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TDMS Study 97013-95 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                       WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                   DATE: 10/08/03       
EXPERIMENT: 97013 TEST: 95                                                                                     TIME: 10:10:14       
TEST TYPE:  26-39 WEEKS                         CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-65406                              ROUTE: DOSED WATER                                             NTP C#: 97013J       
PATHOLOGIST: MISSING                                                                                           CAS: 75-27-4         
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                                                             FINAL/MICE                                                             
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                       WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                   DATE: 10/08/03       
EXPERIMENT: 97013 TEST: 95                                                                                     TIME: 10:10:14       
TEST TYPE:  26-39 WEEKS                         CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-65406                              ROUTE: DOSED WATER                                             NTP C#: 97013J       
PATHOLOGIST: MISSING                                                                                           CAS: 75-27-4         
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF     WATER DISINFECTION MODEL (BROMODICHLOR                                                                       
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Kidney                                 Cyst                                                                                         
                                       Mineralization                                                                               
                                       Nephropathy                                                                                  
Kidney: Renal Tubule                   Degeneration                                                                                 
                                       Dilatation                                                                                   
Lung: Perivascular                     Inflammation                                                                                 
Skin: Control Epidermis                Hyperplasia                                                                                  
Testes                                 Mineralization                                                                               
Testes: Germinal Epithelium            Degeneration                                                                                 
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Kidney                                 Cyst                                                                                         
                                       Hydronephrosis                                                                               
Liver                                  Infiltration Cellular                                                                        
                                       Inflammation                                                                                 
Liver: Hepatocyte                      Fatty Change                                                                                 
                                       Vacuolization Cytoplasmic                                                                    
Stomach, Forestomach: Epithelium       Hyperplasia                                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  10/08/03                           EXPERIMENT: 97013 TEST: 95                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (BROMO
DICHLOR                                                                                                                             
                                         Terminal Sacrifice at 43 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/10 (50%)   4/10 (40%)   4/10 (40%)   4/10 (40%)  |0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)    | 
|POLY-3 RATE (b)    |     5/8.26       4/9.09       4/8.76       4/9.83      |0/7.13       0/8.65       0/7.16       0/6.87       | 
|POLY-3 PERCENT (g) |     60.5%        44.0%        45.7%        40.7%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/6 (50%)    4/9 (44%)    4/8 (50%)    4/9 (44%)   |0/5 (0%)     0/8 (0%)     0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     247          296 (T)      296 (T)      296 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.238N     P=0.256N     P=0.327N     P=0.242N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.332N     P=0.420N     P=0.450N     P=0.361N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.357N     P=0.447N     P=0.455N     P=0.398N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.327N     P=0.405N     P=0.467N     P=0.349N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.263N     P=0.374N     P=0.385N     P=0.325N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.436N     P=0.500N     P=0.500N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.330N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex: Subcapsular                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/10 (10%)   1/10 (10%)   2/10 (20%)   0/10 (0%)   |6/10 (60%)   5/10 (50%)   7/10 (70%)   8/10 (80%)   | 
|POLY-3 RATE (b)    |     1/7.67       1/9.09       2/8.76       0/9.83      |6/8.04       5/9.48       7/8.68       8/8.98       | 
|POLY-3 PERCENT (g) |     13.0%        11.0%        22.8%        0.0%        |74.7%        52.7%        80.6%        89.1%        | 
|TERMINAL (d)       |     1/6 (17%)    1/9 (11%)    2/8 (25%)    0/9 (0%)    |5/5 (100%)   4/8 (50%)    3/4 (75%)    4/4 (100%)   | 
|FIRST INCIDENCE    |     296 (T)      296 (T)      296 (T)      ---         |136          164          232          136          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.280N     P=0.673N     P=0.607      P=0.419N    |P=0.062      P=0.154N     P=0.373      P=0.213      | 
|POLY 3             |     P=0.293N     P=0.723N     P=0.549      P=0.451N    |P=0.143      P=0.325N     P=0.622      P=0.435      | 
|POLY 1.5           |     P=0.314N     P=0.739N     P=0.533      P=0.467N    |P=0.150      P=0.387N     P=0.551      P=0.384      | 
|POLY 6             |     P=0.280N     P=0.706N     P=0.561      P=0.437N    |P=0.137      P=0.257N     P=0.730      P=0.527      | 
|LOGISTIC REGRESSION|     P=0.280N     P=0.673N     P=0.607      (e)         |P=0.135      P=0.450N     P=0.538      P=0.298      | 
|COCH-ARM / FISHERS |     P=0.361N     P=0.763N     P=0.500      P=0.500N    |P=0.157      P=0.500N     P=0.500      P=0.314      | 
|ORDER RESTRICTED   |     P=0.255N     (e)          (e)          (e)         |P=0.150      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/08/03                           EXPERIMENT: 97013 TEST: 95                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (BROMOD
ICHLOR                                                                                                                              
                                         Terminal Sacrifice at 43 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Casts Protein                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/10 (20%)   0/10 (0%)    1/10 (10%)   4/10 (40%)  |0/10 (0%)    1/10 (10%)   0/10 (0%)    2/10 (20%)   | 
|POLY-3 RATE (b)    |     2/7.67       0/9.09       1/9.55       4/9.83      |0/7.13       1/8.65       0/7.16       2/7.13       | 
