National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/19306

TDMS Study 97013-04 Pathology Tables

NTP Experiment-Test: 97013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 06/11/04
Route: DOSED WATER                                                                                                Time: 08:29:19

                                                         FINAL #1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  75-27-4

       Lock Date:  07/19/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 002    0 MG/L
                               Include 004    175 MG/L
                               Include 006    350 MG/L
                               Include 008    700 MG/L
                               Include 001    0 MG/L
                               Include 003    175 MG/L
                               Include 005    350 MG/L
                               Include 007    700 MG/L



























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 97013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 06/11/04    
Route: DOSED WATER                                                                                                Time: 08:29:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Natural Death                                                                1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           15           14           15                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Infiltration Cellular, Lymphocyte                1 (7%)       4 (27%)      4 (27%)      1 (7%)                                
      Inflammation                                    13 (87%)     13 (87%)     12 (80%)     12 (80%)                               
      Necrosis                                                      2 (13%)      2 (13%)      1 (7%)                                
      Hepatocyte, Fatty Change                                      1 (7%)       1 (7%)      10 (67%)                               
      Hepatocyte, Vacuolization Cytoplasmic           11 (73%)     10 (67%)      7 (47%)     11 (73%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Subcapsular, Hyperplasia                        13 (87%)     12 (80%)     14 (93%)     14 (93%)                               
   Parathyroid Gland                                               (1)                                                              
      Cyst                                                          1 (100%)                                                        
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Cyst                                                                       1 (7%)       2 (13%)                               
   Thyroid Gland                                      (15)         (15)         (15)         (14)                                   
      Cyst                                                          1 (7%)                                                          
      C-Cell, Hyperplasia                                           1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 06/11/04    
Route: DOSED WATER                                                                                                Time: 08:29:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (15)         (15)                                   
      Angiectasis                                                                             1 (7%)                                
      Cyst                                             2 (13%)      1 (7%)       2 (13%)      5 (33%)                               
   Uterus                                             (15)         (15)         (15)         (15)                                   
      Inflammation                                     1 (7%)                    1 (7%)       1 (7%)                                
      Endometrium, Hyperplasia, Cystic                 8 (53%)      7 (47%)      9 (60%)      8 (53%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Lymphoid Follicle, Atrophy                                                 1 (7%)                                             
      Lymphoid Follicle, Hyperplasia                                                          1 (7%)                                
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                                                    1 (7%)                                             
      Cyst                                             6 (40%)     11 (73%)      9 (60%)     11 (73%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Congestion                                                                 1 (7%)                                             
      Infiltration Cellular, Lymphocyte                1 (7%)       1 (7%)       1 (7%)                                             
      Inflammation                                                                            1 (7%)                                
      Thrombosis                                                                 1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 06/11/04    
Route: DOSED WATER                                                                                                Time: 08:29:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Casts Protein                                    3 (20%)     10 (67%)      7 (47%)      6 (40%)                               
      Nephropathy                                      2 (13%)      2 (13%)      2 (13%)                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 06/11/04    
Route: DOSED WATER                                                                                                Time: 08:29:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           15           15           15                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Inflammation                                    12 (80%)     14 (93%)     13 (87%)     13 (87%)                               
      Hepatocyte, Fatty Change                         4 (27%)      5 (33%)      1 (7%)                                             
      Hepatocyte, Vacuolization Cytoplasmic           15 (100%)    15 (100%)    13 (87%)     11 (73%)                               
   Mesentery                                                                    (1)                                                 
      Fat, Necrosis                                                              1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Hyperplasia                                                   2 (13%)                                                         
      Hypertrophy                                                   2 (13%)                   2 (13%)                               
      Subcapsular, Hyperplasia                         2 (13%)      3 (20%)      1 (7%)       3 (20%)                               
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Cyst                                             3 (20%)      1 (7%)       1 (7%)       4 (27%)                               
   Thyroid Gland                                      (15)         (14)         (15)         (15)                                   
      Cyst                                             1 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 06/11/04    
Route: DOSED WATER                                                                                                Time: 08:29:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Epididymis                                         (15)         (15)         (15)         (15)                                   
      Granuloma Sperm                                               1 (7%)                    1 (7%)                                
      Inflammation                                                               1 (7%)                                             
   Testes                                             (15)         (15)         (15)         (15)                                   
      Mineralization                                                1 (7%)       1 (7%)       2 (13%)                               
      Germinal Epithelium, Degeneration                             2 (13%)                   1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Cyst                                             9 (60%)     12 (80%)      6 (40%)      9 (60%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Fibrosis                                                      1 (7%)                                                          
      Infiltration Cellular, Histiocyte                             1 (7%)                                                          
      Alveolar Epithelium, Hyperplasia                              1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)                                                              
      Cataract                                                      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 06/11/04    
Route: DOSED WATER                                                                                                Time: 08:29:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Casts Protein                                    1 (7%)       5 (33%)      4 (27%)      7 (47%)                               
      Cyst                                                                                    1 (7%)                                
      Mineralization                                                                          1 (7%)                                
      Nephropathy                                      7 (47%)      3 (20%)     11 (73%)     13 (87%)                               
      Cortex, Crystals                                                                        1 (7%)                                
      Renal Tubule, Degeneration                                                 9 (60%)     12 (80%)                               
      Renal Tubule, Dilatation                                      5 (33%)      4 (27%)      6 (40%)                               
      Renal Tubule, Vacuolization Cytoplasmic         14 (93%)      1 (7%)                                                          
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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