma Sperm                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    2/50 (4%)    2/50 (4%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     1/42.26      2/46.25      2/44.19      2/43.55     |                                                    | 
|POLY-3 PERCENT (g) |     2.4%         4.3%         4.5%         4.6%        |                                                    | 
|TERMINAL (d)       |     1/31 (3%)    1/38 (3%)    1/34 (3%)    2/31 (7%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      659          596          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.416      P=0.566      P=0.524      P=0.500     |                                                    | 
|POLY 3             |     P=0.445      P=0.531      P=0.516      P=0.510     |                                                    | 
|POLY 1.5           |     P=0.451      P=0.521      P=0.512      P=0.510     |                                                    | 
|POLY 6             |     P=0.435      P=0.544      P=0.520      P=0.508     |                                                    | 
|LOGISTIC REGRESSION|     P=0.449      P=0.521      P=0.507      P=0.500     |                                                    | 
|COCH-ARM / FISHERS |     P=0.453      P=0.508      P=0.508      P=0.508     |                                                    | 
|ORDER RESTRICTED   |     P=0.477      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    1/50 (2%)    6/50 (12%)  |0/50 (0%)    0/50 (0%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/42.26      1/45.99      1/43.74      6/43.55     |0/45.94      0/45.44      2/44.32      2/45.85      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         2.3%         13.8%       |0.0%         0.0%         4.5%         4.4%         | 
|TERMINAL (d)       |     0/31 (0%)    1/38 (3%)    1/34 (3%)    6/31 (19%)  |0/38 (0%)    0/35 (0%)    1/32 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      729 (T)     |---          ---          724          593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.541      P=0.518      P=0.017 *   |P=0.062      (e)          P=0.206      P=0.252      | 
|POLY 3             |     P=0.002 **   P=0.517      P=0.507      P=0.016 *   |P=0.067      (e)          P=0.229      P=0.237      | 
|POLY 1.5           |     P=0.002 **   P=0.511      P=0.506      P=0.017 *   |P=0.066      (e)          P=0.233      P=0.236      | 
|POLY 6             |     P=0.002 **   P=0.523      P=0.508      P=0.016 *   |P=0.067      (e)          P=0.223      P=0.237      | 
|LOGISTIC REGRESSION|     (e)          P=0.541      P=0.518      P=0.017 *   |P=0.070      (e)          P=0.207      P=0.272      | 
|COCH-ARM / FISHERS |     P=0.002 **   P=0.505      P=0.505      P=0.014 *   |P=0.067      (e)          P=0.247      P=0.247      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.109      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |2/50 (4%)    2/50 (4%)    3/50 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/42.26      0/45.99      2/43.74      2/43.55     |2/45.94      2/46.28      3/44.34      3/45.70      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.6%         4.6%        |4.4%         4.3%         6.8%         6.6%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    2/34 (6%)    2/31 (7%)   |2/38 (5%)    0/35 (0%)    2/32 (6%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |729 (T)      487          718          593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.054      (e)          P=0.259      P=0.238     |P=0.305      P=0.677      P=0.423      P=0.451      | 
|POLY 3             |     P=0.064      (e)          P=0.245      P=0.244     |P=0.345      P=0.691N     P=0.484      P=0.498      | 
|POLY 1.5           |     P=0.066      (e)          P=0.244      P=0.244     |P=0.347      P=0.693N     P=0.492      P=0.497      | 
|POLY 6             |     P=0.060      (e)          P=0.245      P=0.242     |P=0.341      P=0.690N     P=0.471      P=0.497      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.259      P=0.238     |P=0.362      P=0.673N     P=0.436      P=0.503      | 
|COCH-ARM / FISHERS |     P=0.068      (e)          P=0.253      P=0.253     |P=0.351      P=0.691N     P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.121      (e)          (e)          (e)         |P=0.494      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Cornea                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    4/50 (8%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.26      0/45.99      1/43.74      1/43.55     |1/45.94      0/45.44      4/44.34      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         2.3%        |2.2%         0.0%         9.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    1/34 (3%)    1/31 (3%)   |1/38 (3%)    0/35 (0%)    3/32 (9%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |729 (T)      ---          718          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.183      (e)          P=0.518      P=0.500     |P=0.532      P=0.516N     P=0.134      P=0.534N     | 
|POLY 3             |     P=0.199      (e)          P=0.507      P=0.506     |P=0.579      P=0.502N     P=0.168      P=0.504N     | 
|POLY 1.5           |     P=0.202      (e)          P=0.506      P=0.506     |P=0.580      P=0.502N     P=0.173      P=0.503N     | 
|POLY 6             |     P=0.192      (e)          P=0.508      P=0.505     |P=0.575      P=0.503N     P=0.159      P=0.506N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.518      P=0.500     |P=0.549      (e)          P=0.138      (e)          | 
|COCH-ARM / FISHERS |     P=0.203      (e)          P=0.505      P=0.505     |P=0.583      P=0.500N     P=0.181      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.257      (e)          (e)          (e)         |P=0.216N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/49 (10%)   1/50 (2%)    1/50 (2%)    1/50 (2%)   |2/49 (4%)    4/50 (8%)    4/50 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     5/42.72      1/45.99      1/43.74      1/43.55     |2/46.68      4/45.44      4/44.55      2/45.13      | 
|POLY-3 PERCENT (g) |     11.7%        2.2%         2.3%         2.3%        |4.3%         8.8%         9.0%         4.4%         | 
|TERMINAL (d)       |     3/31 (10%)   1/38 (3%)    1/34 (3%)    1/31 (3%)   |0/38 (0%)    4/35 (11%)   2/32 (6%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     631          729 (T)      729 (T)      729 (T)     |555          729 (T)      668          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.143N     P=0.072N     P=0.093N     P=0.109N    |P=0.505N     P=0.313      P=0.299      P=0.663      | 
|POLY 3             |     P=0.130N     P=0.085N     P=0.095N     P=0.096N    |P=0.463N     P=0.325      P=0.316      P=0.682      | 
|POLY 1.5           |     P=0.124N     P=0.090N     P=0.096N     P=0.096N    |P=0.452N     P=0.333      P=0.329      P=0.689      | 
|POLY 6             |     P=0.138N     P=0.080N     P=0.096N     P=0.099N    |P=0.479N     P=0.316      P=0.297      P=0.672      | 
|LOGISTIC REGRESSION|     P=0.126N     P=0.087N     P=0.095N     P=0.096N    |P=0.430N     P=0.380      P=0.400      P=0.630N     | 
|COCH-ARM / FISHERS |     P=0.120N     P=0.098N     P=0.098N     P=0.098N    |P=0.435N     P=0.349      P=0.349      P=0.684N     | 
|ORDER RESTRICTED   |     P=0.024N*    (e)          (e)          (e)         |P=0.433      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/49 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/43.02      0/45.99      0/43.74      0/43.55     |0/45.94      1/44.57      0/44.30      2/46.07      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         0.0%        |0.0%         2.2%         0.0%         4.3%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    1/35 (3%)    0/32 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     458          ---          ---          ---         |---          729 (T)      ---          279          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.361N     P=0.492N     P=0.496N     P=0.488N    |P=0.161      P=0.484      (e)          P=0.221      | 
|POLY 3             |     P=0.373N     P=0.487N     P=0.497N     P=0.498N    |P=0.180      P=0.494      (e)          P=0.238      | 
|POLY 1.5           |     P=0.370N     P=0.491N     P=0.496N     P=0.496N    |P=0.181      P=0.494      (e)          P=0.238      | 
|POLY 6             |     P=0.377N     P=0.481N     P=0.497N     P=0.500N    |P=0.178      P=0.494      (e)          P=0.236      | 
|LOGISTIC REGRESSION|     P=0.432N     P=0.456N     P=0.453N     P=0.759N    |P=0.244      P=0.484      (e)          P=0.365      | 
|COCH-ARM / FISHERS |     P=0.365N     P=0.495N     P=0.495N     P=0.495N    |P=0.181      P=0.495      (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.118N     (e)          (e)          (e)         |P=0.075      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    1/49 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/43.50      0/45.99      2/45.40      1/43.84     |0/45.94      1/44.60      1/44.61      2/45.63      | 
|POLY-3 PERCENT (g) |     6.9%         0.0%         4.4%         2.3%        |0.0%         2.2%         2.2%         4.4%         | 
|TERMINAL (d)       |     1/31 (3%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     435          ---          367          652         |---          721          643          596          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.474N     P=0.110N     P=0.490N     P=0.300N    |P=0.167      P=0.489      P=0.486      P=0.233      | 
|POLY 3             |     P=0.482N     P=0.109N     P=0.481N     P=0.302N    |P=0.176      P=0.494      P=0.494      P=0.236      | 
|POLY 1.5           |     P=0.474N     P=0.112N     P=0.483N     P=0.300N    |P=0.176      P=0.494      P=0.497      P=0.236      | 
|POLY 6             |     P=0.495N     P=0.105N     P=0.480N     P=0.307N    |P=0.174      P=0.494      P=0.489      P=0.235      | 
|LOGISTIC REGRESSION|     P=0.525N     P=0.131N     P=0.551N     P=0.344N    |P=0.187      P=0.494      P=0.514      P=0.255      | 
|COCH-ARM / FISHERS |     P=0.465N     P=0.117N     P=0.490N     P=0.301N    |P=0.176      P=0.495      P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     P=0.178N     (e)          (e)          (e)         |P=0.116      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum                                                                                                           | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/43 (5%)    2/49 (4%)    3/48 (6%)    1/46 (2%)   |2/47 (4%)    1/46 (2%)    0/49 (0%)    3/46 (7%)    | 
|POLY-3 RATE (b)    |     2/38.04      2/45.31      3/42.49      1/41.04     |2/44.69      1/42.14      0/43.36      3/43.16      | 
|POLY-3 PERCENT (g) |     5.3%         4.4%         7.1%         2.4%        |4.5%         2.4%         0.0%         7.0%         | 
|TERMINAL (d)       |     2/31 (7%)    1/38 (3%)    3/34 (9%)    1/31 (3%)   |2/38 (5%)    1/35 (3%)    0/32 (0%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      684          729 (T)      729 (T)     |729 (T)      729 (T)      ---          596          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.450N     P=0.621N     P=0.542      P=0.500N    |P=0.272      P=0.529N     P=0.277N     P=0.442      | 
|POLY 3             |     P=0.414N     P=0.630N     P=0.550      P=0.473N    |P=0.308      P=0.521N     P=0.244N     P=0.484      | 
|POLY 1.5           |     P=0.409N     P=0.636N     P=0.551      P=0.473N    |P=0.310      P=0.516N     P=0.237N     P=0.487      | 
|POLY 6             |     P=0.427N     P=0.623N     P=0.547      P=0.478N    |P=0.303      P=0.524N     P=0.254N     P=0.480      | 
|LOGISTIC REGRESSION|     P=0.433N     P=0.630N     P=0.542      P=0.500N    |P=0.310      P=0.529N     (e)          P=0.503      | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.641N     P=0.553      P=0.474N    |P=0.311      P=0.508N     P=0.237N     P=0.490      | 
|ORDER RESTRICTED   |     P=0.419N     (e)          (e)          (e)         |P=0.179      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Jejunum                                                                                                         | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/44 (0%)    0/49 (0%)    2/46 (4%)    2/45 (4%)   |0/46 (0%)    2/47 (4%)    0/49 (0%)    2/43 (5%)    | 
|POLY-3 RATE (b)    |     0/38.51      0/45.14      2/40.63      2/39.97     |0/43.63      2/43.12      0/43.86      2/39.98      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.9%         5.0%        |0.0%         4.6%         0.0%         5.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    2/34 (6%)    1/31 (3%)   |0/38 (0%)    2/35 (6%)    0/32 (0%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      694         |---          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.055      (e)          P=0.259      P=0.237     |P=0.308      P=0.220      (e)          P=0.201      | 
|POLY 3             |     P=0.060      (e)          P=0.249      P=0.245     |P=0.322      P=0.234      (e)          P=0.218      | 
|POLY 1.5           |     P=0.062      (e)          P=0.249      P=0.245     |P=0.326      P=0.237      (e)          P=0.219      | 
|POLY 6             |     P=0.058      (e)          P=0.247      P=0.244     |P=0.315      P=0.232      (e)          P=0.215      | 
|LOGISTIC REGRESSION|     P=0.057      (e)          P=0.259      P=0.244     |(e)          P=0.220      (e)          P=0.201      | 
|COCH-ARM / FISHERS |     P=0.062      (e)          P=0.258      P=0.253     |P=0.332      P=0.253      (e)          P=0.231      | 
|ORDER RESTRICTED   |     P=0.122      (e)          (e)          (e)         |P=0.102      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     34/46 (74%)  32/50 (64%)  26/50 (52%)  13/49 (27%) |2/49 (4%)    5/49 (10%)   3/49 (6%)    3/46 (7%)    | 
|POLY-3 RATE (b)    |     34/44.32     32/47.58     26/44.70     13/44.65    |2/45.58      5/45.12      3/44.36      3/42.85      | 
|POLY-3 PERCENT (g) |     76.7%        67.3%        58.2%        29.1%       |4.4%         11.1%        6.8%         7.0%         | 
|TERMINAL (d)       |     24/31 (77%)  27/38 (71%)  22/34 (65%)  8/31 (26%)  |2/38 (5%)    3/35 (9%)    2/32 (6%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     435          573          604          489         |729 (T)      682          634          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001N**   P=0.096N     P=0.039N*    P<0.001N**  |P=0.563N     P=0.196      P=0.434      P=0.421      | 
|POLY 3             |     P<0.001N**   P=0.214N     P=0.042N*    P<0.001N**  |P=0.526N     P=0.212      P=0.488      P=0.472      | 
|POLY 1.5           |     P<0.001N**   P=0.217N     P=0.032N*    P<0.001N**  |P=0.525N     P=0.213      P=0.494      P=0.472      | 
|POLY 6             |     P<0.001N**   P=0.204N     P=0.060N     P<0.001N**  |P=0.532N     P=0.212      P=0.476      P=0.470      | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.176N     P=0.019N*    P<0.001N**  |P=0.525N     P=0.209      P=0.490      P=0.421      | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.205N     P=0.022N*    P<0.001N**  |P=0.525N     P=0.218      P=0.500      P=0.470      | 
|ORDER RESTRICTED   |     P<0.001N**   (e)          (e)          (e)         |P=0.383      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/49 (18%)   13/50 (26%)  14/50 (28%)  11/50 (22%) |0/49 (0%)    1/50 (2%)    0/50 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     9/42.32      13/45.99     14/44.70     11/44.29    |0/45.58      1/45.70      0/44.30      1/45.07      | 
|POLY-3 PERCENT (g) |     21.3%        28.3%        31.3%        24.8%       |0.0%         2.2%         0.0%         2.2%         | 
|TERMINAL (d)       |     8/31 (26%)   13/38 (34%)  12/34 (35%)  6/31 (19%)  |0/38 (0%)    0/35 (0%)    0/32 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     715          729 (T)      573          659         |---          659          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.357      P=0.423      P=0.232      P=0.397     |P=0.467      P=0.509      (e)          P=0.466      | 
|POLY 3             |     P=0.484      P=0.304      P=0.205      P=0.445     |P=0.476      P=0.501      (e)          P=0.498      | 
|POLY 1.5           |     P=0.487      P=0.280      P=0.196      P=0.436     |P=0.479      P=0.502      (e)          P=0.499      | 
|POLY 6             |     P=0.477      P=0.332      P=0.215      P=0.453     |P=0.472      P=0.500      (e)          P=0.495      | 
|LOGISTIC REGRESSION|     P=0.421      P=0.402      P=0.193      P=0.417     |P=0.480      P=0.529      (e)          P=0.466      | 
|COCH-ARM / FISHERS |     P=0.484      P=0.251      P=0.185      P=0.421     |P=0.481      P=0.505      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.374      (e)          (e)          (e)         |P=0.249      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hydronephrosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    2/50 (4%)    0/50 (0%)    4/50 (8%)   |0/49 (0%)    0/50 (0%)    1/50 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     4/42.57      2/46.74      0/43.74      4/44.02     |0/45.58      0/45.44      1/44.30      1/45.25      | 