|POLY-3 PERCENT (g) |     26.1%        0.0%         10.5%        40.7%       |0.0%         11.6%        0.0%         28.1%        | 
|TERMINAL (d)       |     2/6 (33%)    0/9 (0%)     0/8 (0%)     4/9 (44%)   |0/5 (0%)     1/8 (13%)    0/4 (0%)     1/4 (25%)    | 
|FIRST INCIDENCE    |     296 (T)      ---          177          296 (T)     |---          296 (T)      ---          268          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.152      P=0.147N     P=0.406N     P=0.541     |P=0.093      P=0.594      (e)          P=0.231      | 
|POLY 3             |     P=0.098      P=0.185N     P=0.420N     P=0.450     |P=0.123      P=0.538      (e)          P=0.219      | 
|POLY 1.5           |     P=0.095      P=0.200N     P=0.446N     P=0.404     |P=0.126      P=0.526      (e)          P=0.221      | 
|POLY 6             |     P=0.096      P=0.169N     P=0.400N     P=0.489     |P=0.119      P=0.551      (e)          P=0.220      | 
|LOGISTIC REGRESSION|     P=0.086      (e)          P=0.540N     P=0.541     |P=0.103      P=0.594      (e)          P=0.215      | 
|COCH-ARM / FISHERS |     P=0.091      P=0.237N     P=0.500N     P=0.314     |P=0.132      P=0.500      (e)          P=0.237      | 
|ORDER RESTRICTED   |     P=0.093      (e)          (e)          (e)         |P=0.061      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/10 (30%)   1/10 (10%)   1/10 (10%)   0/10 (0%)   |0/10 (0%)    1/10 (10%)   5/10 (50%)   2/10 (20%)   | 
|POLY-3 RATE (b)    |     3/7.67       1/9.09       1/8.76       0/9.83      |0/7.13       1/8.65       5/8.13       2/7.78       | 
|POLY-3 PERCENT (g) |     39.1%        11.0%        11.4%        0.0%        |0.0%         11.6%        61.5%        25.7%        | 
|TERMINAL (d)       |     3/6 (50%)    1/9 (11%)    1/8 (13%)    0/9 (0%)    |0/5 (0%)     1/8 (13%)    2/4 (50%)    1/4 (25%)    | 
|FIRST INCIDENCE    |     296 (T)      296 (T)      296 (T)      ---         |---          296 (T)      256          136          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.035N*    P=0.150N     P=0.183N     P=0.049N*   |P=0.103      P=0.594      P=0.022 *    P=0.226      | 
|POLY 3             |     P=0.050N     P=0.222N     P=0.233N     P=0.053N    |P=0.124      P=0.538      P=0.009 **   P=0.241      | 
|POLY 1.5           |     P=0.052N     P=0.248N     P=0.251N     P=0.064N    |P=0.129      P=0.526      P=0.008 **   P=0.238      | 
|POLY 6             |     P=0.049N*    P=0.196N     P=0.219N     P=0.044N*   |P=0.113      P=0.551      P=0.009 **   P=0.241      | 
|LOGISTIC REGRESSION|     P=0.035N*    P=0.150N     P=0.183N     (e)         |P=0.136      P=0.594      P=0.018 *    P=0.227      | 
|COCH-ARM / FISHERS |     P=0.062N     P=0.291N     P=0.291N     P=0.105N    |P=0.143      P=0.500      P=0.016 *    P=0.237      | 
|ORDER RESTRICTED   |     P=0.012N*    (e)          (e)          (e)         |P=0.026 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/08/03                           EXPERIMENT: 97013 TEST: 95                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (BROMOD
ICHLOR                                                                                                                              
                                         Terminal Sacrifice at 43 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hydronephrosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/10 (10%)   0/10 (0%)    2/10 (20%)   0/10 (0%)   |2/10 (20%)   0/10 (0%)    0/10 (0%)    0/10 (0%)    | 
|POLY-3 RATE (b)    |     1/8.54       0/9.09       2/9.55       0/9.83      |2/7.82       0/8.65       0/7.16       0/6.87       | 
|POLY-3 PERCENT (g) |     11.7%        0.0%         21.0%        0.0%        |25.6%        0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/6 (0%)     0/9 (0%)     1/8 (13%)    0/9 (0%)    |0/5 (0%)     0/8 (0%)     0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     150          ---          177          ---         |225          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.416N     P=0.521N     P=0.559      P=0.500N    |P=0.134N     P=0.196N     P=0.270N     P=0.275N     | 
|POLY 3             |     P=0.424N     P=0.487N     P=0.540      P=0.472N    |P=0.107N     P=0.199N     P=0.242N     P=0.253N     | 
|POLY 1.5           |     P=0.433N     P=0.494N     P=0.527      P=0.481N    |P=0.106N     P=0.204N     P=0.230N     P=0.238N     | 
|POLY 6             |     P=0.419N     P=0.477N     P=0.553      P=0.463N    |P=0.110N     P=0.198N     P=0.273N     P=0.272N     | 
|LOGISTIC REGRESSION|     P=0.591      P=0.580N     P=0.283      (e)         |P=0.109N     P=0.238N     P=0.228N     P=0.229N     | 
|COCH-ARM / FISHERS |     P=0.460N     P=0.500N     P=0.500      P=0.500N    |P=0.110N     P=0.237N     P=0.237N     P=0.237N     | 
|ORDER RESTRICTED   |     P=0.287N     (e)          (e)          (e)         |P=0.031N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    0/10 (0%)    2/10 (20%)  |0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%)   | 
|POLY-3 RATE (b)    |     0/7.67       0/9.09       0/8.76       2/9.83      |0/7.13       0/8.65       0/7.16       1/7.13       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         20.4%       |0.0%         0.0%         0.0%         14.0%        | 
|TERMINAL (d)       |     0/6 (0%)     0/9 (0%)     0/8 (0%)     2/9 (22%)   |0/5 (0%)     0/8 (0%)     0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          296 (T)     |---          ---          ---          268          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.059      (e)          (e)          P=0.327     |P=0.206      (e)          (e)          P=0.531      | 
|POLY 3             |     P=0.046 *    (e)          (e)          P=0.288     |P=0.186      (e)          (e)          P=0.500      | 
|POLY 1.5           |     P=0.043 *    (e)          (e)          P=0.267     |P=0.190      (e)          (e)          P=0.500      | 
|POLY 6             |     P=0.047 *    (e)          (e)          P=0.306     |P=0.183      (e)          (e)          P=0.503      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.327     |P=0.189      (e)          (e)          P=0.496      | 
|COCH-ARM / FISHERS |     P=0.043 *    (e)          (e)          P=0.237     |P=0.196      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.046 *    (e)          (e)          (e)         |P=0.117      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/08/03                           EXPERIMENT: 97013 TEST: 95                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (BROMOD
ICHLOR                                                                                                                              
                                         Terminal Sacrifice at 43 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/10 (40%)   7/10 (70%)   8/10 (80%)   9/10 (90%)  |4/10 (40%)   2/10 (20%)   4/10 (40%)   2/10 (20%)   | 
|POLY-3 RATE (b)    |     4/8.54       7/9.09       8/9.21       9/10.00     |4/8.60       2/8.65       4/8.65       2/7.13       | 
|POLY-3 PERCENT (g) |     46.8%        77.0%        86.8%        90.0%       |46.5%        23.1%        46.3%        28.1%        | 
|TERMINAL (d)       |     3/6 (50%)    7/9 (78%)    7/8 (88%)    8/9 (89%)   |2/5 (40%)    2/8 (25%)    2/4 (50%)    1/4 (25%)    | 
|FIRST INCIDENCE    |     150          296 (T)      242          278         |136          296 (T)      96           268          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.134      P=0.490      P=0.250      P=0.234     |P=0.468N     P=0.177N     P=0.615      P=0.375N     | 
|POLY 3             |     P=0.039 *    P=0.203      P=0.080      P=0.048 *   |P=0.420N     P=0.306N     P=0.678N     P=0.412N     | 
|POLY 1.5           |     P=0.025 *    P=0.184      P=0.075      P=0.033 *   |P=0.386N     P=0.306N     P=0.659N     P=0.375N     | 
