National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/11673

TDMS Study 97013-96 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Battelle Columbus                   WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                            DATE: 10/08/03  
EXPERIMENT: 97013 TEST: 96                                                                                        TIME: 15:23:49    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: 26-39 WEEKS                              ROUTE: DOSED WATER                                            NTP:  C97013J     
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                                                             FINAL/MICE                                                             
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BATTELLE COLUMBUS                                WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)             DATE: 10/08/03    
EXPERIMENT: 97013 TEST: 96                                                                                        TIME: 15:32:26    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: 26                                       ROUTE: DOSED WATER                                            NTP:  97013J      
CONT: NO1-ES-65406                                                                                                CAS: 75-27-4      
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                        
                                26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                             
==================================================================================================================================  
           0 MG/L                     175 MG/L                           350 MG/L                           700 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1     3.5    23.0       1.8     22.5    0.51       14      2.2     23.0    0.63       34      0.9     22.8    0.26       28       
  2     3.5    23.8       2.8     23.3    0.80       21      2.7     23.0    0.77       40      2.2     20.3    0.63       74       
  3     3.2    24.8       2.7     24.2    0.84       20      2.6     24.1    0.81       38      2.2     22.8    0.69       67       
  4     3.3    25.5       2.8     25.4    0.85       20      2.7     25.5    0.82       38      2.3     24.3    0.70       66       
  5     3.3    26.3       2.9     26.5    0.88       19      2.7     26.0    0.82       36      2.2     24.6    0.67       64       
  6     2.3    27.2       2.1     27.5    0.91       14      2.0     26.4    0.87       26      1.7     25.0    0.74       48       
  7     3.4    29.1       3.0     28.9    0.88       18      2.8     27.4    0.82       35      2.6     25.7    0.76       72       
  8     3.7    29.4       3.2     29.8    0.86       19      3.2     28.2    0.86       39      2.7     27.1    0.73       70       
  9     3.6    31.7       3.0     31.0    0.83       17      3.0     28.9    0.83       37      2.5     28.2    0.69       63       
 10     3.7    33.5       3.2     32.3    0.86       17      3.1     30.8    0.84       35      2.8     29.5    0.76       66       
 11     3.7    34.6       3.1     32.7    0.84       17      3.1     30.9    0.84       35      2.6     30.3    0.70       59       
 12     3.6    35.7       2.9     34.8    0.81       15      3.1     32.4    0.86       33      2.6     31.7    0.72       57       
 13     3.6    36.8       3.3     35.1    0.92       16      3.0     33.5    0.83       32      2.7     31.3    0.75       60       
 14     3.7    37.4       3.0     36.2    0.81       15      3.0     33.9    0.81       31      2.7     31.8    0.73       59       
 15     3.9    38.2       3.0     37.0    0.77       14      3.1     34.8    0.79       31      2.6     32.9    0.67       56       
 16     4.0    39.3       3.0     38.0    0.75       14      3.2     35.6    0.80       31      2.7     33.5    0.68       57       
 17     4.0    40.5       3.3     39.8    0.83       15      3.3     37.0    0.83       31      3.0     34.4    0.75       61       
 18     4.0    41.5       3.1     40.2    0.78       13      3.3     38.0    0.83       31      3.3     34.5    0.83       67       
 19     4.0    41.3       3.2     41.3    0.80       14      3.2     38.3    0.80       30      2.8     35.7    0.70       56       
 20     4.3    41.5       3.2     41.8    0.74       13      3.2     38.9    0.74       28      2.9     36.6    0.67       56       
 21     4.0    43.0       3.1     42.3    0.78       13      3.2     39.1    0.80       29      2.7     37.2    0.68       51       
 22     4.4    43.7       3.1     43.5    0.70       13      3.3     40.2    0.75       29      2.9     36.6    0.66       56       
 23     4.3    44.9       3.1     43.9    0.72       12      3.1     41.5    0.72       26      3.1     37.1    0.72       58       
 24     4.1    45.8       2.8     44.5    0.68       11      3.1     41.6    0.76       26      2.6     37.6    0.63       49       
