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TDMS Study 88004-05 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                      DIVINYLBENZENE                                    DATE: 12/17/03       
EXPERIMENT: 88004 TEST: 05                                                                                     TIME: 11:44:02       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 88004B       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 1321-74-0       
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                                                           FINAL #1 RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                      DIVINYLBENZENE                                    DATE: 12/17/03       
EXPERIMENT: 88004 TEST: 05                                                                                     TIME: 11:44:02       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 88004B       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 1321-74-0       
Rats(FISCHER 344)                                                                                                                   
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Brain                                                                              
                                                 Clitoral/Preputial Gland                                                           
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Nose                                                                               
                                                 Ovary                                                                              
                                                 Pancreas                                                                           
                                                 Pituitary Gland                                                                    
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                      DIVINYLBENZENE                                    DATE: 12/17/03       
EXPERIMENT: 88004 TEST: 05                                                                                     TIME: 11:44:02       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 88004B       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 1321-74-0       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                     DIVINYLBENZENE                                                                               
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Medulla                        Pheochromocytoma Benign                                                                      
                                       Pheochromocytoma: Benign, Complex, Malignant, NOS                                            
Kidney: Renal Tubule                   Carcinoma                                                                                    
Skin                                   Basal Cell Adenoma                                                                           
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                           
                                       Malignant Tumors                                                                             
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
Mammary Gland                          Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                 
Pituitary Gland: Pars Distalis or Unspecified Site                                                                                  
                                       Adenoma                                                                                      
Thyroid Gland: C-Cell                  Adenoma                                                                                      
All Organs                             Histiocytic Sarcoma                                                                          
                                       Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                           
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 1       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -                      DIVINYLBENZENE       
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/50 (24%)  4/50 (8%)    9/50 (18%)   7/50 (14%)  |2/50 (4%)    2/50 (4%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     12/44.11     4/45.38      9/44.10      7/45.14     |2/42.30      2/43.64      3/43.84      2/38.10      | 
|POLY-3 PERCENT (g) |     27.2%        8.8%         20.4%        15.5%       |4.7%         4.6%         6.8%         5.3%         | 
|TERMINAL (d)       |     8/31 (26%)   4/35 (11%)   8/32 (25%)   6/32 (19%)  |2/33 (6%)    1/30 (3%)    3/33 (9%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     623          729 (T)      722          674         |731 (T)      696          731 (T)      656          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.256N     P=0.017N*    P=0.286N     P=0.136N    |P=0.410      P=0.668      P=0.500      P=0.552      | 
|POLY 3             |     P=0.248N     P=0.021N*    P=0.308N     P=0.136N    |P=0.506      P=0.683N     P=0.516      P=0.656      | 
|POLY 1.5           |     P=0.247N     P=0.024N*    P=0.314N     P=0.141N    |P=0.534      P=0.686N     P=0.511      P=0.674      | 
|POLY 6             |     P=0.255N     P=0.018N*    P=0.305N     P=0.133N    |P=0.461      P=0.685N     P=0.520      P=0.623      | 
|LOGISTIC REGRESSION|     P=0.233N     P=0.019N*    P=0.273N     P=0.125N    |P=0.472      P=0.693N     P=0.500      P=0.634      | 
|COCH-ARM / FISHERS |     P=0.257N     P=0.027N*    P=0.312N     P=0.154N    |P=0.569      P=0.691N     P=0.500      P=0.691N     | 
|ORDER RESTRICTED   |     P=0.094N     (e)          (e)          (e)         |P=0.607      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/43.15      2/45.38      2/44.10      1/45.12     |0/42.30      0/43.50      1/44.53      1/38.21      | 
|POLY-3 PERCENT (g) |     2.3%         4.4%         4.5%         2.2%        |0.0%         0.0%         2.3%         2.6%         | 
|TERMINAL (d)       |     1/31 (3%)    2/35 (6%)    1/32 (3%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      722          680         |---          ---          497          589          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.552N     P=0.543      P=0.514      P=0.742N    |P=0.232      (e)          P=0.509      P=0.485      | 
|POLY 3             |     P=0.541N     P=0.518      P=0.508      P=0.751N    |P=0.204      (e)          P=0.510      P=0.480      | 
|POLY 1.5           |     P=0.545N     P=0.508      P=0.502      P=0.754N    |P=0.218      (e)          P=0.507      P=0.489      | 
|POLY 6             |     P=0.537N     P=0.531      P=0.514      P=0.747N    |P=0.182      (e)          P=0.513      P=0.462      | 
|LOGISTIC REGRESSION|     P=0.546N     P=0.543      P=0.521      P=0.756N    |P=0.327      (e)          P=0.456      P=0.535      | 
|COCH-ARM / FISHERS |     P=0.556N     P=0.500      P=0.500      P=0.753N    |P=0.236      (e)          P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.540N     (e)          (e)          (e)         |P=0.232      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 2       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  6/50 (12%)   11/50 (22%)  8/50 (16%)  |2/50 (4%)    2/50 (4%)    4/50 (8%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     13/44.11     6/45.38      11/44.13     8/45.33     |2/42.30      2/43.64      4/44.53      3/38.58      | 
|POLY-3 PERCENT (g) |     29.5%        13.2%        24.9%        17.7%       |4.7%         4.6%         9.0%         7.8%         | 
|TERMINAL (d)       |     9/31 (29%)   6/35 (17%)   9/32 (28%)   6/32 (19%)  |2/33 (6%)    1/30 (3%)    3/33 (9%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     623          729 (T)      722          674         |731 (T)      696          497          589          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.250N     P=0.036N*    P=0.375N     P=0.143N    |P=0.226      P=0.668      P=0.341      P=0.361      | 
