National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/19248

TDMS Study 93020-08 Pathology Tables

NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/19/04
Route: SKIN APPLICATION                                    DIISOPROPYLCARBODIIMIDE                                Time: 09:22:22

                                                         FINAL #1 MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  693-13-0

       Lock Date:  03/14/03

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/19/04    
Route: SKIN APPLICATION                                    DIISOPROPYLCARBODIIMIDE                                Time: 09:22:22    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      5            5            6            4                                     
    Moribund Sacrifice                                12           11            4            5                                     
    Accidently Killed                                               1            1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           32           38           40                                     
    Natural Death                                                   1                                                               
    Moribund Sacrifice                                                           1                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (42)         (47)         (42)         (47)                                   
      Cyst                                                          1 [1.0]                                                         
   Intestine Large, Cecum                             (46)         (45)         (44)         (47)                                   
      Cyst                                             1 [1.0]                                                                      
      Edema                                                                                   1 [3.0]                               
   Intestine Small, Duodenum                          (46)         (46)         (44)         (47)                                   
      Hyperplasia, Lymphoid                                         1 [3.0]                                                         
      Perforation                                                                1 [3.0]                                            
   Intestine Small, Jejunum                           (47)         (45)         (44)         (46)                                   
      Inflammation, Focal                                           1 [2.0]                                                         
      Epithelium, Hyperplasia, Focal                                                          1 [2.0]                               
      Peyer's Patch, Hyperplasia, Lymphoid                          1 [3.0]                                                         
   Intestine Small, Ileum                             (46)         (44)         (45)         (47)                                   
      Peyer's Patch, Hyperplasia, Lymphoid             1 [3.0]                                                                      
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                               1 [2.0]      2 [2.5]                                                         
      Clear Cell Focus                                                                        1                                     
      Congestion                                       1 [2.0]                                                                      
      Eosinophilic Focus                               6            1            6                                                  
      Hematopoietic Cell Proliferation                              2 [3.0]                   1 [2.0]                               
      Hyperplasia, Focal, Lymphoid                                  1 [2.0]      2 [2.0]                                            
      Infiltration Cellular, Polymorphonuclear                      1 [3.0]                   1 [3.0]                               
      Infiltration Cellular, Mixed Cell               16 [1.6]      9 [1.7]     10 [1.2]     22 [1.2]                               
      Mineralization, Focal                                         1 [3.0]                                                         
      Necrosis, Focal                                                            1 [2.0]                                            
      Hepatocyte, Basophilic Focus                     1                         1            1                                     
      Hepatocyte, Clear Cell Focus                     3            2                         1                                     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/19/04    
Route: SKIN APPLICATION                                    DIISOPROPYLCARBODIIMIDE                                Time: 09:22:22    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Eosinophilic Focus                                             4                                                  
      Hepatocyte, Karyomegaly                          1 [1.0]                                                                      
      Hepatocyte, Mixed Cell Focus                     2                         1            6                                     
      Hepatocyte, Necrosis, Focal                      3 [1.3]      3 [3.0]      1 [1.0]      1 [1.0]                               
      Hepatocyte, Vacuolization Cytoplasmic            5 [1.8]      3 [2.3]      1 [1.0]      5 [2.2]                               
   Mesentery                                          (23)         (20)         (14)         (18)                                   
      Hemorrhage                                                                 1 [3.0]                                            
      Infiltration Cellular, Lymphoid                  1 [3.0]                                                                      
      Infiltration Cellular, Mixed Cell                1 [3.0]                                                                      
      Inflammation                                     3 [3.3]      5 [3.2]                   1 [2.0]                               
      Artery, Inflammation                                                                    1 [2.0]                               
      Fat, Necrosis, Focal                            17 [2.6]     13 [2.7]      9 [2.3]     15 [2.3]                               
   Pancreas                                           (50)         (48)         (50)         (50)                                   
      Inflammation, Focal                              1 [2.0]                                                                      
