National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/19302

TDMS Study 97013-04 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Battelle Columbus                   WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                            DATE: 05/18/05  
EXPERIMENT: 97013 TEST: 04                                                                                        TIME: 09:03:49    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: SUBCHRON 26-WEEK                         ROUTE: DOSED WATER                                            NTP:  C97013E     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BATTELLE COLUMBUS                                WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)             DATE: 05/18/05    
EXPERIMENT: 97013 TEST: 04                                                                                        TIME:  9:09:52    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: SUBCHRONIC (26-WEEK)                     ROUTE: DOSED WATER                                            NTP:  97013E      
CONT: NO1-ES-65406                                                                                                CAS: 75-27-4      
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                        
                       SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    
==================================================================================================================================  
           0 MG/L                     175 MG/L                           350 MG/L                           700 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1     3.7    22.8       2.2     23.0    0.59       17      1.4     22.9    0.38       21      1.2     22.5    0.32       37       
  2     3.7    24.2       2.9     23.7    0.78       21      2.5     21.8    0.68       41      2.2     20.1    0.59       76       
  3     3.6    25.6       3.1     25.0    0.86       22      2.5     24.2    0.69       36      2.5     22.0    0.69       81       
  4     3.4    26.7       2.9     26.2    0.85       20      2.5     25.2    0.74       35      2.3     24.1    0.68       68       
  5     3.6    27.9       3.0     26.9    0.83       20      2.7     26.4    0.75       36      2.4     24.8    0.67       69       
  6     3.3    28.3       2.9     28.1    0.88       18      2.7     26.9    0.82       35      2.4     24.8    0.73       69       
  7     3.7    30.2       3.1     28.5    0.84       19      2.8     27.4    0.76       35      2.7     25.2    0.73       74       
  8     4.0    31.1       3.3     30.3    0.83       19      2.9     28.3    0.73       36      2.6     26.0    0.65       71       
  9     3.7    33.0       3.1     32.1    0.84       17      2.8     29.7    0.76       33      2.6     27.2    0.70       67       
 10     4.0    34.7       3.2     33.5    0.80       17      3.0     30.7    0.75       34      2.8     27.9    0.70       70       
 11     3.7    36.1       3.2     35.2    0.86       16      2.9     32.1    0.78       32      3.1     27.9    0.84       77       
 12     3.7    37.0       3.1     36.3    0.84       15      2.7     33.1    0.73       28      2.9     29.0    0.78       70       
 13     3.9    38.4       3.2     37.3    0.82       15      2.9     33.3    0.74       30      2.9     29.6    0.74       68       
 14     4.0    38.9       3.2     38.3    0.80       15      2.9     34.2    0.73       30      2.8     30.1    0.70       65       
 15     4.0    39.8       3.2     38.9    0.80       14      2.9     35.2    0.73       29      2.8     30.8    0.70       64       
 16     3.8    40.8       3.2     39.2    0.84       14      2.7     36.1    0.71       27      2.8     31.2    0.74       62       
 17     4.1    42.0       3.3     40.6    0.80       14      3.0     37.1    0.73       28      2.8     32.1    0.68       62       
 18     4.0    42.9       3.4     40.8    0.85       15      3.1     37.5    0.78       29      2.9     33.0    0.73       62       
 19     3.9    43.4       3.1     42.0    0.79       13      3.0     37.6    0.77       28      2.9     33.3    0.74       61       
 20     3.9    43.8       3.2     43.0    0.82       13      3.1     38.8    0.79       28      2.8     33.9    0.72       58       
 21     4.1    45.1       3.2     43.7    0.78       13      3.1     39.4    0.76       28      3.0     34.7    0.73       61       
 22     4.0    45.9       3.4     44.2    0.85       13      3.6     39.6    0.90       31      3.0     34.8    0.75       61       
 23     4.0    46.4       3.2     45.0    0.80       12      3.0     41.0    0.75       26      3.0     35.1    0.75       61       
 24     4.0    47.1       2.9     45.6    0.73       11      2.9     41.1    0.73       25      2.8     36.9    0.70       53       
 25     3.9    47.4       3.3     45.2    0.85       13      3.0     41.5    0.77       26      3.1     36.0    0.79       61       