|POLY 3             |     P=0.236N     P=0.050N     P=0.405N     P=0.140N    |P=0.300      P=0.683N     P=0.361      P=0.458      | 
|POLY 1.5           |     P=0.237N     P=0.056N     P=0.411N     P=0.148N    |P=0.325      P=0.686N     P=0.352      P=0.478      | 
|POLY 6             |     P=0.239N     P=0.043N*    P=0.401N     P=0.136N    |P=0.263      P=0.685N     P=0.367      P=0.423      | 
|LOGISTIC REGRESSION|     P=0.225N     P=0.041N*    P=0.358N     P=0.132N    |P=0.342      P=0.693N     P=0.341      P=0.474      | 
|COCH-ARM / FISHERS |     P=0.251N     P=0.062N     P=0.408N     P=0.163N    |P=0.357      P=0.691N     P=0.339      P=0.500      | 
|ORDER RESTRICTED   |     P=0.130N     (e)          (e)          (e)         |P=0.400      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Astrocytoma Malignant                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.15      0/45.38      2/44.07      0/44.93     |0/42.30      0/43.50      1/44.71      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         0.0%        |0.0%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/30 (0%)    0/35 (0%)    2/32 (6%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          374          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.600      (e)          P=0.252      (e)         |P=0.692      (e)          P=0.500      (e)          | 
|POLY 3             |     P=0.614      (e)          P=0.247      (e)         |P=0.633      (e)          P=0.511      (e)          | 
|POLY 1.5           |     P=0.611      (e)          P=0.244      (e)         |P=0.662      (e)          P=0.507      (e)          | 
|POLY 6             |     P=0.615      (e)          P=0.252      (e)         |P=0.581      (e)          P=0.513      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.252      (e)         |P=0.619N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.598      (e)          P=0.253      (e)         |P=0.694      (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.256      (e)          (e)          (e)         |P=0.393      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 3       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.15      1/45.87      3/44.07      0/44.93     |0/42.30      0/43.50      1/44.71      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         6.8%         0.0%        |0.0%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/30 (0%)    0/35 (0%)    3/32 (9%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          582          729 (T)      ---         |---          ---          374          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.630N     P=0.509      P=0.132      (e)         |P=0.692      (e)          P=0.500      (e)          | 
|POLY 3             |     P=0.614N     P=0.517      P=0.126      (e)         |P=0.633      (e)          P=0.511      (e)          | 
|POLY 1.5           |     P=0.619N     P=0.510      P=0.124      (e)         |P=0.662      (e)          P=0.507      (e)          | 
|POLY 6             |     P=0.612N     P=0.526      P=0.130      (e)         |P=0.581      (e)          P=0.513      (e)          | 
|LOGISTIC REGRESSION|     P=0.629N     P=0.531      P=0.132      (e)         |P=0.619N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.629N     P=0.505      P=0.125      (e)         |P=0.694      (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.231      (e)          (e)          (e)         |P=0.393      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    2/50 (4%)    0/50 (0%)    2/49 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/41.16      2/46.40      0/44.07      2/44.42     |0/42.30      0/43.50      1/43.88      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         4.3%         0.0%         4.5%        |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/30 (0%)    0/35 (0%)    0/32 (0%)    0/31 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          393          ---          638         |---          ---          722          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.256      P=0.257      (e)          P=0.257     |P=0.655      (e)          P=0.506      (e)          | 
|POLY 3             |     P=0.264      P=0.265      (e)          P=0.254     |P=0.635      (e)          P=0.507      (e)          | 
|POLY 1.5           |     P=0.258      P=0.256      (e)          P=0.250     |P=0.663      (e)          P=0.505      (e)          | 
|POLY 6             |     P=0.271      P=0.276      (e)          P=0.260     |P=0.584      (e)          P=0.509      (e)          | 
|LOGISTIC REGRESSION|     P=0.206      P=0.281      (e)          P=0.214     |P=0.669      (e)          P=0.508      (e)          | 
|COCH-ARM / FISHERS |     P=0.249      P=0.258      (e)          P=0.253     |P=0.694      (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.130      (e)          (e)          (e)         |P=0.389      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 4       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   8/48 (17%)   2/50 (4%)    9/50 (18%)  |1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/43.75      8/44.47      2/44.24      9/45.84     |1/42.30      0/43.50      1/43.84      1/38.36      | 
|POLY-3 PERCENT (g) |     11.4%        18.0%        4.5%         19.6%       |2.4%         0.0%         2.3%         2.6%         | 
|TERMINAL (d)       |     3/31 (10%)   7/34 (21%)   1/32 (3%)    6/32 (19%)  |1/33 (3%)    0/30 (0%)    1/33 (3%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     543          704          687          614         |731 (T)      ---          731 (T)      523          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.240      P=0.343      P=0.207N     P=0.225     |P=0.486      P=0.519N     P=0.762      P=0.729      | 
|POLY 3             |     P=0.255      P=0.285      P=0.211N     P=0.218     |P=0.503      P=0.494N     P=0.753N     P=0.739      | 
|POLY 1.5           |     P=0.248      P=0.270      P=0.216N     P=0.209     |P=0.519      P=0.496N     P=0.755N     P=0.749      | 
|POLY 6             |     P=0.262      P=0.306      P=0.204N     P=0.230     |P=0.478      P=0.496N     P=0.751N     P=0.718      | 
|LOGISTIC REGRESSION|     P=0.249      P=0.297      P=0.215N     P=0.200     |P=0.553      (e)          P=0.762      P=0.745N     | 
|COCH-ARM / FISHERS |     P=0.240      P=0.250      P=0.218N     P=0.194     |P=0.539      P=0.500N     P=0.753N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.190      (e)          (e)          (e)         |P=0.500      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   8/48 (17%)   3/50 (6%)    10/50 (20%) |1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     6/43.75      8/44.47      3/44.24      10/45.84    |1/42.30      0/43.50      1/43.84      2/38.97      | 
|POLY-3 PERCENT (g) |     13.7%        18.0%        6.8%         21.8%       |2.4%         0.0%         2.3%         5.1%         | 
|TERMINAL (d)       |     4/31 (13%)   7/34 (21%)   2/32 (6%)    7/32 (22%)  |1/33 (3%)    0/30 (0%)    1/33 (3%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     543          704          687          614         |731 (T)      ---          731 (T)      523          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.218      P=0.462      P=0.230N     P=0.239     |P=0.209      P=0.519N     P=0.762      P=0.474      | 
|POLY 3             |     P=0.233      P=0.399      P=0.236N     P=0.234     |P=0.226      P=0.494N     P=0.753N     P=0.471      | 
|POLY 1.5           |     P=0.228      P=0.380      P=0.242N     P=0.224     |P=0.235      P=0.496N     P=0.755N     P=0.485      | 
|POLY 6             |     P=0.239      P=0.423      P=0.228N     P=0.247     |P=0.212      P=0.496N     P=0.751N     P=0.445      | 
|LOGISTIC REGRESSION|     P=0.230      P=0.418      P=0.235N     P=0.221     |P=0.289      (e)          P=0.762      P=0.554      | 
