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https://ntp.niehs.nih.gov/go/18942

TDMS Study 93020-07 Pathology Tables

NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 1
TEST TYPE: CHRONIC                              INITIAL AND CURRENT BODY WEIGHT                                   DATE: 06/30/04
ROUTE: SKIN APPLICATION                                                                                           TIME: 11:09:46

                                                         EIS REPORT 03


       FACILITY:  Southern Research Institute

       NTP C#:  93020D

       CONTRACT NUMBER:  N01-ES 05451

       CAS NUMBER:  693-13-0

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 2
TEST TYPE: CHRONIC                              INITIAL AND CURRENT BODY WEIGHT                                   DATE: 06/30/04
ROUTE: SKIN APPLICATION                                     EISRPT03                                              TIME: 11:09:46
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: F 344-RATS                 SEX: FEMALE      WEEK ON DOSE: 105    FIRST DOSE: 04/24/00
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            50     89.6    7.3        30    324.9   29.0                     30    235.2   27.7

 10 MG/KG           50     90.1    7.4        32    314.4   25.7        96.7         32    223.5   24.7

 20 MG/KG           50     91.2    7.8        32    312.0   30.1        96.0         32    221.1   30.1

 40 MG/KG           50     90.0    7.1        25    286.9   19.7        88.3         25    199.4   18.8




----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: F 344-RATS                 SEX: MALE        WEEK ON DOSE: 105    FIRST DOSE: 04/24/00
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            50    101.0    8.3        20    474.2   39.4                     20    374.8   37.6

 10 MG/KG           50    100.1    8.4        30    467.3   32.2        98.5         30    368.9   33.1

 20 MG/KG           50    100.8    8.1        32    472.7   38.4        99.6         32    373.1   37.8

 40 MG/KG           50    102.2    8.1        17    379.4   26.4        80.0         17    276.5   28.2

                                               -----------------------------------
                                               ---------- END-OF-REPORT ----------
                                               -----------------------------------