National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/11669

TDMS Study 97013-95 Pathology Tables

NTP Experiment-Test: 97013-95         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/08/03
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 10:11:33

                                                           FINAL/MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  75-27-4

       Lock Date:  07/19/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 97013-95         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/08/03    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 10:11:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      2                         1            1                                     
    Moribund Sacrifice                                 3            2            5            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 5            8            4            4                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (10)         (10)         (10)         (10)                                   
      Necrosis                                         1 [1.0]                                                                      
      Epithelium, Regeneration                         1 [1.0]                                                                      
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 1 [2.0]      3 [1.3]      1 [1.0]      1 [1.0]                               
      Infiltration Cellular                            2 [2.5]                                                                      
      Inflammation                                     5 [1.2]     10 [1.2]      8 [1.3]      7 [1.0]                               
      Necrosis                                         2 [1.0]                   2 [1.0]                                            
      Hepatocyte, Fatty Change                                      6 [1.2]      6 [2.0]      6 [2.7]                               
      Hepatocyte, Vacuolization Cytoplasmic            5 [1.0]      8 [1.5]      8 [1.9]      8 [1.9]                               
   Mesentery                                          (1)          (1)                       (1)                                    
      Inflammation, Suppurative                        1 [2.0]                                                                      
      Artery, Inflammation                                          1 [2.0]                   1 [2.0]                               
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Hyperkeratosis                                                             1 [1.0]                                            
      Epithelium, Hyperplasia                          3 [1.3]                   1 [2.0]      1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 1 [1.0]                                                                      
      Subcapsular, Hyperplasia                         6 [1.0]      5 [1.0]      7 [1.0]      8 [1.0]                               
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Cyst                                             2 [1.0]      3 [1.0]      1 [1.0]      2 [1.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-95         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/08/03    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 10:11:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      1 [1.0]                                                                      
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Cyst                                                          1 [2.0]      1 [1.0]                                            
      Inflammation                                     2 [1.0]      1 [1.0]      1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)                                                                           
      Inflammation                                     1 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (10)         (10)                                   
      Atrophy                                          2 [2.0]      2 [2.0]      1 [2.0]      2 [2.0]                               
      Cyst                                             1 [1.0]      1 [2.0]      1 [1.0]                                            
      Inflammation                                                  2 [1.5]                                                         
      Inflammation, Suppurative                        2 [4.0]                                                                      
   Oviduct                                            (1)                                                                           
      Inflammation                                     1 [2.0]                                                                      
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Inflammation                                     1 [3.0]                   1 [1.0]                                            
      Endometrium, Hyperplasia, Cystic                 7 [1.6]      9 [1.6]      6 [1.7]      6 [1.3]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (2)                                                                           
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
        Cell                                           1 [2.0]                                                                      
      Renal, Hyperplasia                               1 [2.0]                                                                      
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                                    1 [2.0]                                            
      Hyperplasia                                                   1 [2.0]      2 [2.0]                                            
      Infiltration Cellular, Plasma Cell               1 [1.0]      1 [2.0]                   2 [1.5]                               
   Lymph Node, Mesenteric                             (10)         (10)         (9)          (10)                                   
      Hematopoietic Cell Proliferation                 1 [2.0]                                                                      
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                                    1 [3.0]      1 [2.0]                               
      Hematopoietic Cell Proliferation                 3 [3.0]      3 [1.7]                   2 [1.0]                               
   Thymus                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                          4 [2.5]      2 [1.5]      2 [3.0]      2 [3.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-95         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/08/03    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 10:11:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Cyst                                             3 [1.0]      3 [1.3]      3 [1.3]      4 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (8)          (8)          (8)          (6)                                    
      Abscess                                                       1                                                               
      Hyperkeratosis                                                                          1 [2.0]                               
      Hyperplasia, Focal                                                                      1 [2.0]                               
      Ulcer                                                                                   1 [4.0]                               
      Control Epidermis, Hyperplasia                                1 [2.0]                                                         
      Epidermis, Hyperplasia, Focal                                                           1 [3.0]                               
      Subcutaneous Tissue, Inflammation                             1 [4.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Inflammation                                                               2 [1.0]                                            
      Alveolar Epithelium, Hyperplasia                 1 [2.0]                   2 [1.5]      1 [2.0]                               
      Perivascular, Inflammation                                    1 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Casts Protein                                                 1 [1.0]                   2 [1.0]                               