|COCH-ARM / FISHERS |     P=0.220      P=0.355      P=0.243N     P=0.207     |P=0.247      P=0.500N     P=0.753N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.180      (e)          (e)          (e)         |P=0.196      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 5       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    2/49 (4%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      0/45.37      0/44.07      2/44.14     |0/42.30      0/43.50      0/43.33      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    0/32 (0%)    1/32 (3%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          682         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.046 *    (e)          (e)          P=0.252     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.044 *    (e)          (e)          P=0.242     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.239     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.044 *    (e)          (e)          P=0.246     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.046 *    (e)          (e)          P=0.240     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.045 *    (e)          (e)          P=0.242     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.031 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      0/45.37      0/44.07      0/44.93     |0/42.30      2/43.90      2/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.6%         4.6%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)   |0/33 (0%)    1/30 (3%)    2/33 (6%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          617          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.597N     P=0.237      P=0.238      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.551N     P=0.245      P=0.245      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.527N     P=0.243      P=0.242      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.592N     P=0.245      P=0.246      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.534N     P=0.233      P=0.238      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.500N     P=0.247      P=0.247      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.288      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 6       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      0/45.37      0/44.07      0/44.93     |0/42.30      2/43.90      3/43.92      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.6%         6.8%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)   |0/33 (0%)    1/30 (3%)    2/33 (6%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          617          711          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.612      P=0.237      P=0.128      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.596N     P=0.245      P=0.125      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.566N     P=0.243      P=0.123      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.558      P=0.245      P=0.127      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.574N     P=0.233      P=0.127      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.531N     P=0.247      P=0.121      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.242      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      0/45.37      0/44.07      0/44.93     |0/42.30      2/43.90      3/43.92      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.6%         6.8%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)   |0/33 (0%)    1/30 (3%)    2/33 (6%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          617          711          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.612      P=0.237      P=0.128      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.596N     P=0.245      P=0.125      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.566N     P=0.243      P=0.123      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.558      P=0.245      P=0.127      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.574N     P=0.233      P=0.127      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.531N     P=0.247      P=0.121      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.242      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 7       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.15      1/45.38      0/44.07      1/44.93     |0/42.30      0/43.50      0/43.84      2/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         2.2%        |0.0%         0.0%         0.0%         5.3%         | 
|TERMINAL (d)       |     0/31 (0%)    1/35 (3%)    0/32 (0%)    1/32 (3%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    2/22 (9%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |---          ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.403      P=0.524      (e)          P=0.506     |P=0.023 *    (e)          (e)          P=0.154      | 
|POLY 3             |     P=0.417      P=0.510      (e)          P=0.508     |P=0.041 *    (e)          (e)          P=0.212      | 
|POLY 1.5           |     P=0.413      P=0.504      (e)          P=0.505     |P=0.043 *    (e)          (e)          P=0.224      | 
|POLY 6             |     P=0.421      P=0.518      (e)          P=0.511     |P=0.039 *    (e)          (e)          P=0.193      | 
|LOGISTIC REGRESSION|     (e)          P=0.524      (e)          P=0.506     |(e)          (e)          (e)          P=0.154      | 
|COCH-ARM / FISHERS |     P=0.405      P=0.500      (e)          P=0.500     |P=0.046 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.259      (e)          (e)          (e)         |P=0.022 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/43.15      1/45.38      1/44.07      1/44.93     |0/42.30      0/43.50      0/43.84      2/37.73      | 
|POLY-3 PERCENT (g) |     2.3%         2.2%         2.3%         2.2%        |0.0%         0.0%         0.0%         5.3%         | 
|TERMINAL (d)       |     1/31 (3%)    1/35 (3%)    1/32 (3%)    1/32 (3%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    2/22 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.633      P=0.735N     P=0.755N     P=0.755N    |P=0.023 *    (e)          (e)          P=0.154      | 
|POLY 3             |     P=0.627N     P=0.749N     P=0.756N     P=0.752N    |P=0.041 *    (e)          (e)          P=0.212      | 
|POLY 1.5           |     P=0.628N     P=0.756N     P=0.759N     P=0.755N    |P=0.043 *    (e)          (e)          P=0.224      | 
|POLY 6             |     P=0.628N     P=0.741N     P=0.752N     P=0.749N    |P=0.039 *    (e)          (e)          P=0.193      | 
|LOGISTIC REGRESSION|     P=0.633      P=0.735N     P=0.755N     P=0.755N    |(e)          (e)          (e)          P=0.154      | 
|COCH-ARM / FISHERS |     P=0.634      P=0.753N     P=0.753N     P=0.753N    |P=0.046 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.735N     (e)          (e)          (e)         |P=0.022 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 8       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |3/50 (6%)    5/50 (10%)   4/50 (8%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.15      0/45.38      1/44.07      0/44.93     |3/42.30      5/44.54      4/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.3%         0.0%        |7.1%         11.2%        9.1%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    0/35 (0%)    1/32 (3%)    0/32 (0%)   |3/33 (9%)    2/30 (7%)    4/33 (12%)   0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |731 (T)      374          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.406N     P=0.476N     P=0.755N     P=0.494N    |P=0.150N     P=0.320      P=0.500      P=0.200N     | 
|POLY 3             |     P=0.406N     P=0.490N     P=0.756N     P=0.492N    |P=0.110N     P=0.385      P=0.520      P=0.140N     | 
|POLY 1.5           |     P=0.404N     P=0.496N     P=0.759N     P=0.495N    |P=0.095N     P=0.377      P=0.513      P=0.130N     | 
|POLY 6             |     P=0.410N     P=0.482N     P=0.752N     P=0.489N    |P=0.140N     P=0.385      P=0.523      P=0.160N     | 