 25     4.0    46.0       3.1     44.6    0.78       12      3.4     40.7    0.85       29      2.9     36.4    0.73       56       
 26     4.1    46.8       3.2     44.3    0.78       13      3.2     41.1    0.78       27      2.8     39.7    0.68       50       
 27     4.4    47.4       3.2     45.4    0.73       12      3.4     41.5    0.77       29      3.0     40.4    0.68       53       
 28     4.2    47.9       3.2     45.8    0.76       12      3.4     42.5    0.81       28      3.2     39.6    0.76       57       
 29     4.3    48.2       3.1     46.3    0.72       12      3.4     42.9    0.79       28      3.4     41.0    0.79       58       
 30     3.9    48.3       3.0     46.4    0.77       11      3.2     41.6    0.82       26      2.8     41.4    0.72       47       
 31     4.7    47.2       3.4     46.2    0.72       13      3.4     42.6    0.72       28      3.1     40.9    0.66       52       
 32     4.4    47.0       3.2     46.7    0.73       12      3.4     44.3    0.77       26      2.9     42.4    0.66       47       
 33     5.0    49.1       3.4     47.5    0.68       12      3.4     44.1    0.68       27      2.9     43.0    0.58       48       
 34     4.6    49.8       3.4     47.7    0.74       13      3.4     44.9    0.74       27      3.2     44.1    0.70       50       
 35     4.6    50.1       3.3     47.7    0.72       12      3.5     45.3    0.76       27      3.0     43.4    0.65       49       
 36     4.8    49.9       3.5     48.3    0.73       13      3.7     45.4    0.77       29      2.9     43.0    0.60       48       
 37     4.9    49.7       3.2     47.2    0.65       12      3.5     45.5    0.71       27      2.9     44.5    0.59       45       
 38     4.9    50.3       3.5     48.7    0.71       12      3.7     46.5    0.76       28      3.1     45.0    0.63       48       
 39     4.7    50.9       3.6     48.2    0.77       13      3.6     46.7    0.77       27      3.4     44.5    0.72       53       
==================================================================================================================================  
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                        
                                26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                             
==================================================================================================================================  
           0 MG/L                     175 MG/L                           350 MG/L                           700 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
 40     4.6    51.0       3.3     48.5     0.72      12      3.5     45.8     0.76      27      3.4     44.3     0.74      53       
 41     4.7    51.3       3.5     48.8     0.74      12      3.5     46.1     0.74      27      3.5     44.3     0.74      55       
 42     4.6    51.6       3.3     49.1     0.72      12      3.6     45.6     0.78      28      3.4     43.7     0.74      54       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    3.4    29.3       2.8     28.8     0.83      17      2.8     27.7     0.82      35      2.3     26.4     0.68      61       
SD(D)   0.4               0.4              0.10       2      0.4              0.06       4      0.5              0.13      12       
CV(E)  11.2              14.6             12.2     13.5     13.1              7.6     10.3     22.4             19.5     19.7       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.4    46.2       3.2     44.7     0.74      13      3.3     41.8     0.77      28      3.0     39.6     0.69      53       
SD(D)   0.4               0.2              0.04       1      0.2              0.04       2      0.2              0.06       5       
CV(E)   8.1               5.5              5.3      7.2      5.6              5.0      5.9      8.2              8.3      9.3       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                      
                                26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                             
==================================================================================================================================  
           0 MG/L                     175 MG/L                           350 MG/L                           700 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1     3.6    18.8       1.9     18.7     0.53      18      1.4     18.4     0.39      26      1.8     19.1     0.50      66       
  2     3.7    19.5       2.8     19.6     0.76      25      3.2     18.7     0.86      59      3.0     19.4     0.81     108       
  3     3.7    20.0       3.1     20.5     0.84      26      3.1     19.5     0.84      55      3.1     19.6     0.84     109       
  4     3.6    21.0       3.2     21.4     0.89      26      3.4     20.7     0.94      57      3.3     21.5     0.92     108       
  5     4.0    21.3       3.6     21.5     0.90      29      3.8     21.0     0.95      63      3.7     21.7     0.93     120       