|POLY 6             |     P=0.060      P=0.241      P=0.096      P=0.071     |P=0.452N     P=0.302N     P=0.652      P=0.438N     | 
|LOGISTIC REGRESSION|     P=0.046 *    P=0.238      P=0.111      P=0.043 *   |P=0.311N     P=0.334N     P=0.666      P=0.314N     | 
|COCH-ARM / FISHERS |     P=0.018 *    P=0.185      P=0.085      P=0.029 *   |P=0.320N     P=0.314N     P=0.675N     P=0.314N     | 
|ORDER RESTRICTED   |     P=0.014 *    (e)          (e)          (e)         |P=0.371N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    2/10 (20%)   6/10 (60%)  |0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)    | 
|POLY-3 RATE (b)    |     0/7.67       0/9.09       2/9.21       6/9.83      |0/7.13       0/8.65       0/7.16       0/6.87       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         21.7%        61.1%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/6 (0%)     0/9 (0%)     1/8 (13%)    6/9 (67%)   |0/5 (0%)     0/8 (0%)     0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          242          296 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P=0.285      P=0.024 *   |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   (e)          P=0.270      P=0.005 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   (e)          P=0.254      P=0.003 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   (e)          P=0.287      P=0.008 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   (e)          P=0.223      P=0.024 *   |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P=0.237      P=0.005 **  |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/08/03                           EXPERIMENT: 97013 TEST: 95                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (BROMOD
ICHLOR                                                                                                                              
                                         Terminal Sacrifice at 43 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/10 (10%)   8/10 (80%)   8/10 (80%)   10/10 (100%)|0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)    | 
|POLY-3 RATE (b)    |     1/7.67       8/9.09       8/10.00      10/10.00    |0/7.13       0/8.65       0/7.16       0/6.87       | 
|POLY-3 PERCENT (g) |     13.0%        88.0%        80.0%        100.0%      |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/6 (17%)    8/9 (89%)    6/8 (75%)    9/9 (100%)  |0/5 (0%)     0/8 (0%)     0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     296 (T)      296 (T)      177          278         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.005 **   P=0.015 *    P=0.021 *    P=0.003 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   P<0.001 **   P=0.002 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   P<0.001 **   P=0.005 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.015 *    P=0.004 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.003 **   P=0.003 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%)  |0/10 (0%)    0/10 (0%)    2/10 (20%)   1/10 (10%)   | 
|POLY-3 RATE (b)    |     0/7.67       0/9.09       0/8.76       1/9.83      |0/7.13       0/8.65       2/7.77       1/6.87       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         10.2%       |0.0%         0.0%         25.7%        14.6%        | 
|TERMINAL (d)       |     0/6 (0%)     0/9 (0%)     0/8 (0%)     1/9 (11%)   |0/5 (0%)     0/8 (0%)     0/4 (0%)     1/4 (25%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          296 (T)     |---          ---          256          296 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.228      (e)          (e)          P=0.581     |P=0.214      (e)          P=0.220      P=0.455      | 
|POLY 3             |     P=0.225      (e)          (e)          P=0.549     |P=0.191      (e)          P=0.241      P=0.492      | 
|POLY 1.5           |     P=0.217      (e)          (e)          P=0.533     |P=0.209      (e)          P=0.236      P=0.496      | 
|POLY 6             |     P=0.230      (e)          (e)          P=0.562     |P=0.173      (e)          P=0.241      P=0.488      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.581     |P=0.221      (e)          P=0.229      P=0.455      | 
|COCH-ARM / FISHERS |     P=0.196      (e)          (e)          P=0.500     |P=0.239      (e)          P=0.237      P=0.500      | 
|ORDER RESTRICTED   |     P=0.169      (e)          (e)          (e)         |P=0.165      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/08/03                           EXPERIMENT: 97013 TEST: 95                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (BROMOD
ICHLOR                                                                                                                              
                                         Terminal Sacrifice at 43 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    1/10 (10%)   1/10 (10%)   1/10 (10%)  |1/10 (10%)   3/10 (30%)   1/10 (10%)   1/10 (10%)   | 
|POLY-3 RATE (b)    |     0/7.67       1/9.09       1/8.76       1/9.83      |1/8.04       3/10.00      1/7.68       1/7.78       | 
|POLY-3 PERCENT (g) |     0.0%         11.0%        11.4%        10.2%       |12.4%        30.0%        13.0%        12.9%        | 
|TERMINAL (d)       |     0/6 (0%)     1/9 (11%)    1/8 (13%)    1/9 (11%)   |0/5 (0%)     1/8 (13%)    0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     ---          296 (T)      296 (T)      296 (T)     |136          164          232          136          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.454      P=0.581      P=0.557      P=0.581     |P=0.471N     P=0.404      P=0.733N     P=0.743N     | 
|POLY 3             |     P=0.476      P=0.534      P=0.527      P=0.549     |P=0.465N     P=0.378      P=0.755      P=0.758      | 
|POLY 1.5           |     P=0.447      P=0.521      P=0.518      P=0.533     |P=0.453N     P=0.347      P=0.757      P=0.760      | 
|POLY 6             |     P=0.499      P=0.548      P=0.533      P=0.562     |P=0.483N     P=0.414      P=0.747      P=0.755      | 
|LOGISTIC REGRESSION|     (e)          P=0.581      P=0.557      P=0.581     |P=0.374N     P=0.101      P=0.768      P=0.779      | 
|COCH-ARM / FISHERS |     P=0.380      P=0.500      P=0.500      P=0.500     |P=0.441N     P=0.291      P=0.763N     P=0.763N     | 
|ORDER RESTRICTED   |     P=0.356      (e)          (e)          (e)         |P=0.509N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)   |2/10 (20%)   0/10 (0%)    0/10 (0%)    0/10 (0%)    | 
|POLY-3 RATE (b)    |     0/7.67       0/9.09       0/8.76       0/9.83      |2/7.82       0/8.65       0/7.16       0/6.87       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |25.6%        0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/6 (0%)     0/9 (0%)     0/8 (0%)     0/9 (0%)    |0/5 (0%)     0/8 (0%)     0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |225          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.134N     P=0.196N     P=0.270N     P=0.275N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.107N     P=0.199N     P=0.242N     P=0.253N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.106N     P=0.204N     P=0.230N     P=0.238N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.110N     P=0.198N     P=0.273N     P=0.272N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.109N     P=0.238N     P=0.228N     P=0.229N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.110N     P=0.237N     P=0.237N     P=0.237N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.031N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/08/03                           EXPERIMENT: 97013 TEST: 95                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (BROMOD
ICHLOR                                                                                                                              
