National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/11681

TDMS Study 97013-96 Pathology Tables

NTP Experiment-Test: 97013-96  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03
Route: DOSED WATER                                                                                                Time: 15:28:19

                                                           FINAL/MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  75-27-4

       Lock Date:  07/19/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 97013-96  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03  
Route: DOSED WATER                                                                                                Time: 15:28:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1            1                         1                                     
    Natural Death                                                                             1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9            9           10            8                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Polyp Stromal                                    2 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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NTP Experiment-Test: 97013-96  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03  
Route: DOSED WATER                                                                                                Time: 15:28:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (1)          (2)                                                              
      Carcinoma, Metastatic, Skin                      1 (100%)                                                                     
      Mediastinal, Osteosarcoma, Metastatic, Bone                   1 (50%)                                                         
      Renal, Carcinoma, Metastatic, Skin               1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                                                             (1)                                    
      Carcinoma                                                                               1 (100%)                              
   Skin                                               (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                                            (2)                                                              
      Vertebra, Osteosarcoma                                        2 (100%)                                                        
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Carcinoma, Metastatic, Skin                      1 (10%)                                                                      
      Osteosarcoma, Metastatic, Bone                                1 (10%)                                                         
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (10%)                                                                      
   Pleura                                                          (1)                                                              
      Osteosarcoma, Metastatic, Bone                                1 (100%)                                                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-96  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03  
Route: DOSED WATER                                                                                                Time: 15:28:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                      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NTP Experiment-Test: 97013-96  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03  
Route: DOSED WATER                                                                                                Time: 15:28:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)             3           2                       1                                       
     Total Primary Neoplasms                            3           2                       1                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                  2                                                                           
     Total Benign Neoplasms                             2                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1           2                       1                                       
     Total Malignant Neoplasms                          1           2                       1                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1                                                               
     Total Metastatic Neoplasm                          4           3                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-96  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03  
Route: DOSED WATER                                                                                                Time: 15:28:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1                                      3                                     
    Natural Death                                                                1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9           10            9            7                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (10)         (10)         (10)         (10)                                   
   Intestine Small, Jejunum                           (10)         (10)         (9)          (10)                                   
   Intestine Small, Ileum                             (10)         (10)         (10)         (10)                                   
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hepatocellular Adenoma                                        1 (10%)      1 (10%)                                            
   Mesentery                                                                    (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)         (10)         (10)         (10)                                   
   Prostate                                                                                  (1)                                    
      Sarcoma                                                                                 1 (100%)                              
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                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-96  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03  
Route: DOSED WATER                                                                                                Time: 15:28:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
   Lymph Node, Mesenteric                             (10)         (10)         (10)         (10)                                   
   Spleen                                             (10)         (10)         (10)         (10)                                   
   Thymus                                             (10)         (10)         (10)         (10)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                              (1)                                                 
      Rhabdomyosarcoma                                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Alveolar/Bronchiolar Carcinoma                                                          1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-96  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03  
Route: DOSED WATER                                                                                                Time: 15:28:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(10)        *(10)        *(10)        *(10)                                   
      Lymphoma Malignant                               1 (10%)                   2 (20%)                                            
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-96  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03  
Route: DOSED WATER                                                                                                Time: 15:28:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)             1           1           4           2                                       
     Total Primary Neoplasms                            1           1           4           2                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                              1           1                                                   
     Total Benign Neoplasms                                         1           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                       3           2                                       
     Total Malignant Neoplasms                          1                       3           2                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                                                          
     Total Metastatic Neoplasm                                                                                                      
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
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