|POLY-3 PERCENT (g) |     9.4%         4.3%         0.0%         9.1%        |0.0%         0.0%         2.3%         2.2%         | 
|TERMINAL (d)       |     2/31 (7%)    0/38 (0%)    0/34 (0%)    2/31 (7%)   |0/38 (0%)    0/35 (0%)    1/32 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     669          582          ---          623         |---          ---          729 (T)      682          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.468      P=0.274N     P=0.059N     P=0.633     |P=0.187      (e)          P=0.466      P=0.495      | 
|POLY 3             |     P=0.494      P=0.295N     P=0.056N     P=0.625N    |P=0.203      (e)          P=0.494      P=0.499      | 
|POLY 1.5           |     P=0.504      P=0.309N     P=0.057N     P=0.626N    |P=0.202      (e)          P=0.499      P=0.499      | 
|POLY 6             |     P=0.479      P=0.279N     P=0.056N     P=0.628N    |P=0.201      (e)          P=0.487      P=0.496      | 
|LOGISTIC REGRESSION|     P=0.516      P=0.343N     P=0.058N     P=0.629N    |P=0.200      (e)          P=0.466      P=0.503      | 
|COCH-ARM / FISHERS |     P=0.514      P=0.329N     P=0.056N     P=0.631N    |P=0.200      (e)          P=0.505      P=0.500      | 
|ORDER RESTRICTED   |     P=0.256N     (e)          (e)          (e)         |P=0.246      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/49 (10%)   5/50 (10%)   6/50 (12%)   5/50 (10%)  |7/49 (14%)   2/50 (4%)    5/50 (10%)   8/49 (16%)   | 
|POLY-3 RATE (b)    |     5/42.31      5/45.99      6/43.94      5/43.64     |7/45.66      2/45.47      5/44.34      8/45.94      | 
|POLY-3 PERCENT (g) |     11.8%        10.9%        13.7%        11.5%       |15.3%        4.4%         11.3%        17.4%        | 
|TERMINAL (d)       |     4/31 (13%)   5/38 (13%)   4/34 (12%)   4/31 (13%)  |6/38 (16%)   1/35 (3%)    4/32 (13%)   5/32 (16%)   | 
|FIRST INCIDENCE    |     717          729 (T)      691          707         |710          721          718          593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.455      P=0.497N     P=0.557      P=0.622     |P=0.104      P=0.104N     P=0.504N     P=0.392      | 
|POLY 3             |     P=0.522      P=0.577N     P=0.527      P=0.611N    |P=0.154      P=0.079N     P=0.400N     P=0.505      | 
|POLY 1.5           |     P=0.533      P=0.594N     P=0.521      P=0.612N    |P=0.153      P=0.078N     P=0.384N     P=0.504      | 
|POLY 6             |     P=0.504      P=0.557N     P=0.533      P=0.615N    |P=0.152      P=0.081N     P=0.425N     P=0.502      | 
|LOGISTIC REGRESSION|     P=0.475      P=0.518N     P=0.530      P=0.629     |P=0.143      P=0.086N     P=0.475N     P=0.496      | 
|COCH-ARM / FISHERS |     P=0.541      P=0.617N     P=0.514      P=0.617N    |P=0.149      P=0.075N     P=0.365N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.663      (e)          (e)          (e)         |P=0.208      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    7/50 (14%)   4/50 (8%)    5/50 (10%)  |3/49 (6%)    8/50 (16%)   6/50 (12%)   8/49 (16%)   | 
|POLY-3 RATE (b)    |     3/42.26      7/45.99      4/43.74      5/43.79     |3/45.58      8/45.84      6/44.30      8/45.32      | 
|POLY-3 PERCENT (g) |     7.1%         15.2%        9.2%         11.4%       |6.6%         17.5%        13.6%        17.7%        | 
|TERMINAL (d)       |     3/31 (10%)   7/38 (18%)   4/34 (12%)   3/31 (10%)  |3/38 (8%)    7/35 (20%)   6/32 (19%)   6/32 (19%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      691         |729 (T)      615          729 (T)      676          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.495      P=0.249      P=0.551      P=0.355     |P=0.140      P=0.079      P=0.162      P=0.062      | 
|POLY 3             |     P=0.550N     P=0.193      P=0.519      P=0.376     |P=0.206      P=0.100      P=0.227      P=0.096      | 
|POLY 1.5           |     P=0.547N     P=0.182      P=0.516      P=0.374     |P=0.211      P=0.102      P=0.239      P=0.098      | 
|POLY 6             |     P=0.558N     P=0.208      P=0.521      P=0.375     |P=0.196      P=0.098      P=0.210      P=0.092      | 
|LOGISTIC REGRESSION|     P=0.504      P=0.249      P=0.551      P=0.360     |P=0.190      P=0.098      P=0.162      P=0.085      | 
|COCH-ARM / FISHERS |     P=0.548N     P=0.167      P=0.511      P=0.369     |P=0.214      P=0.106      P=0.254      P=0.100      | 
|ORDER RESTRICTED   |     P=0.374      (e)          (e)          (e)         |P=0.094      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/49 (12%)   3/50 (6%)    2/50 (4%)    2/50 (4%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     6/42.59      3/46.51      2/43.74      2/43.66     |0/45.58      0/45.44      0/44.30      0/45.07      | 
|POLY-3 PERCENT (g) |     14.1%        6.5%         4.6%         4.6%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     4/31 (13%)   1/38 (3%)    2/34 (6%)    1/31 (3%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     662          659          729 (T)      702         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.153N     P=0.170N     P=0.116N     P=0.147N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.131N     P=0.200N     P=0.123N     P=0.124N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.125N     P=0.214N     P=0.125N     P=0.124N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.142N     P=0.185N     P=0.123N     P=0.126N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.125N     P=0.215N     P=0.120N     P=0.126N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.119N     P=0.233N     P=0.128N     P=0.128N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.069N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     36/49 (73%)  44/50 (88%)  42/50 (84%)  39/50 (78%) |14/49 (29%)  8/50 (16%)   15/50 (30%)  12/49 (24%)  | 
|POLY-3 RATE (b)    |     36/46.07     44/47.62     42/47.50     39/46.87    |14/45.75     8/45.70      15/44.86     12/45.82     | 
|POLY-3 PERCENT (g) |     78.1%        92.4%        88.4%        83.2%       |30.6%        17.5%        33.4%        26.2%        | 
|TERMINAL (d)       |     27/31 (87%)  37/38 (97%)  32/34 (94%)  29/31 (94%) |11/38 (29%)  5/35 (14%)   11/32 (34%)  9/32 (28%)   | 
|FIRST INCIDENCE    |     435          573          431          476         |710          694          629          593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.262      P=0.538      P=0.337      P=0.351     |P=0.246      P=0.167N     P=0.307      P=0.584N     | 
|POLY 3             |     P=0.487N     P=0.034 *    P=0.128      P=0.352     |P=0.396      P=0.110N     P=0.475      P=0.407N     | 
|POLY 1.5           |     P=0.465N     P=0.037 *    P=0.130      P=0.367     |P=0.395      P=0.108N     P=0.498      P=0.407N     | 
|POLY 6             |     P=0.533N     P=0.035 *    P=0.136      P=0.327     |P=0.388      P=0.111N     P=0.438      P=0.413N     | 
|LOGISTIC REGRESSION|     P=0.486N     P=0.104      P=0.159      P=0.421     |P=0.355      P=0.118N     P=0.387      P=0.433N     | 
|COCH-ARM / FISHERS |     P=0.455N     P=0.056      P=0.150      P=0.385     |P=0.384      P=0.103N     P=0.526      P=0.410N     | 
|ORDER RESTRICTED   |     P=0.106      (e)          (e)          (e)         |P=0.422      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Accumulation, Hyaline Droplet                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |1/49 (2%)    1/50 (2%)    2/50 (4%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/42.26      0/45.99      1/44.61      0/43.55     |1/45.58      1/45.52      2/45.17      2/45.53      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |2.2%         2.2%         4.4%         4.4%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |1/38 (3%)    0/35 (0%)    0/32 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          367          ---         |729 (T)      710          573          596          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.637      (e)          P=0.504      (e)         |P=0.298      P=0.743      P=0.480      P=0.465      | 
|POLY 3             |     P=0.624      (e)          P=0.511      (e)         |P=0.314      P=0.760      P=0.497      P=0.500      | 
|POLY 1.5           |     P=0.630      (e)          P=0.508      (e)         |P=0.314      P=0.759N     P=0.502      P=0.500      | 
|POLY 6             |     P=0.614      (e)          P=0.513      (e)         |P=0.311      P=0.759      P=0.489      P=0.497      | 
|LOGISTIC REGRESSION|     P=0.463      (e)          (e)          (e)         |P=0.294      P=0.761      P=0.561      P=0.504      | 
|COCH-ARM / FISHERS |     P=0.635      (e)          P=0.505      (e)         |P=0.310      P=0.747N     P=0.508      P=0.500      | 
|ORDER RESTRICTED   |     P=0.390      (e)          (e)          (e)         |P=0.441      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    3/50 (6%)    0/50 (0%)    1/50 (2%)   |0/49 (0%)    2/50 (4%)    1/50 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     1/42.26      3/47.28      0/43.74      1/43.93     |0/45.58      2/46.27      1/44.65      1/45.25      | 
|POLY-3 PERCENT (g) |     2.4%         6.3%         0.0%         2.3%        |0.0%         4.3%         2.2%         2.2%         | 
|TERMINAL (d)       |     1/31 (3%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      562          ---          623         |---          490          629          682          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.283N     P=0.358      P=0.482N     P=0.755N    |P=0.586      P=0.237      P=0.495      P=0.495      | 
|POLY 3             |     P=0.265N     P=0.347      P=0.493N     P=0.752N    |P=0.593      P=0.241      P=0.496      P=0.499      | 
|POLY 1.5           |     P=0.266N     P=0.332      P=0.494N     P=0.753N    |P=0.595      P=0.241      P=0.500      P=0.499      | 
|POLY 6             |     P=0.265N     P=0.365      P=0.492N     P=0.752N    |P=0.588      P=0.240      P=0.490      P=0.496      | 
|LOGISTIC REGRESSION|     P=0.274N     P=0.271      (e)          P=0.761N    |P=0.571      P=0.313      P=0.539      P=0.503      | 
|COCH-ARM / FISHERS |     P=0.270N     P=0.316      P=0.495N     P=0.747N    |P=0.597      P=0.253      P=0.505      P=0.500      | 
|ORDER RESTRICTED   |     P=0.284N     (e)          (e)          (e)         |P=0.272      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    1/50 (2%)    3/50 (6%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/42.26      1/45.99      1/43.74      3/43.55     |0/45.58      0/45.44      0/44.30      0/45.07      | 
|POLY-3 PERCENT (g) |     2.4%         2.2%         2.3%         6.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    1/38 (3%)    1/34 (3%)    3/31 (10%)  |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.131      P=0.716N     P=0.741N     P=0.304     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.156      P=0.742N     P=0.753N     P=0.316     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.159      P=0.748N     P=0.754N     P=0.316     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.150      P=0.734N     P=0.752N     P=0.313     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.131      P=0.716N     P=0.741N     P=0.304     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.161      P=0.747N     P=0.747N     P=0.316     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.191      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    3/50 (6%)    2/50 (4%)    7/50 (14%)  |1/49 (2%)    0/50 (0%)    3/50 (6%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     1/42.72      3/46.25      2/44.60      7/44.95     |1/45.58      0/45.44      3/45.03      1/45.07      | 
|POLY-3 PERCENT (g) |     2.3%         6.5%         4.5%         15.6%       |2.2%         0.0%         6.7%         2.2%         | 
|TERMINAL (d)       |     0/31 (0%)    2/38 (5%)    0/34 (0%)    3/31 (10%)  |1/38 (3%)    0/35 (0%)    1/32 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     596          659          573          469         |729 (T)      ---          479          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.020 *    P=0.364      P=0.510      P=0.040 *   |P=0.321      P=0.516N     P=0.268      P=0.723      | 
|POLY 3             |     P=0.021 *    P=0.334      P=0.515      P=0.035 *   |P=0.362      P=0.501N     P=0.301      P=0.758      | 
|POLY 1.5           |     P=0.021 *    P=0.325      P=0.512      P=0.035 *   |P=0.363      P=0.499N     P=0.307      P=0.759      | 
|POLY 6             |     P=0.021 *    P=0.345      P=0.519      P=0.035 *   |P=0.358      P=0.502N     P=0.291      P=0.755      | 
|LOGISTIC REGRESSION|     P=0.022 *    P=0.297      P=0.496      P=0.030 *   |P=0.354      (e)          P=0.349      P=0.723      | 
|COCH-ARM / FISHERS |     P=0.022 *    P=0.316      P=0.508      P=0.032 *   |P=0.360      P=0.495N     P=0.316      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.011 *    (e)          (e)          (e)         |P=0.262      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |1/49 (2%)    2/50 (4%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/42.26      0/45.99      1/43.85      0/43.55     |1/45.61      2/45.44      0/44.30      0/45.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         0.0%        |2.2%         4.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    2/35 (6%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          699          ---         |723          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.620      (e)          P=0.505      (e)         |P=0.144N     P=0.472      P=0.533N     P=0.539N     | 
|POLY 3             |     P=0.626      (e)          P=0.507      (e)         |P=0.125N     P=0.499      P=0.506N     P=0.502N     | 
|POLY 1.5           |     P=0.632      (e)          P=0.506      (e)         |P=0.123N     P=0.502      P=0.501N     P=0.501N     | 
|POLY 6             |     P=0.616      (e)          P=0.509      (e)         |P=0.128N     P=0.496      P=0.513N     P=0.505N     | 
|LOGISTIC REGRESSION|     P=0.635      (e)          P=0.506      (e)         |P=0.135N     P=0.487      P=0.519N     P=0.509N     | 
|COCH-ARM / FISHERS |     P=0.635      (e)          P=0.505      (e)         |P=0.121N     P=0.508      P=0.495N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.388      (e)          (e)          (e)         |P=0.169N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |0/49 (0%)    1/50 (2%)    3/50 (6%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     2/42.26      0/45.99      1/43.74      2/43.79     |0/45.58      1/45.58      3/44.49      3/45.07      | 
|POLY-3 PERCENT (g) |     4.7%         0.0%         2.3%         4.6%        |0.0%         2.2%         6.7%         6.7%         | 
|TERMINAL (d)       |     2/31 (7%)    0/38 (0%)    1/34 (3%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    1/32 (3%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      691         |---          694          692          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.332      P=0.195N     P=0.468N     P=0.689     |P=0.050      P=0.500      P=0.098      P=0.092      | 
|POLY 3             |     P=0.351      P=0.219N     P=0.488N     P=0.681N    |P=0.062      P=0.500      P=0.114      P=0.117      | 
|POLY 1.5           |     P=0.359      P=0.225N     P=0.490N     P=0.683N    |P=0.063      P=0.501      P=0.118      P=0.118      | 
|POLY 6             |     P=0.340      P=0.212N     P=0.486N     P=0.682N    |P=0.060      P=0.499      P=0.109      P=0.114      | 
|LOGISTIC REGRESSION|     P=0.351      (e)          P=0.468N     P=0.687N    |P=0.062      P=0.508      P=0.114      P=0.092      | 
|COCH-ARM / FISHERS |     P=0.367      P=0.242N     P=0.492N     P=0.684N    |P=0.064      P=0.505      P=0.125      P=0.121      | 
|ORDER RESTRICTED   |     P=0.393N     (e)          (e)          (e)         |P=0.073      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/49 (20%)  13/50 (26%)  23/50 (46%)  13/50 (26%) |3/49 (6%)    1/50 (2%)    8/50 (16%)   5/49 (10%)   | 
|POLY-3 RATE (b)    |     10/42.26     13/45.99     23/43.85     13/44.38    |3/45.91      1/45.62      8/44.99      5/45.18      | 
|POLY-3 PERCENT (g) |     23.7%        28.3%        52.5%        29.3%       |6.5%         2.2%         17.8%        11.1%        | 
|TERMINAL (d)       |     10/31 (32%)  13/38 (34%)  22/34 (65%)  11/31 (36%) |1/38 (3%)    0/35 (0%)    5/32 (16%)   4/32 (13%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      699          476         |658          682          617          702          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.110      P=0.534      P=0.006 **   P=0.309     |P=0.062      P=0.318N     P=0.071      P=0.292      | 
|POLY 3             |     P=0.215      P=0.401      P=0.004 **   P=0.363     |P=0.076      P=0.308N     P=0.092      P=0.348      | 
|POLY 1.5           |     P=0.225      P=0.373      P=0.004 **   P=0.355     |P=0.078      P=0.304N     P=0.098      P=0.352      | 
|POLY 6             |     P=0.192      P=0.436      P=0.003 **   P=0.363     |P=0.071      P=0.311N     P=0.083      P=0.337      | 
|LOGISTIC REGRESSION|     P=0.141      P=0.534      P=0.004 **   P=0.335     |P=0.079      P=0.291N     P=0.102      P=0.350      | 
