TDMS Study 96017-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) DATE: 05/19/04
EXPERIMENT: 96017 TEST: 06 TIME: 09:31:13
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: C96017
PATHOLOGIST: HEATH, JAMES CAS: 631-64-1
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1 MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID) DATE: 05/19/04
EXPERIMENT: 96017 TEST: 06 TIME: 09:31:13
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: C96017
PATHOLOGIST: HEATH, JAMES CAS: 631-64-1
WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/L |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 435 451 458 482 514 596 601 626 631 632 |
| 655 662 669 703 710 710 715 717 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 297 562 573 582 596 659 659 684 690 691 |
| 717 721 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 367 431 521 573 576 596 604 625 626 631 |
| 653 654 691 699 708 714 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1000 MG/L |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 469 476 489 558 563 597 623 627 637 652 |
| 659 659 689 691 692 694 702 706 707 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/L | 100.0 100.0 100.0 100.0 100.0 91.8 89.8 85.7 75.5 63.3 |
| | |
| | |
|50 MG/L | 100.0 100.0 100.0 98.0 98.0 98.0 98.0 90.0 86.0 76.0 |
| | |
| | |
|500 MG/L | 100.0 100.0 100.0 100.0 98.0 96.0 94.0 86.0 76.0 68.0 |
| | |
| | |
|1000 | 100.0 100.0 100.0 100.0 100.0 96.0 94.0 88.0 76.0 62.0 |
|MG/L | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/L 50 MG/L 500 MG/L 1000 |
| MG/L |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 63.3% 76.0% 68.0% 62.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.428 P=0.221N P=0.813N P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 609.3 619.3 604.3 625.8 |
|NATURAL DEATHS (C) | (23.2) (33.6) (24.2) (18.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 685.0 702.7 689.1 689.8 |
|(STANDARD ERROR) | (11.8) (10.3) (11.2) ( 9.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 474 517 555 563 591 621 653 658 710 714 |
| 720 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 383 487 490 584 601 615 659 682 694 697 |
| 706 710 715 721 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 479 507 553 573 617 618 622 629 634 643 |
| 659 668 680 692 701 712 718 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1000 MG/L |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 279 430 593 596 629 636 659 671 676 682 |
| 682 688 702 715 717 719 721 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/L | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 90.0 84.0 76.0 |
| | |
| | |
|50 MG/L | 100.0 100.0 100.0 100.0 98.0 98.0 94.0 90.0 86.0 70.0 |
| | |
| | |
|500 MG/L | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 92.0 78.0 64.0 |
| | |
| | |
|1000 | 100.0 100.0 100.0 98.0 98.0 96.0 96.0 92.0 86.0 64.0 |
|MG/L | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/L 50 MG/L 500 MG/L 1000 |
| MG/L |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 76.0% 70.0% 64.0% 64.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.276 P=0.658 P=0.273 P=0.309 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 624.9 631.2 634.9 639.8 |
|NATURAL DEATHS (C) | (24.6) (27.0) (16.6) (26.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 704.0 699.7 695.1 696.9 |
|(STANDARD ERROR) | ( 8.5) (10.2) ( 8.7) (11.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/L = 1
50 MG/L = 2
500 MG/L = 3
1000 MG/L = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1 4
|
| 2 3 31 1 44 2
| 3 11 4 4 3 22
95 +
| 1 14 3 4 2 2
| 44332 2
| 1 1
P 90 + 1 4 3 1 2
E |
R | 33 4
C | 13 41 2 2
E 85 +
N | 11 22
T | 33 4
|
S 80 + 1 1 4 2 2
U |
R | 1 1
V | 3 4 3 2 2
I 75 + 11
V | 1 331
A | 3 3
L | 11
70 + 44
|
| 4411 3
|
65 +
| 1 1
| 4 4
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 18 obs hidden.
WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/L = 1
50 MG/L = 2
500 MG/L = 3
1000 MG/L = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 13
|
| 4 2 4 132 31
|
96 + 4 31 31 4
|
| 2 3113 2 44
|
92 + 13 2 12 34
|
P | 12 2144
E |
R 88 + 21 4 1 2
C |
E | 33 24 2
N |
T 84 + 33 1 442 2 1
|
S | 33 44
U |
R 80 + 3 3 2211
V |
I | 33 44 2211
V |
A 76 + 3 34 4221 1
L |
| 33 4 4
|
72 + 3 3 22
|
| 33 2 2
|
68 + 33
|
| 33
|
64 + 43 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 7 obs hidden.