      Acinus, Atrophy, Diffuse                                      2 [4.0]                                                         
      Acinus, Atrophy, Focal                           1 [4.0]      2 [3.5]      1 [1.0]      3 [2.7]                               
      Duct, Cyst, Focal, Multiple                                   2 [3.5]                   1 [4.0]                               
   Stomach, Forestomach                               (50)         (49)         (50)         (50)                                   
      Diverticulum                                                               1 [1.0]      1 [1.0]                               
      Erosion                                          2 [2.0]                   2 [1.5]                                            
      Inflammation, Focal                              1 [2.0]                   1 [2.0]      1 [3.0]                               
      Ulcer                                            1 [2.0]      1 [2.0]                   2 [2.5]                               
      Epithelium, Hyperplasia                          4 [1.8]      4 [1.8]      2 [2.0]      1 [3.0]                               
   Stomach, Glandular                                 (49)         (48)         (47)         (50)                                   
      Erosion                                                                                 1 [1.0]                               
      Glands, Hyperplasia, Focal                                    1 [2.0]                                                         
   Tooth                                              (1)          (1)          (1)          (2)                                    
      Malformation                                                  1 [3.0]                   1 [3.0]                               
      Peridontal Tissue, Inflammation, Chronic                                   1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (49)         (50)                                   
      Cardiomyopathy                                                3 [1.7]      1 [1.0]      1 [1.0]                               
      Infiltration Cellular, Polymorphonuclear                      1 [2.0]                                                         
      Infiltration Cellular, Mixed Cell                1 [2.0]                                                                      
      Inflammation, Chronic, Focal                                  1 [2.0]                                                         
      Thrombosis                                       4 [3.0]                   2 [3.5]                                            
      Artery, Inflammation, Chronic                    1 [2.0]                   1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/19/04    
Route: SKIN APPLICATION                                    DIISOPROPYLCARBODIIMIDE                                Time: 09:22:22    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)                                   
      Accessory Adrenal Cortical Nodule                2 [1.0]      1 [1.0]      1 [1.0]      3 [1.3]                               
      Angiectasis                                                   1 [2.0]                                                         
      Cytoplasmic Alteration, Focal                    1 [1.0]      2 [1.5]      1 [2.0]                                            
      Degeneration, Cystic                             1 [2.0]                   1 [3.0]      1 [2.0]                               
      Infiltration Cellular, Polymorphonuclear         1 [3.0]                                                                      
      Inflammation, Suppurative                                     1 [3.0]                                                         
      Necrosis, Focal                                                                         1 [3.0]                               
   Adrenal Medulla                                    (49)         (50)         (49)         (49)                                   
      Angiectasis                                                   1 [2.0]                                                         
      Hyperplasia                                                                             1 [2.0]                               
      Inflammation, Suppurative                                     1 [2.0]                                                         
   Islets, Pancreatic                                 (50)         (49)         (50)         (50)                                   
      Hyperplasia                                                   2 [2.0]      1 [2.0]                                            
   Parathyroid Gland                                  (46)         (43)         (49)         (49)                                   
      Cyst                                             2 [2.0]      2 [2.0]                   1 [2.0]                               
   Pituitary Gland                                    (48)         (50)         (50)         (46)                                   
      Angiectasis                                      3 [2.0]      1 [2.0]      1 [2.0]      3 [1.7]                               
      Cyst                                                                       1 [3.0]                                            
      Hemorrhage                                                                 1 [3.0]                                            
      Pars Distalis, Cytoplasmic Alteration, Focal     2 [1.5]                   4 [1.5]      1 [1.0]                               
      Pars Distalis, Degeneration, Cystic, Focal       1 [2.0]                                                                      
      Pars Distalis, Hyperplasia, Focal                3 [2.3]      2 [2.0]      7 [2.0]      3 [2.0]                               
      Pars Intermedia, Hyperplasia, Focal                                        1 [2.0]                                            
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Cyst                                                          2 [2.0]      3 [2.7]      1 [2.0]                               
      Inflammation, Chronic, Focal                                               1 [1.0]                                            
      C-Cell, Hyperplasia                                           2 [1.5]                                                         
      Follicle, Degeneration, Cystic, Focal           14 [1.8]     14 [1.9]     18 [1.7]     12 [1.9]                               
      Follicular Cell, Hyperplasia, Focal              1 [1.0]     11 [1.5]      9 [1.3]      4 [1.5]                               
      Follicular Cell, Vacuolization Cytoplasmic,                                                                                   