|COCH-ARM / FISHERS |     P=0.230      P=0.337      P=0.006 **   P=0.337     |P=0.080      P=0.301N     P=0.106      P=0.357      | 
|ORDER RESTRICTED   |     P=0.061      (e)          (e)          (e)         |P=0.071      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/49 (31%)  10/50 (20%)  15/50 (30%)  17/50 (34%) |7/49 (14%)   6/50 (12%)   10/50 (20%)  9/49 (18%)   | 
|POLY-3 RATE (b)    |     15/42.69     10/46.14     15/44.66     17/44.93    |7/45.58      6/45.44      10/44.63     9/45.11      | 
|POLY-3 PERCENT (g) |     35.1%        21.7%        33.6%        37.8%       |15.4%        13.2%        22.4%        20.0%        | 
|TERMINAL (d)       |     13/31 (42%)  9/38 (24%)   12/34 (35%)  12/31 (39%) |7/38 (18%)   6/35 (17%)   8/32 (25%)   8/32 (25%)   | 
|FIRST INCIDENCE    |     626          690          596          476         |729 (T)      729 (T)      680          719          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.087      P=0.065N     P=0.483N     P=0.410     |P=0.120      P=0.565N     P=0.181      P=0.256      | 
|POLY 3             |     P=0.149      P=0.118N     P=0.529N     P=0.484     |P=0.206      P=0.502N     P=0.279      P=0.383      | 
|POLY 1.5           |     P=0.157      P=0.136N     P=0.543N     P=0.470     |P=0.210      P=0.496N     P=0.294      P=0.388      | 
|POLY 6             |     P=0.135      P=0.100N     P=0.513N     P=0.491     |P=0.195      P=0.509N     P=0.256      P=0.371      | 
|LOGISTIC REGRESSION|     P=0.127      P=0.087N     P=0.539N     P=0.451     |P=0.156      P=0.565N     P=0.216      P=0.274      | 
|COCH-ARM / FISHERS |     P=0.161      P=0.163N     P=0.560N     P=0.442     |P=0.209      P=0.484N     P=0.314      P=0.393      | 
|ORDER RESTRICTED   |     P=0.261      (e)          (e)          (e)         |P=0.308      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/49 (4%)    4/50 (8%)    2/50 (4%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/42.26      0/45.99      0/43.74      1/43.55     |2/46.14      4/46.65      2/44.95      2/45.16      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.3%        |4.3%         8.6%         4.5%         4.4%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    1/31 (3%)   |1/38 (3%)    1/35 (3%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |555          383          617          717          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.170      (e)          (e)          P=0.500     |P=0.398N     P=0.327      P=0.672      P=0.655      | 
|POLY 3             |     P=0.183      (e)          (e)          P=0.506     |P=0.383N     P=0.342      P=0.684      P=0.686      | 
|POLY 1.5           |     P=0.184      (e)          (e)          P=0.506     |P=0.377N     P=0.344      P=0.692      P=0.690      | 
|POLY 6             |     P=0.179      (e)          (e)          P=0.505     |P=0.393N     P=0.340      P=0.674      P=0.680      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.500     |P=0.390N     P=0.439      P=0.632N     P=0.691N     | 
|COCH-ARM / FISHERS |     P=0.185      (e)          (e)          P=0.505     |P=0.369N     P=0.349      P=0.684N     P=0.691N     | 
|ORDER RESTRICTED   |     P=0.126      (e)          (e)          (e)         |P=0.527N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/42.26      1/46.44      0/43.74      0/43.55     |0/45.58      0/45.44      0/44.30      2/45.30      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.4%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          596          ---          ---         |---          ---          ---          682          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.414N     P=0.509      (e)          (e)         |P=0.041 *    (e)          (e)          P=0.226      | 
|POLY 3             |     P=0.401N     P=0.519      (e)          (e)         |P=0.041 *    (e)          (e)          P=0.236      | 
|POLY 1.5           |     P=0.406N     P=0.512      (e)          (e)         |P=0.041 *    (e)          (e)          P=0.237      | 
|POLY 6             |     P=0.395N     P=0.526      (e)          (e)         |P=0.040 *    (e)          (e)          P=0.233      | 
|LOGISTIC REGRESSION|     P=0.424N     P=0.486      (e)          (e)         |P=0.042 *    (e)          (e)          P=0.238      | 
|COCH-ARM / FISHERS |     P=0.412N     P=0.505      (e)          (e)         |P=0.042 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.392N     (e)          (e)          (e)         |P=0.029 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/49 (4%)    1/50 (2%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/42.26      0/45.99      0/43.74      0/43.55     |2/45.58      1/45.62      0/44.30      0/45.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.4%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |2/38 (5%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      682          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.124N     P=0.516N     P=0.277N     P=0.277N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.108N     P=0.500N     P=0.244N     P=0.240N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.108N     P=0.498N     P=0.239N     P=0.238N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.111N     P=0.501N     P=0.252N     P=0.243N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.109N     P=0.499N     (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.107N     P=0.492N     P=0.242N     P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.076N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    4/50 (8%)    2/50 (4%)    2/50 (4%)   |7/49 (14%)   7/50 (14%)   4/50 (8%)    9/49 (18%)   | 
|POLY-3 RATE (b)    |     2/43.76      4/46.42      2/44.24      2/43.81     |7/45.66      7/46.04      4/44.73      9/46.06      | 
|POLY-3 PERCENT (g) |     4.6%         8.6%         4.5%         4.6%        |15.3%        15.2%        8.9%         19.5%        | 
|TERMINAL (d)       |     0/31 (0%)    2/38 (5%)    1/34 (3%)    1/31 (3%)   |6/38 (16%)   3/35 (9%)    2/32 (6%)    4/32 (13%)   | 
|FIRST INCIDENCE    |     435          659          576          659         |710          659          617          593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.391N     P=0.404      P=0.677N     P=0.681N    |P=0.290      P=0.563      P=0.358N     P=0.301      | 
|POLY 3             |     P=0.375N     P=0.365      P=0.690N     P=0.694N    |P=0.368      P=0.607N     P=0.272N     P=0.399      | 
|POLY 1.5           |     P=0.368N     P=0.356      P=0.689N     P=0.690N    |P=0.369      P=0.605N     P=0.262N     P=0.397      | 
|POLY 6             |     P=0.384N     P=0.378      P=0.691N     P=0.690     |P=0.361      P=0.606N     P=0.289N     P=0.399      | 
|LOGISTIC REGRESSION|     P=0.363N     P=0.275      P=0.698      P=0.634     |P=0.364      P=0.612      P=0.286N     P=0.389      | 
|COCH-ARM / FISHERS |     P=0.360N     P=0.349      P=0.684N     P=0.684N    |P=0.365      P=0.597N     P=0.251N     P=0.393      | 
|ORDER RESTRICTED   |     P=0.528N     (e)          (e)          (e)         |P=0.309      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    7/50 (14%)   8/50 (16%)   4/50 (8%)   |2/49 (4%)    6/50 (12%)   3/50 (6%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     3/43.46      7/46.48      8/43.74      4/44.07     |2/45.58      6/45.44      3/44.30      1/45.07      | 
|POLY-3 PERCENT (g) |     6.9%         15.1%        18.3%        9.1%        |4.4%         13.2%        6.8%         2.2%         | 
|TERMINAL (d)       |     1/31 (3%)    5/38 (13%)   8/34 (24%)   2/31 (7%)   |2/38 (5%)    6/35 (17%)   3/32 (9%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     458          596          729 (T)      627         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.538      P=0.236      P=0.128      P=0.514     |P=0.163N     P=0.108      P=0.421      P=0.560N     | 
|POLY 3             |     P=0.529N     P=0.186      P=0.099      P=0.508     |P=0.123N     P=0.132      P=0.487      P=0.504N     | 
|POLY 1.5           |     P=0.518N     P=0.177      P=0.102      P=0.510     |P=0.121N     P=0.135      P=0.497      P=0.502N     | 
|POLY 6             |     P=0.548N     P=0.197      P=0.095      P=0.503     |P=0.128N     P=0.128      P=0.471      P=0.509N     | 
|LOGISTIC REGRESSION|     P=0.512N     P=0.145      P=0.108      P=0.486     |P=0.163N     P=0.108      P=0.421      P=0.560N     | 
|COCH-ARM / FISHERS |     P=0.507N     P=0.167      P=0.106      P=0.511     |P=0.120N     P=0.141      P=0.510      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.242      (e)          (e)          (e)         |P=0.159N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/49 (16%)   7/50 (14%)   3/50 (6%)    5/50 (10%)  |3/49 (6%)    2/50 (4%)    3/50 (6%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     8/44.20      7/47.09      3/43.74      5/45.07     |3/46.31      2/45.72      3/44.53      2/45.88      | 
|POLY-3 PERCENT (g) |     18.1%        14.9%        6.9%         11.1%       |6.5%         4.4%         6.7%         4.4%         | 
|TERMINAL (d)       |     2/31 (7%)    3/38 (8%)    3/34 (9%)    0/31 (0%)   |2/38 (5%)    0/35 (0%)    2/32 (6%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     482          573          729 (T)      623         |474          659          668          596          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.201N     P=0.386N     P=0.096N     P=0.279N    |P=0.528N     P=0.517N     P=0.602      P=0.526N     | 
|POLY 3             |     P=0.168N     P=0.447N     P=0.100N     P=0.262N    |P=0.495N     P=0.506N     P=0.644      P=0.504N     | 
|POLY 1.5           |     P=0.161N     P=0.463N     P=0.097N     P=0.262N    |P=0.494N     P=0.501N     P=0.656      P=0.503N     | 
|POLY 6             |     P=0.179N     P=0.429N     P=0.107N     P=0.265N    |P=0.499N     P=0.509N     P=0.628      P=0.508N     | 
|LOGISTIC REGRESSION|     P=0.150N     P=0.537N     P=0.096N     P=0.287N    |P=0.509N     P=0.443N     P=0.618N     P=0.495N     | 
|COCH-ARM / FISHERS |     P=0.154N     P=0.483N     P=0.094N     P=0.264N    |P=0.496N     P=0.490N     P=0.651N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.154N     (e)          (e)          (e)         |P=0.516N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Tension Lipidosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |1/49 (2%)    3/50 (6%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/42.26      1/46.48      1/44.19      2/43.55     |1/46.12      3/46.14      0/44.30      0/45.07      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         2.3%         4.6%        |2.2%         6.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    2/31 (7%)   |0/38 (0%)    2/35 (6%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          582          596          729 (T)     |563          487          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.164      P=0.513      P=0.504      P=0.238     |P=0.085N     P=0.293      P=0.500N     P=0.496N     | 
|POLY 3             |     P=0.175      P=0.519      P=0.509      P=0.244     |P=0.078N     P=0.305      P=0.508N     P=0.505N     | 
|POLY 1.5           |     P=0.177      P=0.513      P=0.507      P=0.244     |P=0.076N     P=0.308      P=0.503N     P=0.502N     | 
|POLY 6             |     P=0.170      P=0.526      P=0.511      P=0.242     |P=0.082N     P=0.302      P=0.516N     P=0.509N     | 
|LOGISTIC REGRESSION|     P=0.176      P=0.488      P=0.500      P=0.238     |P=0.076N     P=0.386      P=0.445N     P=0.466N     | 
|COCH-ARM / FISHERS |     P=0.177      P=0.505      P=0.505      P=0.253     |P=0.075N     P=0.316      P=0.495N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.123      (e)          (e)          (e)         |P=0.118N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    4/50 (8%)    0/50 (0%)    5/50 (10%)  |0/49 (0%)    1/50 (2%)    4/50 (8%)    4/49 (8%)    | 
|POLY-3 RATE (b)    |     4/44.26      4/47.52      0/43.74      5/44.38     |0/45.58      1/45.50      4/46.14      4/45.69      | 
|POLY-3 PERCENT (g) |     9.0%         8.4%         0.0%         11.3%       |0.0%         2.2%         8.7%         8.8%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    1/31 (3%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     435          297          ---          597         |---          715          479          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.493      P=0.585N     P=0.065N     P=0.497     |P=0.025 *    P=0.490      P=0.064      P=0.060      | 
|POLY 3             |     P=0.506      P=0.604N     P=0.061N     P=0.502     |P=0.025 *    P=0.500      P=0.062      P=0.060      | 
|POLY 1.5           |     P=0.517      P=0.614N     P=0.060N     P=0.507     |P=0.024 *    P=0.501      P=0.063      P=0.061      | 
|POLY 6             |     P=0.493      P=0.592N     P=0.063N     P=0.494     |P=0.024 *    P=0.498      P=0.060      P=0.060      | 
|LOGISTIC REGRESSION|     P=0.521      P=0.456      P=0.054N     P=0.461     |P=0.016 *    P=0.500      P=0.075      P=0.064      | 
|COCH-ARM / FISHERS |     P=0.532      P=0.631N     P=0.056N     P=0.513     |P=0.024 *    P=0.505      P=0.061      P=0.059      | 
|ORDER RESTRICTED   |     P=0.262      (e)          (e)          (e)         |P=0.035 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/49 (16%)   9/50 (18%)   4/50 (8%)    10/50 (20%) |2/49 (4%)    7/50 (14%)   4/50 (8%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     8/43.46      9/45.99      4/43.74      10/44.63    |2/46.05      7/45.75      4/44.88      2/45.18      | 
|POLY-3 PERCENT (g) |     18.4%        19.6%        9.2%         22.4%       |4.3%         15.3%        8.9%         4.4%         | 
|TERMINAL (d)       |     6/31 (19%)   9/38 (24%)   4/34 (12%)   8/31 (26%)  |1/38 (3%)    5/35 (14%)   2/32 (6%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     458          729 (T)      729 (T)      489         |591          682          629          702          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.386      P=0.547N     P=0.142N     P=0.408     |P=0.265N     P=0.073      P=0.295      P=0.656      | 
|POLY 3             |     P=0.460      P=0.551      P=0.172N     P=0.420     |P=0.221N     P=0.077      P=0.325      P=0.687      | 
|POLY 1.5           |     P=0.469      P=0.536      P=0.170N     P=0.421     |P=0.216N     P=0.080      P=0.335      P=0.690      | 
|POLY 6             |     P=0.444      P=0.569      P=0.174N     P=0.414     |P=0.232N     P=0.075      P=0.311      P=0.681      | 
|LOGISTIC REGRESSION|     P=0.461      P=0.553      P=0.165N     P=0.416     |P=0.212N     P=0.085      P=0.378      P=0.692N     | 
|COCH-ARM / FISHERS |     P=0.475      P=0.518      P=0.168N     P=0.416     |P=0.212N     P=0.085      P=0.349      P=0.691N     | 
|ORDER RESTRICTED   |     P=0.327      (e)          (e)          (e)         |P=0.276N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Kupffer Cell                                                                                                              | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |3/49 (6%)    0/50 (0%)    0/50 (0%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     1/42.26      1/46.04      1/44.02      1/43.92     |3/45.66      0/45.44      0/44.30      3/45.75      | 
|POLY-3 PERCENT (g) |     2.4%         2.2%         2.3%         2.3%        |6.6%         0.0%         0.0%         6.6%         | 
|TERMINAL (d)       |     1/31 (3%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |2/38 (5%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      717          653          627         |710          ---          ---          593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.601      P=0.712N     P=0.747N     P=0.755N    |P=0.301      P=0.137N     P=0.156N     P=0.616      | 
|POLY 3             |     P=0.620      P=0.741N     P=0.752N     P=0.752N    |P=0.331      P=0.120N     P=0.124N     P=0.661N     | 
|POLY 1.5           |     P=0.620N     P=0.748N     P=0.754N     P=0.753N    |P=0.330      P=0.118N     P=0.120N     P=0.661N     | 
|POLY 6             |     P=0.614      P=0.734N     P=0.750N     P=0.752N    |P=0.329      P=0.121N     P=0.131N     P=0.661      | 
|LOGISTIC REGRESSION|     P=0.618N     P=0.732N     P=0.758N     P=0.760N    |P=0.327      P=0.123N     P=0.136N     P=0.660N     | 
|COCH-ARM / FISHERS |     P=0.619N     P=0.747N     P=0.747N     P=0.747N    |P=0.328      P=0.117N     P=0.117N     P=0.661N     | 
|ORDER RESTRICTED   |     P=0.730N     (e)          (e)          (e)         |P=0.186N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.26      0/45.99      0/43.74      0/43.55     |0/45.94      0/45.44      2/45.00      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.4%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          617          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.520      (e)          P=0.234      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.511      (e)          P=0.233      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.513      (e)          P=0.235      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.508      (e)          P=0.228      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.556      (e)          P=0.251      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.518      (e)          P=0.247      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.243      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/43.47      0/45.99      1/43.82      2/44.34     |0/45.94      0/45.44      0/44.30      0/45.13      | 
