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TDMS Study 88004-05 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                      DIVINYLBENZENE                                    DATE: 12/17/03       
EXPERIMENT: 88004 TEST: 05                                                                                     TIME: 11:48:39       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 88004B       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 1321-74-0       
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                                                           FINAL #1 RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                      DIVINYLBENZENE                                    DATE: 12/17/03       
EXPERIMENT: 88004 TEST: 05                                                                                     TIME: 11:48:39       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 88004B       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 1321-74-0       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                     DIVINYLBENZENE                                                                               
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Heart                                  Cardiomyopathy                                                                               
Kidney                                 Nephropathy Chronic                                                                          
Liver                                  Hepatodiaphragmatic Nodule                                                                   
Lung                                   Inflammation Chronic Focal                                                                   
Mesentery                              Necrosis                                                                                     
Nose                                   Foreign Body                                                                                 
                                       Inflammation                                                                                 
Nose: Glands                           Dilatation                                                                                   
Nose: Goblet Cell                      Hyperplasia                                                                                  
Nose: Olfactory Epithelium             Degeneration                                                                                 
                                       Hyperplasia Basal Cell                                                                       
Pancreas: Acinus                       Atrophy                                                                                      
Stomach, Forestomach                   Ulcer                                                                                        
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
Trachea: Glands                        Degeneration Cystic                                                                          
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Vacuolization Cytoplasmic                                                                    
Clitoral Gland                         Cyst                                                                                         
Heart                                  Cardiomyopathy                                                                               
Kidney                                 Nephropathy Chronic                                                                          
Kidney: Cortex                         Infarct                                                                                      
Liver                                  Clear Cell Focus                                                                             
Lung                                   Inflammation Chronic Focal                                                                   
Nose                                   Inflammation                                                                                 
Nose: Glands                           Dilatation                                                                                   
Nose: Olfactory Epithelium             Degeneration                                                                                 
                                       Degeneration Hyaline                                                                         
                                       Hyperplasia Basal Cell                                                                       
Nose: Respiratory Epithelium           Degeneration Hyaline                                                                         
===============================================================                                                                     
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                      DIVINYLBENZENE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/43.25      0/45.38      0/44.07      2/45.12     |0/42.30      0/43.50      0/43.84      1/38.02      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         4.4%        |0.0%         0.0%         0.0%         2.6%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    0/32 (0%)    1/32 (3%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     704          ---          ---          680         |---          ---          ---          653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.250      P=0.463N     P=0.489N     P=0.525     |P=0.159      (e)          (e)          P=0.448      | 
|POLY 3             |     P=0.245      P=0.490N     P=0.496N     P=0.515     |P=0.184      (e)          (e)          P=0.479      | 
|POLY 1.5           |     P=0.247      P=0.496N     P=0.499N     P=0.509     |P=0.190      (e)          (e)          P=0.489      | 
|POLY 6             |     P=0.242      P=0.483N     P=0.493N     P=0.520     |P=0.174      (e)          (e)          P=0.461      | 