         Focal                                                                                1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (5)          (8)          (3)          (4)                                    
      Mediastinum, Infiltration Cellular, Lymphoid     1 [3.0]                                1 [2.0]                               
      Mediastinum, Inflammation, Suppurative                        1 [3.0]                   1 [3.0]                               
      Nasal, Hemorrhage                                             1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/19/04    
Route: SKIN APPLICATION                                    DIISOPROPYLCARBODIIMIDE                                Time: 09:22:22    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (46)         (48)         (48)         (47)                                   
      Degeneration, Cystic                                                       1 [3.0]                                            
      Inflammation, Chronic                            1 [3.0]                                                                      
   Ovary                                              (49)         (50)         (49)         (49)                                   
      Angiectasis                                      2 [3.5]      3 [2.7]      1 [4.0]      1 [3.0]                               
      Cyst                                            14 [2.6]     16 [2.6]     13 [2.8]     18 [2.6]                               
      Hemorrhage                                       2 [2.5]                                                                      
      Hyperplasia, Lymphoid                                         1 [3.0]                                                         
      Inflammation, Suppurative                        2 [3.5]      2 [3.0]                   2 [3.5]                               
      Thrombosis                                       2 [3.0]      1 [4.0]      1 [4.0]                                            
      Bilateral, Cyst                                                            1 [3.0]                                            
      Bilateral, Inflammation, Suppurative             1 [3.0]                                1 [3.0]                               
      Interstitial Cell, Hyperplasia                                1 [3.0]                                                         
   Oviduct                                            (3)          (1)                                                              
      Inflammation, Suppurative                        3 [3.0]                                                                      
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       1 [3.0]                                                                      
      Hyperplasia, Lymphoid                            1 [3.0]                   1 [3.0]                                            
      Inflammation, Suppurative                        5 [2.6]      8 [3.0]      6 [2.7]      2 [1.5]                               
      Thrombosis                                                                              1 [3.0]                               
      Cervix, Hypertrophy                                           1 [3.0]                                                         
      Endometrium, Hyperplasia, Cystic                46 [2.7]     44 [2.9]     47 [2.8]     49 [2.8]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (49)                                   
      Hyperplasia                                     14 [3.1]      5 [3.4]     10 [2.9]      2 [3.0]                               
   Lymph Node                                         (11)         (13)         (10)         (10)                                   
      Hyperplasia, Lymphoid                                                      1 [3.0]                                            
      Bronchial, Hyperplasia, Lymphoid                                           1 [3.0]                                            
      Iliac, Ectasia                                                1 [3.0]      1 [3.0]      3 [2.7]                               
      Iliac, Hemorrhage                                2 [3.0]                                                                      
      Iliac, Hyperplasia, Lymphoid                     2 [2.5]      2 [3.5]      2 [3.0]      2 [2.5]                               
      Inguinal, Hyperplasia, Lymphoid                  1 [3.0]                                                                      
      Mediastinal, Ectasia                             1 [3.0]                                                                      
      Mediastinal, Hemorrhage                                       1 [3.0]                                                         
      Mediastinal, Hyperplasia                                      1 [3.0]                                                         
      Mediastinal, Hyperplasia, Lymphoid               1 [2.0]      2 [3.0]      1 [3.0]      3 [3.0]                               
      Pancreatic, Hemorrhage                                        1 [3.0]                                                         
      Pancreatic, Hyperplasia, Lymphoid                1 [3.0]      1 [3.0]                   1 [3.0]                               
      Renal, Ectasia                                                1 [3.0]                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/19/04    
Route: SKIN APPLICATION                                    DIISOPROPYLCARBODIIMIDE                                Time: 09:22:22    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Renal, Hyperplasia, Lymphoid                     1 [3.0]      1 [4.0]      2 [2.5]                                            
   Lymph Node, Mandibular                             (47)         (49)         (49)         (48)                                   
      Hemorrhage                                       1 [3.0]                                                                      
      Hyperplasia, Lymphoid                            6 [3.0]      4 [3.0]      2 [2.5]      1 [3.0]                               
   Lymph Node, Mesenteric                             (47)         (48)         (49)         (50)                                   
      Ectasia                                          1 [3.0]      1 [3.0]      5 [3.2]      2 [3.0]                               
      Hematopoietic Cell Proliferation                              1 [3.0]                                                         
      Hemorrhage                                                                              1 [3.0]                               
      Hyperplasia, Lymphoid                            3 [3.0]      6 [3.2]      2 [3.0]      5 [3.0]                               
   Spleen                                             (49)         (49)         (50)         (50)                                   
