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TDMS Study 97013-04 Pathology Tables

NTP Experiment-Test: 97013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:34:21

                                                         FINAL #1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  75-27-4

       Lock Date:  07/19/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 002    0 MG/L
                               Include 004    175 MG/L
                               Include 006    350 MG/L
                               Include 008    700 MG/L
                               Include 001    0 MG/L
                               Include 003    175 MG/L
                               Include 005    350 MG/L
                               Include 007    700 MG/L


























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 97013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:34:21    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Natural Death                                                                1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           15           14           15                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Infiltration Cellular, Lymphocyte                1 [1.0]      4 [1.0]      4 [1.3]      1 [2.0]                               
      Inflammation                                    13 [1.0]     13 [1.0]     12 [1.0]     12 [1.0]                               
      Necrosis                                                      2 [1.0]      2 [1.0]      1 [1.0]                               
      Hepatocyte, Fatty Change                                      1 [1.0]      1 [1.0]     10 [1.0]                               
      Hepatocyte, Vacuolization Cytoplasmic           11 [1.0]     10 [1.0]      7 [1.0]     11 [1.2]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Subcapsular, Hyperplasia                        13 [1.0]     12 [1.0]     14 [1.0]     14 [1.0]                               
   Parathyroid Gland                                               (1)                                                              
      Cyst                                                          1 [2.0]                                                         
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Cyst                                                                       1 [1.0]      2 [1.0]                               
   Thyroid Gland                                      (15)         (15)         (15)         (14)                                   
      Cyst                                                          1 [1.0]                                                         
      C-Cell, Hyperplasia                                           1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:34:21    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (15)         (15)                                   
      Angiectasis                                                                             1 [2.0]                               
      Cyst                                             2 [1.0]      1 [1.0]      2 [1.0]      5 [1.0]                               
   Uterus                                             (15)         (15)         (15)         (15)                                   
      Inflammation                                     1 [1.0]                   1 [1.0]      1 [1.0]                               
      Endometrium, Hyperplasia, Cystic                 8 [1.4]      7 [1.3]      9 [1.2]      8 [1.3]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Lymphoid Follicle, Atrophy                                                 1 [2.0]                                            
      Lymphoid Follicle, Hyperplasia                                                          1 [2.0]                               
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                                                    1 [2.0]                                            
      Cyst                                             6 [1.0]     11 [1.0]      9 [1.1]     11 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Congestion                                                                 1 [2.0]                                            
      Infiltration Cellular, Lymphocyte                1 [1.0]      1 [1.0]      1 [1.0]                                            
      Inflammation                                                                            1 [1.0]                               
      Thrombosis                                                                 1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:34:21    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Casts Protein                                    3 [1.0]     10 [1.0]      7 [1.0]      6 [1.0]                               
      Nephropathy                                      2 [1.0]      2 [1.0]      2 [1.0]                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:34:21    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           15           15           15                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Inflammation                                    12 [1.0]     14 [1.0]     13 [1.0]     13 [1.0]                               
      Hepatocyte, Fatty Change                         4 [1.0]      5 [1.2]      1 [1.0]                                            
      Hepatocyte, Vacuolization Cytoplasmic           15 [3.1]     15 [2.7]     13 [1.9]     11 [1.2]                               
   Mesentery                                                                    (1)                                                 
      Fat, Necrosis                                                              1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Hyperplasia                                                   2 [1.5]                                                         
      Hypertrophy                                                   2 [1.0]                   2 [1.0]                               
      Subcapsular, Hyperplasia                         2 [1.0]      3 [1.0]      1 [1.0]      3 [1.0]                               
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Cyst                                             3 [1.0]      1 [1.0]      1 [1.0]      4 [1.0]                               
   Thyroid Gland                                      (15)         (14)         (15)         (15)                                   
      Cyst                                             1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:34:21    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Epididymis                                         (15)         (15)         (15)         (15)                                   
      Granuloma Sperm                                               1 [2.0]                   1 [2.0]                               
      Inflammation                                                               1 [2.0]                                            
   Testes                                             (15)         (15)         (15)         (15)                                   
      Mineralization                                                1 [1.0]      1 [1.0]      2 [1.0]                               
      Germinal Epithelium, Degeneration                             2 [1.5]                   1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Cyst                                             9 [1.0]     12 [1.2]      6 [1.0]      9 [1.1]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Fibrosis                                                      1 [1.0]                                                         
      Infiltration Cellular, Histiocyte                             1 [1.0]                                                         
      Alveolar Epithelium, Hyperplasia                              1 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)                                                              
      Cataract                                                      1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04    
Route: DOSED WATER                             WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:34:21    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Casts Protein                                    1 [1.0]      5 [1.0]      4 [1.0]      7 [1.3]                               
      Cyst                                                                                    1 [2.0]                               
      Mineralization                                                                          1 [1.0]                               
      Nephropathy                                      7 [1.0]      3 [1.0]     11 [1.5]     13 [2.1]                               
      Cortex, Crystals                                                                        1 [1.0]                               
      Renal Tubule, Degeneration                                                 9 [1.0]     12 [1.0]                               
      Renal Tubule, Dilatation                                      5 [1.0]      4 [1.0]      6 [1.2]                               
      Renal Tubule, Vacuolization Cytoplasmic         14 [1.4]      1 [1.0]                                                         
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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