|POLY-3 PERCENT (g) |     4.6%         0.0%         2.3%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     451          ---          708          489         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.345      P=0.233N     P=0.494N     P=0.688N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.354      P=0.225N     P=0.497N     P=0.687N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.361      P=0.228N     P=0.496N     P=0.686N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.344      P=0.220N     P=0.499N     P=0.691N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.336      P=0.234N     P=0.504N     P=0.620     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.367      P=0.242N     P=0.492N     P=0.684N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.401N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/50 (0%)    0/50 (0%)    4/50 (8%)   |0/50 (0%)    2/50 (4%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     2/43.28      0/45.99      0/43.74      4/44.28     |0/45.94      2/45.47      2/44.81      3/45.31      | 
|POLY-3 PERCENT (g) |     4.6%         0.0%         0.0%         9.0%        |0.0%         4.4%         4.5%         6.6%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    1/31 (3%)   |0/38 (0%)    1/35 (3%)    1/32 (3%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     451          ---          ---          623         |---          721          573          682          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.067      P=0.224N     P=0.240N     P=0.345     |P=0.117      P=0.225      P=0.223      P=0.102      | 
|POLY 3             |     P=0.066      P=0.224N     P=0.235N     P=0.347     |P=0.135      P=0.235      P=0.232      P=0.116      | 
|POLY 1.5           |     P=0.069      P=0.228N     P=0.234N     P=0.348     |P=0.137      P=0.236      P=0.234      P=0.117      | 
|POLY 6             |     P=0.063      P=0.219N     P=0.236N     P=0.345     |P=0.133      P=0.234      P=0.226      P=0.115      | 
|LOGISTIC REGRESSION|     P=0.069      P=0.244N     P=0.229N     P=0.312     |P=0.139      P=0.232      P=0.251      P=0.117      | 
|COCH-ARM / FISHERS |     P=0.073      P=0.242N     P=0.242N     P=0.349     |P=0.139      P=0.247      P=0.247      P=0.121      | 
|ORDER RESTRICTED   |     P=0.035 *    (e)          (e)          (e)         |P=0.075      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |5/50 (10%)   5/50 (10%)   1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     3/42.26      0/45.99      1/43.74      0/43.55     |5/45.98      5/45.44      1/44.69      3/45.13      | 
|POLY-3 PERCENT (g) |     7.1%         0.0%         2.3%         0.0%        |10.9%        11.0%        2.2%         6.7%         | 
|TERMINAL (d)       |     3/31 (10%)   0/38 (0%)    1/34 (3%)    0/31 (0%)   |4/38 (11%)   5/35 (14%)   0/32 (0%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |720          729 (T)      618          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.172N     P=0.087N     P=0.272N     P=0.120N    |P=0.221N     P=0.578      P=0.144N     P=0.453N     | 
|POLY 3             |     P=0.169N     P=0.104N     P=0.293N     P=0.113N    |P=0.169N     P=0.623      P=0.108N     P=0.367N     | 
|POLY 1.5           |     P=0.162N     P=0.109N     P=0.295N     P=0.113N    |P=0.167N     P=0.625      P=0.105N     P=0.364N     | 
|POLY 6             |     P=0.178N     P=0.099N     P=0.291N     P=0.114N    |P=0.173N     P=0.621      P=0.113N     P=0.373N     | 
|LOGISTIC REGRESSION|     P=0.172N     (e)          P=0.272N     (e)         |P=0.179N     P=0.595      P=0.108N     P=0.424N     | 
|COCH-ARM / FISHERS |     P=0.156N     P=0.117N     P=0.301N     P=0.117N    |P=0.164N     P=0.630N     P=0.102N     P=0.357N     | 
|ORDER RESTRICTED   |     P=0.018N*    (e)          (e)          (e)         |P=0.191N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    6/50 (12%)   3/50 (6%)    6/50 (12%)  |1/50 (2%)    2/50 (4%)    2/50 (4%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     2/42.63      6/46.44      3/44.24      6/44.19     |1/45.97      2/45.84      2/44.70      4/45.31      | 
|POLY-3 PERCENT (g) |     4.7%         12.9%        6.8%         13.6%       |2.2%         4.4%         4.5%         8.8%         | 
|TERMINAL (d)       |     1/31 (3%)    5/38 (13%)   2/34 (6%)    4/31 (13%)  |0/38 (0%)    1/35 (3%)    0/32 (0%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     626          596          576          558         |723          615          622          682          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.231      P=0.197      P=0.529      P=0.139     |P=0.104      P=0.481      P=0.465      P=0.142      | 
|POLY 3             |     P=0.278      P=0.162      P=0.517      P=0.144     |P=0.121      P=0.499      P=0.490      P=0.174      | 
|POLY 1.5           |     P=0.281      P=0.153      P=0.514      P=0.143     |P=0.122      P=0.499      P=0.495      P=0.176      | 
|POLY 6             |     P=0.270      P=0.173      P=0.519      P=0.141     |P=0.117      P=0.500      P=0.482      P=0.172      | 
|LOGISTIC REGRESSION|     P=0.278      P=0.145      P=0.507      P=0.142     |P=0.125      P=0.506      P=0.507      P=0.171      | 
|COCH-ARM / FISHERS |     P=0.280      P=0.141      P=0.510      P=0.141     |P=0.125      P=0.500      P=0.500      P=0.181      | 
|ORDER RESTRICTED   |     P=0.126      (e)          (e)          (e)         |P=0.108      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.26      2/45.99      0/43.74      1/43.55     |0/45.94      0/45.44      0/44.30      0/45.13      | 
|POLY-3 PERCENT (g) |     2.4%         4.4%         0.0%         2.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    2/38 (5%)    0/34 (0%)    1/31 (3%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.429N     P=0.571      P=0.482N     P=0.762     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.397N     P=0.529      P=0.493N     P=0.754N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.397N     P=0.520      P=0.494N     P=0.754N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.398N     P=0.541      P=0.492N     P=0.756N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.429N     P=0.571      (e)          P=0.762     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.397N     P=0.508      P=0.495N     P=0.747N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.390N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    6/50 (12%)   6/50 (12%)   7/50 (14%)  |3/50 (6%)    3/50 (6%)    0/50 (0%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     2/42.26      6/45.99      6/44.25      7/44.04     |3/45.94      3/45.44      0/44.30      4/45.29      | 
|POLY-3 PERCENT (g) |     4.7%         13.1%        13.6%        15.9%       |6.5%         6.6%         0.0%         8.8%         | 
|TERMINAL (d)       |     2/31 (7%)    6/38 (16%)   5/34 (15%)   5/31 (16%)  |3/38 (8%)    3/35 (9%)    0/32 (0%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      573          637         |729 (T)      729 (T)      ---          688          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.101      P=0.206      P=0.164      P=0.086     |P=0.417      P=0.625      P=0.153N     P=0.415      | 
|POLY 3             |     P=0.141      P=0.161      P=0.147      P=0.088     |P=0.484      P=0.657      P=0.125N     P=0.492      | 
|POLY 1.5           |     P=0.143      P=0.152      P=0.144      P=0.087     |P=0.487      P=0.658      P=0.122N     P=0.494      | 
|POLY 6             |     P=0.136      P=0.173      P=0.150      P=0.087     |P=0.477      P=0.656      P=0.131N     P=0.488      | 
|LOGISTIC REGRESSION|     P=0.123      P=0.206      P=0.145      P=0.085     |P=0.456      P=0.625      (e)          P=0.474      | 
|COCH-ARM / FISHERS |     P=0.142      P=0.141      P=0.141      P=0.085     |P=0.492      P=0.661N     P=0.121N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.086      (e)          (e)          (e)         |P=0.281      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/48 (10%)   2/50 (4%)    3/48 (6%)    7/48 (15%)  |0/48 (0%)    1/49 (2%)    1/47 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/42.94      2/46.79      3/42.98      7/43.27     |0/44.45      1/45.27      1/42.40      1/45.24      | 
|POLY-3 PERCENT (g) |     11.6%        4.3%         7.0%         16.2%       |0.0%         2.2%         2.4%         2.2%         | 
|TERMINAL (d)       |     2/31 (7%)    0/38 (0%)    0/32 (0%)    1/30 (3%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     514          562          573          558         |---          487          724          702          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.126      P=0.175N     P=0.346N     P=0.391     |P=0.397      P=0.500      P=0.472      P=0.480      | 
|POLY 3             |     P=0.115      P=0.183N     P=0.355N     P=0.384     |P=0.420      P=0.504      P=0.491      P=0.504      | 
|POLY 1.5           |     P=0.120      P=0.190N     P=0.356N     P=0.384     |P=0.423      P=0.504      P=0.493      P=0.505      | 
|POLY 6             |     P=0.108      P=0.175N     P=0.356N     P=0.382     |P=0.415      P=0.503      P=0.486      P=0.501      | 
|LOGISTIC REGRESSION|     P=0.124      P=0.245N     P=0.363N     P=0.354     |P=0.469      P=0.684      P=0.481      P=0.508      | 
|COCH-ARM / FISHERS |     P=0.126      P=0.201N     P=0.357N     P=0.379     |P=0.429      P=0.505      P=0.495      P=0.510      | 
|ORDER RESTRICTED   |     P=0.137      (e)          (e)          (e)         |P=0.319      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/50 (0%)    0/48 (0%)    0/48 (0%)   |1/48 (2%)    1/49 (2%)    0/47 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/42.28      0/45.99      0/41.74      0/41.64     |1/44.45      1/44.57      0/42.38      2/46.19      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         0.0%         0.0%        |2.3%         2.2%         0.0%         4.3%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/32 (0%)    0/30 (0%)   |1/38 (3%)    1/35 (3%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     435          ---          ---          ---         |729 (T)      729 (T)      ---          430          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.365N     P=0.500N     P=0.504N     P=0.496N    |P=0.355      P=0.743      P=0.534N     P=0.483      | 
|POLY 3             |     P=0.378N     P=0.483N     P=0.503N     P=0.503N    |P=0.386      P=0.760N     P=0.509N     P=0.513      | 
|POLY 1.5           |     P=0.374N     P=0.487N     P=0.502N     P=0.501N    |P=0.386      P=0.759N     P=0.507N     P=0.513      | 
|POLY 6             |     P=0.382N     P=0.479N     P=0.504N     P=0.506N    |P=0.384      P=0.760      P=0.514N     P=0.511      | 
|LOGISTIC REGRESSION|     P=0.448N     P=0.433N     P=0.420N     (e)         |P=0.431      P=0.743      (e)          P=0.607      | 
|COCH-ARM / FISHERS |     P=0.369N     P=0.490N     P=0.500N     P=0.500N    |P=0.386      P=0.747N     P=0.505N     P=0.515      | 
|ORDER RESTRICTED   |     P=0.123N     (e)          (e)          (e)         |P=0.290      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/50 (0%)    1/48 (2%)    0/48 (0%)   |0/48 (0%)    2/49 (4%)    2/47 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/41.74      0/45.99      1/41.74      0/41.64     |0/44.45      2/44.57      2/42.70      1/45.18      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         2.4%         0.0%        |0.0%         4.5%         4.7%         2.2%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    1/32 (3%)    0/30 (0%)   |0/38 (0%)    2/35 (6%)    1/32 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     662          ---          729 (T)      ---         |---          729 (T)      643          717          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.504N     P=0.470N     P=0.754N     P=0.495N    |P=0.499      P=0.220      P=0.213      P=0.479      | 
|POLY 3             |     P=0.502N     P=0.481N     P=0.761      P=0.500N    |P=0.536      P=0.238      P=0.228      P=0.503      | 
|POLY 1.5           |     P=0.495N     P=0.485N     P=0.760N     P=0.500N    |P=0.540      P=0.239      P=0.230      P=0.505      | 
|POLY 6             |     P=0.511N     P=0.476N     P=0.759      P=0.504N    |P=0.529      P=0.236      P=0.224      P=0.500      | 
|LOGISTIC REGRESSION|     P=0.488N     P=0.505N     P=0.762N     P=0.505N    |P=0.543      P=0.220      P=0.238      P=0.502      | 
|COCH-ARM / FISHERS |     P=0.487N     P=0.490N     P=0.753N     P=0.500N    |P=0.548      P=0.253      P=0.242      P=0.510      | 
|ORDER RESTRICTED   |     P=0.252N     (e)          (e)          (e)         |P=0.219      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/48 (31%)  14/50 (28%)  6/48 (13%)   7/48 (15%)  |13/48 (27%)  6/49 (12%)   8/47 (17%)   9/50 (18%)   | 
|POLY-3 RATE (b)    |     15/41.67     14/46.59     6/41.80      7/42.36     |13/45.65     6/45.66      8/42.82      9/45.97      | 
|POLY-3 PERCENT (g) |     36.0%        30.1%        14.4%        16.5%       |28.5%        13.1%        18.7%        19.6%        | 
|TERMINAL (d)       |     12/31 (39%)  12/38 (32%)  5/32 (16%)   5/30 (17%)  |10/38 (26%)  4/35 (11%)   6/32 (19%)   7/32 (22%)   | 
|FIRST INCIDENCE    |     710          596          714          597         |563          490          617          430          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.026N*    P=0.269N     P=0.020N*    P=0.055N    |P=0.539      P=0.091N     P=0.275N     P=0.362N     | 
|POLY 3             |     P=0.012N*    P=0.357N     P=0.018N*    P=0.034N*   |P=0.426N     P=0.059N     P=0.202N     P=0.226N     | 
|POLY 1.5           |     P=0.012N*    P=0.395N     P=0.020N*    P=0.037N*   |P=0.415N     P=0.057N     P=0.189N     P=0.216N     | 
|POLY 6             |     P=0.014N*    P=0.315N     P=0.018N*    P=0.033N*   |P=0.448N     P=0.062N     P=0.225N     P=0.246N     | 
|LOGISTIC REGRESSION|     P=0.017N*    P=0.321N     P=0.020N*    P=0.043N*   |P=0.398N     P=0.051N     P=0.179N     P=0.198N     | 
|COCH-ARM / FISHERS |     P=0.013N*    P=0.448N     P=0.023N*    P=0.044N*   |P=0.403N     P=0.056N     P=0.175N     P=0.202N     | 
|ORDER RESTRICTED   |     P=0.018N*    (e)          (e)          (e)         |P=0.130N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/48 (15%)   8/50 (16%)   1/48 (2%)    7/48 (15%)  |18/48 (38%)  25/49 (51%)  17/47 (36%)  23/50 (46%)  | 
|POLY-3 RATE (b)    |     7/43.43      8/47.18      1/41.74      7/42.84     |18/45.65     25/46.11     17/44.64     23/46.41     | 
|POLY-3 PERCENT (g) |     16.1%        17.0%        2.4%         16.3%       |39.4%        54.2%        38.1%        49.6%        | 
|TERMINAL (d)       |     2/31 (7%)    4/38 (11%)   1/32 (3%)    2/30 (7%)   |15/38 (40%)  19/35 (54%)  12/32 (38%)  17/32 (53%)  | 
|FIRST INCIDENCE    |     482          573          729 (T)      597         |563          584          507          593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.402N     P=0.592N     P=0.035N*    P=0.602     |P=0.257      P=0.079      P=0.466      P=0.092      | 
|POLY 3             |     P=0.381N     P=0.569      P=0.034N*    P=0.604     |P=0.464      P=0.111      P=0.533N     P=0.220      | 
|POLY 1.5           |     P=0.367N     P=0.554      P=0.032N*    P=0.609     |P=0.476      P=0.115      P=0.530N     P=0.232      | 
|POLY 6             |     P=0.403N     P=0.585      P=0.037N*    P=0.592     |P=0.439      P=0.110      P=0.547N     P=0.203      | 
|LOGISTIC REGRESSION|     P=0.345N     P=0.475      P=0.033N*    P=0.599     |P=0.482      P=0.117      P=0.522N     P=0.233      | 
|COCH-ARM / FISHERS |     P=0.353N     P=0.535      P=0.029N*    P=0.613N    |P=0.499      P=0.128      P=0.531N     P=0.259      | 
|ORDER RESTRICTED   |     P=0.261N     (e)          (e)          (e)         |P=0.255      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/46 (9%)    2/49 (4%)    1/49 (2%)    9/47 (19%)  |0/49 (0%)    0/49 (0%)    2/48 (4%)    1/45 (2%)    | 
|POLY-3 RATE (b)    |     4/41.43      2/45.32      1/43.67      9/42.69     |0/45.58      0/44.88      2/43.21      1/41.11      | 
|POLY-3 PERCENT (g) |     9.7%         4.4%         2.3%         21.1%       |0.0%         0.0%         4.6%         2.4%         | 
|TERMINAL (d)       |     0/31 (0%)    1/38 (3%)    0/34 (0%)    4/31 (13%)  |0/38 (0%)    0/35 (0%)    1/32 (3%)    0/28 (0%)    | 
|FIRST INCIDENCE    |     596          690          714          627         |---          ---          724          721          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.017 *    P=0.278N     P=0.177N     P=0.129     |P=0.162      (e)          P=0.206      P=0.473      | 
|POLY 3             |     P=0.016 *    P=0.296N     P=0.162N     P=0.124     |P=0.177      (e)          P=0.225      P=0.479      | 
|POLY 1.5           |     P=0.017 *    P=0.301N     P=0.160N     P=0.125     |P=0.179      (e)          P=0.229      P=0.481      | 