      Accessory Spleen                                                           1                                                  
      Atrophy                                                                    1 [2.0]                                            
      Congestion                                       1 [3.0]                                                                      
      Hematopoietic Cell Proliferation                24 [2.8]     21 [2.8]     18 [2.6]     13 [2.8]                               
      Hyperplasia, Histiocytic                         1 [3.0]                                                                      
      Hyperplasia, Lymphoid                            6 [2.7]     12 [2.6]     12 [2.5]      6 [2.3]                               
      Capsule, Inflammation, Chronic, Focal            1 [2.0]                                                                      
   Thymus                                             (46)         (48)         (44)         (47)                                   
      Hyperplasia, Lymphoid                            5 [2.8]      4 [3.0]      4 [3.0]      1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (49)                                   
      Dilatation                                       1 [2.0]                                                                      
      Hyperplasia                                                                             1 [2.0]                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Ulcer                                            1 [3.0]                                                                      
      Control Dermis, Hyperplasia, Focal                                                      1 [1.0]                               
      Control Dermis, Inflammation, Focal              1 [2.0]                   1 [2.0]      1 [1.0]                               
      Control Epidermis, Hyperplasia, Focal            1 [3.0]                                1 [1.0]                               
      Epidermis, Hyperplasia, Focal                    1 [3.0]                                                                      
      Site of Application - Dermis, Fibrosis                                                  1 [1.0]                               
      Site of Application - Dermis, Inflammation,                                                                                   
         Focal                                         3 [1.3]      2 [2.5]      7 [1.4]      2 [1.5]                               
      Site of Application - Epidermis, Hyperplasia     5 [2.0]      3 [1.7]      7 [1.4]      7 [1.3]                               
      Site of Application, Ulcer                       2 [3.0]      1 [2.0]                                                         
      Subcutaneous Tissue, Angiectasis, Focal                       1 [2.0]                                                         
      Subcutaneous Tissue, Edema                       1 [3.0]      2 [2.5]                   1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/19/04    
Route: SKIN APPLICATION                                    DIISOPROPYLCARBODIIMIDE                                Time: 09:22:22    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - CONT                                                                                                       
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                     3 [2.3]      1 [2.0]      1 [2.0]      2 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression, Focal                               2 [3.0]      2 [3.5]                   1 [3.0]                               
      Hemorrhage, Focal                                1 [1.0]      2 [2.0]                                                         
      Infarct                                          1                                                                            
      Inflammation, Focal                                           1 [1.0]                                                         
      Cerebellum, Hippocampus, Necrosis                1 [2.0]                                                                      
      Cerebrum, Atrophy, Focal                                      1 [4.0]                                                         
      Hippocampus, Necrosis, Acute                                  1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       2 [3.0]                   1 [3.0]      1 [2.0]                               
      Foreign Body                                                                            1 [1.0]                               
      Hemorrhage                                                    1 [3.0]                                                         
      Hyperplasia, Histiocytic                                      1 [3.0]                   1 [3.0]                               
      Infiltration Cellular, Polymorphonuclear                      2 [3.0]                                                         
      Mineralization, Focal                            1 [2.0]                                                                      
      Alveolar Epithelium, Hyperplasia, Focal          1 [1.0]      2 [1.0]      1 [2.0]      2 [1.5]                               
      Mediastinum, Hyperplasia, Lymphoid                            2 [3.0]                                                         
   Nose                                               (50)         (50)         (49)         (50)                                   
      Inflammation                                                               1 [2.0]                                            
      Nasolacrimal Duct, Inflammation                  1 [2.0]                   1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (47)         (48)         (49)         (49)                                   
      Atrophy                                          1 [4.0]                   2 [4.0]                                            
      Phthisis Bulbi                                                             1                                                  
      Cornea, Hyperplasia, Squamous                                 1 [2.0]      1 [1.0]                                            
      Cornea, Inflammation, Chronic                                 1 [2.0]                                                         
      Iris, Synechia                                                1                                                               
      Lens, Cataract                                                1 [3.0]                                                         
   Harderian Gland                                    (50)         (49)         (50)         (50)                                   