  6     2.9    22.2       2.3     22.4     0.79      18      2.7     22.0     0.93      43      2.9     22.7     1.00      89       
  7     4.1    22.5       3.7     22.8     0.90      29      3.8     21.8     0.93      61      4.3     23.1     1.05     130       
  8     4.2    23.0       3.8     23.5     0.90      28      3.8     22.8     0.90      58      4.0     23.5     0.95     118       
  9     3.8    23.7       3.9     23.6     1.03      29      3.7     23.3     0.97      56      4.1     23.9     1.08     121       
 10     4.0    24.2       4.0     24.4     1.00      28      3.7     23.9     0.93      54      4.1     24.9     1.03     116       
 11     4.2    24.0       3.7     25.1     0.88      26      3.5     24.0     0.83      52      4.0     24.6     0.95     113       
 12     4.4    23.9       3.7     25.9     0.84      25      3.7     24.3     0.84      54      4.3     24.8     0.98     123       
 13     4.3    24.9       3.7     26.5     0.86      25      3.6     25.3     0.84      50      4.2     25.3     0.98     115       
 14     5.0    25.6       3.8     26.9     0.76      25      3.8     25.6     0.76      52      4.3     26.1     0.86     116       
 15     4.3    25.6       3.8     27.1     0.88      24      3.7     25.6     0.86      51      4.1     26.1     0.95     111       
 16     4.6    25.8       3.8     27.2     0.83      24      3.8     26.5     0.83      50      4.3     26.4     0.93     114       
 17     4.7    27.0       4.2     28.4     0.89      26      3.8     27.4     0.81      48      4.5     27.3     0.96     116       
 18     4.7    27.6       3.8     29.0     0.81      23      3.8     27.8     0.81      48      4.4     28.3     0.94     109       
 19     4.9    27.9       4.1     29.4     0.84      24      3.7     28.0     0.76      46      4.4     28.9     0.90     107       
 20     4.5    28.7       4.1     30.6     0.91      23      3.7     28.7     0.82      45      4.4     28.7     0.98     107       
 21     4.4    28.7       4.0     30.0     0.91      23      3.8     28.4     0.86      47      4.5     28.3     1.02     112       
 22     4.4    29.5       4.2     31.0     0.95      24      3.9     29.6     0.89      46      4.4     30.0     1.00     104       
 23     4.5    30.4       3.9     32.1     0.87      21      3.7     30.8     0.82      42      4.4     31.0     0.98     100       
 24     4.0    30.8       3.4     32.5     0.85      18      3.7     31.2     0.93      42      4.1     32.1     1.03      90       
 25     4.3    31.5       4.0     32.0     0.93      22      3.8     30.9     0.88      43      4.5     32.0     1.05      99       
 26     4.3    32.1       3.8     31.9     0.88      21      3.6     32.3     0.84      39      4.2     32.3     0.98      91       
 27     4.8    32.9       4.0     31.6     0.83      22      3.7     32.8     0.77      40      4.4     33.6     0.92      92       
 28     4.5    34.0       3.9     34.3     0.87      20      3.7     33.8     0.82      38      4.3     35.3     0.96      85       
 29     4.6    35.3       4.1     35.3     0.89      20      3.7     35.3     0.80      37      4.3     35.2     0.93      86       
 30     4.5    36.3       3.8     36.3     0.84      18      3.5     36.5     0.78      34      3.8     36.9     0.84      72       
 31     4.5    35.4       4.1     36.1     0.91      20      3.7     36.4     0.82      36      4.2     34.5     0.93      86       
 32     4.8    37.0       4.0     37.3     0.83      19      3.5     36.6     0.73      33      4.6     34.4     0.96      95       
 33     4.8    37.8       4.0     37.8     0.83      18      3.7     37.4     0.77      35      5.0     36.0     1.04      96       
 34     5.1    38.3       4.1     39.3     0.80      18      3.7     39.1     0.73      33      4.5     38.6     0.88      82       
 35     5.3    39.0       4.0     39.7     0.75      18      3.7     38.9     0.70      33      4.4     39.3     0.83      78       
 36     5.0    39.7       3.9     40.4     0.78      17      3.8     38.9     0.76      34      4.3     39.9     0.86      76       
 37     5.3    39.4       4.0     40.8     0.75      17      3.7     38.9     0.70      34      4.2     39.5     0.79      74       
 38     5.6    40.8       4.1     41.4     0.73      17      3.7     40.2     0.66      32      4.2     39.4     0.75      75       
 39     5.0    41.5       3.8     42.3     0.76      16      3.8     41.2     0.76      32      4.2     40.0     0.84      73       
==================================================================================================================================  
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                      
                                26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                             
==================================================================================================================================  