      Cyst                                                          1 [1.0]      5 [1.0]      2 [1.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-95         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/08/03    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 10:11:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Hydronephrosis                                   2 [1.5]                                                                      
      Infarct                                                                    1 [2.0]                                            
      Inflammation                                     1 [3.0]                                                                      
      Mineralization                                                                          1 [1.0]                               
      Nephropathy                                      4 [1.3]      2 [1.0]      4 [1.3]      2 [1.0]                               
      Glomerulus, Inflammation,                                                                                                     
        Membranoproliferative                          1 [4.0]                                1 [3.0]                               
      Renal Tubule, Accumulation, Hyaline Droplet      1 [1.0]                                                                      
      Renal Tubule, Hypertrophy                                                  2 [1.0]      1 [1.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-95         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/08/03    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 10:11:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 4                                      1                                     
    Natural Death                                                   1            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 6            9            8            9                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                                                    (1)                                                 
      Inflammation                                                               1 [1.0]                                            
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                              1 [1.0]      1 [1.0]      1 [1.0]                               
      Inflammation                                     5 [1.2]      4 [1.0]      8 [1.0]      7 [1.1]                               
      Necrosis                                                                   1 [1.0]      1 [1.0]                               
      Hepatocyte, Fatty Change                                      3 [1.0]      2 [1.0]                                            
      Hepatocyte, Vacuolization Cytoplasmic            7 [1.9]      9 [1.3]      8 [1.6]      8 [1.4]                               
   Mesentery                                          (1)                       (1)                                                 
      Fat, Necrosis                                    1 [2.0]                   1 [2.0]                                            
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Hyperkeratosis                                                1 [2.0]                                                         
      Epithelium, Hyperplasia                          1 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Hypertrophy                                      5 [1.2]      4 [1.3]      4 [1.5]      4 [1.3]                               
      Subcapsular, Hyperplasia                         1 [1.0]      1 [1.0]      2 [1.5]                                            
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Cyst                                             2 [1.0]      3 [1.0]      1 [1.0]                                            
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Cyst                                             2 [1.0]      2 [1.0]      1 [1.0]      2 [1.0]                               
      Follicle, Cyst                                                1 [1.0]                   1 [2.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-95         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/08/03    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 10:11:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (1)                                                                           
      Duct, Ectasia                                    1 [2.0]                                                                      
   Testes                                             (10)         (10)         (10)         (10)                                   
      Mineralization                                   2 [1.0]                                                                      
      Germinal Epithelium, Degeneration                3 [1.7]                   1 [1.0]      1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
      Angiectasis                                                                1 [2.0]                                            
      Hyperplasia                                                                1 [2.0]                                            
      Infiltration Cellular, Plasma Cell               1 [2.0]      1 [1.0]      1 [2.0]      2 [2.0]                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                       1 [2.0]                                                         
      Hematopoietic Cell Proliferation                              1 [1.0]      1 [1.0]      1 [1.0]                               
   Thymus                                             (9)          (9)          (10)         (10)                                   
      Atrophy                                          1 [2.0]      1 [3.0]      1 [4.0]                                            
      Cyst                                             2 [1.0]      3 [1.0]      4 [1.0]      5 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (8)          (8)          (8)          (8)                                    
      Hyperplasia                                                   2 [1.5]      1 [2.0]      1 [2.0]                               
      Inflammation                                     1 [1.0]                                                                      
      Control Epidermis, Hyperplasia                   2 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-95         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/08/03    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 10:11:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Infiltration Cellular, Histiocyte                1 [1.0]                                                                      
      Inflammation                                                  2 [1.0]      1 [1.0]                                            
      Alveolar Epithelium, Hyperplasia                 1 [1.0]                                1 [1.0]                               
      Perivascular, Inflammation                                                 1 [1.0]      3 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Casts Protein                                    2 [1.0]                   1 [1.0]      4 [1.0]                               
      Cyst                                             3 [1.0]      1 [1.0]      1 [1.0]                                            
      Hydronephrosis                                   1 [2.0]                   2 [1.0]                                            
      Infiltration Cellular, Plasma Cell                                         1 [1.0]                                            
      Mineralization                                                                          2 [1.0]                               
      Nephropathy                                      4 [1.0]      7 [1.0]      8 [1.3]      9 [1.6]                               
      Artery, Inflammation                                          1 [1.0]                                                         
      Glomerulus, Inflammation,                                                                                                     
        Membranoproliferative                                                                 1 [1.0]                               
      Renal Tubule, Degeneration                                                 2 [2.0]      6 [1.7]                               
      Renal Tubule, Dilatation                         1 [1.0]      8 [1.0]      8 [1.0]     10 [1.6]                               
      Renal Tubule, Hypertrophy                                                               1 [1.0]                               
      Renal Tubule, Vacuolization Cytoplasmic          1 [1.0]                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.