      Cyst                                                                                    1 [2.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/19/04    
Route: SKIN APPLICATION                                    DIISOPROPYLCARBODIIMIDE                                Time: 09:22:22    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
      Inflammation                                                  2 [2.5]                                                         
      Epithelium, Hyperplasia, Focal                   1 [2.0]      1 [2.0]      1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (49)         (50)         (49)                                   
      Congestion                                       1 [3.0]                                                                      
      Cyst                                             1 [1.0]                   4 [1.8]                                            
      Hydronephrosis                                                             1 [3.0]      1 [3.0]                               
      Hyperplasia, Lymphoid                            2 [2.5]      2 [2.5]      1 [2.0]      1 [2.0]                               
      Infarct                                          3 [1.3]      2 [2.0]      1 [2.0]      1 [2.0]                               
      Infiltration Cellular, Polymorphonuclear                      1 [2.0]                                                         
      Infiltration Cellular, Mixed Cell                             1 [2.0]                                                         
      Inflammation                                     1 [3.0]      1 [3.0]                                                         
      Metaplasia, Focal, Osseous                       5 [1.6]      2 [2.0]                   1 [1.0]                               
      Nephropathy                                     13 [1.1]      8 [1.0]     11 [1.1]     18 [1.2]                               
      Capsule, Congestion                              1 [2.0]                                                                      
      Papilla, Necrosis                                1 [3.0]                                                                      
      Renal Tubule, Accumulation, Hyaline Droplet      3 [3.0]      1 [2.0]                   2 [3.0]                               
      Renal Tubule, Necrosis                           1 [4.0]                                                                      
      Renal Tubule, Vacuolization Cytoplasmic,                                                                                      
         Focal                                         1 [2.0]      1 [1.0]      1 [2.0]                                            
   Urinary Bladder                                    (50)         (50)         (49)         (50)                                   
      Angiectasis                                      1 [2.0]                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/19/04    
Route: SKIN APPLICATION                                    DIISOPROPYLCARBODIIMIDE                                Time: 09:22:22    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 5            1            2            5                                     
    Natural Death                                      6            9           10            8                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           40           38           36                                     
    Moribund Sacrifice                                 1                                                                            
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (42)         (43)         (41)                                   
      Cyst                                             1 [2.0]      1 [2.0]      2 [1.5]                                            
      Epithelium, Degeneration, Hyaline                             1 [3.0]      1 [3.0]                                            
      Epithelium, Hyperplasia                                                    1 [3.0]                                            
   Intestine Small, Duodenum                          (46)         (44)         (44)         (40)                                   
      Ectopic Tissue                                                1 [2.0]                                                         
      Serosa, Inflammation, Chronic                                                           1 [3.0]                               
   Intestine Small, Jejunum                           (46)         (43)         (44)         (40)                                   
      Cyst                                                                                    1 [3.0]                               
      Inflammation, Focal                                           1 [3.0]      1 [2.0]                                            
      Necrosis                                         1 [4.0]                                                                      
      Peyer's Patch, Hyperplasia, Lymphoid             1 [3.0]      1 [3.0]                   1 [3.0]                               
   Intestine Small, Ileum                             (46)         (44)         (44)         (40)                                   
      Peyer's Patch, Hyperplasia, Lymphoid             1 [3.0]                                                                      
   Liver                                              (50)         (50)         (50)         (49)                                   
      Atrophy                                          1 [2.0]                                                                      
      Basophilic Focus                                 1                                                                            
      Clear Cell Focus                                 2            1            1            2                                     
      Eosinophilic Focus                               2            1            1            4                                     
      Fibrosis, Focal                                  1 [2.0]                                                                      
      Hemorrhage, Focal                                                                       1 [3.0]                               
      Hepatodiaphragmatic Nodule                                                              1 [2.0]                               
      Hyperplasia, Focal, Histiocytic                               1 [3.0]                                                         
      Infarct                                                                    1 [3.0]      1 [4.0]                               
      Infiltration Cellular, Polymorphonuclear         1 [4.0]                                                                      