                                         Terminal Sacrifice at 43 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/10 (50%)   4/10 (40%)   8/10 (80%)   7/10 (70%)  |5/10 (50%)   10/10 (100%) 8/10 (80%)   7/10 (70%)   | 
|POLY-3 RATE (b)    |     5/9.13       4/9.09       8/8.76       7/10.00     |5/7.49       10/10.00     8/9.61       7/8.29       | 
|POLY-3 PERCENT (g) |     54.8%        44.0%        91.3%        70.0%       |66.8%        100.0%       83.3%        84.4%        | 
|TERMINAL (d)       |     2/6 (33%)    4/9 (44%)    8/8 (100%)   6/9 (67%)   |4/5 (80%)    8/8 (100%)   3/4 (75%)    4/4 (100%)   | 
|FIRST INCIDENCE    |     150          296 (T)      296 (T)      278         |256          164          96           136          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.389      P=0.303N     P=0.418      P=0.633N    |P=0.169      P=0.320      P=0.154      P=0.221      | 
|POLY 3             |     P=0.197      P=0.503N     P=0.097      P=0.418     |P=0.548      P=0.068      P=0.411      P=0.403      | 
|POLY 1.5           |     P=0.177      P=0.505N     P=0.127      P=0.392     |P=0.532      P=0.028 *    P=0.321      P=0.376      | 
|POLY 6             |     P=0.205      P=0.501N     P=0.067      P=0.431     |P=0.558      P=0.129      P=0.477      P=0.436      | 
|LOGISTIC REGRESSION|     P=0.224      P=0.487N     P=0.229      P=0.303     |P=0.391      P=0.031 *    P=0.178      P=0.272      | 
|COCH-ARM / FISHERS |     P=0.138      P=0.500N     P=0.175      P=0.325     |P=0.451      P=0.016 *    P=0.175      P=0.325      | 
|ORDER RESTRICTED   |     P=0.108      (e)          (e)          (e)         |P=0.146      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    1/10 (10%)   1/10 (10%)  |2/10 (20%)   0/10 (0%)    2/10 (20%)   0/10 (0%)    | 
|POLY-3 RATE (b)    |     0/7.67       0/9.09       1/8.76       1/10.00     |2/8.04       0/8.65       2/7.16       0/6.87       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         11.4%        10.0%       |24.9%        0.0%         27.9%        0.0%         | 
|TERMINAL (d)       |     0/6 (0%)     0/9 (0%)     1/8 (13%)    0/9 (0%)    |1/5 (20%)    0/8 (0%)     2/4 (50%)    0/4 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          296 (T)      278         |136          ---          296 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.287      (e)          P=0.557      P=0.571     |P=0.307N     P=0.179N     P=0.645      P=0.252N     | 
|POLY 3             |     P=0.298      (e)          P=0.527      P=0.552     |P=0.284N     P=0.205N     P=0.668      P=0.260N     | 
|POLY 1.5           |     P=0.278      (e)          P=0.518      P=0.535     |P=0.267N     P=0.212N     P=0.684      P=0.247N     | 
|POLY 6             |     P=0.315      (e)          P=0.533      P=0.567     |P=0.300N     P=0.195N     P=0.633      P=0.270N     | 
|LOGISTIC REGRESSION|     P=0.252      (e)          P=0.557      P=0.503     |P=0.237N     P=0.312N     P=0.711N     P=0.222N     | 
|COCH-ARM / FISHERS |     P=0.231      (e)          P=0.500      P=0.500     |P=0.238N     P=0.237N     P=0.709N     P=0.237N     | 
|ORDER RESTRICTED   |     P=0.284      (e)          (e)          (e)         |P=0.119N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/08/03                           EXPERIMENT: 97013 TEST: 95                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (BROMOD
ICHLOR                                                                                                                              
                                         Terminal Sacrifice at 43 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Fatty Change                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    3/10 (30%)   2/10 (20%)   0/10 (0%)   |0/10 (0%)    6/10 (60%)   6/10 (60%)   6/10 (60%)   | 
|POLY-3 RATE (b)    |     0/7.67       3/9.09       2/9.21       0/9.83      |0/7.13       6/8.65       6/7.77       6/8.00       | 
|POLY-3 PERCENT (g) |     0.0%         33.0%        21.7%        0.0%        |0.0%         69.4%        77.2%        75.0%        | 
|TERMINAL (d)       |     0/6 (0%)     3/9 (33%)    1/8 (13%)    0/9 (0%)    |0/5 (0%)     6/8 (75%)    4/4 (100%)   4/4 (100%)   | 
|FIRST INCIDENCE    |     ---          296 (T)      242          ---         |---          296 (T)      256          151          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.319N     P=0.186      P=0.285      (e)         |P<0.001 **   P=0.024 *    P=0.004 **   P=0.006 **   | 
|POLY 3             |     P=0.269N     P=0.125      P=0.270      (e)         |P=0.007 **   P=0.002 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P=0.310N     P=0.112      P=0.254      (e)         |P=0.008 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P=0.238N     P=0.142      P=0.287      (e)         |P=0.006 **   P=0.003 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.364N     P=0.186      P=0.223      (e)         |P=0.006 **   P=0.024 *    P=0.003 **   P=0.006 **   | 
|COCH-ARM / FISHERS |     P=0.404N     P=0.105      P=0.237      (e)         |P=0.021 *    P=0.005 **   P=0.005 **   P=0.005 **   | 
|ORDER RESTRICTED   |     P=0.192N     (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/10 (70%)   9/10 (90%)   8/10 (80%)   8/10 (80%)  |5/10 (50%)   8/10 (80%)   8/10 (80%)   8/10 (80%)   | 
|POLY-3 RATE (b)    |     7/7.84       9/9.09       8/8.76       8/9.83      |5/7.13       8/8.65       8/8.64       8/9.16       | 
|POLY-3 PERCENT (g) |     89.3%        99.0%        91.3%        81.4%       |70.1%        92.5%        92.6%        87.4%        | 
|TERMINAL (d)       |     6/6 (100%)   9/9 (100%)   8/8 (100%)   8/9 (89%)   |5/5 (100%)   8/8 (100%)   4/4 (100%)   4/4 (100%)   | 
|FIRST INCIDENCE    |     278          296 (T)      296 (T)      296 (T)     |296 (T)      296 (T)      232          136          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.076N     P=0.450N     P=0.473N     P=0.241N    |P=0.014 *    P=1.000      P=0.065      P=0.081      | 
|POLY 3             |     P=0.259N     P=0.614      P=0.823      P=0.587N    |P=0.413      P=0.273      P=0.276      P=0.396      | 
|POLY 1.5           |     P=0.431N     P=0.393      P=0.682      P=0.700N    |P=0.283      P=0.227      P=0.206      P=0.292      | 
|POLY 6             |     P=0.144N     P=0.956      P=0.970      P=0.489N    |P=0.611      P=0.355      P=0.397      P=0.544      | 
|LOGISTIC REGRESSION|     P=0.063N     P=0.450N     P=0.473N     P=0.250N    |P=0.059      P=1.000      P=0.108      P=0.140      | 
|COCH-ARM / FISHERS |     P=0.500      P=0.291      P=0.500      P=0.500     |P=0.154      P=0.175      P=0.175      P=0.175      | 
|ORDER RESTRICTED   |     P=0.236N     (e)          (e)          (e)         |P=0.128      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/08/03                           EXPERIMENT: 97013 TEST: 95                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (BROMOD
ICHLOR                                                                                                                              
                                         Terminal Sacrifice at 43 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    2/10 (20%)   1/10 (10%)   0/10 (0%)   |0/10 (0%)    0/10 (0%)    2/10 (20%)   0/10 (0%)    | 
|POLY-3 RATE (b)    |     0/7.67       2/10.00      1/8.76       0/9.83      |0/7.13       0/8.65       2/8.13       0/6.87       | 
|POLY-3 PERCENT (g) |     0.0%         20.0%        11.4%        0.0%        |0.0%         0.0%         24.6%        0.0%         | 
|TERMINAL (d)       |     0/6 (0%)     1/9 (11%)    1/8 (13%)    0/9 (0%)    |0/5 (0%)     0/8 (0%)     1/4 (25%)    0/4 (0%)     | 
|FIRST INCIDENCE    |     ---          134          296 (T)      ---         |---          ---          96           ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.412N     P=0.284      P=0.557      (e)         |P=0.554      (e)          P=0.215      (e)          | 