 26     4.1    47.8       3.3     46.3    0.80       12      3.1     42.7    0.76       26      3.1     36.5    0.76       59       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    3.7    30.5       3.0     29.7    0.82       18      2.6     27.9    0.72       33      2.5     25.5    0.68       69       
SD(D)   0.2               0.3             0.07        2      0.4             0.11        5      0.5             0.12       11       
CV(E)   5.1               8.7             8.8      12.5     15.7            15.0      14.5     18.7            18.1      15.3       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.0    43.9       3.2     42.5    0.81       13      3.0     38.6    0.76       28      2.9     33.7    0.73       61       
SD(D)   0.1               0.1             0.03        1      0.2             0.05        2      0.1             0.03        3       
CV(E)   2.3               4.1             4.3       7.8      6.3             6.4       6.8      4.6             4.1       4.9       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                      
                       SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    
==================================================================================================================================  
           0 MG/L                     175 MG/L                           350 MG/L                           700 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1     4.1    18.9       2.3     18.9     0.56      22      1.6     18.8     0.39      30      1.4     18.6     0.34      54       
  2     4.1    19.6       2.9     19.6     0.71      26      2.8     19.3     0.68      51      2.7     19.1     0.66      98       
  3     4.3    20.8       3.6     20.2     0.84      31      3.2     20.0     0.74      56      3.1     20.0     0.72     107       
  4     3.8    21.8       3.5     21.4     0.92      28      3.6     21.4     0.95      59      3.3     21.1     0.87     110       
  5     4.1    22.1       3.5     21.9     0.85      28      3.7     21.9     0.90      59      3.8     22.0     0.93     120       
  6     4.1    22.0       3.6     21.9     0.88      29      3.7     22.4     0.90      58      3.7     22.3     0.90     117       
  7     4.2    22.3       4.0     22.1     0.95      31      4.0     21.8     0.95      65      3.9     21.9     0.93     126       
  8     4.1    23.3       3.8     22.5     0.93      29      3.9     23.2     0.95      59      3.6     22.7     0.88     112       
  9     4.2    23.6       3.7     23.0     0.88      28      3.7     23.5     0.88      55      3.9     22.4     0.93     121       
 10     4.1    24.6       3.8     23.7     0.93      28      3.8     24.3     0.93      55      3.8     24.1     0.93     112       
 11     4.1    24.7       3.8     24.4     0.93      27      3.8     24.6     0.93      54      3.6     24.1     0.88     105       
 12     4.2    25.3       3.8     24.5     0.90      27      3.9     25.2     0.93      54      3.7     24.6     0.88     104       
 13     3.9    26.5       3.7     25.2     0.95      26      3.7     25.8     0.95      50      3.6     24.9     0.92     101       
 14     4.1    27.1       3.8     26.0     0.93      25      3.8     27.0     0.93      50      3.5     25.9     0.85      96       
 15     4.1    27.9       3.8     26.4     0.93      25      3.8     27.3     0.93      48      3.7     26.3     0.90      98       
 16     4.2    29.0       4.0     26.4     0.95      27      3.9     27.8     0.93      50      3.7     26.9     0.88      97       
 17     4.3    28.7       4.0     26.8     0.93      26      4.1     28.3     0.95      51      3.9     28.4     0.91      96       
 18     4.4    29.1       4.2     27.6     0.95      27      4.1     28.7     0.93      50      4.0     27.6     0.91     100       
 19     4.3    29.8       4.0     28.1     0.93      25      4.0     29.2     0.93      48      3.9     27.5     0.91      99       
 20     4.3    30.6       4.1     29.1     0.95      25      3.9     29.4     0.91      46      4.0     28.3     0.93      98       
 21     4.3    31.5       3.9     29.7     0.91      23      4.0     30.4     0.93      46      3.9     29.2     0.91      95       
 22     4.4    32.7       4.2     30.8     0.95      24      4.3     30.9     0.98      49      4.0     30.0     0.91      92       
 23     4.3    34.0       3.9     32.2     0.91      21      3.8     32.9     0.88      41      4.0     30.4     0.93      92       
 24     4.1    35.3       3.5     32.1     0.85      19      3.4     33.2     0.83      36      3.7     30.8     0.90      83       
 25     4.3    35.6       4.3     32.1     1.00      23      4.1     32.6     0.95      44      3.9     31.3     0.91      88       
 26     4.3    36.4       4.1     33.2     0.95      21      3.9     34.0     0.91      40      3.9     31.7     0.91      85       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.1    22.7       3.5     22.2     0.86      28      3.5     22.5     0.85      54      3.4     22.1     0.83     107       