|POLY 6             |     P=0.015 *    P=0.292N     P=0.168N     P=0.123     |P=0.172      (e)          P=0.219      P=0.476      | 
|LOGISTIC REGRESSION|     P=0.020 *    P=0.321N     P=0.167N     P=0.122     |P=0.163      (e)          P=0.207      P=0.473      | 
|COCH-ARM / FISHERS |     P=0.020 *    P=0.309N     P=0.162N     P=0.124     |P=0.180      (e)          P=0.242      P=0.479      | 
|ORDER RESTRICTED   |     P=0.008 **   (e)          (e)          (e)         |P=0.158      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/46 (2%)    1/49 (2%)    3/49 (6%)    3/47 (6%)   |2/49 (4%)    0/49 (0%)    2/48 (4%)    1/45 (2%)    | 
|POLY-3 RATE (b)    |     1/40.50      1/45.16      3/43.61      3/41.59     |2/45.62      0/44.88      2/43.19      1/41.33      | 
|POLY-3 PERCENT (g) |     2.5%         2.2%         6.9%         7.2%        |4.4%         0.0%         4.6%         2.4%         | 
|TERMINAL (d)       |     1/31 (3%)    1/38 (3%)    3/34 (9%)    3/31 (10%)  |1/38 (3%)    0/35 (0%)    2/32 (6%)    0/28 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |720          ---          729 (T)      659          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.113      P=0.716N     P=0.338      P=0.304     |P=0.515      P=0.258N     P=0.629      P=0.548N     | 
|POLY 3             |     P=0.134      P=0.736N     P=0.332      P=0.314     |P=0.554      P=0.241N     P=0.674      P=0.534N     | 
|POLY 1.5           |     P=0.138      P=0.741N     P=0.332      P=0.315     |P=0.555      P=0.240N     P=0.680      P=0.532N     | 
|POLY 6             |     P=0.127      P=0.731N     P=0.330      P=0.311     |P=0.548      P=0.242N     P=0.664      P=0.540N     | 
|LOGISTIC REGRESSION|     P=0.113      P=0.716N     P=0.338      P=0.304     |P=0.549      P=0.242N     P=0.645      P=0.528N     | 
|COCH-ARM / FISHERS |     P=0.139      P=0.737N     P=0.333      P=0.317     |P=0.554      P=0.247N     P=0.684      P=0.532N     | 
|ORDER RESTRICTED   |     P=0.243      (e)          (e)          (e)         |P=0.448N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/46 (17%)   5/49 (10%)   9/49 (18%)   7/47 (15%)  |1/49 (2%)    1/49 (2%)    1/48 (2%)    5/45 (11%)   | 
|POLY-3 RATE (b)    |     8/41.22      5/45.16      9/44.84      7/42.95     |1/45.58      1/45.00      1/43.58      5/41.77      | 
|POLY-3 PERCENT (g) |     19.4%        11.1%        20.1%        16.3%       |2.2%         2.2%         2.3%         12.0%        | 
|TERMINAL (d)       |     5/31 (16%)   5/38 (13%)   5/34 (15%)   3/31 (10%)  |1/38 (3%)    0/35 (0%)    0/32 (0%)    1/28 (4%)    | 
|FIRST INCIDENCE    |     601          729 (T)      521          563         |729 (T)      697          618          596          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.378      P=0.173N     P=0.562      P=0.496N    |P=0.019 *    P=0.749      P=0.741      P=0.079      | 
|POLY 3             |     P=0.448      P=0.218N     P=0.577      P=0.465N    |P=0.017 *    P=0.758      P=0.751      P=0.082      | 
|POLY 1.5           |     P=0.450      P=0.225N     P=0.571      P=0.470N    |P=0.017 *    P=0.758      P=0.753      P=0.082      | 
|POLY 6             |     P=0.443      P=0.211N     P=0.575      P=0.464N    |P=0.017 *    P=0.758      P=0.746      P=0.080      | 
|LOGISTIC REGRESSION|     P=0.446      P=0.208N     P=0.559      P=0.483N    |P=0.018 *    P=0.760      P=0.756N     P=0.087      | 
|COCH-ARM / FISHERS |     P=0.446      P=0.236N     P=0.558      P=0.482N    |P=0.018 *    P=0.753N     P=0.747      P=0.084      | 
|ORDER RESTRICTED   |     P=0.521N     (e)          (e)          (e)         |P=0.018 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/46 (4%)    8/49 (16%)   3/49 (6%)    6/47 (13%)  |8/49 (16%)   9/49 (18%)   7/48 (15%)   5/45 (11%)   | 
|POLY-3 RATE (b)    |     2/40.50      8/45.62      3/43.61      6/41.72     |8/45.68      9/46.69      7/44.48      5/41.84      | 
|POLY-3 PERCENT (g) |     4.9%         17.5%        6.9%         14.4%       |17.5%        19.3%        15.7%        12.0%        | 
|TERMINAL (d)       |     2/31 (7%)    7/38 (18%)   3/34 (9%)    5/31 (16%)  |6/38 (16%)   5/35 (14%)   4/32 (13%)   2/28 (7%)    | 
|FIRST INCIDENCE    |     729 (T)      596          729 (T)      694         |714          383          573          593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.367      P=0.086      P=0.542      P=0.132     |P=0.274N     P=0.444      P=0.604      P=0.425N     | 
|POLY 3             |     P=0.428      P=0.067      P=0.534      P=0.141     |P=0.211N     P=0.520      P=0.522N     P=0.334N     | 
|POLY 1.5           |     P=0.431      P=0.062      P=0.533      P=0.141     |P=0.208N     P=0.512      P=0.519N     P=0.333N     | 
|POLY 6             |     P=0.419      P=0.073      P=0.531      P=0.139     |P=0.220N     P=0.528      P=0.531N     P=0.340N     | 
|LOGISTIC REGRESSION|     P=0.396      P=0.068      P=0.542      P=0.130     |P=0.198N     P=0.525      P=0.514N     P=0.338N     | 
|COCH-ARM / FISHERS |     P=0.430      P=0.056      P=0.530      P=0.141     |P=0.202N     P=0.500      P=0.518N     P=0.334N     | 
|ORDER RESTRICTED   |     P=0.138      (e)          (e)          (e)         |P=0.333N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Iliac                                                                                                                | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/1 (0%)     0/2 (0%)     0/5 (0%)     0/1 (0%)    |1/12 (8%)    1/13 (8%)    1/11 (9%)    2/8 (25%)    | 
|POLY-3 RATE (b)    |     0/1.00       0/1.68       0/3.48       0/0.64      |1/10.41      1/11.03      1/9.54       2/7.28       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |9.6%         9.1%         10.5%        27.5%        | 
|TERMINAL (d)       |     0/1 (0%)     0/0 (0%)     0/2 (0%)     0/0 (0%)    |1/8 (13%)    1/7 (14%)    1/6 (17%)    2/4 (50%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.134      P=0.738      P=0.702      P=0.249      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.208      P=0.750N     P=0.743      P=0.368      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.206      P=0.748N     P=0.744      P=0.364      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.203      P=0.750N     P=0.735      P=0.367      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.134      P=0.738      P=0.702      P=0.249      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.191      P=0.740N     P=0.739      P=0.344      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.245      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Inguinal                                                                                                             | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/1 (0%)     0/2 (0%)     1/5 (20%)    0/1 (0%)    |0/12 (0%)    2/13 (15%)   0/11 (0%)    0/8 (0%)     | 
|POLY-3 RATE (b)    |     0/1.00       0/1.68       1/3.76       0/0.64      |0/10.41      2/11.73      0/9.54       0/7.28       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         26.6%        0.0%        |0.0%         17.1%        0.0%         0.0%         | 
|TERMINAL (d)       |     0/1 (0%)     0/0 (0%)     0/2 (0%)     0/0 (0%)    |0/8 (0%)     1/7 (14%)    0/6 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          653          ---         |---          490          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.629      (e)          P=0.516      (e)         |P=0.272N     P=0.225      (e)          (e)          | 
|POLY 3             |     P=0.585      (e)          P=0.771      (e)         |P=0.279N     P=0.256      (e)          (e)          | 
|POLY 1.5           |     P=0.609      (e)          P=0.780      (e)         |P=0.280N     P=0.252      (e)          (e)          | 
|POLY 6             |     P=0.546      (e)          P=0.760      (e)         |P=0.283N     P=0.262      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.705      (e)          P=0.832      (e)         |P=0.355N     P=0.273      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.701      (e)          P=0.833      (e)         |P=0.286N     P=0.260      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.625      (e)          (e)          (e)         |P=0.338N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |5/50 (10%)   6/50 (12%)   2/50 (4%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     0/42.26      0/45.99      0/43.74      0/43.55     |5/46.76      6/46.07      2/44.56      5/45.85      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |10.7%        13.0%        4.5%         10.9%        | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |3/38 (8%)    2/35 (6%)    1/32 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |563          615          659          593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.462N     P=0.467      P=0.272N     P=0.572      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.412N     P=0.490      P=0.236N     P=0.618      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.406N     P=0.493      P=0.227N     P=0.621      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.423N     P=0.487      P=0.251N     P=0.612      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.389N     P=0.509      P=0.204N     P=0.614N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.397N     P=0.500      P=0.218N     P=0.630N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.401N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/7 (71%)    6/7 (86%)    7/10 (70%)   4/7 (57%)   |22/28 (79%)  18/20 (90%)  11/16 (69%)  13/19 (68%)  | 
|POLY-3 RATE (b)    |     5/6.75       6/6.55       7/8.86       4/6.86      |22/27.98     18/19.61     11/14.89     13/17.85     | 
|POLY-3 PERCENT (g) |     74.1%        91.7%        79.0%        58.4%       |78.6%        91.8%        73.9%        72.9%        | 
|TERMINAL (d)       |     5/6 (83%)    5/5 (100%)   7/8 (88%)    2/4 (50%)   |14/19 (74%)  12/12 (100%) 8/8 (100%)   10/13 (77%)  | 
|FIRST INCIDENCE    |     729 (T)      684          729 (T)      563         |474          584          634          688          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.536N     P=0.275      P=0.702      P=0.621     |P=0.092N     P=0.402      P=0.437N     P=0.218N     | 
|POLY 3             |     P=0.192N     P=0.450      P=0.650      P=0.485N    |P=0.181N     P=0.204      P=0.511N     P=0.463N     | 
|POLY 1.5           |     P=0.214N     P=0.472      P=0.679      P=0.492N    |P=0.142N     P=0.229      P=0.438N     P=0.401N     | 
|POLY 6             |     P=0.162N     P=0.423      P=0.622      P=0.474N    |P=0.260N     P=0.165      P=0.636N     P=0.557N     | 
|LOGISTIC REGRESSION|     P=0.353N     P=0.281      P=0.702      P=0.472N    |P=0.087N     P=0.238      P=0.365N     P=0.335N     | 
|COCH-ARM / FISHERS |     P=0.231N     P=0.500      P=0.686N     P=0.500N    |P=0.105N     P=0.261      P=0.354N     P=0.327N     | 
|ORDER RESTRICTED   |     P=0.231N     (e)          (e)          (e)         |P=0.261N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    1/50 (2%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/41.89      1/46.14      3/44.31      0/43.55     |0/45.94      0/45.44      0/44.30      1/45.31      | 
|POLY-3 PERCENT (g) |     2.4%         2.2%         6.8%         0.0%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    1/34 (3%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     655          691          596          ---         |---          ---          ---          682          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.460N     P=0.730N     P=0.319      P=0.495N    |P=0.181      (e)          (e)          P=0.495      | 
|POLY 3             |     P=0.445N     P=0.739N     P=0.325      P=0.492N    |P=0.183      (e)          (e)          P=0.497      | 
|POLY 1.5           |     P=0.437N     P=0.744N     P=0.323      P=0.491N    |P=0.184      (e)          (e)          P=0.498      | 
|POLY 6             |     P=0.460N     P=0.733N     P=0.327      P=0.495N    |P=0.182      (e)          (e)          P=0.496      | 
|LOGISTIC REGRESSION|     P=0.428N     P=0.762      P=0.316      P=0.500N    |P=0.187      (e)          (e)          P=0.507      | 
|COCH-ARM / FISHERS |     P=0.430N     P=0.742N     P=0.324      P=0.490N    |P=0.184      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.238N     (e)          (e)          (e)         |P=0.117      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/49 (10%)   3/47 (6%)    9/47 (19%)   7/49 (14%)   | 
|POLY-3 RATE (b)    |                                                        |5/44.98      3/42.71      9/43.31      7/45.33      | 
|POLY-3 PERCENT (g) |                                                        |11.1%        7.0%         20.8%        15.4%        | 
|TERMINAL (d)       |                                                        |4/37 (11%)   3/34 (9%)    5/29 (17%)   6/32 (19%)   | 
|FIRST INCIDENCE    |                                                        |720          729 (T)      479          659          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.092      P=0.403N     P=0.121      P=0.292      | 
|POLY 3             |                                                        |P=0.141      P=0.385N     P=0.170      P=0.384      | 
|POLY 1.5           |                                                        |P=0.141      P=0.384N     P=0.172      P=0.383      | 
|POLY 6             |                                                        |P=0.138      P=0.385N     P=0.164      P=0.381      | 
|LOGISTIC REGRESSION|                                                        |P=0.136      P=0.390N     P=0.188      P=0.365      | 
|COCH-ARM / FISHERS |                                                        |P=0.136      P=0.381N     P=0.171      P=0.380      | 
|ORDER RESTRICTED   |                                                        |P=0.161      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |14/49 (29%)  12/47 (26%)  14/47 (30%)  22/49 (45%)  | 
|POLY-3 RATE (b)    |                                                        |14/45.45     12/43.05     14/42.22     22/46.08     | 
|POLY-3 PERCENT (g) |                                                        |30.8%        27.9%        33.2%        47.8%        | 
|TERMINAL (d)       |                                                        |12/37 (32%)  9/34 (27%)   11/29 (38%)  16/32 (50%)  | 
|FIRST INCIDENCE    |                                                        |591          694          573          596          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.008 **   P=0.498N     P=0.330      P=0.031 *    | 
|POLY 3             |                                                        |P=0.024 *    P=0.472N     P=0.497      P=0.071      | 
|POLY 1.5           |                                                        |P=0.024 *    P=0.470N     P=0.517      P=0.071      | 
|POLY 6             |                                                        |P=0.021 *    P=0.471N     P=0.464      P=0.068      | 
|LOGISTIC REGRESSION|                                                        |P=0.022 *    P=0.468N     P=0.467      P=0.069      | 
|COCH-ARM / FISHERS |                                                        |P=0.025 *    P=0.458N     P=0.537      P=0.071      | 
|ORDER RESTRICTED   |                                                        |P=0.039 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/46 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |0/49 (0%)    1/49 (2%)    1/49 (2%)    3/47 (6%)    | 
|POLY-3 RATE (b)    |     0/40.18      0/45.99      0/43.74      0/43.10     |0/45.58      1/44.95      1/44.08      3/43.81      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.2%         2.3%         6.9%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          710          712          688          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.053      P=0.485      P=0.468      P=0.099      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.057      P=0.497      P=0.493      P=0.111      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.058      P=0.498      P=0.497      P=0.112      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.056      P=0.497      P=0.488      P=0.111      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.058      P=0.499      P=0.494      P=0.113      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.058      P=0.500      P=0.500      P=0.113      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.034 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/46 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |0/49 (0%)    0/49 (0%)    1/49 (2%)    3/47 (6%)    | 