           0 MG/L                     175 MG/L                           350 MG/L                           700 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
 40     4.8    42.4       3.6     43.5     0.75      15      3.6     41.2     0.75      30      4.2     39.7     0.88      73       
 41     5.1    43.6       3.9     44.2     0.76      16      3.9     42.5     0.76      32      4.6     39.9     0.90      80       
 42     4.4    44.5       3.6     43.6     0.82      15      3.7     43.9     0.84      29      4.3     40.4     0.98      74       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    3.9    22.2       3.3     22.8     0.86      25      3.3     22.0     0.86      53      3.6     22.6     0.92     110       
SD(D)   0.4               0.7              0.12       4      0.7              0.15      10      0.7              0.15      17       
CV(E)  10.1              19.6             14.3     14.8     20.6             17.4     18.3     20.8             16.0     15.1       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.7    34.1       3.9     34.9     0.84      20      3.7     34.0     0.79      39      4.4     33.8     0.93      92       
SD(D)   0.4               0.2              0.06       3      0.1              0.06       7      0.2              0.07      15       
CV(E)   7.8               4.8              7.4     16.2      2.5              7.8     17.8      4.7              8.0     16.2       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                   DIAGNOSTIC TRAILER REPORT                                                                                        
                   WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                               
                   26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                                          
=========================================================================================================                           
           0 MG/L                  175 MG/L                 350 MG/L                 700 MG/L                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               23.0  10                 22.5  10                 23.0  10                 22.8  10                               
  1   3.5   710   23.0  10     1.8   689   22.5  10     2.2   685   23.0  10     0.9   685   22.8  10                               
  2   3.5  1612   23.8  10     2.8  1620   23.3  10     2.7  1661   23.0  10     2.2  1685   20.3  10                               
  3   3.2  1527   24.8  10     2.7  1658   24.2  10     2.6  1605   24.1  10     2.2  1660   22.8  10                               
  4   3.3  1696   25.5  10     2.8  1696   25.4  10     2.7  1700   25.5  10     2.3  1620   24.3  10                               
  5   3.3   958   26.3  10     2.9   970   26.5  10     2.7   863   26.0  10     2.2   869   24.6  10                               
  6   2.3  2183   27.2  10     2.1  2196   27.5  10     2.0  2182   26.4  10     1.7  2020   25.0  10                               
  7   3.4  1526   29.1  10     3.0  1594   28.9  10     2.8  1645   27.4  10     2.6  1426   25.7  10                               
  8   3.7  1645   29.4  10     3.2  1634   29.8  10     3.2  1641   28.2  10     2.7  1635   27.1  10                               
  9   3.6  1695   31.7  10     3.0  1700   31.0  10     3.0  1690   28.9  10     2.5  1695   28.2  10                               
 10   3.7  1680   33.5  10     3.2  1472   32.3  10     3.1  1680   30.8  10     2.8  1624   29.5  10                               
 11   3.7  1700   34.6  10     3.1  1343   32.7  10     3.1  1601   30.9  10     2.6  1606   30.3  10                               
 12   3.6  1563   35.7  10     2.9  1443   34.8  10     3.1  1660   32.4  10     2.6  1355   31.7  10                               
 13   3.6  1589   36.8  10     3.3  1585   35.1  10     3.0  1690   33.5  10     2.7  1516   31.3  10                               
 14   3.7  1596   37.4  10     3.0  1657   36.2  10     3.0  1700   33.9  10     2.7  1358   31.8  10                               
 15   3.9  1665   38.2  10     3.0  1670   37.0  10     3.1  1591   34.8  10     2.6  1425   32.9   9                               
 16   4.0  1670   39.3  10     3.0  1594   38.0  10     3.2  1600   35.6  10     2.7  1427   33.5   9                               
 17   4.0  1710   40.5  10     3.3  1579   39.8  10     3.3  1700   37.0  10     3.0  1340   34.4   9                               
 18   4.0  1593   41.5  10     3.1  1571   40.2  10     3.3  1594   38.0  10     3.3  1325   34.5   9                               
 19   4.0  1525   41.3  10     3.2  1618   41.3  10     3.2  1666   38.3  10     2.8  1521   35.7   9                               
 20   4.3  1587   41.5  10     3.2  1690   41.8  10     3.2  1680   38.9  10     2.9  1423   36.6   9                               
 21   4.0  1695   43.0  10     3.1  1695   42.3  10     3.2  1549   39.1  10     2.7  1448   37.2   9                               
