National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/11691

TDMS Study 97013-96 Pathology Tables

NTP Experiment-Test: 97013-96         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/08/03
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 15:33:20

                                                           FINAL/MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  75-27-4

       Lock Date:  07/19/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 97013-96         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/08/03    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 15:33:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1            1                         1                                     
    Natural Death                                                                             1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9            9           10            8                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 2 [1.0]      1 [3.0]                   1 [2.0]                               
      Infiltration Cellular                                         1 [1.0]                                                         
      Infiltration Cellular, Lymphocyte                2 [2.0]      4 [1.0]      4 [1.5]      2 [1.0]                               
      Inflammation                                     8 [1.0]      7 [1.0]      8 [1.0]      7 [1.0]                               
      Necrosis                                         3 [1.0]      2 [1.0]      1 [1.0]      1 [2.0]                               
      Hepatocyte, Fatty Change                         2 [1.0]      2 [1.0]      3 [1.0]      6 [1.7]                               
      Hepatocyte, Vacuolization Cytoplasmic            9 [1.6]      9 [1.4]     10 [1.6]      8 [1.8]                               
      Serosa, Inflammation                                                                    1 [1.0]                               
   Mesentery                                                       (1)                       (1)                                    
      Inflammation                                                                            1 [2.0]                               
      Fat, Necrosis                                                 1 [4.0]                                                         
   Salivary Glands                                                              (1)                                                 
      Atrophy                                                                    1 [2.0]                                            
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Hyperkeratosis                                                1 [2.0]                   2 [1.0]                               
      Inflammation                                                               1 [1.0]                                            
      Epithelium, Hyperplasia                                       2 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Subcapsular, Hyperplasia                         9 [1.0]     10 [1.0]     10 [1.0]      8 [1.1]                               
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-96         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/08/03    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 15:33:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Cyst                                             1 [1.0]                                                                      
      Hyperplasia                                                                             1 [1.0]                               
      Pars Intermedia, Hyperplasia                                               1 [2.0]                                            
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Inflammation                                                               1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (9)          (10)         (10)                                   
      Angiectasis                                                   1 [1.0]                                                         
      Atrophy                                                                                 1 [2.0]                               
      Cyst                                             3 [1.0]      2 [1.0]      1 [1.0]      2 [1.5]                               
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Inflammation                                     2 [1.0]      1 [1.0]      2 [1.0]      1 [1.0]                               
      Endometrium, Hyperplasia, Cystic                 8 [1.6]      8 [1.5]      8 [1.8]      6 [1.8]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (1)          (2)                                                              
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
        Cell                                                        1 [3.0]                                                         
   Lymph Node, Mandibular                             (10)         (10)         (10)         (9)                                    
      Atrophy                                          1 [3.0]                                                                      
      Hematopoietic Cell Proliferation                              1 [1.0]                                                         
      Hyperplasia, Atypical                                                      1 [2.0]                                            
   Lymph Node, Mesenteric                             (10)         (10)         (10)         (10)                                   
      Atrophy                                          1 [3.0]                                                                      
      Hematopoietic Cell Proliferation                 1 [1.0]      1 [2.0]                                                         
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                                                 1 [4.0]                               
      Hematopoietic Cell Proliferation                 2 [2.0]      1 [4.0]                   2 [2.0]                               
   Thymus                                             (10)         (9)          (10)         (10)                                   
      Atrophy                                          2 [2.5]      1 [2.0]                   2 [3.5]                               
      Cyst                                             7 [1.4]      6 [1.2]      8 [1.3]      8 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-96         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/08/03    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 15:33:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (1)                                                                           
      Ulcer                                            1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Hemorrhage                                                    1 [2.0]                                                         
      Infiltration Cellular, Lymphocyte                1 [2.0]                                1 [1.0]                               
      Infiltration Cellular, Histiocyte                             1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Accumulation, Hyaline Droplet                                                           1 [1.0]                               
      Casts Protein                                    8 [1.0]      1 [1.0]      5 [1.0]      3 [1.0]                               