|POLY-3 RATE (b)    |     0/40.18      0/45.99      0/43.74      0/43.10     |0/45.58      0/44.88      1/44.01      3/43.81      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         2.3%         6.9%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    1/32 (3%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          729 (T)      688          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.013 *    (e)          P=0.466      P=0.099      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.014 *    (e)          P=0.493      P=0.111      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.014 *    (e)          P=0.496      P=0.112      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.014 *    (e)          P=0.487      P=0.111      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.015 *    (e)          P=0.466      P=0.113      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.015 *    (e)          P=0.500      P=0.113      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.018 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Cytoplasmic Alteration                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/46 (4%)    2/50 (4%)    2/50 (4%)    0/49 (0%)   |1/49 (2%)    0/49 (0%)    0/49 (0%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     2/40.18      2/46.16      2/44.70      0/43.10     |1/45.58      0/44.88      0/44.01      0/43.65      | 
|POLY-3 PERCENT (g) |     5.0%         4.3%         4.5%         0.0%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/31 (7%)    1/38 (3%)    0/34 (0%)    0/31 (0%)   |1/38 (3%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      684          576          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.172N     P=0.621N     P=0.670N     P=0.238N    |P=0.389N     P=0.516N     P=0.534N     P=0.534N     | 
|POLY 3             |     P=0.156N     P=0.643N     P=0.655N     P=0.221N    |P=0.373N     P=0.503N     P=0.507N     P=0.509N     | 
|POLY 1.5           |     P=0.153N     P=0.652N     P=0.658N     P=0.221N    |P=0.372N     P=0.502N     P=0.504N     P=0.508N     | 
|POLY 6             |     P=0.163N     P=0.634N     P=0.653N     P=0.224N    |P=0.375N     P=0.504N     P=0.513N     P=0.510N     | 
|LOGISTIC REGRESSION|     P=0.150N     P=0.642N     P=0.669N     (e)         |P=0.389N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.151N     P=0.659N     P=0.659N     P=0.232N    |P=0.371N     P=0.500N     P=0.500N     P=0.510N     | 
|ORDER RESTRICTED   |     P=0.174N     (e)          (e)          (e)         |P=0.129N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Parathyroid Gland                                                                                                                | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/45 (0%)    2/47 (4%)    3/49 (6%)    4/47 (9%)   |2/45 (4%)    1/49 (2%)    1/47 (2%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     0/39.35      2/43.50      3/42.74      4/41.57     |2/41.58      1/44.44      1/41.63      3/44.58      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         7.0%         9.6%        |4.8%         2.3%         2.4%         6.7%         | 
|TERMINAL (d)       |     0/29 (0%)    2/36 (6%)    3/33 (9%)    2/29 (7%)   |2/34 (6%)    1/34 (3%)    1/31 (3%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      563         |729 (T)      729 (T)      729 (T)      596          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.045 *    P=0.287      P=0.144      P=0.067     |P=0.257      P=0.500N     P=0.532N     P=0.470      | 
|POLY 3             |     P=0.059      P=0.260      P=0.133      P=0.067     |P=0.302      P=0.477N     P=0.500N     P=0.532      | 
|POLY 1.5           |     P=0.061      P=0.254      P=0.134      P=0.067     |P=0.303      P=0.475N     P=0.493N     P=0.533      | 
|POLY 6             |     P=0.057      P=0.266      P=0.132      P=0.066     |P=0.299      P=0.479N     P=0.510N     P=0.529      | 
|LOGISTIC REGRESSION|     P=0.057      P=0.287      P=0.144      P=0.068     |P=0.298      P=0.500N     P=0.532N     P=0.538      | 
|COCH-ARM / FISHERS |     P=0.061      P=0.258      P=0.137      P=0.064     |P=0.305      P=0.468N     P=0.484N     P=0.541      | 
|ORDER RESTRICTED   |     P=0.041 *    (e)          (e)          (e)         |P=0.318      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/45 (0%)    0/50 (0%)    0/48 (0%)    0/48 (0%)   |2/47 (4%)    3/49 (6%)    1/49 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/39.54      0/45.99      0/42.09      0/42.44     |2/43.58      3/44.46      1/43.30      1/44.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.6%         6.8%         2.3%         2.3%         | 
|TERMINAL (d)       |     0/30 (0%)    0/38 (0%)    0/33 (0%)    0/31 (0%)   |2/36 (6%)    2/34 (6%)    1/31 (3%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      724          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.266N     P=0.474      P=0.552N     P=0.552N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.221N     P=0.509      P=0.502N     P=0.496N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.218N     P=0.512      P=0.495N     P=0.492N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.226N     P=0.506      P=0.514N     P=0.501N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.255N     P=0.485      P=0.552N     P=0.552N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.212N     P=0.520      P=0.484N     P=0.484N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.329N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/45 (16%)   7/50 (14%)   7/48 (15%)   5/48 (10%)  |2/47 (4%)    2/49 (4%)    1/49 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     7/39.54      7/45.99      7/42.24      5/42.70     |2/43.58      2/44.44      1/43.30      1/44.24      | 
|POLY-3 PERCENT (g) |     17.7%        15.2%        16.6%        11.7%       |4.6%         4.5%         2.3%         2.3%         | 
|TERMINAL (d)       |     7/30 (23%)   7/38 (18%)   6/33 (18%)   4/31 (13%)  |2/36 (6%)    2/34 (6%)    1/31 (3%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      691          659         |729 (T)      729 (T)      729 (T)      702          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.364N     P=0.423N     P=0.542N     P=0.353N    |P=0.361N     P=0.675      P=0.552N     P=0.546N     | 
|POLY 3             |     P=0.304N     P=0.493N     P=0.562N     P=0.324N    |P=0.313N     P=0.687N     P=0.502N     P=0.495N     | 
|POLY 1.5           |     P=0.298N     P=0.509N     P=0.562N     P=0.327N    |P=0.310N     P=0.684N     P=0.495N     P=0.492N     | 
|POLY 6             |     P=0.315N     P=0.477N     P=0.564N     P=0.326N    |P=0.318N     P=0.690N     P=0.514N     P=0.499N     | 
|LOGISTIC REGRESSION|     P=0.348N     P=0.423N     P=0.575N     P=0.346N    |P=0.332N     P=0.675      P=0.552N     P=0.502N     | 
|COCH-ARM / FISHERS |     P=0.293N     P=0.529N     P=0.562N     P=0.334N    |P=0.304N     P=0.676N     P=0.484N     P=0.484N     | 
|ORDER RESTRICTED   |     P=0.365N     (e)          (e)          (e)         |P=0.436N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/45 (2%)    0/50 (0%)    1/48 (2%)    0/48 (0%)   |4/47 (9%)    9/49 (18%)   4/49 (8%)    7/49 (14%)   | 
|POLY-3 RATE (b)    |     1/39.54      0/45.99      1/42.09      0/42.44     |4/43.58      9/44.44      4/43.65      7/45.04      | 
|POLY-3 PERCENT (g) |     2.5%         0.0%         2.4%         0.0%        |9.2%         20.3%        9.2%         15.5%        | 
|TERMINAL (d)       |     1/30 (3%)    0/38 (0%)    1/33 (3%)    0/31 (0%)   |4/36 (11%)   9/34 (27%)   3/31 (10%)   5/31 (16%)   | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |729 (T)      729 (T)      629          593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.501N     P=0.453N     P=0.741N     P=0.493N    |P=0.425      P=0.091      P=0.568      P=0.202      | 
|POLY 3             |     P=0.489N     P=0.470N     P=0.747N     P=0.486N    |P=0.534      P=0.121      P=0.643N     P=0.280      | 
|POLY 1.5           |     P=0.484N     P=0.474N     P=0.746N     P=0.486N    |P=0.536      P=0.125      P=0.632N     P=0.280      | 
|POLY 6             |     P=0.497N     P=0.466N     P=0.748N     P=0.488N    |P=0.530      P=0.117      P=0.629      P=0.277      | 
|LOGISTIC REGRESSION|     P=0.501N     (e)          P=0.741N     (e)         |P=0.520      P=0.091      P=0.629      P=0.281      | 
|COCH-ARM / FISHERS |     P=0.479N     P=0.474N     P=0.736N     P=0.484N    |P=0.542      P=0.133      P=0.619N     P=0.287      | 
|ORDER RESTRICTED   |     P=0.237N     (e)          (e)          (e)         |P=0.301      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     25/49 (51%)  26/50 (52%)  33/50 (66%)  33/50 (66%) |                                                    | 
|POLY-3 RATE (b)    |     25/44.73     26/47.96     33/48.56     33/45.60    |                                                    | 
|POLY-3 PERCENT (g) |     55.9%        54.2%        68.0%        72.4%       |                                                    | 
|TERMINAL (d)       |     15/31 (48%)  20/38 (53%)  20/34 (59%)  24/31 (77%) |                                                    | 
|FIRST INCIDENCE    |     482          562          367          558         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.022 *    P=0.327N     P=0.207      P=0.112     |                                                    | 
|POLY 3             |     P=0.020 *    P=0.519N     P=0.158      P=0.070     |                                                    | 
|POLY 1.5           |     P=0.027 *    P=0.560N     P=0.131      P=0.081     |                                                    | 
|POLY 6             |     P=0.013 *    P=0.479N     P=0.188      P=0.056     |                                                    | 
|LOGISTIC REGRESSION|     P=0.033 *    P=0.559N     P=0.097      P=0.098     |                                                    | 
|COCH-ARM / FISHERS |     P=0.038 *    P=0.541      P=0.095      P=0.095     |                                                    | 
|ORDER RESTRICTED   |     P=0.063      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     21/49 (43%)  30/50 (60%)  24/50 (48%)  28/50 (56%) |                                                    | 
|POLY-3 RATE (b)    |     21/44.19     30/47.54     24/46.26     28/46.53    |                                                    | 
|POLY-3 PERCENT (g) |     47.5%        63.1%        51.9%        60.2%       |                                                    | 
|TERMINAL (d)       |     13/31 (42%)  24/38 (63%)  17/34 (50%)  18/31 (58%) |                                                    | 
|FIRST INCIDENCE    |     435          562          573          489         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.199      P=0.280      P=0.467      P=0.149     |                                                    | 
|POLY 3             |     P=0.358      P=0.094      P=0.418      P=0.154     |                                                    | 
|POLY 1.5           |     P=0.357      P=0.078      P=0.398      P=0.146     |                                                    | 
|POLY 6             |     P=0.351      P=0.114      P=0.445      P=0.158     |                                                    | 
|LOGISTIC REGRESSION|     P=0.321      P=0.098      P=0.391      P=0.141     |                                                    | 
|COCH-ARM / FISHERS |     P=0.345      P=0.066      P=0.378      P=0.134     |                                                    | 
|ORDER RESTRICTED   |     P=0.170      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    4/50 (8%)    0/50 (0%)    1/49 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     0/41.26      4/46.53      0/43.74      1/43.48     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         8.6%         0.0%         2.3%        |                                                    | 
|TERMINAL (d)       |     0/30 (0%)    3/38 (8%)    0/34 (0%)    0/31 (0%)   |                                                    | 
|FIRST INCIDENCE    |     ---          562          ---          623         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.306N     P=0.094      (e)          P=0.509     |                                                    | 
|POLY 3             |     P=0.270N     P=0.077      (e)          P=0.510     |                                                    | 
|POLY 1.5           |     P=0.277N     P=0.072      (e)          P=0.508     |                                                    | 
|POLY 6             |     P=0.263N     P=0.083      (e)          P=0.512     |                                                    | 
|LOGISTIC REGRESSION|     P=0.291N     P=0.064      (e)          P=0.476     |                                                    | 
|COCH-ARM / FISHERS |     P=0.290N     P=0.064      (e)          P=0.505     |                                                    | 
|ORDER RESTRICTED   |     P=0.241      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.26      0/45.99      0/43.74      2/43.55     |0/45.94      0/44.57      0/44.30      0/45.13      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         0.0%         4.6%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    0/38 (0%)    0/34 (0%)    2/31 (7%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.176      P=0.459N     P=0.482N     P=0.500     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.192      P=0.483N     P=0.493N     P=0.510     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.196      P=0.489N     P=0.494N     P=0.510     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.186      P=0.477N     P=0.492N     P=0.508     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.176      (e)          (e)          P=0.500     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.201      P=0.495N     P=0.495N     P=0.508     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.136      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    4/50 (8%)    6/50 (12%)   1/50 (2%)   |15/50 (30%)  13/49 (27%)  16/50 (32%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |     3/42.37      4/45.99      6/43.74      1/43.55     |15/46.02     13/44.69     16/45.07     10/45.68     | 
|POLY-3 PERCENT (g) |     7.1%         8.7%         13.7%        2.3%        |32.6%        29.1%        35.5%        21.9%        | 
|TERMINAL (d)       |     2/31 (7%)    4/38 (11%)   6/34 (18%)   1/31 (3%)   |14/38 (37%)  11/35 (31%)  14/32 (44%)  7/32 (22%)   | 
|FIRST INCIDENCE    |     703          729 (T)      729 (T)      729 (T)     |710          706          617          593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.297N     P=0.602      P=0.283      P=0.314N    |P=0.370N     P=0.510N     P=0.289      P=0.318N     | 
|POLY 3             |     P=0.256N     P=0.545      P=0.257      P=0.295N    |P=0.201N     P=0.447N     P=0.471      P=0.179N     | 
|POLY 1.5           |     P=0.249N     P=0.530      P=0.255      P=0.295N    |P=0.203N     P=0.445N     P=0.486      P=0.180N     | 
|POLY 6             |     P=0.270N     P=0.561      P=0.257      P=0.298N    |P=0.205N     P=0.447N     P=0.444      P=0.179N     | 
|LOGISTIC REGRESSION|     P=0.295N     P=0.583      P=0.263      P=0.301N    |P=0.238N     P=0.466N     P=0.389      P=0.201N     | 
|COCH-ARM / FISHERS |     P=0.246N     P=0.511      P=0.254      P=0.301N    |P=0.202N     P=0.437N     P=0.500      P=0.178N     | 
|ORDER RESTRICTED   |     P=0.155N     (e)          (e)          (e)         |P=0.201N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Seminal Vesicle                                                                                                                  | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    5/50 (10%)   1/50 (2%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     3/42.72      5/46.68      1/43.74      0/43.55     |                                                    | 
|POLY-3 PERCENT (g) |     7.0%         10.7%        2.3%         0.0%        |                                                    | 
|TERMINAL (d)       |     2/31 (7%)    2/38 (5%)    1/34 (3%)    0/31 (0%)   |                                                    | 
|FIRST INCIDENCE    |     596          582          729 (T)      ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.022N*    P=0.448      P=0.280N     P=0.121N    |                                                    | 
|POLY 3             |     P=0.017N*    P=0.406      P=0.296N     P=0.115N    |                                                    | 
|POLY 1.5           |     P=0.017N*    P=0.390      P=0.297N     P=0.114N    |                                                    | 
|POLY 6             |     P=0.018N*    P=0.426      P=0.297N     P=0.117N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.017N*    P=0.357      P=0.296N     P=0.117N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.017N*    P=0.369      P=0.301N     P=0.117N    |                                                    | 
|ORDER RESTRICTED   |     P=0.041N*    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Cyst Epithelial Inclusion                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.26      2/45.99      0/43.74      0/43.55     |0/45.94      0/45.44      0/44.30      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    2/38 (5%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.240N     P=0.284      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.214N     P=0.256      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.218N     P=0.250      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.210N     P=0.264      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.284      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.225N     P=0.253      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.258N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    2/50 (4%)    0/50 (0%)    3/50 (6%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/42.34      2/46.44      0/43.74      3/44.08     |2/45.94      1/45.44      1/44.30      1/45.92      | 