|POLY 3             |     P=0.360N     P=0.293      P=0.527      (e)         |P=0.531      (e)          P=0.253      (e)          | 
|POLY 1.5           |     P=0.391N     P=0.269      P=0.518      (e)         |P=0.557      (e)          P=0.251      (e)          | 
|POLY 6             |     P=0.335N     P=0.315      P=0.533      (e)         |P=0.510      (e)          P=0.239      (e)          | 
|LOGISTIC REGRESSION|     P=0.629N     P=0.150      P=0.557      (e)         |P=0.624      (e)          P=0.198      (e)          | 
|COCH-ARM / FISHERS |     P=0.460N     P=0.237      P=0.500      (e)         |P=0.597      (e)          P=0.237      (e)          | 
|ORDER RESTRICTED   |     P=0.324N     (e)          (e)          (e)         |P=0.252      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/10 (10%)   0/10 (0%)    0/10 (0%)    1/10 (10%)  |1/10 (10%)   0/10 (0%)    2/10 (20%)   1/10 (10%)   | 
|POLY-3 RATE (b)    |     1/7.67       0/9.09       0/8.76       1/9.83      |1/7.13       0/8.65       2/8.39       1/6.87       | 
|POLY-3 PERCENT (g) |     13.0%        0.0%         0.0%         10.2%       |14.0%        0.0%         23.9%        14.6%        | 
|TERMINAL (d)       |     1/6 (17%)    0/9 (0%)     0/8 (0%)     1/9 (11%)   |1/5 (20%)    0/8 (0%)     0/4 (0%)     1/4 (25%)    | 
|FIRST INCIDENCE    |     296 (T)      ---          ---          296 (T)     |296 (T)      ---          96           296 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.655      P=0.419N     P=0.443N     P=0.673N    |P=0.439      P=0.406N     P=0.453      P=0.723      | 
|POLY 3             |     P=0.608      P=0.466N     P=0.473N     P=0.704N    |P=0.435      P=0.461N     P=0.560      P=0.759      | 
|POLY 1.5           |     P=0.606      P=0.479N     P=0.482N     P=0.723N    |P=0.460      P=0.474N     P=0.547      P=0.761      | 
|POLY 6             |     P=0.605      P=0.451N     P=0.466N     P=0.687N    |P=0.409      P=0.449N     P=0.557      P=0.757      | 
|LOGISTIC REGRESSION|     P=0.655      (e)          (e)          P=0.673N    |P=0.517      (e)          P=0.483      P=0.723      | 
|COCH-ARM / FISHERS |     P=0.597      P=0.500N     P=0.500N     P=0.763N    |P=0.500      P=0.500N     P=0.500      P=0.763N     | 
|ORDER RESTRICTED   |     P=0.330N     (e)          (e)          (e)         |P=0.386      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/08/03                           EXPERIMENT: 97013 TEST: 95                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (BROMOD
ICHLOR                                                                                                                              
                                         Terminal Sacrifice at 43 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Perivascular                                                                                                               | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    1/10 (10%)   3/10 (30%)  |0/10 (0%)    1/10 (10%)   0/10 (0%)    0/10 (0%)    | 
|POLY-3 RATE (b)    |     0/7.67       0/9.09       1/8.76       3/9.83      |0/7.13       1/9.17       0/7.16       0/6.87       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         11.4%        30.5%       |0.0%         10.9%        0.0%         0.0%         | 
|TERMINAL (d)       |     0/6 (0%)     0/9 (0%)     1/8 (13%)    3/9 (33%)   |0/5 (0%)     0/8 (0%)     0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          296 (T)      296 (T)     |---          232          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.027 *    (e)          P=0.557      P=0.186     |P=0.580N     P=0.550      (e)          (e)          | 
|POLY 3             |     P=0.019 *    (e)          P=0.527      P=0.146     |P=0.547N     P=0.549      (e)          (e)          | 
|POLY 1.5           |     P=0.017 *    (e)          P=0.518      P=0.127     |P=0.551N     P=0.532      (e)          (e)          | 
|POLY 6             |     P=0.021 *    (e)          P=0.533      P=0.163     |P=0.551N     P=0.567      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.557      P=0.186     |P=0.556N     P=0.441      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.016 *    (e)          P=0.500      P=0.105     |P=0.568N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.029 *    (e)          (e)          (e)         |P=0.429N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    1/10 (10%)   0/10 (0%)   |0/10 (0%)    1/10 (10%)   2/10 (20%)   0/10 (0%)    | 
|POLY-3 RATE (b)    |     0/7.67       0/9.09       1/8.76       0/9.83      |0/7.13       1/9.48       2/8.65       0/6.87       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         11.4%        0.0%        |0.0%         10.6%        23.1%        0.0%         | 
|TERMINAL (d)       |     0/6 (0%)     0/9 (0%)     1/8 (13%)    0/9 (0%)    |0/5 (0%)     0/8 (0%)     0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          296 (T)      ---         |---          164          96           ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.732      (e)          P=0.557      (e)         |P=0.629N     P=0.545      P=0.267      (e)          | 
|POLY 3             |     P=0.767      (e)          P=0.527      (e)         |P=0.637      P=0.556      P=0.270      (e)          | 
|POLY 1.5           |     P=0.746      (e)          P=0.518      (e)         |P=0.640N     P=0.538      P=0.260      (e)          | 
|POLY 6             |     P=0.771N     (e)          P=0.533      (e)         |P=0.613      P=0.571      P=0.269      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.557      (e)         |P=0.576N     P=0.261      P=0.160      (e)          | 
|COCH-ARM / FISHERS |     P=0.696      (e)          P=0.500      (e)         |P=0.620N     P=0.500      P=0.237      (e)          | 
|ORDER RESTRICTED   |     P=0.407      (e)          (e)          (e)         |P=0.351      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/08/03                           EXPERIMENT: 97013 TEST: 95                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (BROMOD
ICHLOR                                                                                                                              
                                         Terminal Sacrifice at 43 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Infiltration Cellular Plasma Cell                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/10 (10%)   1/10 (10%)   1/10 (10%)   2/10 (20%)  |1/10 (10%)   1/10 (10%)   0/10 (0%)    2/10 (20%)   | 
|POLY-3 RATE (b)    |     1/8.54       1/10.00      1/8.76       2/9.83      |1/7.13       1/9.17       0/7.16       2/8.03       | 
|POLY-3 PERCENT (g) |     11.7%        10.0%        11.4%        20.4%       |14.0%        10.9%        0.0%         24.9%        | 
|TERMINAL (d)       |     0/6 (0%)     0/9 (0%)     1/8 (13%)    2/9 (22%)   |1/5 (20%)    0/8 (0%)     0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     150          134          296 (T)      296 (T)     |296 (T)      232          ---          136          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.407      P=0.749      P=0.729N     P=0.595     |P=0.339      P=0.679N     P=0.545N     P=0.504      | 
|POLY 3             |     P=0.377      P=0.725N     P=0.757N     P=0.551     |P=0.360      P=0.704N     P=0.499N     P=0.544      | 
|POLY 1.5           |     P=0.368      P=0.738N     P=0.758N     P=0.533     |P=0.364      P=0.725N     P=0.497N     P=0.530      | 
|POLY 6             |     P=0.383      P=0.711N     P=0.755N     P=0.567     |P=0.351      P=0.680N     P=0.513N     P=0.558      | 
|LOGISTIC REGRESSION|     P=0.110      (e)          P=0.693      P=0.280     |P=0.382      P=0.777N     (e)          P=0.503      | 