|LOGISTIC REGRESSION|     P=0.406N     (e)          P=0.755N     (e)         |P=0.091N     P=0.353      P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.500N     P=0.753N     P=0.500N    |P=0.079N     P=0.357      P=0.500      P=0.121N     | 
|ORDER RESTRICTED   |     P=0.243N     (e)          (e)          (e)         |P=0.090N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |3/50 (6%)    6/50 (12%)   4/50 (8%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.15      1/45.38      1/44.07      0/44.93     |3/42.30      6/44.77      4/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     2.3%         2.2%         2.3%         0.0%        |7.1%         13.4%        9.1%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    1/35 (3%)    1/32 (3%)    0/32 (0%)   |3/33 (9%)    2/30 (7%)    4/33 (12%)   0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |731 (T)      374          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.311N     P=0.735N     P=0.755N     P=0.494N    |P=0.134N     P=0.219      P=0.500      P=0.200N     | 
|POLY 3             |     P=0.307N     P=0.749N     P=0.756N     P=0.492N    |P=0.093N     P=0.270      P=0.520      P=0.140N     | 
|POLY 1.5           |     P=0.308N     P=0.756N     P=0.759N     P=0.495N    |P=0.079N     P=0.262      P=0.513      P=0.130N     | 
|POLY 6             |     P=0.306N     P=0.741N     P=0.752N     P=0.489N    |P=0.122N     P=0.272      P=0.523      P=0.160N     | 
|LOGISTIC REGRESSION|     P=0.311N     P=0.735N     P=0.755N     (e)         |P=0.075N     P=0.238      P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.311N     P=0.753N     P=0.753N     P=0.500N    |P=0.066N     P=0.243      P=0.500      P=0.121N     | 
|ORDER RESTRICTED   |     P=0.320N     (e)          (e)          (e)         |P=0.067N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 9       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroadenoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    5/50 (10%)   2/50 (4%)   |20/50 (40%)  22/50 (44%)  19/50 (38%)  14/50 (28%)  | 
|POLY-3 RATE (b)    |     1/43.15      0/45.38      5/44.58      2/44.93     |20/43.01     22/45.41     19/44.55     14/39.80     | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         11.2%        4.5%        |46.5%        48.4%        42.7%        35.2%        | 
|TERMINAL (d)       |     1/31 (3%)    0/35 (0%)    4/32 (13%)   2/32 (6%)   |15/33 (46%)  12/30 (40%)  13/33 (39%)  8/22 (36%)   | 
|FIRST INCIDENCE    |     729 (T)      ---          578          729 (T)     |631          617          666          523          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.228      P=0.476N     P=0.111      P=0.511     |P=0.476N     P=0.335      P=0.484N     P=0.572      | 
|POLY 3             |     P=0.240      P=0.490N     P=0.108      P=0.514     |P=0.133N     P=0.512      P=0.441N     P=0.200N     | 
|POLY 1.5           |     P=0.239      P=0.496N     P=0.104      P=0.509     |P=0.104N     P=0.478      P=0.462N     P=0.169N     | 
|POLY 6             |     P=0.237      P=0.482N     P=0.114      P=0.519     |P=0.202N     P=0.538      P=0.428N     P=0.280N     | 
|LOGISTIC REGRESSION|     P=0.240      (e)          P=0.106      P=0.511     |P=0.201N     P=0.470      P=0.426N     P=0.309N     | 
|COCH-ARM / FISHERS |     P=0.232      P=0.500N     P=0.102      P=0.500     |P=0.080N     P=0.420      P=0.500N     P=0.146N     | 
|ORDER RESTRICTED   |     P=0.097      (e)          (e)          (e)         |P=0.204N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma or Adenoma                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    5/50 (10%)   2/50 (4%)   |20/50 (40%)  23/50 (46%)  19/50 (38%)  14/50 (28%)  | 
|POLY-3 RATE (b)    |     1/43.15      1/45.38      5/44.58      2/44.93     |20/43.01     23/45.64     19/44.55     14/39.80     | 
|POLY-3 PERCENT (g) |     2.3%         2.2%         11.2%        4.5%        |46.5%        50.4%        42.7%        35.2%        | 
|TERMINAL (d)       |     1/31 (3%)    1/35 (3%)    4/32 (13%)   2/32 (6%)   |15/33 (46%)  12/30 (40%)  13/33 (39%)  8/22 (36%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      578          729 (T)     |631          617          666          523          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.298      P=0.735N     P=0.111      P=0.511     |P=0.455N     P=0.276      P=0.484N     P=0.572      | 
|POLY 3             |     P=0.316      P=0.749N     P=0.108      P=0.514     |P=0.119N     P=0.438      P=0.441N     P=0.200N     | 
|POLY 1.5           |     P=0.313      P=0.756N     P=0.104      P=0.509     |P=0.092N     P=0.401      P=0.462N     P=0.169N     | 
|POLY 6             |     P=0.315      P=0.741N     P=0.114      P=0.519     |P=0.186N     P=0.471      P=0.428N     P=0.280N     | 
|LOGISTIC REGRESSION|     P=0.312      P=0.735N     P=0.106      P=0.511     |P=0.178N     P=0.389      P=0.426N     P=0.309N     | 
|COCH-ARM / FISHERS |     P=0.302      P=0.753N     P=0.102      P=0.500     |P=0.070N     P=0.343      P=0.500N     P=0.146N     | 
|ORDER RESTRICTED   |     P=0.182      (e)          (e)          (e)         |P=0.172N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 10      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    5/50 (10%)   2/50 (4%)   |22/50 (44%)  25/50 (50%)  21/50 (42%)  14/50 (28%)  | 
|POLY-3 RATE (b)    |     1/43.15      1/45.38      5/44.58      2/44.93     |22/43.01     25/46.62     21/44.55     14/39.80     | 
|POLY-3 PERCENT (g) |     2.3%         2.2%         11.2%        4.5%        |51.2%        53.6%        47.1%        35.2%        | 
|TERMINAL (d)       |     1/31 (3%)    1/35 (3%)    4/32 (13%)   2/32 (6%)   |17/33 (52%)  12/30 (40%)  15/33 (46%)  8/22 (36%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      578          729 (T)     |631          374          666          523          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.298      P=0.735N     P=0.111      P=0.511     |P=0.330N     P=0.276      P=0.484N     P=0.461N     | 
|POLY 3             |     P=0.316      P=0.749N     P=0.108      P=0.514     |P=0.057N     P=0.491      P=0.435N     P=0.099N     | 
|POLY 1.5           |     P=0.313      P=0.756N     P=0.104      P=0.509     |P=0.041N*    P=0.435      P=0.458N     P=0.082N     | 
|POLY 6             |     P=0.315      P=0.741N     P=0.114      P=0.519     |P=0.103N     P=0.539      P=0.420N     P=0.153N     | 
|LOGISTIC REGRESSION|     P=0.312      P=0.735N     P=0.106      P=0.511     |P=0.077N     P=0.391      P=0.418N     P=0.189N     | 
|COCH-ARM / FISHERS |     P=0.302      P=0.753N     P=0.102      P=0.500     |P=0.029N*    P=0.344      P=0.500N     P=0.072N     | 
|ORDER RESTRICTED   |     P=0.182      (e)          (e)          (e)         |P=0.088N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     36/50 (72%)  30/50 (60%)  31/50 (62%)  29/49 (59%) |37/50 (74%)  34/50 (68%)  39/50 (78%)  28/50 (56%)  | 
|POLY-3 RATE (b)    |     36/47.03     30/47.41     31/46.48     29/45.96    |37/46.77     34/46.44     39/47.30     28/42.25     | 
|POLY-3 PERCENT (g) |     76.6%        63.3%        66.7%        63.1%       |79.1%        73.2%        82.5%        66.3%        | 
|TERMINAL (d)       |     24/31 (77%)  22/35 (63%)  20/32 (63%)  19/32 (59%) |26/33 (79%)  22/30 (73%)  27/33 (82%)  16/22 (73%)  | 
|FIRST INCIDENCE    |     506          569          586          614         |455          374          493          529          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.167N     P=0.066N     P=0.191N     P=0.106N    |P=0.358      P=0.511N     P=0.468      P=0.484      | 
|POLY 3             |     P=0.150N     P=0.113N     P=0.197N     P=0.109N    |P=0.138N     P=0.330N     P=0.438      P=0.114N     | 
|POLY 1.5           |     P=0.145N     P=0.135N     P=0.208N     P=0.113N    |P=0.084N     P=0.318N     P=0.425      P=0.073N     | 
|POLY 6             |     P=0.162N     P=0.088N     P=0.181N     P=0.108N    |P=0.275N     P=0.368N     P=0.450      P=0.234N     | 
|LOGISTIC REGRESSION|     P=0.121N     P=0.117N     P=0.175N     P=0.086N    |P=0.100N     P=0.266N     P=0.476      P=0.086N     | 
|COCH-ARM / FISHERS |     P=0.157N     P=0.146N     P=0.198N     P=0.129N    |P=0.044N*    P=0.330N     P=0.408      P=0.046N*    | 