|POLY-3 PERCENT (g) |     7.1%         4.3%         0.0%         6.8%        |4.4%         2.2%         2.3%         2.2%         | 
|TERMINAL (d)       |     2/31 (7%)    1/38 (3%)    0/34 (0%)    1/31 (3%)   |2/38 (5%)    1/35 (3%)    1/32 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     710          596          ---          659         |729 (T)      729 (T)      729 (T)      430          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.552      P=0.429N     P=0.112N     P=0.659     |P=0.483N     P=0.529N     P=0.560N     P=0.542N     | 
|POLY 3             |     P=0.582      P=0.458N     P=0.113N     P=0.644N    |P=0.440N     P=0.504N     P=0.513N     P=0.500N     | 
|POLY 1.5           |     P=0.588      P=0.472N     P=0.114N     P=0.647N    |P=0.439N     P=0.503N     P=0.507N     P=0.500N     | 
|POLY 6             |     P=0.572      P=0.442N     P=0.112N     P=0.643N    |P=0.444N     P=0.505N     P=0.523N     P=0.502N     | 
|LOGISTIC REGRESSION|     P=0.583N     P=0.484N     P=0.112N     P=0.650N    |P=0.420N     P=0.529N     P=0.560N     P=0.439N     | 
|COCH-ARM / FISHERS |     P=0.583N     P=0.490N     P=0.117N     P=0.651N    |P=0.439N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.330N     (e)          (e)          (e)         |P=0.415N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Epidermis                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    2/50 (4%)    0/50 (0%)    3/50 (6%)   |2/50 (4%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/42.34      2/46.04      0/43.74      3/44.08     |2/45.94      1/45.44      2/44.30      1/45.92      | 
|POLY-3 PERCENT (g) |     7.1%         4.3%         0.0%         6.8%        |4.4%         2.2%         4.5%         2.2%         | 
|TERMINAL (d)       |     2/31 (7%)    1/38 (3%)    0/34 (0%)    1/31 (3%)   |2/38 (5%)    1/35 (3%)    2/32 (6%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     710          717          ---          659         |729 (T)      729 (T)      729 (T)      430          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.544      P=0.413N     P=0.112N     P=0.659     |P=0.540N     P=0.529N     P=0.632      P=0.542N     | 
|POLY 3             |     P=0.584      P=0.462N     P=0.113N     P=0.644N    |P=0.489N     P=0.504N     P=0.681      P=0.500N     | 
|POLY 1.5           |     P=0.588N     P=0.474N     P=0.114N     P=0.647N    |P=0.489N     P=0.503N     P=0.687      P=0.500N     | 
|POLY 6             |     P=0.576      P=0.448N     P=0.112N     P=0.643N    |P=0.493N     P=0.505N     P=0.670      P=0.502N     | 
|LOGISTIC REGRESSION|     P=0.585      P=0.437N     P=0.112N     P=0.650N    |P=0.477N     P=0.529N     P=0.632      P=0.439N     | 
|COCH-ARM / FISHERS |     P=0.583N     P=0.490N     P=0.117N     P=0.651N    |P=0.490N     P=0.500N     P=0.691N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.330N     (e)          (e)          (e)         |P=0.443N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/47 (38%)  20/50 (40%)  28/50 (56%)  38/50 (76%) |34/50 (68%)  42/50 (84%)  35/50 (70%)  34/48 (71%)  | 
|POLY-3 RATE (b)    |     18/44.04     20/48.29     28/49.55     38/49.22    |34/47.57     42/48.19     35/48.20     34/47.67     | 
|POLY-3 PERCENT (g) |     40.9%        41.4%        56.5%        77.2%       |71.5%        87.2%        72.6%        71.3%        | 
|TERMINAL (d)       |     9/30 (30%)   14/38 (37%)  13/34 (38%)  22/31 (71%) |27/38 (71%)  31/35 (89%)  22/32 (69%)  20/32 (63%)  | 
|FIRST INCIDENCE    |     435          297          367          469         |555          383          479          430          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.463N     P=0.118      P=0.002 **  |P=0.504      P=0.039 *    P=0.198      P=0.283      | 
|POLY 3             |     P<0.001 **   P=0.563      P=0.094      P<0.001 **  |P=0.161N     P=0.042 *    P=0.542      P=0.583N     | 
|POLY 1.5           |     P<0.001 **   P=0.547      P=0.080      P<0.001 **  |P=0.204N     P=0.045 *    P=0.530      P=0.547      | 
|POLY 6             |     P<0.001 **   P=0.574      P=0.114      P<0.001 **  |P=0.125N     P=0.040 *    P=0.539      P=0.537N     | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.443      P=0.049 *    P<0.001 **  |P=0.275N     P=0.038 *    P=0.461      P=0.469      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.515      P=0.061      P<0.001 **  |P=0.282N     P=0.050      P=0.500      P=0.466      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.276N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |5/50 (10%)   5/50 (10%)   1/50 (2%)    2/48 (4%)    | 
|POLY-3 RATE (b)    |     0/40.70      1/46.25      1/43.88      1/43.84     |5/47.01      5/46.06      1/44.64      2/44.76      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         2.3%         2.3%        |10.6%        10.9%        2.2%         4.5%         | 
|TERMINAL (d)       |     0/30 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |2/38 (5%)    3/35 (9%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          659          691          652         |563          584          634          593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.412      P=0.534      P=0.511      P=0.510     |P=0.095N     P=0.597      P=0.133N     P=0.244N     | 
|POLY 3             |     P=0.430      P=0.525      P=0.515      P=0.515     |P=0.083N     P=0.617      P=0.114N     P=0.236N     | 
|POLY 1.5           |     P=0.432      P=0.520      P=0.514      P=0.514     |P=0.081N     P=0.621      P=0.108N     P=0.235N     | 
|POLY 6             |     P=0.425      P=0.532      P=0.516      P=0.514     |P=0.086N     P=0.613      P=0.123N     P=0.242N     | 
|LOGISTIC REGRESSION|     P=0.433      P=0.499      P=0.513      P=0.503     |P=0.084N     P=0.613N     P=0.086N     P=0.243N     | 
|COCH-ARM / FISHERS |     P=0.431      P=0.515      P=0.515      P=0.515     |P=0.081N     P=0.630N     P=0.102N     P=0.235N     | 
|ORDER RESTRICTED   |     P=0.342      (e)          (e)          (e)         |P=0.130N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/47 (9%)    7/50 (14%)   3/50 (6%)    8/50 (16%)  |0/50 (0%)    1/50 (2%)    2/50 (4%)    2/48 (4%)    | 
|POLY-3 RATE (b)    |     4/41.39      7/47.78      3/44.53      8/45.45     |0/45.94      1/45.58      2/44.55      2/44.26      | 
|POLY-3 PERCENT (g) |     9.7%         14.7%        6.7%         17.6%       |0.0%         2.2%         4.5%         4.5%         | 
|TERMINAL (d)       |     1/30 (3%)    1/38 (3%)    0/34 (0%)    2/31 (7%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     626          562          596          558         |---          694          668          702          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.253      P=0.365      P=0.482N     P=0.203     |P=0.147      P=0.500      P=0.216      P=0.214      | 
|POLY 3             |     P=0.294      P=0.349      P=0.460N     P=0.224     |P=0.159      P=0.498      P=0.230      P=0.229      | 
|POLY 1.5           |     P=0.298      P=0.327      P=0.462N     P=0.219     |P=0.159      P=0.499      P=0.234      P=0.229      | 
|POLY 6             |     P=0.285      P=0.375      P=0.460N     P=0.227     |P=0.156      P=0.498      P=0.225      P=0.227      | 
|LOGISTIC REGRESSION|     P=0.303      P=0.254      P=0.471N     P=0.197     |P=0.157      P=0.502      P=0.239      P=0.229      | 
|COCH-ARM / FISHERS |     P=0.298      P=0.299      P=0.465N     P=0.210     |P=0.156      P=0.500      P=0.247      P=0.237      | 
|ORDER RESTRICTED   |     P=0.211      (e)          (e)          (e)         |P=0.149      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/47 (6%)    6/50 (12%)   6/50 (12%)   6/50 (12%)  |8/50 (16%)   11/50 (22%)  14/50 (28%)  12/48 (25%)  | 
|POLY-3 RATE (b)    |     3/40.70      6/46.02      6/44.02      6/43.55     |8/46.54      11/45.52     14/45.70     12/44.97     | 
|POLY-3 PERCENT (g) |     7.4%         13.0%        13.6%        13.8%       |17.2%        24.2%        30.6%        26.7%        | 
|TERMINAL (d)       |     3/30 (10%)   5/38 (13%)   5/34 (15%)   6/31 (19%)  |6/38 (16%)   10/35 (29%)  11/32 (34%)  10/32 (31%)  | 
|FIRST INCIDENCE    |     729 (T)      721          653          729 (T)     |563          710          507          430          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.245      P=0.370      P=0.300      P=0.254     |P=0.120      P=0.245      P=0.061      P=0.135      | 
|POLY 3             |     P=0.312      P=0.306      P=0.281      P=0.275     |P=0.191      P=0.285      P=0.100      P=0.198      | 
|POLY 1.5           |     P=0.321      P=0.292      P=0.278      P=0.277     |P=0.192      P=0.292      P=0.106      P=0.200      | 
|POLY 6             |     P=0.295      P=0.322      P=0.284      P=0.269     |P=0.181      P=0.276      P=0.089      P=0.189      | 
|LOGISTIC REGRESSION|     P=0.258      P=0.353      P=0.277      P=0.254     |P=0.184      P=0.293      P=0.111      P=0.196      | 
|COCH-ARM / FISHERS |     P=0.326      P=0.275      P=0.275      P=0.275     |P=0.183      P=0.306      P=0.114      P=0.197      | 
|ORDER RESTRICTED   |     P=0.298      (e)          (e)          (e)         |P=0.155      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Diverticulum                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/42.26      2/45.99      1/44.24      0/43.55     |0/45.58      0/45.44      0/44.30      0/45.07      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         2.3%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    2/38 (5%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      576          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.341N     P=0.284      P=0.509      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.316N     P=0.256      P=0.509      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.319N     P=0.250      P=0.507      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.316N     P=0.264      P=0.511      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.322N     P=0.284      P=0.501      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.323N     P=0.253      P=0.505      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.336N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |0/49 (0%)    1/50 (2%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/42.72      0/45.99      1/44.19      2/44.65     |0/45.58      1/45.44      0/44.30      0/45.07      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.3%         4.5%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    1/35 (3%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     596          ---          596          476         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.196      P=0.491N     P=0.757N     P=0.515     |P=0.437N     P=0.484      (e)          (e)          | 
|POLY 3             |     P=0.190      P=0.485N     P=0.753N     P=0.515     |P=0.423N     P=0.499      (e)          (e)          | 
|POLY 1.5           |     P=0.193      P=0.490N     P=0.754N     P=0.513     |P=0.420N     P=0.501      (e)          (e)          | 
|POLY 6             |     P=0.184      P=0.480N     P=0.752N     P=0.515     |P=0.428N     P=0.498      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.157      P=0.514N     P=0.764      P=0.417     |(e)          P=0.484      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.193      P=0.495N     P=0.747N     P=0.508     |P=0.415N     P=0.505      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.236      (e)          (e)          (e)         |P=0.382N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 45      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    1/50 (2%)    3/50 (6%)    6/50 (12%)  |1/49 (2%)    2/50 (4%)    2/50 (4%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     3/42.91      1/45.99      3/44.67      6/44.10     |1/45.66      2/45.70      2/44.68      1/45.23      | 
|POLY-3 PERCENT (g) |     7.0%         2.2%         6.7%         13.6%       |2.2%         4.4%         4.5%         2.2%         | 
|TERMINAL (d)       |     2/31 (7%)    1/38 (3%)    1/34 (3%)    4/31 (13%)  |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     514          729 (T)      367          597         |710          682          643          688          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.043 *    P=0.247N     P=0.627N     P=0.248     |P=0.541N     P=0.486      P=0.453      P=0.738      | 
|POLY 3             |     P=0.051      P=0.281N     P=0.644N     P=0.255     |P=0.517N     P=0.500      P=0.492      P=0.758      | 
|POLY 1.5           |     P=0.053      P=0.288N     P=0.646N     P=0.255     |P=0.514N     P=0.502      P=0.499      P=0.759      | 
|POLY 6             |     P=0.047 *    P=0.272N     P=0.643N     P=0.251     |P=0.523N     P=0.499      P=0.482      P=0.756      | 
|LOGISTIC REGRESSION|     P=0.057      P=0.313N     P=0.662      P=0.252     |P=0.515N     P=0.509      P=0.523      P=0.761N     | 
|COCH-ARM / FISHERS |     P=0.056      P=0.301N     P=0.651N     P=0.254     |P=0.513N     P=0.508      P=0.508      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.079      (e)          (e)          (e)         |P=0.542      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    2/50 (4%)    2/50 (4%)    2/50 (4%)   |1/49 (2%)    1/50 (2%)    1/50 (2%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     2/42.97      2/46.79      2/44.61      2/44.25     |1/45.58      1/45.58      1/44.53      3/45.68      | 
|POLY-3 PERCENT (g) |     4.7%         4.3%         4.5%         4.5%        |2.2%         2.2%         2.3%         6.6%         | 
|TERMINAL (d)       |     1/31 (3%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |1/38 (3%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     482          562          431          558         |729 (T)      694          668          596          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.569      P=0.643N     P=0.677N     P=0.682N    |P=0.146      P=0.751      P=0.733      P=0.280      | 
|POLY 3             |     P=0.581      P=0.663N     P=0.681N     P=0.684N    |P=0.158      P=0.761      P=0.755      P=0.306      | 
|POLY 1.5           |     P=0.587N     P=0.673N     P=0.683N     P=0.684N    |P=0.158      P=0.759N     P=0.760      P=0.306      | 
|POLY 6             |     P=0.570      P=0.650N     P=0.679N     P=0.685N    |P=0.156      P=0.759      P=0.749      P=0.304      | 
|LOGISTIC REGRESSION|     P=0.576      P=0.659      P=0.695      P=0.665     |P=0.152      P=0.762N     P=0.757N     P=0.308      | 
|COCH-ARM / FISHERS |     P=0.583N     P=0.684N     P=0.684N     P=0.684N    |P=0.156      P=0.747N     P=0.747N     P=0.309      | 
|ORDER RESTRICTED   |     P=0.724N     (e)          (e)          (e)         |P=0.189      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 46      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    3/50 (6%)    4/50 (8%)    7/50 (14%)  |4/49 (8%)    5/50 (10%)   0/50 (0%)    4/49 (8%)    | 
|POLY-3 RATE (b)    |     4/43.02      3/46.70      4/45.85      7/44.62     |4/46.04      5/45.85      0/44.30      4/45.34      | 
|POLY-3 PERCENT (g) |     9.3%         6.4%         8.7%         15.7%       |8.7%         10.9%        0.0%         8.8%         | 
|TERMINAL (d)       |     3/31 (10%)   1/38 (3%)    1/34 (3%)    3/31 (10%)  |2/38 (5%)    1/35 (3%)    0/32 (0%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     458          596          367          597         |621          682          ---          688          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.110      P=0.419N     P=0.610N     P=0.273     |P=0.419N     P=0.470      P=0.085N     P=0.574      | 
|POLY 3             |     P=0.117      P=0.455N     P=0.608N     P=0.281     |P=0.366N     P=0.497      P=0.065N     P=0.635      | 
|POLY 1.5           |     P=0.121      P=0.470N     P=0.616N     P=0.279     |P=0.360N     P=0.502      P=0.062N     P=0.639      | 
|POLY 6             |     P=0.111      P=0.435N     P=0.600N     P=0.284     |P=0.378N     P=0.493      P=0.071N     P=0.626      | 
|LOGISTIC REGRESSION|     P=0.119      P=0.530N     P=0.633      P=0.267     |P=0.355N     P=0.513      P=0.057N     P=0.643N     | 
|COCH-ARM / FISHERS |     P=0.124      P=0.489N     P=0.631N     P=0.274     |P=0.355N     P=0.513      P=0.056N     P=0.643N     | 
|ORDER RESTRICTED   |     P=0.174      (e)          (e)          (e)         |P=0.254N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/47 (4%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/49 (0%)    1/50 (2%)    0/50 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     2/41.83      2/46.79      1/43.82      0/43.55     |0/45.58      1/45.50      0/44.30      1/45.53      | 
|POLY-3 PERCENT (g) |     4.8%         4.3%         2.3%         0.0%        |0.0%         2.2%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     626          562          708          ---         |---          715          ---          596          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.125N     P=0.640N     P=0.490N     P=0.241N    |P=0.478      P=0.490      (e)          P=0.509      | 