|COCH-ARM / FISHERS |     P=0.343      P=0.763N     P=0.763N     P=0.500     |P=0.361      P=0.763N     P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.450      (e)          (e)          (e)         |P=0.285      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/10 (20%)   2/10 (20%)   1/10 (10%)   2/10 (20%)   | 
|POLY-3 RATE (b)    |                                                        |2/7.13       2/8.65       1/7.42       2/6.87       | 
|POLY-3 PERCENT (g) |                                                        |28.0%        23.1%        13.5%        29.1%        | 
|TERMINAL (d)       |                                                        |2/5 (40%)    2/8 (25%)    0/4 (0%)     2/4 (50%)    | 
|FIRST INCIDENCE    |                                                        |296 (T)      296 (T)      268          296 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.489      P=0.518N     P=0.575N     P=0.638      | 
|POLY 3             |                                                        |P=0.597      P=0.633N     P=0.485N     P=0.702      | 
|POLY 1.5           |                                                        |P=0.602N     P=0.657N     P=0.487N     P=0.705      | 
|POLY 6             |                                                        |P=0.576      P=0.608N     P=0.497N     P=0.699      | 
|LOGISTIC REGRESSION|                                                        |P=0.557      P=0.518N     P=0.533N     P=0.638      | 
|COCH-ARM / FISHERS |                                                        |P=0.584N     P=0.709N     P=0.500N     P=0.709N     | 
|ORDER RESTRICTED   |                                                        |P=0.588      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/08/03                           EXPERIMENT: 97013 TEST: 95                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (BROMOD
ICHLOR                                                                                                                              
                                         Terminal Sacrifice at 43 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/10 (20%)   2/10 (20%)   0/10 (0%)    0/10 (0%)    | 
|POLY-3 RATE (b)    |                                                        |2/7.82       2/8.65       0/7.16       0/6.87       | 
|POLY-3 PERCENT (g) |                                                        |25.6%        23.1%        0.0%         0.0%         | 
|TERMINAL (d)       |                                                        |0/5 (0%)     2/8 (25%)    0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |                                                        |225          296 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.117N     P=0.569N     P=0.270N     P=0.275N     | 
|POLY 3             |                                                        |P=0.085N     P=0.669N     P=0.242N     P=0.253N     | 
|POLY 1.5           |                                                        |P=0.079N     P=0.676N     P=0.230N     P=0.238N     | 
|POLY 6             |                                                        |P=0.098N     P=0.668N     P=0.273N     P=0.272N     | 
|LOGISTIC REGRESSION|                                                        |P=0.080N     P=0.679N     P=0.228N     P=0.229N     | 
|COCH-ARM / FISHERS |                                                        |P=0.077N     P=0.709N     P=0.237N     P=0.237N     | 
|ORDER RESTRICTED   |                                                        |P=0.117N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/10 (20%)   3/10 (30%)   1/10 (10%)   0/10 (0%)   |2/10 (20%)   3/10 (30%)   1/10 (10%)   2/10 (20%)   | 
|POLY-3 RATE (b)    |     2/8.54       3/9.09       1/8.76       0/9.83      |2/7.13       3/8.65       1/7.68       2/7.13       | 
|POLY-3 PERCENT (g) |     23.4%        33.0%        11.4%        0.0%        |28.0%        34.7%        13.0%        28.1%        | 
|TERMINAL (d)       |     1/6 (17%)    3/9 (33%)    1/8 (13%)    0/9 (0%)    |2/5 (40%)    3/8 (38%)    0/4 (0%)     1/4 (25%)    | 
|FIRST INCIDENCE    |     150          296 (T)      296 (T)      ---         |296 (T)      296 (T)      232          268          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.060N     P=0.645      P=0.432N     P=0.196N    |P=0.570      P=0.683N     P=0.524N     P=0.661      | 
|POLY 3             |     P=0.067N     P=0.532      P=0.491N     P=0.193N    |P=0.513N     P=0.599      P=0.472N     P=0.715      | 
|POLY 1.5           |     P=0.073N     P=0.515      P=0.493N     P=0.204N    |P=0.507N     P=0.566      P=0.480N     P=0.711      | 
|POLY 6             |     P=0.061N     P=0.557      P=0.486N     P=0.182N    |P=0.520N     P=0.632      P=0.478N     P=0.714N     | 
|LOGISTIC REGRESSION|     P=0.095N     P=0.489      P=0.570N     P=0.461N    |P=0.560N     P=0.683N     P=0.498N     P=0.701      | 
|COCH-ARM / FISHERS |     P=0.089N     P=0.500      P=0.500N     P=0.237N    |P=0.500N     P=0.500      P=0.500N     P=0.709N     | 
|ORDER RESTRICTED   |     P=0.074N     (e)          (e)          (e)         |P=0.506N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/08/03                           EXPERIMENT: 97013 TEST: 95                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (BROMOD
ICHLOR                                                                                                                              
                                         Terminal Sacrifice at 43 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/8 (0%)     2/8 (25%)    1/8 (13%)    1/8 (13%)   |0/8 (0%)     0/8 (0%)     0/8 (0%)     0/6 (0%)     | 
|POLY-3 RATE (b)    |     0/7.41       2/8.00       1/7.55       1/8.00      |0/6.96       0/7.48       0/6.48       0/5.41       | 
|POLY-3 PERCENT (g) |     0.0%         25.0%        13.3%        12.5%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/6 (0%)     2/8 (25%)    1/7 (14%)    0/7 (0%)    |0/5 (0%)     0/7 (0%)     0/4 (0%)     0/3 (0%)     | 
|FIRST INCIDENCE    |     ---          296 (T)      296 (T)      278         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.538      P=0.298      P=0.531      P=0.571     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.536      P=0.241      P=0.504      P=0.515     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.520      P=0.232      P=0.502      P=0.508     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.561      P=0.254      P=0.508      P=0.526     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.499      P=0.298      P=0.531      P=0.375     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.500      P=0.233      P=0.500      P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.268      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Control Epidermis                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/8 (25%)    0/8 (0%)     0/8 (0%)     0/8 (0%)    |0/8 (0%)     1/8 (13%)    0/8 (0%)     0/6 (0%)     | 
|POLY-3 RATE (b)    |     2/7.41       0/8.00       0/7.55       0/7.83      |0/6.96       1/7.48       0/6.48       0/5.41       | 
|POLY-3 PERCENT (g) |     27.0%        0.0%         0.0%         0.0%        |0.0%         13.4%        0.0%         0.0%         | 
|TERMINAL (d)       |     2/6 (33%)    0/8 (0%)     0/7 (0%)     0/7 (0%)    |0/5 (0%)     1/7 (14%)    0/4 (0%)     0/3 (0%)     | 
|FIRST INCIDENCE    |     296 (T)      ---          ---          ---         |---          296 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.100N     P=0.170N     P=0.196N     P=0.196N    |P=0.671N     P=0.567      (e)          (e)          | 
|POLY 3             |     P=0.105N     P=0.203N     P=0.216N     P=0.207N    |P=0.614N     P=0.514      (e)          (e)          | 
|POLY 1.5           |     P=0.102N     P=0.212N     P=0.219N     P=0.214N    |P=0.612N     P=0.508      (e)          (e)          | 