|ORDER RESTRICTED   |     P=0.121N     (e)          (e)          (e)         |P=0.107N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 11      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      2/45.38      0/44.07      0/43.95     |0/42.30      0/43.50      0/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    2/35 (6%)    0/32 (0%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.406N     P=0.265      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.394N     P=0.248      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.401N     P=0.242      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.386N     P=0.257      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.265      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.409N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.254N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Adenoma                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      0/45.38      1/44.58      3/44.93     |0/42.30      0/43.50      0/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         6.7%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    0/32 (0%)    3/32 (9%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          578          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.020 *    (e)          P=0.504      P=0.126     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.020 *    (e)          P=0.507      P=0.126     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.020 *    (e)          P=0.503      P=0.123     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.020 *    (e)          P=0.512      P=0.128     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.020 *    (e)          P=0.535      P=0.126     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.020 *    (e)          P=0.500      P=0.121     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.023 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 12      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Adenoma, Basosquamous Tumor Benign, or                                                                           | 
|     Trichoepithelioma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.15      0/45.38      1/44.58      3/44.93     |0/42.30      0/43.50      0/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.2%         6.7%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    0/35 (0%)    0/32 (0%)    3/32 (9%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          578          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.095      P=0.476N     P=0.754N     P=0.316     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.097      P=0.490N     P=0.753N     P=0.320     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.098      P=0.496N     P=0.758N     P=0.315     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.096      P=0.482N     P=0.748N     P=0.324     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.098      (e)          P=0.759N     P=0.316     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.097      P=0.500N     P=0.753N     P=0.309     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.089      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      | 
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    3/50 (6%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.15      0/45.38      1/44.58      3/44.93     |0/42.30      1/43.50      0/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.2%         6.7%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    0/35 (0%)    0/32 (0%)    3/32 (9%)   |0/33 (0%)    1/30 (3%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          578          729 (T)     |---          731 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.095      P=0.476N     P=0.754N     P=0.316     |P=0.625N     P=0.481      (e)          (e)          | 
|POLY 3             |     P=0.097      P=0.490N     P=0.753N     P=0.320     |P=0.563N     P=0.506      (e)          (e)          | 
|POLY 1.5           |     P=0.098      P=0.496N     P=0.758N     P=0.315     |P=0.565N     P=0.504      (e)          (e)          | 
|POLY 6             |     P=0.096      P=0.482N     P=0.748N     P=0.324     |P=0.561N     P=0.504      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.098      (e)          P=0.759N     P=0.316     |(e)          P=0.481      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.097      P=0.500N     P=0.753N     P=0.309     |P=0.567N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.089      (e)          (e)          (e)         |P=0.405N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 13      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    3/50 (6%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/43.52      0/45.38      1/44.58      3/44.93     |0/42.30      1/43.50      0/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     4.6%         0.0%         2.2%         6.7%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    0/35 (0%)    0/32 (0%)    3/32 (9%)   |0/33 (0%)    1/30 (3%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     623          ---          578          729 (T)     |---          731 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.243      P=0.217N     P=0.491N     P=0.518     |P=0.625N     P=0.481      (e)          (e)          | 
|POLY 3             |     P=0.241      P=0.228N     P=0.492N     P=0.515     |P=0.563N     P=0.506      (e)          (e)          | 
|POLY 1.5           |     P=0.244      P=0.233N     P=0.497N     P=0.510     |P=0.565N     P=0.504      (e)          (e)          | 
|POLY 6             |     P=0.237      P=0.221N     P=0.485N     P=0.518     |P=0.561N     P=0.504      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.239      P=0.239N     P=0.488N     P=0.518     |(e)          P=0.481      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.242      P=0.247N     P=0.500N     P=0.500     |P=0.567N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.195      (e)          (e)          (e)         |P=0.405N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   7/50 (14%)   4/50 (8%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/44.12      7/45.64      4/44.07      3/45.64     |0/42.30      0/43.50      0/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     11.3%        15.3%        9.1%         6.6%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/31 (10%)   6/35 (17%)   4/32 (13%)   1/32 (3%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     536          659          729 (T)      569         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.194N     P=0.457      P=0.483N     P=0.334N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.183N     P=0.403      P=0.501N     P=0.338N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.187N     P=0.388      P=0.504N     P=0.344N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.180N     P=0.424      P=0.498N     P=0.332N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.191N     P=0.387      P=0.497N     P=0.406N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.196N     P=0.380      P=0.500N     P=0.357N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.235N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 14      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   8/50 (16%)   4/50 (8%)    5/50 (10%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     6/44.15      8/45.71      4/44.07      5/45.67     |0/42.30      0/43.50      0/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     13.6%        17.5%        9.1%         11.0%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/31 (10%)   6/35 (17%)   4/32 (13%)   2/32 (6%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     536          659          729 (T)      569         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.312N     P=0.476      P=0.353N     P=0.469N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.297N     P=0.413      P=0.370N     P=0.476N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.302N     P=0.396      P=0.373N     P=0.484N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.295N     P=0.437      P=0.367N     P=0.469N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.303N     P=0.399      P=0.365N     P=0.525N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.313N     P=0.387      P=0.370N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.343N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     38/50 (76%)  45/50 (90%)  43/50 (86%)  42/50 (84%) |                                                    | 