SD(D)   0.1               0.4              0.11       3      0.7              0.16       8      0.7              0.17      18       
CV(E)   3.1              12.4             12.9      9.1     18.6             19.0     15.1     20.1             20.4     16.6       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.3    31.4       4.0     29.3     0.93      24      3.9     30.1     0.92      46      3.8     28.8     0.90      94       
SD(D)   0.1               0.2              0.03       2      0.2              0.04       5      0.1              0.02       5       
CV(E)   2.2               5.2              3.7      9.5      5.5              3.9     10.1      3.8              2.2      5.7       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
          DIAGNOSTIC TRAILER REPORT                                                                                                 
          WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                                        
          SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                                 
=========================================================================================================                           
           0 MG/L                  175 MG/L                 350 MG/L                 700 MG/L                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               22.8  15                 23.0  15                 22.9  15                 22.5  15                               
  1   3.7  1035   22.8  15     2.2   951   23.0  15     1.4   963   22.9  15     1.2   942   22.5  15                               
  2   3.7  2426   24.2  15     2.9  2324   23.7  15     2.5  2288   21.8  15     2.2  2500   20.1  15                               
  3   3.6  2329   25.6  15     3.1  2509   25.0  15     2.5  2379   24.2  15     2.5  2428   22.0  15                               
  4   3.4  2371   26.7  15     2.9  2467   26.2  15     2.5  2495   25.2  15     2.3  2175   24.1  15                               
  5   3.6  2359   27.9  15     3.0  2324   26.9  15     2.7  2418   26.4  15     2.4  1950   24.8  15                               
  6   3.3  2395   28.3  15     2.9  2118   28.1  15     2.7  2257   26.9  15     2.4  2421   24.8  15                               
  7   3.7  2389   30.2  15     3.1  2360   28.5  15     2.8  2222   27.4  15     2.7  2320   25.2  15                               
  8   4.0  2379   31.1  15     3.3  2393   30.3  15     2.9  2371   28.3  15     2.6  2475   26.0  15                               
  9   3.7  2523   33.0  15     3.1  2550   32.1  15     2.8  2277   29.7  15     2.6  2454   27.2  15                               
 10   4.0  2342   34.7  15     3.2  2393   33.5  15     3.0  2058   30.7  15     2.8  2267   27.9  15                               
 11   3.7  2331   36.1  15     3.2  2434   35.2  15     2.9  2277   32.1  15     3.1  2061   27.9  15                               
 12   3.7  2448   37.0  15     3.1  2439   36.3  15     2.7  2303   33.1  15     2.9  2375   29.0  15                               
 13   3.9  2516   38.4  15     3.2  2493   37.3  15     2.9  2227   33.3  15     2.9  2295   29.6  15                               
 14   4.0  2421   38.9  15     3.2  2447   38.3  15     2.9  2419   34.2  15     2.8  2185   30.1  15                               
 15   4.0  2530   39.8  15     3.2  2294   38.9  15     2.9  2430   35.2  15     2.8  2465   30.8  15                               
 16   3.8  2555   40.8  15     3.2  2380   39.2  15     2.7  2374   36.1  15     2.8  2442   31.2  15                               
 17   4.1  2550   42.0  15     3.3  2362   40.6  15     3.0  2324   37.1  15     2.8  2565   32.1  15                               
 18   4.0  2377   42.9  15     3.4  2158   40.8  15     3.1  2119   37.5  15     2.9  2357   33.0  15                               
 19   3.9  2530   43.4  15     3.1  2580   42.0  15     3.0  2210   37.6  15     2.9  2402   33.3  15                               
 20   3.9  2424   43.8  15     3.2  2530   43.0  15     3.1  2488   38.8  15     2.8  2530   33.9  15                               
 21   4.1  2442   45.1  15     3.2  2444   43.7  15     3.1  2184   39.4  15     3.0  2346   34.7  15                               
 22   4.0  2490   45.9  15     3.4  2324   44.2  15     3.6  1984   39.6  15     3.0  2320   34.8  15                               
 23   4.0  2510   46.4  15     3.2  2520   45.0  15     3.0  2523   41.0  15     3.0  2326   35.1  15                               
 24   4.0  2290   47.1  15     2.9  2418   45.6  15     2.9  2112   41.1  15     2.8  2094   36.9  15                               
 25   3.9  2511   47.4  15     3.3  2333   45.2  15     3.0  2366   41.5  15     3.1  2341   36.0  15                               
 26   4.1  2385   47.8  15     3.3  2418   46.3  15     3.1  2485   42.7  15     3.1  2396   36.5  15                               
 27   3.9  1447                3.1  1470                2.8  1372                3.1  1372                                          