|POLY 6             |     P=0.110N     P=0.190N     P=0.210N     P=0.198N    |P=0.617N     P=0.525      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.100N     (e)          (e)          (e)         |(e)          P=0.567      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.109N     P=0.233N     P=0.233N     P=0.233N    |P=0.614N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.017N*    (e)          (e)          (e)         |P=0.439N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/08/03                           EXPERIMENT: 97013 TEST: 95                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (BROMOD
ICHLOR                                                                                                                              
                                         Terminal Sacrifice at 43 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    1/10 (10%)   1/10 (10%)   1/10 (10%)  |3/10 (30%)   3/10 (30%)   0/10 (0%)    2/10 (20%)   | 
|POLY-3 RATE (b)    |     0/7.67       1/9.09       1/8.76       1/9.83      |3/8.72       3/10.00      0/7.16       2/8.03       | 
|POLY-3 PERCENT (g) |     0.0%         11.0%        11.4%        10.2%       |34.4%        30.0%        0.0%         24.9%        | 
|TERMINAL (d)       |     0/6 (0%)     1/9 (11%)    1/8 (13%)    1/9 (11%)   |0/5 (0%)     1/8 (13%)    0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     ---          296 (T)      296 (T)      296 (T)     |136          164          ---          136          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.454      P=0.581      P=0.557      P=0.581     |P=0.352N     P=0.546N     P=0.140N     P=0.496N     | 
|POLY 3             |     P=0.476      P=0.534      P=0.527      P=0.549     |P=0.354N     P=0.610N     P=0.128N     P=0.542N     | 
|POLY 1.5           |     P=0.447      P=0.521      P=0.518      P=0.533     |P=0.328N     P=0.631N     P=0.112N     P=0.523N     | 
|POLY 6             |     P=0.499      P=0.548      P=0.533      P=0.562     |P=0.391N     P=0.591N     P=0.162N     P=0.562N     | 
|LOGISTIC REGRESSION|     (e)          P=0.581      P=0.557      P=0.581     |P=0.242N     P=0.508      P=0.105N     P=0.488N     | 
|COCH-ARM / FISHERS |     P=0.380      P=0.500      P=0.500      P=0.500     |P=0.296N     P=0.686N     P=0.105N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.356      (e)          (e)          (e)         |P=0.249N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/10 (10%)   0/10 (0%)    0/10 (0%)    0/10 (0%)   |3/10 (30%)   0/10 (0%)    1/10 (10%)   1/10 (10%)   | 
|POLY-3 RATE (b)    |     1/8.09       0/9.09       0/8.76       0/9.83      |3/7.13       0/8.65       1/8.13       1/6.95       | 
|POLY-3 PERCENT (g) |     12.4%        0.0%         0.0%         0.0%        |42.1%        0.0%         12.3%        14.4%        | 
|TERMINAL (d)       |     0/6 (0%)     0/9 (0%)     0/8 (0%)     0/9 (0%)    |3/5 (60%)    0/8 (0%)     0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     247          ---          ---          ---         |296 (T)      ---          96           288          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.286N     P=0.477N     P=0.500N     P=0.455N    |P=0.377N     P=0.040N*    P=0.355N     P=0.355N     | 
|POLY 3             |     P=0.333N     P=0.477N     P=0.484N     P=0.461N    |P=0.317N     P=0.056N     P=0.228N     P=0.287N     | 
|POLY 1.5           |     P=0.324N     P=0.485N     P=0.487N     P=0.472N    |P=0.304N     P=0.067N     P=0.241N     P=0.287N     | 
|POLY 6             |     P=0.340N     P=0.469N     P=0.484N     P=0.455N    |P=0.336N     P=0.046N*    P=0.236N     P=0.284N     | 
|LOGISTIC REGRESSION|     P=0.354N     P=0.528N     P=0.539N     P=0.627N    |P=0.283N     (e)          P=0.290N     P=0.315N     | 
|COCH-ARM / FISHERS |     P=0.304N     P=0.500N     P=0.500N     P=0.500N    |P=0.286N     P=0.105N     P=0.291N     P=0.291N     | 
|ORDER RESTRICTED   |     P=0.092N     (e)          (e)          (e)         |P=0.068N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/08/03                           EXPERIMENT: 97013 TEST: 95                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (BROMOD
ICHLOR                                                                                                                              
                                         Terminal Sacrifice at 43 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/10 (20%)   0/10 (0%)    0/10 (0%)    0/10 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     2/8.09       0/9.09       0/8.76       0/9.83      |                                                    | 
|POLY-3 PERCENT (g) |     24.7%        0.0%         0.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     1/6 (17%)    0/9 (0%)     0/8 (0%)     0/9 (0%)    |                                                    | 
|FIRST INCIDENCE    |     247          ---          ---          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.095N     P=0.184N     P=0.208N     P=0.174N    |                                                    | 
|POLY 3             |     P=0.114N     P=0.197N     P=0.204N     P=0.181N    |                                                    | 
|POLY 1.5           |     P=0.109N     P=0.207N     P=0.209N     P=0.193N    |                                                    | 
|POLY 6             |     P=0.118N     P=0.188N     P=0.204N     P=0.174N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.109N     P=0.222N     P=0.221N     P=0.229N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.110N     P=0.237N     P=0.237N     P=0.237N    |                                                    | 
|ORDER RESTRICTED   |     P=0.012N*    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/10 (30%)   0/10 (0%)    1/10 (10%)   1/10 (10%)  |                                                    | 
|POLY-3 RATE (b)    |     3/8.09       0/9.09       1/8.76       1/9.83      |                                                    | 
|POLY-3 PERCENT (g) |     37.1%        0.0%         11.4%        10.2%       |                                                    | 
|TERMINAL (d)       |     2/6 (33%)    0/9 (0%)     1/8 (13%)    1/9 (11%)   |                                                    | 
|FIRST INCIDENCE    |     247          ---          296 (T)      296 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.217N     P=0.070N     P=0.222N     P=0.179N    |                                                    | 
|POLY 3             |     P=0.277N     P=0.070N     P=0.255N     P=0.217N    |                                                    | 
|POLY 1.5           |     P=0.277N     P=0.078N     P=0.262N     P=0.237N    |                                                    | 
|POLY 6             |     P=0.281N     P=0.064N     P=0.254N     P=0.205N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.245N     P=0.089N     P=0.245N     P=0.230N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.286N     P=0.105N     P=0.291N     P=0.291N    |                                                    | 
|ORDER RESTRICTED   |     P=0.048N*    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/08/03                           EXPERIMENT: 97013 TEST: 95                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (BROMOD
ICHLOR                                                                                                                              
                                         Terminal Sacrifice at 43 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/9 (11%)    1/9 (11%)    1/10 (10%)   0/10 (0%)   |4/10 (40%)   2/10 (20%)   2/10 (20%)   2/10 (20%)   | 
|POLY-3 RATE (b)    |     1/7.09       1/9.00       1/9.55       0/9.83      |4/8.17       2/9.17       2/8.52       2/7.71       | 
|POLY-3 PERCENT (g) |     14.1%        11.1%        10.5%        0.0%        |48.9%        21.8%        23.5%        25.9%        | 
