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TDMS Study 88004-05 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Northwest                                  DIVINYLBENZENE                                             DATE: 12/17/03  
EXPERIMENT: 88004 TEST: 05                                                                                        TIME: 11:33:36    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                        NTP:  C88004B     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: BATTELLE NORTHWEST                               DIVINYLBENZENE                                              DATE: 12/17/03    
EXPERIMENT: 88004 TEST: 05                                                                                        TIME: 11:43:22    
SPECIES: RATS, FISCHER 344                                                                                                          
TEST TYPE: TWO YEAR                                 ROUTE: RESPIRATORY EX                                         NTP:  88004B      
CONT: NO1-ES-75410                                                                                                CAS: 1321-74-0    
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE                                                     
                              TWO YEAR RESPIRATORY EX STUDY OF DIVINYLBENZENE                                                       
==========================================================================================================                          
WEEK     CONTROL                100 PPM                  200 PPM                  400 PPM                                           
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B        93.2       50        91.4     98.1    50      91.1     97.7    50      91.4     98.1    50                               
  1        93.2       50        91.4     98.1    50      91.1     97.7    50      91.4     98.1    50                               
  5       198.3       50       191.9     96.8    50     191.9     96.8    50     182.2     91.9    50                               
  9       257.0       50       254.2     98.9    50     261.2    101.6    50     246.6     96.0    50                               
 13       302.6       50       300.5     99.3    50     310.7    102.7    50     293.5     97.0    50                               
 17       340.2       50       337.3     99.1    49     345.8    101.6    50     327.3     96.2    50                               
 21       364.8       50       359.7     98.6    49     371.4    101.8    49     348.0     95.4    50                               
 25       386.6       50       379.8     98.2    49     394.3    102.0    49     369.5     95.6    50                               
 29       406.1       50       397.1     97.8    49     411.5    101.3    49     386.9     95.3    50                               
 33       418.1       50       412.2     98.6    49     427.1    102.2    49     399.9     95.6    50                               
 37       436.2       50       423.8     97.2    49     441.1    101.1    49     412.7     94.6    50                               
 41       446.9       50       434.5     97.2    49     452.9    101.3    49     419.8     93.9    50                               
 45       454.9       50       442.5     97.3    49     460.6    101.3    49     428.3     94.2    50                               
 49       462.2       50       448.7     97.1    49     467.7    101.2    49     435.0     94.1    50                               
 53       473.3       49       458.4     96.9    49     479.6    101.3    49     446.7     94.4    50                               
 57       482.3       49       464.4     96.3    49     485.8    100.7    49     454.8     94.3    50                               
 61       489.7       49       472.8     96.5    48     494.3    100.9    49     462.7     94.5    50                               
 65       496.1       49       478.7     96.5    48     500.1    100.8    49     467.9     94.3    50                               
 69       499.9       49       483.7     96.8    48     505.9    101.2    48     467.2     93.5    50                               
 73       501.2       49       485.6     96.9    48     506.9    101.1    48     469.3     93.6    50                               
 77       508.4       48       488.6     96.1    48     511.0    100.5    48     472.5     92.9    49                               
 81       512.7       45       496.2     96.8    48     517.1    100.9    47     472.1     92.1    49                               
 85       511.8       45       504.1     98.5    46     521.4    101.9    44     475.4     92.9    46                               
 89       519.5       41       507.8     97.7    45     519.7    100.0    44     477.2     91.9    44                               
 92       514.9       40       508.3     98.7    45     523.9    101.7    42     477.2     92.7    43                               
 94       514.9       39       508.4     98.7    45     521.7    101.3    42     480.4     93.3    42                               
 96       508.1       39       510.3    100.4    42     521.3    102.6    40     480.9     94.6    42                               
 98       511.8       36       510.2     99.7    42     522.2    102.0    39     479.1     93.6    41                               
100       510.0       35       517.1    101.4    41     514.5    100.9    38     476.0     93.3    37                               
102       514.1       33       516.3    100.4    40     507.7     98.8    36     472.2     91.8    36                               
104       502.5       33       519.7    103.4    37     494.7     98.4    35     469.2     93.4    34                               
TERM. SAC.            31                         35                       32                       32                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE                                                   
                              TWO YEAR RESPIRATORY EX STUDY OF DIVINYLBENZENE                                                       
==========================================================================================================                          
WEEK     CONTROL                100 PPM                  200 PPM                  400 PPM                                           
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B        80.1       50        78.5     98.0    50      78.6     98.1    50      78.3     97.8    50                               
  1        80.1       50        78.5     98.0    50      78.6     98.1    50      78.3     97.8    50                               
  5       138.5       50       138.5    100.0    50     134.6     97.2    50     132.4     95.6    50                               
  9       164.3       50       167.6    102.0    50     165.5    100.7    50     163.5     99.5    50                               
 13       181.1       50       185.5    102.4    50     183.5    101.3    50     183.0    101.0    50                               
 17       190.4       50       198.5    104.3    50     194.3    102.0    50     191.3    100.5    50                               
 21       200.3       50       202.9    101.3    50     202.3    101.0    50     199.9     99.8    50                               
 25       209.8       50       218.2    104.0    50     212.1    101.1    50     209.4     99.8    49                               
 29       219.0       50       225.0    102.7    50     219.7    100.3    50     214.4     97.9    49                               
 33       225.7       50       232.2    102.9    50     225.9    100.1    50     220.9     97.9    49                               
 37       234.9       50       241.5    102.8    50     234.7     99.9    50     229.0     97.5    49                               
 41       241.7       50       249.7    103.3    50     242.3    100.2    50     234.0     96.8    49                               
 45       248.9       50       257.6    103.5    50     249.3    100.2    50     240.2     96.5    49                               
 49       258.2       50       267.3    103.5    50     255.0     98.8    50     245.6     95.1    49                               
 53       272.6       50       279.0    102.3    50     264.6     97.1    50     256.0     93.9    49                               
 57       283.0       50       287.7    101.7    49     277.1     97.9    49     264.5     93.5    49                               
 61       295.2       50       299.7    101.5    49     289.5     98.1    49     277.8     94.1    49                               
 65       303.8       47       306.5    100.9    49     295.6     97.3    49     282.8     93.1    49                               
 69       306.4       46       311.6    101.7    49     300.0     97.9    49     289.1     94.4    49                               
 73       313.4       44       317.3    101.2    48     309.2     98.7    45     294.6     94.0    49                               
 77       318.3       43       323.0    101.5    47     314.0     98.6    45     296.4     93.1    45                               
 81       330.9       41       330.7     99.9    45     318.9     96.4    45     299.3     90.5    41                               
 85       338.8       41       338.2     99.8    44     326.7     96.4    43     303.3     89.5    38                               
 89       339.9       41       339.7     99.9    44     329.0     96.8    42     310.8     91.4    34                               
 92       344.3       39       343.5     99.8    43     335.6     97.5    42     317.0     92.1    30                               
 94       343.5       39       345.1    100.5    41     335.6     97.7    42     313.1     91.1    30                               
 96       344.0       39       347.0    100.9    41     338.0     98.3    41     318.1     92.5    26                               
 98       345.1       39       347.9    100.8    38     340.4     98.6    39     320.7     92.9    26                               
100       346.8       38       340.4     98.2    37     338.4     97.6    39     318.8     91.9    25                               
102       348.0       36       341.1     98.0    34     334.2     96.0    38     316.7     91.0    25                               
104       355.3       33       340.0     95.7    31     335.7     94.5    35     316.7     89.1    22                               
TERM. SAC.            33                         30                       33                       22                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.