 22   4.4  1432   43.7  10     3.1  1512   43.5  10     3.3  1660   40.2  10     2.9  1212   36.6   9                               
 23   4.3  1670   44.9  10     3.1  1655   43.9  10     3.1  1597   41.5  10     3.1  1145   37.1   9                               
 24   4.1  1705   45.8  10     2.8  1400   44.5  10     3.1  1616   41.6  10     2.6  1226   37.6   9                               
 25   4.0  1658   46.0  10     3.1  1557   44.6  10     3.4  1466   40.7  10     2.9  1152   36.4   9                               
 26   4.1  1536   46.8  10     3.2  1569   44.3  10     3.2  1555   41.1  10     2.8  1149   39.7   8                               
 27   4.4  1563   47.4  10     3.2  1614   45.4  10     3.4  1605   41.5  10     3.0  1254   40.4   8                               
 28   4.2  1670   47.9  10     3.2  1646   45.8  10     3.4  1602   42.5  10     3.2  1189   39.6   8                               
 29   4.3  1680   48.2  10     3.1  1614   46.3  10     3.4  1680   42.9  10     3.4  1277   41.0   8                               
 30   3.9  1690   48.3  10     3.0  1450   46.4  10     3.2  1481   41.6  10     2.8  1190   41.4   8                               
 31   4.7  1512   47.2  10     3.4  1517   46.2  10     3.4  1680   42.6  10     3.1  1068   40.9   8                               
 32   4.4  1397   47.0  10     3.2  1568   46.7  10     3.4  1599   44.3  10     2.9  1183   42.4   8                               
 33   5.0  1412   49.1   9     3.4  1697   47.5  10     3.4  1671   44.1  10     2.9  1344   43.0   8                               
 34   4.6  1500   49.8   9     3.4  1568   47.7  10     3.4  1523   44.9  10     3.2  1328   44.1   8                               
 35   4.6  1361   50.1   9     3.3  1660   47.7  10     3.5  1594   45.3  10     3.0  1211   43.4   8                               
 36   4.8  1516   49.9   9     3.5  1660   48.3  10     3.7  1680   45.4  10     2.9   973   43.0   8                               
 37   4.9  1314   49.7   9     3.2  1587   47.2  10     3.5  1590   45.5  10     2.9  1187   44.5   7                               
 38   4.9  1508   50.3   9     3.5  1613   48.7  10     3.7  1654   46.5  10     3.1   925   45.0   7                               
 39   4.7  1417   50.9   9     3.6  1448   48.2  10     3.6  1562   46.7  10     3.4   839   44.5   7                               
 40   4.6  1419   51.0   9     3.3  1710   48.5  10     3.5  1363   45.8  10     3.4   810   44.3   7                               
 41   4.7  1440   51.3   9     3.5  1505   48.8  10     3.5  1140   46.1   9     3.5   897   44.3   7                               
 42   4.6  1535   51.6   9     3.3  1581   49.1  10     3.6  1317   45.6   9     3.4  1111   43.7   7                               
 43   4.3   873                3.1   860                3.3   852                3.1   486                                          
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           29.3                     28.8                     27.7                     26.4                                   
14 TO 52          46.2                     44.7                     41.8                     39.6                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                   DIAGNOSTIC TRAILER REPORT                                                                                        
                   WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                             
                   26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                                          
=========================================================================================================                           
           0 MG/L                  175 MG/L                 350 MG/L                 700 MG/L                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               18.8  10                 18.7  10                 18.4  10                 19.1  10                               
  1   3.6   685   18.8  10     1.9   715   18.7  10     1.4   710   18.4  10     1.8   710   19.1  10                               
  2   3.7  1651   19.5  10     2.8  1638   19.6  10     3.2  1582   18.7  10     3.0  1632   19.4  10                               
  3   3.7  1573   20.0  10     3.1  1640   20.5  10     3.1  1611   19.5  10     3.1  1690   19.6  10                               
  4   3.6  1529   21.0  10     3.2  1695   21.4  10     3.4  1700   20.7  10     3.3  1602   21.5  10                               
  5   4.0   960   21.3  10     3.6   965   21.5  10     3.8   970   21.0  10     3.7   965   21.7  10                               
  6   2.9  2038   22.2  10     2.3  2111   22.4  10     2.7  2173   22.0  10     2.9  1964   22.7  10                               
  7   4.1  1720   22.5  10     3.7  1476   22.8  10     3.8  1379   21.8  10     4.3  1619   23.1  10                               
  8   4.2  1566   23.0  10     3.8  1636   23.5  10     3.8  1640   22.8  10     4.0  1635   23.5  10                               