      Infiltration Cellular, Lymphocyte                1 [1.0]      4 [1.0]                   1 [1.0]                               
      Mineralization                                                                          1 [2.0]                               
      Nephropathy                                      3 [1.0]      1 [3.0]      8 [1.0]                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-96         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/08/03    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 15:33:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1                                      3                                     
    Natural Death                                                                1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9           10            9            7                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                                                                 (1)                                    
      Muscularis, Degeneration                                                                1 [1.0]                               
   Liver                                              (10)         (10)         (10)         (10)                                   
      Atypia Cellular                                                                         1 [2.0]                               
      Clear Cell Focus                                              1                                                               
      Hematopoietic Cell Proliferation                                                        1 [1.0]                               
      Infiltration Cellular, Lymphocyte                1 [1.0]      2 [1.0]                                                         
      Inflammation                                     9 [1.0]      5 [1.0]      7 [1.0]      6 [1.0]                               
      Necrosis                                                                                2 [1.5]                               
      Hepatocyte, Fatty Change                         8 [1.1]      4 [1.0]      3 [1.3]      4 [1.0]                               
      Hepatocyte, Vacuolization Cytoplasmic            9 [3.9]     10 [3.6]     10 [2.8]      9 [2.4]                               
   Salivary Glands                                                                           (2)                                    
      Inflammation                                                                            2 [1.0]                               
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Inflammation                                                                            1 [1.0]                               
      Epithelium, Hyperplasia                          1 [2.0]      1 [2.0]      1 [1.0]      1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Hyperplasia                                                   1 [1.0]                                                         
      Hypertrophy                                      2 [1.0]      4 [1.3]      2 [1.0]                                            
      Subcapsular, Hyperplasia                         2 [1.0]      2 [1.0]      3 [1.0]      2 [1.0]                               
   Islets, Pancreatic                                              (1)                                                              
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-96         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/08/03    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 15:33:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                                   1 [2.0]                                                         
   Parathyroid Gland                                               (1)                                                              
      Cyst                                                          1 [2.0]                                                         
   Pituitary Gland                                    (10)         (9)          (10)         (10)                                   
      Cyst                                             4 [1.0]      3 [1.3]      3 [1.0]      3 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Testes                                             (10)         (10)         (10)         (10)                                   
      Mineralization                                                1 [1.0]                                                         
      Germinal Epithelium, Degeneration                2 [1.0]      2 [1.5]      1 [1.0]      3 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                                                 1 [2.0]                               
   Lymph Node, Mesenteric                             (10)         (10)         (10)         (10)                                   
      Atrophy                                          1 [2.0]                                2 [2.0]                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                                                 3 [2.0]                               
      Hematopoietic Cell Proliferation                 1 [2.0]                                                                      
   Thymus                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                                    1 [2.0]      3 [3.3]                               
      Cyst                                             8 [1.0]      7 [1.3]      3 [1.0]      4 [1.3]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-96         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 10/08/03    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 15:33:20    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Alveolar Epithelium, Hyperplasia                                           1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                                           (1)                                    
      Inflammation                                                                            1 [2.0]                               
   Lacrimal Gland                                     (1)                                    (1)                                    
      Inflammation                                     1 [2.0]                                1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Casts Protein                                                              1 [1.0]                                            
      Hydronephrosis                                                             1 [1.0]      1 [1.0]                               
      Infiltration Cellular, Lymphocyte                1 [2.0]                                                                      
      Mineralization                                                             1 [2.0]      1 [3.0]                               
      Nephropathy                                      5 [1.0]      4 [1.0]      9 [1.2]      8 [1.4]                               
      Renal Tubule, Degeneration                                                 6 [2.2]     10 [2.4]                               
      Renal Tubule, Dilatation                         1 [1.0]                   3 [1.0]      2 [1.0]                               
      Renal Tubule, Necrosis                                                                  1 [1.0]                               
      Renal Tubule, Vacuolization Cytoplasmic         10 [1.6]      5 [1.0]                                                         
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.