|POLY 3             |     P=0.113N     P=0.653N     P=0.484N     P=0.228N    |P=0.479      P=0.500      (e)          P=0.500      | 
|POLY 1.5           |     P=0.110N     P=0.661N     P=0.481N     P=0.225N    |P=0.480      P=0.501      (e)          P=0.500      | 
|POLY 6             |     P=0.119N     P=0.644N     P=0.488N     P=0.233N    |P=0.475      P=0.498      (e)          P=0.498      | 
|LOGISTIC REGRESSION|     P=0.101N     P=0.697N     P=0.478N     P=0.224N    |P=0.470      P=0.500      (e)          P=0.521      | 
|COCH-ARM / FISHERS |     P=0.105N     P=0.668N     P=0.477N     P=0.232N    |P=0.481      P=0.505      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.148N     (e)          (e)          (e)         |P=0.251      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 47      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/49 (18%)   4/50 (8%)    4/50 (8%)    8/50 (16%)  |                                                    | 
|POLY-3 RATE (b)    |     9/43.45      4/46.30      4/44.47      8/44.84     |                                                    | 
|POLY-3 PERCENT (g) |     20.7%        8.6%         9.0%         17.8%       |                                                    | 
|TERMINAL (d)       |     4/31 (13%)   2/38 (5%)    2/34 (6%)    4/31 (13%)  |                                                    | 
|FIRST INCIDENCE    |     596          659          596          558         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.381      P=0.075N     P=0.110N     P=0.510N    |                                                    | 
|POLY 3             |     P=0.436      P=0.091N     P=0.105N     P=0.471N    |                                                    | 
|POLY 1.5           |     P=0.446      P=0.098N     P=0.106N     P=0.472N    |                                                    | 
|POLY 6             |     P=0.418      P=0.085N     P=0.105N     P=0.480N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.456      P=0.104N     P=0.109N     P=0.482N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.455      P=0.109N     P=0.109N     P=0.482N    |                                                    | 
|ORDER RESTRICTED   |     P=0.176N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/42 (33%)  16/45 (36%)  12/46 (26%)  22/47 (47%) |8/44 (18%)   9/47 (19%)   11/47 (23%)  13/48 (27%)  | 
|POLY-3 RATE (b)    |     14/40.05     16/43.58     12/43.62     22/45.15    |8/42.03      9/45.76      11/45.14     13/45.11     | 
|POLY-3 PERCENT (g) |     35.0%        36.7%        27.5%        48.7%       |19.0%        19.7%        24.4%        28.8%        | 
|TERMINAL (d)       |     4/29 (14%)   8/34 (24%)   3/32 (9%)    10/31 (32%) |4/34 (12%)   1/34 (3%)    2/32 (6%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     435          562          367          563         |555          487          479          593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.092      P=0.574N     P=0.377N     P=0.127     |P=0.111      P=0.490      P=0.272      P=0.161      | 
|POLY 3             |     P=0.130      P=0.524      P=0.309N     P=0.143     |P=0.128      P=0.577      P=0.366      P=0.207      | 
|POLY 1.5           |     P=0.133      P=0.514      P=0.306N     P=0.143     |P=0.134      P=0.568      P=0.366      P=0.210      | 
|POLY 6             |     P=0.124      P=0.534      P=0.317N     P=0.141     |P=0.123      P=0.588      P=0.364      P=0.207      | 
|LOGISTIC REGRESSION|     P=0.114      P=0.410      P=0.340N     P=0.101     |P=0.165      P=0.613N     P=0.439      P=0.241      | 
|COCH-ARM / FISHERS |     P=0.136      P=0.503      P=0.305N     P=0.141     |P=0.145      P=0.560      P=0.362      P=0.222      | 
|ORDER RESTRICTED   |     P=0.102      (e)          (e)          (e)         |P=0.225      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 48      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/42 (0%)    1/45 (2%)    1/46 (2%)    1/47 (2%)   |0/44 (0%)    3/47 (6%)    3/47 (6%)    2/48 (4%)    | 
|POLY-3 RATE (b)    |     0/36.42      1/41.16      1/40.52      1/42.19     |0/40.66      3/43.02      3/42.14      2/43.37      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         2.5%         2.4%        |0.0%         7.0%         7.1%         4.6%         | 
|TERMINAL (d)       |     0/29 (0%)    1/34 (3%)    1/32 (3%)    1/31 (3%)   |0/34 (0%)    3/34 (9%)    3/32 (9%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      729 (T)     |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.419      P=0.532      P=0.520      P=0.513     |P=0.363      P=0.121      P=0.110      P=0.225      | 
|POLY 3             |     P=0.454      P=0.524      P=0.521      P=0.529     |P=0.408      P=0.128      P=0.124      P=0.251      | 
|POLY 1.5           |     P=0.453      P=0.520      P=0.520      P=0.527     |P=0.412      P=0.129      P=0.127      P=0.253      | 
|POLY 6             |     P=0.451      P=0.528      P=0.521      P=0.529     |P=0.401      P=0.128      P=0.120      P=0.249      | 
|LOGISTIC REGRESSION|     (e)          P=0.532      P=0.520      P=0.513     |(e)          P=0.121      P=0.110      P=0.225      | 
|COCH-ARM / FISHERS |     P=0.445      P=0.517      P=0.523      P=0.528     |P=0.421      P=0.133      P=0.133      P=0.269      | 
|ORDER RESTRICTED   |     P=0.350      (e)          (e)          (e)         |P=0.140      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/48 (10%)   8/50 (16%)   3/50 (6%)    6/50 (12%)  |10/50 (20%)  26/50 (52%)  16/50 (32%)  14/50 (28%)  | 
|POLY-3 RATE (b)    |     5/42.52      8/46.04      3/43.91      6/43.97     |10/46.75     26/46.85     16/45.64     14/46.25     | 
|POLY-3 PERCENT (g) |     11.8%        17.4%        6.8%         13.7%       |21.4%        55.5%        35.1%        30.3%        | 
|TERMINAL (d)       |     3/31 (10%)   7/38 (18%)   1/34 (3%)    4/31 (13%)  |8/38 (21%)   22/35 (63%)  12/32 (38%)  9/32 (28%)   | 
|FIRST INCIDENCE    |     451          717          699          659         |563          490          573          596          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.488N     P=0.412      P=0.326N     P=0.507     |P=0.393N     P<0.001 **   P=0.066      P=0.157      | 
|POLY 3             |     P=0.413N     P=0.329      P=0.338N     P=0.524     |P=0.232N     P<0.001 **   P=0.107      P=0.229      | 
|POLY 1.5           |     P=0.406N     P=0.317      P=0.337N     P=0.527     |P=0.230N     P<0.001 **   P=0.116      P=0.231      | 
|POLY 6             |     P=0.425N     P=0.343      P=0.339N     P=0.517     |P=0.237N     P<0.001 **   P=0.095      P=0.226      | 
|LOGISTIC REGRESSION|     P=0.417N     P=0.324      P=0.334N     P=0.530     |P=0.238N     P<0.001 **   P=0.117      P=0.234      | 
|COCH-ARM / FISHERS |     P=0.398N     P=0.304      P=0.335N     P=0.529     |P=0.225N     P<0.001 **   P=0.127      P=0.241      | 
|ORDER RESTRICTED   |     P=0.424N     (e)          (e)          (e)         |P=0.033 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 49      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/48 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |8/50 (16%)   1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/41.70      0/45.99      0/43.74      0/43.55     |8/46.38      1/45.44      1/44.30      2/45.59      | 
|POLY-3 PERCENT (g) |     7.2%         0.0%         0.0%         0.0%        |17.3%        2.2%         2.3%         4.4%         | 
|TERMINAL (d)       |     3/31 (10%)   0/38 (0%)    0/34 (0%)    0/31 (0%)   |6/38 (16%)   1/35 (3%)    1/32 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |621          729 (T)      729 (T)      593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.101N     P=0.087N     P=0.105N     P=0.120N    |P=0.116N     P=0.025N*    P=0.033N*    P=0.075N     | 
|POLY 3             |     P=0.097N     P=0.102N     P=0.110N     P=0.111N    |P=0.081N     P=0.017N*    P=0.019N*    P=0.048N*    | 
|POLY 1.5           |     P=0.093N     P=0.106N     P=0.111N     P=0.110N    |P=0.081N     P=0.017N*    P=0.017N*    P=0.047N*    | 
|POLY 6             |     P=0.102N     P=0.097N     P=0.110N     P=0.112N    |P=0.083N     P=0.017N*    P=0.022N*    P=0.049N*    | 
|LOGISTIC REGRESSION|     P=0.101N     (e)          (e)          (e)         |P=0.089N     P=0.019N*    P=0.021N*    P=0.048N*    | 
|COCH-ARM / FISHERS |     P=0.092N     P=0.114N     P=0.114N     P=0.114N    |P=0.086N     P=0.015N*    P=0.015N*    P=0.046N*    | 
|ORDER RESTRICTED   |     P=0.006N**   (e)          (e)          (e)         |P=0.002N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Malformation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/5 (100%)   6/6 (100%)   0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     1/1 (100%)   0/0 (0%)     | 
|POLY-3 RATE (b)    |     5/5.00       6/6.00       0/0.00       0/0.00      |0/0.00       0/0.00       1/1.00       0/0.00       | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       0.0%         0.0%        |0.0%         0.0%         100.0%       0.0%         | 
|TERMINAL (d)       |     3/3 (100%)   5/5 (100%)   0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     626          717          ---          ---         |---          ---          680          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 50      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urethra                                                                                                                          | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     3/3 (100%)   0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|POLY-3 RATE (b)    |     0/0.00       3/3.00       0/0.00       0/0.00      |0/0.00       0/0.00       0/0.00       0/0.00       | 
|POLY-3 PERCENT (g) |     0.0%         100.0%       0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     ---          562          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urethra                                                                                                                          | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     3/3 (100%)   0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|POLY-3 RATE (b)    |     0/0.00       3/3.00       0/0.00       0/0.00      |0/0.00       0/0.00       0/0.00       0/0.00       | 
|POLY-3 PERCENT (g) |     0.0%         100.0%       0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     ---          562          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 51      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    1/50 (2%)    0/49 (0%)   |2/50 (4%)    0/49 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/42.26      0/45.99      1/44.37      0/42.64     |2/46.61      0/44.52      0/44.30      0/45.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         0.0%        |4.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/34 (0%)    0/31 (0%)   |0/38 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          521          ---         |517          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.637      (e)          P=0.517      (e)         |P=0.191N     P=0.253N     P=0.260N     P=0.264N     | 
|POLY 3             |     P=0.622      (e)          P=0.510      (e)         |P=0.176N     P=0.248N     P=0.249N     P=0.245N     | 
|POLY 1.5           |     P=0.628      (e)          P=0.507      (e)         |P=0.176N     P=0.246N     P=0.243N     P=0.243N     | 
|POLY 6             |     P=0.611      (e)          P=0.512      (e)         |P=0.177N     P=0.249N     P=0.257N     P=0.248N     | 
|LOGISTIC REGRESSION|     P=0.600      (e)          P=0.511      (e)         |P=0.190N     P=0.197N     P=0.215N     P=0.246N     | 
|COCH-ARM / FISHERS |     P=0.633      (e)          P=0.505      (e)         |P=0.178N     P=0.253N     P=0.247N     P=0.253N     | 
|ORDER RESTRICTED   |     P=0.390      (e)          (e)          (e)         |P=0.032N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    1/50 (2%)    0/49 (0%)   |3/50 (6%)    5/49 (10%)   3/50 (6%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/42.26      1/45.99      1/43.74      0/42.64     |3/45.98      5/44.55      3/44.68      2/45.07      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         2.3%         0.0%        |6.5%         11.2%        6.7%         4.4%         | 
|TERMINAL (d)       |     0/31 (0%)    1/38 (3%)    1/34 (3%)    0/31 (0%)   |2/38 (5%)    4/35 (11%)   2/32 (6%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |720          721          622          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.539N     P=0.541      P=0.518      (e)         |P=0.296N     P=0.317      P=0.592      P=0.577N     | 
|POLY 3             |     P=0.517N     P=0.517      P=0.507      (e)         |P=0.235N     P=0.339      P=0.649      P=0.509N     | 
|POLY 1.5           |     P=0.517N     P=0.511      P=0.506      (e)         |P=0.234N     P=0.341      P=0.655      P=0.508N     | 
|POLY 6             |     P=0.519N     P=0.523      P=0.508      (e)         |P=0.241N     P=0.337      P=0.638      P=0.514N     | 
|LOGISTIC REGRESSION|     (e)          P=0.541      P=0.518      (e)         |P=0.242N     P=0.328      P=0.650      P=0.547N     | 
|COCH-ARM / FISHERS |     P=0.519N     P=0.505      P=0.505      (e)         |P=0.234N     P=0.346      P=0.661N     P=0.510N     | 
|ORDER RESTRICTED   |     P=0.411N     (e)          (e)          (e)         |P=0.329N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/19/04                           EXPERIMENT: 96017 TEST: 06                                            Page 52      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -    WATER DISINFECTION BYPRODUCTS (DIBROMOAC                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    4/50 (8%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |0/45.94      4/45.44      1/44.65      2/45.39      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         8.8%         2.2%         4.4%         | 
|TERMINAL (d)       |                                                        |0/38 (0%)    4/35 (11%)   0/32 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |                                                        |---          729 (T)      629          659          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.556      P=0.053      P=0.495      P=0.226      | 
|POLY 3             |                                                        |P=0.592      P=0.059      P=0.494      P=0.234      | 
|POLY 1.5           |                                                        |P=0.594      P=0.059      P=0.497      P=0.235      | 
|POLY 6             |                                                        |P=0.587      P=0.058      P=0.490      P=0.233      | 
|LOGISTIC REGRESSION|                                                        |P=0.593N     P=0.053      P=0.515      P=0.239      | 
|COCH-ARM / FISHERS |                                                        |P=0.590N     P=0.059      P=0.500      P=0.247      | 
|ORDER RESTRICTED   |                                                        |P=0.151      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       50 MG/L      500 MG/L     1000        |0 MG/L       50 MG/L      500 MG/L     1000         | 
|                   |                                            MG/L        |                                       MG/L         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |44/50 (88%)  42/50 (84%)  44/50 (88%)  39/50 (78%)  | 
|POLY-3 RATE (b)    |                                                        |44/48.05     42/49.09     44/49.16     39/47.56     | 
|POLY-3 PERCENT (g) |                                                        |91.6%        85.6%        89.5%        82.0%        | 
|TERMINAL (d)       |                                                        |36/38 (95%)  30/35 (86%)  30/32 (94%)  26/32 (81%)  | 
|FIRST INCIDENCE    |                                                        |563          383          479          593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.422      P=0.509      P=0.145      P=0.522      | 
|POLY 3             |                                                        |P=0.178N     P=0.262N     P=0.499N     P=0.127N     | 
|POLY 1.5           |                                                        |P=0.175N     P=0.308N     P=0.543N     P=0.138N     | 
|POLY 6             |                                                        |P=0.183N     P=0.224N     P=0.478N     P=0.118N     | 
|LOGISTIC REGRESSION|                                                        |P=0.168N     P=0.422N     P=0.572      P=0.140N     | 
|COCH-ARM / FISHERS |                                                        |P=0.150N     P=0.387N     P=0.620N     P=0.143N     | 
|ORDER RESTRICTED   |                                                        |P=0.112N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
                                                                                                                                   
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.