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TDMS Study 97013-89 Pathology Tables

NTP  EXP/TEST: 97013-89                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 1
TEST TYPE: 26-39 WEEKS                          INITIAL AND CURRENT BODY WEIGHT                                   DATE: 12/05/03
ROUTE: SKIN APPLICATION                                                                                           TIME: 09:15:32

                                                         EIS REPORT 03


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  97013D

       CONTRACT NUMBER:  N01-ES-65406

       CAS NUMBER:  79-43-6

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 97013-89                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 2
TEST TYPE: 26-39 WEEKS                          INITIAL AND CURRENT BODY WEIGHT                                   DATE: 12/05/03
ROUTE: SKIN APPLICATION                                     EISRPT03                                              TIME: 09:15:32
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: TG.AC HEMI-MICE            SEX: FEMALE      WEEK ON DOSE: 40     FIRST DOSE: 02/17/00
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            10     19.5    1.2         8     25.7    2.0                      8      6.3    2.2

 31.25   MG/KG      10     19.9    0.9         5     27.8    4.2       108.1          5      8.0    3.6

 125MG/KG           10     19.7    0.7         6     29.1    2.1       113.2          6      9.5    1.7

 500MG/KG           10     19.7    1.5         8     35.3   10.0       137.3          8     15.7    9.9




----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: TG.AC HEMI-MICE            SEX: MALE        WEEK ON DOSE: 40     FIRST DOSE: 02/17/00
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            10     22.9    1.2         9     37.4    4.3                      9     14.3    3.8

 31.25   MG/KG      10     22.7    1.0         6     33.9    1.6        90.6          6     11.4    1.2

 125MG/KG           10     22.6    1.3         8     36.5    2.5        97.5          8     13.9    1.4

 500MG/KG           10     22.7    1.2         7     34.3    1.5        91.7          7     11.2    1.9

                                               -----------------------------------
                                               ---------- END-OF-REPORT ----------
                                               -----------------------------------