|TERMINAL (d)       |     0/5 (0%)     0/8 (0%)     0/8 (0%)     0/9 (0%)    |1/5 (20%)    1/8 (13%)    0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     247          134          177          ---         |225          232          96           183          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.284N     P=0.747N     P=0.736N     P=0.455N    |P=0.362N     P=0.218N     P=0.369N     P=0.382N     | 
|POLY 3             |     P=0.257N     P=0.706N     P=0.692N     P=0.435N    |P=0.305N     P=0.251N     P=0.284N     P=0.337N     | 
|POLY 1.5           |     P=0.264N     P=0.724N     P=0.705N     P=0.448N    |P=0.289N     P=0.264N     P=0.276N     P=0.319N     | 
|POLY 6             |     P=0.254N     P=0.692N     P=0.686N     P=0.427N    |P=0.334N     P=0.249N     P=0.331N     P=0.370N     | 
|LOGISTIC REGRESSION|     P=0.728      P=0.708      P=0.687      P=0.607N    |P=0.244N     P=0.303N     P=0.321N     P=0.315N     | 
|COCH-ARM / FISHERS |     P=0.279N     P=0.765N     P=0.737N     P=0.474N    |P=0.269N     P=0.314N     P=0.314N     P=0.314N     | 
|ORDER RESTRICTED   |     P=0.273N     (e)          (e)          (e)         |P=0.230N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/9 (22%)    3/9 (33%)    4/10 (40%)   5/10 (50%)  |3/10 (30%)   3/10 (30%)   3/10 (30%)   4/10 (40%)   | 
|POLY-3 RATE (b)    |     2/6.67       3/8.09       4/8.76       5/10.00     |3/7.13       3/9.48       3/8.03       4/7.78       | 
|POLY-3 PERCENT (g) |     30.0%        37.1%        45.7%        50.0%       |42.1%        31.6%        37.4%        51.5%        | 
|TERMINAL (d)       |     2/5 (40%)    3/8 (38%)    4/8 (50%)    4/9 (44%)   |3/5 (60%)    2/8 (25%)    1/4 (25%)    3/4 (75%)    | 
|FIRST INCIDENCE    |     296 (T)      296 (T)      296 (T)      278         |296 (T)      164          232          136          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.314      P=0.683N     P=0.584      P=0.479     |P=0.218      P=0.448N     P=0.626      P=0.366      | 
|POLY 3             |     P=0.292      P=0.600      P=0.462      P=0.386     |P=0.364      P=0.530N     P=0.630N     P=0.562      | 
|POLY 1.5           |     P=0.242      P=0.560      P=0.431      P=0.324     |P=0.383      P=0.581N     P=0.649N     P=0.545      | 
|POLY 6             |     P=0.337      P=0.642      P=0.490      P=0.446     |P=0.335      P=0.482N     P=0.623N     P=0.572      | 
|LOGISTIC REGRESSION|     P=0.302      P=0.683N     P=0.584      P=0.429     |P=0.368      P=0.645N     P=0.694N     P=0.483      | 
|COCH-ARM / FISHERS |     P=0.150      P=0.500      P=0.370      P=0.220     |P=0.388      P=0.686N     P=0.686N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.358      (e)          (e)          (e)         |P=0.450      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/08/03                           EXPERIMENT: 97013 TEST: 95                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (BROMOD
ICHLOR                                                                                                                              
                                         Terminal Sacrifice at 43 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/10 (20%)   2/10 (20%)   1/10 (10%)   2/10 (20%)  |0/10 (0%)    1/10 (10%)   1/10 (10%)   0/10 (0%)    | 
|POLY-3 RATE (b)    |     2/8.09       2/9.09       1/8.76       2/9.83      |0/7.13       1/9.17       1/7.51       0/6.87       | 
|POLY-3 PERCENT (g) |     24.7%        22.0%        11.4%        20.4%       |0.0%         10.9%        13.3%        0.0%         | 
|TERMINAL (d)       |     1/6 (17%)    2/9 (22%)    1/8 (13%)    2/9 (22%)   |0/5 (0%)     0/8 (0%)     0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     247          296 (T)      296 (T)      296 (T)     |---          232          256          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.468N     P=0.573N     P=0.432N     P=0.562N    |P=0.609N     P=0.550      P=0.500      (e)          | 
|POLY 3             |     P=0.531N     P=0.661N     P=0.471N     P=0.629N    |P=0.606N     P=0.549      P=0.510      (e)          | 
|POLY 1.5           |     P=0.544N     P=0.677N     P=0.477N     P=0.651N    |P=0.599N     P=0.532      P=0.508      (e)          | 
|POLY 6             |     P=0.526N     P=0.647N     P=0.471N     P=0.616N    |P=0.616N     P=0.567      P=0.506      (e)          | 
|LOGISTIC REGRESSION|     P=0.510N     P=0.674N     P=0.471N     P=0.675N    |P=0.588N     P=0.441      P=0.501      (e)          | 
|COCH-ARM / FISHERS |     P=0.584N     P=0.709N     P=0.500N     P=0.709N    |P=0.597N     P=0.500      P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.523N     (e)          (e)          (e)         |P=0.435      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)   |2/10 (20%)   1/10 (10%)   1/10 (10%)   0/10 (0%)    | 
|POLY-3 RATE (b)    |     0/7.67       0/9.09       0/8.76       0/9.83      |2/7.13       1/9.48       1/7.42       0/6.87       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |28.0%        10.6%        13.5%        0.0%         | 
|TERMINAL (d)       |     0/6 (0%)     0/9 (0%)     0/8 (0%)     0/9 (0%)    |2/5 (40%)    0/8 (0%)     0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |296 (T)      164          268          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.183N     P=0.364N     P=0.575N     P=0.277N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.173N     P=0.397N     P=0.485N     P=0.227N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.163N     P=0.430N     P=0.487N     P=0.225N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.186N     P=0.368N     P=0.497N     P=0.229N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.141N     P=0.538N     P=0.533N     (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.143N     P=0.500N     P=0.500N     P=0.237N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.108N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/08/03                           EXPERIMENT: 97013 TEST: 95                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (BROMOD
ICHLOR                                                                                                                              
                                         Terminal Sacrifice at 43 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       175 MG/L     350 MG/L     700 MG/L    |0 MG/L       175 MG/L     350 MG/L     700 MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |7/10 (70%)   9/10 (90%)   6/10 (60%)   6/10 (60%)   | 
|POLY-3 RATE (b)    |                                                        |7/8.05       9/9.48       6/7.77       6/7.82       | 
|POLY-3 PERCENT (g) |                                                        |87.0%        94.9%        77.2%        76.8%        | 
|TERMINAL (d)       |                                                        |5/5 (100%)   8/8 (100%)   4/4 (100%)   4/4 (100%)   | 
|FIRST INCIDENCE    |                                                        |225          164          256          151          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.501      P=0.445N     P=0.689      P=0.690      | 
|POLY 3             |                                                        |P=0.257N     P=0.618      P=0.567N     P=0.555N     | 
|POLY 1.5           |                                                        |P=0.226N     P=0.509      P=0.511N     P=0.501N     | 
|POLY 6             |                                                        |P=0.357N     P=0.673      P=0.744N     P=0.684N     | 
|LOGISTIC REGRESSION|                                                        |P=0.299N     P=0.520      P=0.435N     P=0.540N     | 
|COCH-ARM / FISHERS |                                                        |P=0.242N     P=0.291      P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |                                                        |P=0.281N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).