|POLY-3 RATE (b)    |     38/46.19     45/48.30     43/48.17     42/48.66    |                                                    | 
|POLY-3 PERCENT (g) |     82.3%        93.2%        89.3%        86.3%       |                                                    | 
|TERMINAL (d)       |     30/31 (97%)  33/35 (94%)  30/32 (94%)  28/32 (88%) |                                                    | 
|FIRST INCIDENCE    |     543          393          460          562         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.367      P=0.400      P=0.298      P=0.397     |                                                    | 
|POLY 3             |     P=0.509      P=0.075      P=0.232      P=0.390     |                                                    | 
|POLY 1.5           |     P=0.427      P=0.052      P=0.174      P=0.317     |                                                    | 
|POLY 6             |     P=0.527N     P=0.124      P=0.329      P=0.499     |                                                    | 
|LOGISTIC REGRESSION|     P=0.393      P=0.067      P=0.154      P=0.335     |                                                    | 
|COCH-ARM / FISHERS |     P=0.301      P=0.054      P=0.154      P=0.227     |                                                    | 
|ORDER RESTRICTED   |     P=0.191      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 15      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    5/50 (10%)   2/50 (4%)    2/49 (4%)   |0/50 (0%)    5/50 (10%)   1/50 (2%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     2/43.15      5/45.65      2/44.07      2/43.95     |0/42.30      5/44.49      1/43.84      4/38.55      | 
|POLY-3 PERCENT (g) |     4.6%         11.0%        4.5%         4.6%        |0.0%         11.2%        2.3%         10.4%        | 
|TERMINAL (d)       |     2/31 (7%)    4/35 (11%)   2/32 (6%)    2/32 (6%)   |0/33 (0%)    3/30 (10%)   1/33 (3%)    2/22 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      654          729 (T)      729 (T)     |---          506          731 (T)      563          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.397N     P=0.270      P=0.684N     P=0.684N    |P=0.088      P=0.033 *    P=0.500      P=0.035 *    | 
|POLY 3             |     P=0.388N     P=0.239      P=0.686N     P=0.687N    |P=0.134      P=0.035 *    P=0.507      P=0.049 *    | 
|POLY 1.5           |     P=0.395N     P=0.227      P=0.691N     P=0.692N    |P=0.145      P=0.033 *    P=0.505      P=0.054      | 
|POLY 6             |     P=0.383N     P=0.258      P=0.680N     P=0.683N    |P=0.115      P=0.035 *    P=0.509      P=0.040 *    | 
|LOGISTIC REGRESSION|     P=0.395N     P=0.252      P=0.684N     P=0.684N    |P=0.163      P=0.031 *    P=0.500      P=0.059      | 
|COCH-ARM / FISHERS |     P=0.406N     P=0.218      P=0.691N     P=0.684     |P=0.162      P=0.028 *    P=0.500      P=0.059      | 
|ORDER RESTRICTED   |     P=0.414N     (e)          (e)          (e)         |P=0.035 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   2/50 (4%)    3/49 (6%)   |1/50 (2%)    6/50 (12%)   2/50 (4%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     3/43.15      5/45.65      2/44.07      3/43.95     |1/42.37      6/44.66      2/43.91      4/38.55      | 
|POLY-3 PERCENT (g) |     7.0%         11.0%        4.5%         6.8%        |2.4%         13.4%        4.6%         10.4%        | 
|TERMINAL (d)       |     3/31 (10%)   4/35 (11%)   2/32 (6%)    3/32 (9%)   |0/33 (0%)    3/30 (10%)   1/33 (3%)    2/22 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      654          729 (T)      729 (T)     |716          506          715          563          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.443N     P=0.426      P=0.485N     P=0.650N    |P=0.194      P=0.058      P=0.503      P=0.101      | 
|POLY 3             |     P=0.438N     P=0.388      P=0.490N     P=0.654N    |P=0.282      P=0.064      P=0.512      P=0.150      | 
|POLY 1.5           |     P=0.443N     P=0.370      P=0.497N     P=0.660N    |P=0.304      P=0.062      P=0.508      P=0.163      | 
|POLY 6             |     P=0.435N     P=0.412      P=0.482N     P=0.649N    |P=0.246      P=0.065      P=0.515      P=0.129      | 
|LOGISTIC REGRESSION|     P=0.442N     P=0.410      P=0.485N     P=0.650N    |P=0.320      P=0.056      P=0.514      P=0.164      | 
|COCH-ARM / FISHERS |     P=0.453N     P=0.357      P=0.500N     P=0.651     |P=0.331      P=0.056      P=0.500      P=0.181      | 
|ORDER RESTRICTED   |     P=0.441N     (e)          (e)          (e)         |P=0.143      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 16      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |9/50 (18%)   6/50 (12%)   8/50 (16%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |                                                        |9/42.59      6/44.04      8/45.13      7/38.66      | 
|POLY-3 PERCENT (g) |                                                        |21.1%        13.6%        17.7%        18.1%        | 
|TERMINAL (d)       |                                                        |7/33 (21%)   3/30 (10%)   5/33 (15%)   4/22 (18%)   | 
|FIRST INCIDENCE    |                                                        |687          670          481          589          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.405      P=0.341N     P=0.484N     P=0.498      | 
|POLY 3             |                                                        |P=0.501N     P=0.261N     P=0.447N     P=0.475N     | 
|POLY 1.5           |                                                        |P=0.466N     P=0.269N     P=0.466N     P=0.435N     | 
|POLY 6             |                                                        |P=0.541      P=0.261N     P=0.433N     P=0.547N     | 
|LOGISTIC REGRESSION|                                                        |P=0.510N     P=0.269N     P=0.478N     P=0.563N     | 
|COCH-ARM / FISHERS |                                                        |P=0.420N     P=0.288N     P=0.500N     P=0.393N     | 
|ORDER RESTRICTED   |                                                        |P=0.464N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |0/42.30      2/44.05      0/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |                                                        |0/33 (0%)    1/30 (3%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          561          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.441N     P=0.239      (e)          (e)          | 
|POLY 3             |                                                        |P=0.412N     P=0.246      (e)          (e)          | 
|POLY 1.5           |                                                        |P=0.408N     P=0.243      (e)          (e)          | 
|POLY 6             |                                                        |P=0.422N     P=0.246      (e)          (e)          | 
|LOGISTIC REGRESSION|                                                        |P=0.385N     P=0.221      (e)          (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.405N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |                                                        |P=0.279N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 17      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |9/50 (18%)   8/50 (16%)   8/50 (16%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |                                                        |9/42.59      8/44.58      8/45.13      7/38.66      | 