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           30.5                     29.7                     27.9                     25.5                                   
14 TO 52          43.9                     42.5                     38.6                     33.7                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
          DIAGNOSTIC TRAILER REPORT                                                                                                 
          WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                      
          SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                                 
=========================================================================================================                           
           0 MG/L                  175 MG/L                 350 MG/L                 700 MG/L                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               18.9  15                 18.9  15                 18.8  15                 18.6  15                               
  1   4.1   925   18.9  15     2.3   867   18.9  15     1.6  1011   18.8  15     1.4   822   18.6  15                               
  2   4.1  2354   19.6  15     2.9  2309   19.6  15     2.8  2135   19.3  15     2.7  2306   19.1  15                               
  3   4.3  2426   20.8  15     3.6  2336   20.2  15     3.2  2436   20.0  15     3.1  2423   20.0  15                               
  4   3.8  2565   21.8  15     3.5  2565   21.4  15     3.6  2387   21.4  15     3.3  2440   21.1  15                               
  5   4.1  2350   22.1  15     3.5  2443   21.9  15     3.7  2309   21.9  15     3.8  2442   22.0  15                               
  6   4.1  2440   22.0  15     3.6  2425   21.9  15     3.7  2066   22.4  14     3.7  2371   22.3  15                               
  7   4.2  2355   22.3  15     4.0  2044   22.1  15     4.0  2014   21.8  14     3.9  1713   21.9  15                               
  8   4.1  2386   23.3  15     3.8  2302   22.5  15     3.9  2212   23.2  14     3.6  2398   22.7  15                               
  9   4.2  2515   23.6  15     3.7  2396   23.0  15     3.7  2272   23.5  14     3.9  2349   22.4  15                               
 10   4.1  2375   24.6  15     3.8  2145   23.7  15     3.8  1933   24.3  14     3.8  2182   24.1  15                               
 11   4.1  2217   24.7  15     3.8  2331   24.4  15     3.8  2069   24.6  14     3.6  1960   24.1  15                               
 12   4.2  2452   25.3  15     3.8  2255   24.5  15     3.9  2183   25.2  14     3.7  2348   24.6  15                               
 13   3.9  2297   26.5  15     3.7  2520   25.2  15     3.7  2255   25.8  14     3.6  2421   24.9  15                               
 14   4.1  2520   27.1  15     3.8  2417   26.0  15     3.8  2352   27.0  14     3.5  2447   25.9  15                               
 15   4.1  2357   27.9  15     3.8  2421   26.4  15     3.8  2288   27.3  14     3.7  2427   26.3  15                               
 16   4.2  2366   29.0  15     4.0  2285   26.4  15     3.9  2288   27.8  14     3.7  2302   26.9  15                               
 17   4.3  2350   28.7  15     4.0  2403   26.8  15     4.1  2287   28.3  14     3.9  2523   28.4  15                               
 18   4.4  2351   29.1  15     4.2  2303   27.6  15     4.1  2117   28.7  14     4.0  2260   27.6  15                               
 19   4.3  2580   29.8  15     4.0  2480   28.1  15     4.0  2008   29.2  14     3.9  2408   27.5  15                               
 20   4.3  2452   30.6  15     4.1  2362   29.1  15     3.9  2174   29.4  14     4.0  2320   28.3  15                               
 21   4.3  2368   31.5  15     3.9  2311   29.7  15     4.0  2330   30.4  14     3.9  2356   29.2  15                               
 22   4.4  2470   32.7  15     4.2  2150   30.8  15     4.3  2127   30.9  14     4.0  2126   30.0  15                               
 23   4.3  2520   34.0  15     3.9  2328   32.2  15     3.8  2110   32.9  14     4.0  2527   30.4  15                               
 24   4.1  2330   35.3  15     3.5  2166   32.1  15     3.4  1716   33.2  14     3.7  2301   30.8  15                               
 25   4.3  2201   35.6  15     4.3  2334   32.1  15     4.1  2095   32.6  14     3.9  2435   31.3  15                               
 26   4.3  2423   36.4  15     4.1  2182   33.2  15     3.9  2254   34.0  14     3.9  2373   31.7  15                               
 27   4.0  1470                3.7  1325                3.6  1349                3.8  1470                                          
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           22.7                     22.2                     22.5                     22.1                                   
14 TO 52          31.4                     29.3                     30.1                     28.8                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.