      Infiltration Cellular, Mixed Cell                8 [1.4]      5 [1.4]      5 [1.4]      6 [1.3]                               
      Inflammation, Focal, Granulomatous                                                      1 [3.0]                               
      Pigmentation, Focal                                           1 [3.0]                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/19/04    
Route: SKIN APPLICATION                                    DIISOPROPYLCARBODIIMIDE                                Time: 09:22:22    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Thrombosis                                                                 1 [4.0]                                            
      Bile Duct, Hyperplasia                           1 [2.0]                   1 [3.0]                                            
      Capsule, Inflammation, Chronic                                                          1 [3.0]                               
      Hepatocyte, Clear Cell Focus                    19           17           12            8                                     
      Hepatocyte, Eosinophilic Focus                   2                                                                            
      Hepatocyte, Mixed Cell Focus                     1            2                         2                                     
      Hepatocyte, Necrosis, Focal                      5 [1.8]      3 [2.3]      2 [2.5]      7 [1.9]                               
      Hepatocyte, Vacuolization Cytoplasmic           18 [1.9]     17 [2.0]     17 [1.9]     18 [2.2]                               
   Mesentery                                          (49)         (49)         (50)         (50)                                   
      Fibrosis, Focal                                                            1 [2.0]                                            
      Inflammation                                                  1 [3.0]                   1 [3.0]                               
      Inflammation, Chronic                                                                   1 [3.0]                               
      Artery, Inflammation                                          1 [3.0]                                                         
      Fat, Necrosis, Focal                             4 [2.3]      2 [3.0]      4 [2.0]      4 [2.0]                               
   Pancreas                                           (49)         (50)         (49)         (49)                                   
      Inflammation, Focal                                                        1 [2.0]                                            
      Necrosis, Focal                                               1 [3.0]      1 [2.0]                                            
      Acinus, Atrophy, Focal                                                                  3 [2.7]                               
      Serosa, Inflammation, Chronic                                                           1 [3.0]                               
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                                    1 [3.0]                                            
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Diverticulum                                                                            1 [2.0]                               
      Erosion                                                       1 [2.0]                                                         
      Inflammation, Focal                                                        1 [2.0]      1 [2.0]                               
      Ulcer                                                         1 [2.0]                                                         
      Epithelium, Cyst                                                                        1 [1.0]                               
      Epithelium, Hyperplasia                          2 [2.0]      2 [2.0]      3 [1.7]      2 [2.0]                               
   Stomach, Glandular                                 (50)         (47)         (48)         (47)                                   
      Erosion                                          4 [1.5]      1 [1.0]      1 [1.0]                                            
   Tooth                                              (18)         (11)         (15)         (12)                                   
      Malformation                                    18 [2.5]     11 [2.5]     15 [2.5]     12 [2.5]                               
      Peridontal Tissue, Inflammation, Chronic                                   1 [2.0]                                            
      Pulp, Inflammation                                                         1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                                             1 [2.0]      1 [2.0]                               
      Infiltration Cellular, Mixed Cell                                                       1 [1.0]                               
      Inflammation, Chronic, Focal                                               1 [1.0]                                            
      Thrombosis                                                    1 [4.0]                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/19/04    
Route: SKIN APPLICATION                                    DIISOPROPYLCARBODIIMIDE                                Time: 09:22:22    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Artery, Inflammation, Chronic                                 1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Accessory Adrenal Cortical Nodule                3 [1.0]      2 [1.5]      2 [1.5]      2 [2.0]                               
      Cytoplasmic Alteration, Focal                    9 [1.3]      5 [1.2]      7 [1.4]      4 [1.5]                               
      Degeneration, Cystic                                                                    1 [1.0]                               
      Hyperplasia, Focal, Histiocytic                               1 [2.0]                                                         
      Hypertrophy                                                                1 [4.0]                                            
      Vacuolization Cytoplasmic, Focal                 1 [2.0]                                                                      
   Adrenal Medulla                                    (49)         (50)         (50)         (49)                                   
      Angiectasis                                      1 [3.0]                                                                      
      Hyperplasia, Focal                                                         1 [2.0]                                            