|POLY-3 PERCENT (g) |                                                        |21.1%        17.9%        17.7%        18.1%        | 
|TERMINAL (d)       |                                                        |7/33 (21%)   4/30 (13%)   5/33 (15%)   4/22 (18%)   | 
|FIRST INCIDENCE    |                                                        |687          561          481          589          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.477      P=0.550N     P=0.484N     P=0.498      | 
|POLY 3             |                                                        |P=0.430N     P=0.458N     P=0.447N     P=0.475N     | 
|POLY 1.5           |                                                        |P=0.394N     P=0.472N     P=0.466N     P=0.435N     | 
|POLY 6             |                                                        |P=0.488N     P=0.454N     P=0.433N     P=0.547N     | 
|LOGISTIC REGRESSION|                                                        |P=0.418N     P=0.477N     P=0.478N     P=0.563N     | 
|COCH-ARM / FISHERS |                                                        |P=0.348N     P=0.500N     P=0.500N     P=0.393N     | 
|ORDER RESTRICTED   |                                                        |P=0.561N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Zymbal's Gland                                                                                                                   | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.15      0/45.38      2/44.21      0/44.93     |1/42.47      0/43.50      0/43.84      2/38.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         0.0%        |2.4%         0.0%         0.0%         5.3%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    1/32 (3%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    1/22 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          694          ---         |687          ---          ---          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.596      (e)          P=0.252      (e)         |P=0.173      P=0.505N     P=0.500N     P=0.382      | 
|POLY 3             |     P=0.609      (e)          P=0.242      (e)         |P=0.233      P=0.495N     P=0.494N     P=0.462      | 
|POLY 1.5           |     P=0.607      (e)          P=0.239      (e)         |P=0.237      P=0.496N     P=0.496N     P=0.480      | 
|POLY 6             |     P=0.609      (e)          P=0.247      (e)         |P=0.228      P=0.497N     P=0.493N     P=0.431      | 
|LOGISTIC REGRESSION|     P=0.600      (e)          P=0.243      (e)         |P=0.243      P=0.499N     P=0.499N     P=0.486      | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |P=0.246      P=0.500N     P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.252      (e)          (e)          (e)         |P=0.105      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 18      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.15      0/45.38      0/44.07      0/44.93     |2/43.70      0/43.50      0/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         0.0%        |4.6%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    0/35 (0%)    0/32 (0%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |436          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.305N     P=0.476N     P=0.494N     P=0.494N    |P=0.115N     P=0.232N     P=0.237N     P=0.237N     | 
|POLY 3             |     P=0.314N     P=0.490N     P=0.496N     P=0.492N    |P=0.107N     P=0.238N     P=0.236N     P=0.271N     | 
|POLY 1.5           |     P=0.310N     P=0.496N     P=0.499N     P=0.495N    |P=0.110N     P=0.237N     P=0.236N     P=0.255N     | 
|POLY 6             |     P=0.319N     P=0.482N     P=0.492N     P=0.489N    |P=0.099N     P=0.242N     P=0.237N     P=0.298N     | 
|LOGISTIC REGRESSION|     P=0.305N     (e)          (e)          (e)         |P=0.051N     P=0.306N     P=0.280N     P=0.137N     | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.113N     (e)          (e)          (e)         |P=0.043N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           | 
|     Undifferentiated                                                                                                            | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/50 (44%)  13/50 (26%)  14/50 (28%)  10/50 (20%) |10/50 (20%)  18/50 (36%)  22/50 (44%)  22/50 (44%)  | 
|POLY-3 RATE (b)    |     22/47.44     13/46.73     14/45.29     10/46.51    |10/43.58     18/46.27     22/46.74     22/44.29     | 
|POLY-3 PERCENT (g) |     46.4%        27.8%        30.9%        21.5%       |23.0%        38.9%        47.1%        49.7%        | 
|TERMINAL (d)       |     9/31 (29%)   6/35 (17%)   9/32 (28%)   4/32 (13%)  |6/33 (18%)   8/30 (27%)   12/33 (36%)  5/22 (23%)   | 
|FIRST INCIDENCE    |     355          569          544          569         |477          542          481          516          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.022N*    P=0.039N*    P=0.086N     P=0.016N*   |P<0.001 **   P=0.067      P=0.021 *    P=0.003 **   | 
|POLY 3             |     P=0.013N*    P=0.047N*    P=0.092N     P=0.008N**  |P=0.008 **   P=0.078      P=0.013 *    P=0.007 **   | 
|POLY 1.5           |     P=0.012N*    P=0.049N*    P=0.086N     P=0.008N**  |P=0.009 **   P=0.069      P=0.010 *    P=0.007 **   | 
|POLY 6             |     P=0.014N*    P=0.044N*    P=0.103N     P=0.009N**  |P=0.007 **   P=0.085      P=0.015 *    P=0.006 **   | 
|LOGISTIC REGRESSION|     P=0.014N*    P=0.050N     P=0.072N     P=0.014N*   |P=0.012 *    P=0.061      P=0.010 *    P=0.011 *    | 
|COCH-ARM / FISHERS |     P=0.013N*    P=0.046N*    P=0.072N     P=0.009N**  |P=0.011 *    P=0.059      P=0.009 **   P=0.009 **   | 
|ORDER RESTRICTED   |     P=0.005N**   (e)          (e)          (e)         |P=0.006 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 19      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Benign, Malignant, NOS                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/43.35      2/45.38      1/44.28      2/45.47     |0/42.30      0/43.50      0/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     4.6%         4.4%         2.3%         4.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    2/35 (6%)    0/32 (0%)    1/32 (3%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     675          729 (T)      676          562         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.566N     P=0.649N     P=0.475N     P=0.670N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.567N     P=0.678N     P=0.493N     P=0.677N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.570N     P=0.687N     P=0.498N     P=0.683N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.566N     P=0.665N     P=0.486N     P=0.671N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.579N     P=0.669N     P=0.499N     P=0.674     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.577N     P=0.691N     P=0.500N     P=0.691N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.593N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Malignant                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/43.35      2/45.38      1/44.28      2/45.47     |0/42.30      0/43.50      0/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     4.6%         4.4%         2.3%         4.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    2/35 (6%)    0/32 (0%)    1/32 (3%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     675          729 (T)      676          562         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.566N     P=0.649N     P=0.475N     P=0.670N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.567N     P=0.678N     P=0.493N     P=0.677N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.570N     P=0.687N     P=0.498N     P=0.683N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.566N     P=0.665N     P=0.486N     P=0.671N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.579N     P=0.669N     P=0.499N     P=0.674     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.577N     P=0.691N     P=0.500N     P=0.691N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.593N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 20      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/43.75      2/45.81      0/44.07      0/44.93     |0/42.30      1/44.21      0/43.84      1/37.73      | 