  9   3.8  1525   23.7  10     3.9  1645   23.6  10     3.7  1603   23.3  10     4.1  1476   23.9   9                               
 10   4.0  1456   24.2  10     4.0  1434   24.4  10     3.7  1473   23.9  10     4.1  1344   24.9   9                               
 11   4.2  1431   24.0  10     3.7  1606   25.1  10     3.5  1514   24.0  10     4.0  1193   24.6   9                               
 12   4.4  1495   23.9  10     3.7  1591   25.9  10     3.7  1484   24.3  10     4.3  1422   24.8   9                               
 13   4.3  1547   24.9  10     3.7  1685   26.5  10     3.6  1690   25.3  10     4.2  1521   25.3   9                               
 14   5.0  1685   25.6  10     3.8  1685   26.9  10     3.8  1619   25.6  10     4.3  1515   26.1   9                               
 15   4.3  1419   25.6  10     3.8  1673   27.1  10     3.7  1588   25.6  10     4.1  1440   26.1   9                               
 16   4.6  1403   25.8  10     3.8  1494   27.2  10     3.8  1552   26.5  10     4.3  1503   26.4   9                               
 17   4.7  1578   27.0  10     4.2  1608   28.4  10     3.8  1552   27.4  10     4.5  1408   27.3   9                               
 18   4.7  1498   27.6  10     3.8  1567   29.0  10     3.8  1597   27.8  10     4.4  1499   28.3   9                               
 19   4.9  1624   27.9  10     4.1  1690   29.4  10     3.7  1481   28.0  10     4.4  1327   28.9   9                               
 20   4.5  1656   28.7  10     4.1  1610   30.6  10     3.7  1587   28.7  10     4.4  1517   28.7   9                               
 21   4.4  1694   28.7  10     4.0  1622   30.0  10     3.8  1700   28.4  10     4.5  1524   28.3   9                               
 22   4.4  1293   29.5  10     4.2  1551   31.0  10     3.9  1609   29.6  10     4.4  1336   30.0   9                               
 23   4.5  1665   30.4  10     3.9  1564   32.1  10     3.7  1650   30.8  10     4.4  1428   31.0   9                               
 24   4.0  1634   30.8  10     3.4  1492   32.5  10     3.7  1331   31.2  10     4.1  1196   32.1   9                               
 25   4.3  1654   31.5  10     4.0  1223   32.0  10     3.8  1408   30.9  10     4.5  1363   32.0   9                               
 26   4.3  1603   32.1  10     3.8  1363   31.9  10     3.6  1660   32.3  10     4.2  1411   32.3   9                               
 27   4.8  1545   32.9  10     4.0  1445   31.6  10     3.7  1494   32.8  10     4.4  1279   33.6   9                               
 28   4.5  1503   34.0  10     3.9  1435   34.3   9     3.7  1670   33.8  10     4.3  1335   35.3   9                               
 29   4.6  1515   35.3  10     4.1  1245   35.3   9     3.7  1578   35.3  10     4.3  1411   35.2   9                               
 30   4.5  1695   36.3  10     3.8  1384   36.3   9     3.5  1327   36.5  10     3.8  1336   36.9   9                               
 31   4.5  1581   35.4  10     4.1  1367   36.1   9     3.7  1369   36.4  10     4.2   941   34.5   9                               
 32   4.8  1568   37.0  10     4.0  1282   37.3   9     3.5  1624   36.6  10     4.6  1068   34.4   9                               
 33   4.8  1615   37.8  10     4.0  1470   37.8   9     3.7  1720   37.4  10     5.0  1497   36.0   9                               
 34   5.1  1406   38.3  10     4.1  1308   39.3   9     3.7  1524   39.1  10     4.5  1328   38.6   8                               
 35   5.3  1665   39.0  10     4.0  1470   39.7   9     3.7  1566   38.9  10     4.4  1332   39.3   8                               
 36   5.0  1596   39.7  10     3.9  1374   40.4   9     3.8  1197   38.9  10     4.3  1344   39.9   8                               
 37   5.3  1398   39.4  10     4.0  1429   40.8   9     3.7  1410   38.9  10     4.2  1211   39.5   8                               
 38   5.6  1516   40.8  10     4.1  1227   41.4   9     3.7  1541   40.2  10     4.2  1183   39.4   8                               
 39   5.0  1633   41.5  10     3.8  1494   42.3   9     3.8  1369   41.2  10     4.2  1128   40.0   8                               
 40   4.8  1514   42.4  10     3.6  1368   43.5   9     3.6  1421   41.2  10     4.2  1270   39.7   8                               
 41   5.1  1483   43.6  10     3.9  1270   44.2   9     3.9  1570   42.5  10     4.6  1181   39.9   8                               
 42   4.4  1290   44.5   9     3.6  1314   43.6   9     3.7  1338   43.9  10     4.3   929   40.4   8                               
 43   4.0   682                3.3   683                3.1   882                3.8   639                                          
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           22.2                     22.8                     22.0                     22.6                                   
14 TO 52          34.1                     34.9                     34.0                     33.8                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.