   Islets, Pancreatic                                 (49)         (50)         (49)         (50)                                   
      Hyperplasia                                      2 [2.5]      2 [2.5]      2 [2.5]      1 [2.0]                               
   Parathyroid Gland                                  (49)         (50)         (46)         (47)                                   
      Cyst                                             1 [1.0]                   2 [2.5]      1 [3.0]                               
   Pituitary Gland                                    (48)         (47)         (50)         (49)                                   
      Cyst                                             1 [1.0]      2 [1.0]      3 [1.7]      3 [2.0]                               
      Pars Distalis, Cytoplasmic Alteration, Focal     1 [2.0]                   5 [1.4]                                            
      Pars Distalis, Hyperplasia, Focal                1 [2.0]                                                                      
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                              1 [2.0]      3 [1.7]                                                         
      Follicle, Degeneration, Cystic, Focal            4 [2.0]      6 [2.2]      8 [1.8]      6 [1.7]                               
      Follicular Cell, Hyperplasia, Focal              7 [1.9]      7 [1.3]      8 [1.5]      3 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (3)          (2)                                    
      Hemorrhage                                                                              1 [3.0]                               
      Abdominal, Cyst                                                            1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                                            1 [3.0]      1 [2.0]                               
      Inflammation, Chronic                                                      1 [2.0]      1 [2.0]                               
      Spermatocele                                                  1 [3.0]                                                         
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/19/04    
Route: SKIN APPLICATION                                    DIISOPROPYLCARBODIIMIDE                                Time: 09:22:22    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cyst                                                                                    2 [3.0]                               
      Degeneration, Cystic                             3 [2.7]      1 [3.0]      1 [3.0]      4 [3.0]                               
      Hyperplasia, Lymphoid                                         1 [4.0]                                                         
      Inflammation, Chronic                           11 [3.1]      8 [3.3]     10 [2.9]      6 [3.0]                               
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Inflammation                                                  1 [4.0]                   2 [3.0]                               
      Epithelium, Hyperplasia, Focal                   2 [2.0]      1 [2.0]                                                         
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Cyst                                                          1 [3.0]                                                         
   Testes                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 [2.0]      1 [2.0]                                            
      Interstitial Cell, Hyperplasia, Focal                                      1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (50)                                   
      Hyperplasia                                      9 [2.9]     13 [2.9]     12 [2.9]      7 [2.9]                               
      Thrombosis                                                                              1 [1.0]                               
   Lymph Node                                         (6)          (5)          (5)          (4)                                    
      Bronchial, Hyperplasia, Lymphoid                              1 [3.0]                                                         
      Iliac, Hyperplasia, Lymphoid                                                            1 [3.0]                               
      Inguinal, Hyperplasia, Lymphoid                  2 [3.0]      3 [3.0]      4 [2.8]      1 [3.0]                               
      Mediastinal, Hyperplasia, Lymphoid                                         1 [2.0]                                            
      Pancreatic, Hyperplasia, Lymphoid                             1 [3.0]      1 [3.0]      1 [3.0]                               
   Lymph Node, Mandibular                             (47)         (48)         (47)         (47)                                   
      Hyperplasia, Histiocytic                                                                1 [2.0]                               
      Hyperplasia, Lymphoid                                         1 [3.0]                   1 [3.0]                               
   Lymph Node, Mesenteric                             (50)         (48)         (49)         (48)                                   
      Ectasia                                                                    1 [3.0]                                            
      Hematopoietic Cell Proliferation                              1 [3.0]                                                         
      Hemorrhage                                       3 [3.0]      1 [3.0]      3 [3.0]                                            
      Hyperplasia, Lymphoid                            3 [2.7]      2 [3.0]      4 [3.0]      2 [3.5]                               
   Spleen                                             (49)         (50)         (50)         (47)                                   
      Atrophy                                          1 [3.0]                   1 [2.0]                                            
      Fibrosis, Focal                                                                         1 [3.0]                               
      Hematopoietic Cell Proliferation                15 [2.8]     13 [2.6]     14 [2.8]     13 [2.6]                               
      Hyperplasia, Lymphoid                            2 [3.0]      5 [2.4]      1 [2.0]      1 [3.0]                               
      Thrombosis                                                                              1 [3.0]                               
      Capsule, Inflammation, Chronic                                                          1 [2.0]                               
   Thymus                                             (47)         (44)         (47)         (46)                                   
      Cyst                                             2 [2.0]      1 [2.0]      2 [2.5]                                            