|POLY-3 PERCENT (g) |     2.3%         4.4%         0.0%         0.0%        |0.0%         2.3%         0.0%         2.7%         | 
|TERMINAL (d)       |     0/31 (0%)    1/35 (3%)    0/32 (0%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    1/22 (5%)    | 
|FIRST INCIDENCE    |     536          605          ---          ---         |---          487          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.187N     P=0.522      P=0.500N     P=0.496N    |P=0.373      P=0.517      (e)          P=0.419      | 
|POLY 3             |     P=0.184N     P=0.516      P=0.499N     P=0.495N    |P=0.378      P=0.509      (e)          P=0.477      | 
|POLY 1.5           |     P=0.186N     P=0.507      P=0.500N     P=0.496N    |P=0.391      P=0.506      (e)          P=0.488      | 
|POLY 6             |     P=0.182N     P=0.529      P=0.496N     P=0.493N    |P=0.357      P=0.509      (e)          P=0.458      | 
|LOGISTIC REGRESSION|     P=0.197N     P=0.516      P=0.442N     P=0.674N    |P=0.454      P=0.435      (e)          P=0.419      | 
|COCH-ARM / FISHERS |     P=0.188N     P=0.500      P=0.500N     P=0.500N    |P=0.405      P=0.500      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.171N     (e)          (e)          (e)         |P=0.229      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma or Osteoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/43.75      2/45.81      0/44.07      0/44.93     |0/42.30      1/44.21      0/43.84      1/37.73      | 
|POLY-3 PERCENT (g) |     2.3%         4.4%         0.0%         0.0%        |0.0%         2.3%         0.0%         2.7%         | 
|TERMINAL (d)       |     0/31 (0%)    1/35 (3%)    0/32 (0%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    1/22 (5%)    | 
|FIRST INCIDENCE    |     536          605          ---          ---         |---          487          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.187N     P=0.522      P=0.500N     P=0.496N    |P=0.373      P=0.517      (e)          P=0.419      | 
|POLY 3             |     P=0.184N     P=0.516      P=0.499N     P=0.495N    |P=0.378      P=0.509      (e)          P=0.477      | 
|POLY 1.5           |     P=0.186N     P=0.507      P=0.500N     P=0.496N    |P=0.391      P=0.506      (e)          P=0.488      | 
|POLY 6             |     P=0.182N     P=0.529      P=0.496N     P=0.493N    |P=0.357      P=0.509      (e)          P=0.458      | 
|LOGISTIC REGRESSION|     P=0.197N     P=0.516      P=0.442N     P=0.674N    |P=0.454      P=0.435      (e)          P=0.419      | 
|COCH-ARM / FISHERS |     P=0.188N     P=0.500      P=0.500N     P=0.500N    |P=0.405      P=0.500      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.171N     (e)          (e)          (e)         |P=0.229      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 21      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     49/50 (98%)  49/50 (98%)  48/50 (96%)  48/50 (96%) |43/50 (86%)  42/50 (84%)  45/50 (90%)  36/50 (72%)  | 
|POLY-3 RATE (b)    |     49/49.12     49/49.00     48/48.98     48/49.17    |43/46.94     42/47.57     45/48.01     36/43.88     | 
|POLY-3 PERCENT (g) |     99.8%        100.0%       98.0%        97.6%       |91.6%        88.3%        93.7%        82.0%        | 
|TERMINAL (d)       |     31/31 (100%) 35/35 (100%) 32/32 (100%) 32/32 (100%)|31/33 (94%)  26/30 (87%)  32/33 (97%)  20/22 (91%)  | 
|FIRST INCIDENCE    |     506          393          460          562         |455          374          481          523          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.432N     P=0.210N     P=0.385N     P=0.361N    |P=0.151      P=0.459      P=0.468      P=0.207      | 
|POLY 3             |     P=0.198N     P=1.000      P=0.554N     P=0.477N    |P=0.103N     P=0.418N     P=0.498      P=0.114N     | 
|POLY 1.5           |     P=0.187N     P=0.980      P=0.608N     P=0.446N    |P=0.066N     P=0.437N     P=0.446      P=0.084N     | 
|POLY 6             |     P=0.281N     P=1.000      P=0.526N     P=0.626N    |P=0.248N     P=0.428N     P=0.537      P=0.244N     | 
|LOGISTIC REGRESSION|     P=0.110N     (e)          P=0.629N     P=0.198N    |P=0.095N     P=0.363N     P=0.505      P=0.111N     | 
|COCH-ARM / FISHERS |     P=0.337N     P=0.753N     P=0.500N     P=0.500N    |P=0.043N*    P=0.500N     P=0.380      P=0.070N     | 
|ORDER RESTRICTED   |     P=0.184N     (e)          (e)          (e)         |P=0.078N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     29/50 (58%)  20/50 (40%)  24/50 (48%)  18/50 (36%) |17/50 (34%)  27/50 (54%)  28/50 (56%)  27/50 (54%)  | 
|POLY-3 RATE (b)    |     29/48.05     20/48.14     24/45.66     18/47.96    |17/45.21     27/48.77     28/48.74     27/45.16     | 
|POLY-3 PERCENT (g) |     60.4%        41.6%        52.6%        37.5%       |37.6%        55.4%        57.5%        59.8%        | 
|TERMINAL (d)       |     15/31 (48%)  10/35 (29%)  16/32 (50%)  6/32 (19%)  |9/33 (27%)   11/30 (37%)  14/33 (42%)  8/22 (36%)   | 
|FIRST INCIDENCE    |     355          393          544          562         |436          374          374          516          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.069N     P=0.046N*    P=0.211N     P=0.040N*   |P=0.008 **   P=0.055      P=0.059      P=0.008 **   | 
|POLY 3             |     P=0.037N*    P=0.048N*    P=0.288N     P=0.018N*   |P=0.038 *    P=0.062      P=0.040 *    P=0.025 *    | 
|POLY 1.5           |     P=0.037N*    P=0.053N     P=0.265N     P=0.019N*   |P=0.042 *    P=0.050      P=0.032 *    P=0.027 *    | 
|POLY 6             |     P=0.038N*    P=0.042N*    P=0.322N     P=0.018N*   |P=0.031 *    P=0.074      P=0.048 *    P=0.021 *    | 
|LOGISTIC REGRESSION|     P=0.042N*    P=0.061N     P=0.210N     P=0.032N*   |P=0.082      P=0.027 *    P=0.018 *    P=0.040 *    | 
|COCH-ARM / FISHERS |     P=0.040N*    P=0.055N     P=0.212N     P=0.022N*   |P=0.055      P=0.035 *    P=0.022 *    P=0.035 *    | 
|ORDER RESTRICTED   |     P=0.014N*    (e)          (e)          (e)         |P=0.024 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 22      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                      DIVINYLBENZENE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     50/50 (100%) 49/50 (98%)  49/50 (98%)  49/50 (98%) |46/50 (92%)  46/50 (92%)  49/50 (98%)  47/50 (94%)  | 
|POLY-3 RATE (b)    |     50/50.00     49/49.00     49/49.00     49/49.35    |46/48.43     46/50.00     49/50.00     47/48.56     | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       99.3%       |95.0%        92.0%        98.0%        96.8%        | 
|TERMINAL (d)       |     31/31 (100%) 35/35 (100%) 32/32 (100%) 32/32 (100%)|31/33 (94%)  26/30 (87%)  32/33 (97%)  21/22 (96%)  | 
|FIRST INCIDENCE    |     355          393          460          562         |436          374          374          516          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.457N     P=0.167N     P=0.388N     P=0.362N    |P=0.010 *    P=0.412      P=0.411      P=0.020 *    | 
|POLY 3             |     P=0.660N     P=1.000N     P=1.000N     P=0.968N    |P=0.276      P=0.423N     P=0.391      P=0.528      | 
|POLY 1.5           |     P=0.366N     P=1.000N     P=1.000N     P=0.754N    |P=0.265      P=0.500N     P=0.298      P=0.483      | 
|POLY 6             |     P=1.000N     P=1.000N     P=1.000N     P=1.000N    |P=0.272      P=0.371N     P=0.465      P=0.547      | 
|LOGISTIC REGRESSION|     P=0.062N     (e)          (e)          P=0.288N    |P=0.266      P=0.620N     P=0.208      P=0.387      | 
|COCH-ARM / FISHERS |     P=0.384N     P=0.500N     P=0.500N     P=0.500N    |P=0.344      P=0.643N     P=0.181      P=0.500      | 
|ORDER RESTRICTED   |     P=0.119N     (e)          (e)          (e)         |P=0.273      (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).