      Hyperplasia, Lymphoid                            1 [2.0]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/19/04    
Route: SKIN APPLICATION                                    DIISOPROPYLCARBODIIMIDE                                Time: 09:22:22    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Ulcer                                            1 [3.0]                                                                      
      Epidermis, Hyperplasia, Focal                    1 [1.0]                   1 [1.0]                                            
      Site of Application - Dermis, Inflammation,                                                                                   
         Focal                                         2 [2.0]      2 [2.0]      9 [1.4]      1 [1.0]                               
      Site of Application - Epidermis, Hyperplasia     2 [2.0]      3 [2.3]     10 [1.8]      1 [1.0]                               
      Site of Application, Ulcer                                    1 [2.0]      1 [3.0]                                            
      Subcutaneous Tissue, Angiectasis, Focal                                    1 [3.0]                                            
      Subcutaneous Tissue, Edema                                                              2 [2.5]                               
      Subcutaneous Tissue, Inflammation, Chronic,                                                                                   
         Focal                                                                   1 [3.0]                                            
      Subcutaneous Tissue, Thrombosis                                            1 [3.0]                                            
      Subcutaneous Tissue, Site of Application,                                                                                     
         Infiltration Cellular                                                                1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                     2 [2.0]      2 [2.0]      1 [1.0]                                            
   Skeletal Muscle                                    (2)          (2)          (2)          (5)                                    
      Inflammation, Chronic                                                                   1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       1 [2.0]                   1 [3.0]                                            
      Hyperplasia, Histiocytic                         1 [2.0]      1 [1.0]      4 [3.0]                                            
      Hyperplasia, Lymphoid                            1 [2.0]      1 [1.0]                                                         
      Inflammation, Chronic, Focal                     1 [2.0]                                                                      
      Alveolar Epithelium, Hyperplasia, Focal          4 [1.3]      2 [1.5]      1 [1.0]      3 [1.7]                               
      Mediastinum, Hyperplasia, Lymphoid               1 [2.0]                                                                      
   Nose                                               (49)         (50)         (50)         (50)                                   
      Inflammation                                     2 [2.5]                   1 [2.0]                                            
      Nasolacrimal Duct, Cyst                                       1 [2.0]                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 07/19/04    
Route: SKIN APPLICATION                                    DIISOPROPYLCARBODIIMIDE                                Time: 09:22:22    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Nasolacrimal Duct, Hyperplasia, Focal            1 [2.0]      2 [2.0]      1 [3.0]                                            
      Nasolacrimal Duct, Inflammation                  1 [2.0]                   2 [3.0]      3 [1.7]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (46)         (46)         (47)         (44)                                   
      Atrophy                                          1 [4.0]                                                                      
      Inflammation                                     1 [2.0]                                                                      
      Cornea, Hyperplasia, Squamous                                 1 [2.0]                   1 [1.0]                               
      Cornea, Inflammation, Chronic                    2 [2.0]      3 [2.3]      1 [2.0]      3 [2.7]                               
      Cornea, Necrosis, Focal                                       1 [3.0]                   1 [3.0]                               
      Retrobulbar, Inflammation                                                               1 [2.0]                               
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
      Degeneration, Cystic, Focal                                   1 [2.0]                                                         
      Inflammation                                     1 [4.0]                                1 [1.0]                               
      Epithelium, Hyperplasia, Focal                   3 [2.0]                   3 [1.7]      1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (48)         (48)         (50)         (48)                                   
      Cyst                                             3 [1.7]     10 [2.0]      5 [2.0]      3 [1.7]                               
      Hydronephrosis                                   2 [2.5]      1 [3.0]                                                         
      Infarct                                          2 [1.5]      3 [2.0]      1 [2.0]      1 [2.0]                               
      Infiltration Cellular, Mixed Cell                                          1 [2.0]                                            
      Inflammation                                                                            3 [2.3]                               
      Metaplasia, Focal, Osseous                       4 [1.8]      2 [2.0]      1 [1.0]                                            
      Nephropathy                                     46 [1.4]     44 [1.6]     41 [1.6]     40 [1.4]                               
      Pelvis, Dilatation                                                                      1 [3.0]                               
      Renal Tubule, Hyperplasia, Focal                 2 [1.0]      3 [1.7]                   1 [1.0]                               
   Urinary Bladder                                    (50)         (50)         (49)         (50)                                   
      Inflammation                                                  1 [3.0]                   2 [3.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.