|LOGISTIC REGRESSION|     P=0.249      P=0.495N     P=0.497N     P=0.511     |P=0.209      (e)          (e)          P=0.506      | 
|COCH-ARM / FISHERS |     P=0.246      P=0.500N     P=0.500N     P=0.500     |P=0.198      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.140      (e)          (e)          (e)         |P=0.103      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      2/46.30      0/44.07      0/44.93     |0/42.30      1/43.67      0/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         4.3%         0.0%         0.0%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          393          ---          ---         |---          688          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.402N     P=0.258      (e)          (e)         |P=0.631N     P=0.500      (e)          (e)          | 
|POLY 3             |     P=0.387N     P=0.253      (e)          (e)         |P=0.563N     P=0.506      (e)          (e)          | 
|POLY 1.5           |     P=0.395N     P=0.245      (e)          (e)         |P=0.565N     P=0.505      (e)          (e)          | 
|POLY 6             |     P=0.378N     P=0.263      (e)          (e)         |P=0.561N     P=0.506      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.439N     P=0.270      (e)          (e)         |P=0.574N     P=0.501      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |P=0.567N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.254N     (e)          (e)          (e)         |P=0.405N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   8/50 (16%)   7/50 (14%)   6/50 (12%)  |14/50 (28%)  5/50 (10%)   7/50 (14%)   12/50 (24%)  | 
|POLY-3 RATE (b)    |     8/43.25      8/45.64      7/44.58      6/45.14     |14/43.88     5/44.22      7/43.92      12/38.63     | 
|POLY-3 PERCENT (g) |     18.5%        17.5%        15.7%        13.3%       |31.9%        11.3%        15.9%        31.1%        | 
|TERMINAL (d)       |     7/31 (23%)   6/35 (17%)   4/32 (13%)   4/32 (13%)  |8/33 (24%)   2/30 (7%)    6/33 (18%)   8/22 (36%)   | 
|FIRST INCIDENCE    |     704          682          661          680         |437          638          712          626          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.304N     P=0.494N     P=0.464N     P=0.357N    |P=0.214      P=0.037N*    P=0.077N     P=0.348      | 
|POLY 3             |     P=0.283N     P=0.562N     P=0.474N     P=0.353N    |P=0.425      P=0.016N*    P=0.064N     P=0.562N     | 
|POLY 1.5           |     P=0.289N     P=0.588N     P=0.490N     P=0.365N    |P=0.466      P=0.017N*    P=0.065N     P=0.491N     | 
|POLY 6             |     P=0.280N     P=0.526N     P=0.452N     P=0.340N    |P=0.369      P=0.017N*    P=0.066N     P=0.511      | 
|LOGISTIC REGRESSION|     P=0.282N     P=0.505N     P=0.462N     P=0.338N    |P=0.393      P=0.019N*    P=0.059N     P=0.576N     | 
|COCH-ARM / FISHERS |     P=0.305N     P=0.607N     P=0.500N     P=0.387N    |P=0.524      P=0.020N*    P=0.070N     P=0.410N     | 
|ORDER RESTRICTED   |     P=0.404N     (e)          (e)          (e)         |P=0.120N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/50 (24%)  13/50 (26%)  8/50 (16%)   15/50 (30%) |1/50 (2%)    1/50 (2%)    5/50 (10%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     12/45.00     13/46.24     8/45.08      15/45.98    |1/42.30      1/43.50      5/44.10      2/38.02      | 
|POLY-3 PERCENT (g) |     26.7%        28.1%        17.8%        32.6%       |2.4%         2.3%         11.3%        5.3%         | 
|TERMINAL (d)       |     7/31 (23%)   7/35 (20%)   5/32 (16%)   10/32 (31%) |1/33 (3%)    1/30 (3%)    1/33 (3%)    1/22 (5%)    | 
|FIRST INCIDENCE    |     506          569          544          614         |731 (T)      731 (T)      711          653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.342      P=0.547N     P=0.216N     P=0.382     |P=0.169      P=0.741      P=0.117      P=0.377      | 
|POLY 3             |     P=0.336      P=0.532      P=0.222N     P=0.347     |P=0.230      P=0.755N     P=0.111      P=0.463      | 
|POLY 1.5           |     P=0.336      P=0.509      P=0.228N     P=0.340     |P=0.261      P=0.756N     P=0.107      P=0.480      | 
|POLY 6             |     P=0.333      P=0.564      P=0.214N     P=0.353     |P=0.184      P=0.756N     P=0.113      P=0.432      | 
|LOGISTIC REGRESSION|     P=0.339      P=0.509      P=0.227N     P=0.339     |P=0.214      P=0.741      P=0.112      P=0.441      | 
|COCH-ARM / FISHERS |     P=0.327      P=0.500      P=0.227N     P=0.326     |P=0.302      P=0.753N     P=0.102      P=0.500      | 
|ORDER RESTRICTED   |     P=0.285      (e)          (e)          (e)         |P=0.176      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Compression                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/49 (20%)  5/50 (10%)   8/50 (16%)   6/50 (12%)  |9/50 (18%)   10/50 (20%)  11/50 (22%)  7/50 (14%)   | 
|POLY-3 RATE (b)    |     10/44.31     5/45.88      8/45.62      6/45.59     |9/44.18      10/44.13     11/44.69     7/40.47      | 
|POLY-3 PERCENT (g) |     22.6%        10.9%        17.5%        13.2%       |20.4%        22.7%        24.6%        17.3%        | 
|TERMINAL (d)       |     3/30 (10%)   2/35 (6%)    2/32 (6%)    2/32 (6%)   |3/33 (9%)    5/30 (17%)   8/33 (24%)   1/22 (5%)    | 
|FIRST INCIDENCE    |     506          654          586          614         |501          670          582          529          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.257N     P=0.099N     P=0.365N     P=0.191N    |P=0.510      P=0.455      P=0.423      P=0.571N     | 
|POLY 3             |     P=0.245N     P=0.113N     P=0.370N     P=0.186N    |P=0.407N     P=0.499      P=0.411      P=0.467N     | 
|POLY 1.5           |     P=0.242N     P=0.119N     P=0.379N     P=0.188N    |P=0.369N     P=0.504      P=0.410      P=0.432N     | 
|POLY 6             |     P=0.252N     P=0.105N     P=0.359N     P=0.188N    |P=0.476N     P=0.481      P=0.406      P=0.531N     | 
|LOGISTIC REGRESSION|     P=0.259N     P=0.125N     P=0.378N     P=0.222N    |P=0.334N     P=0.510      P=0.408      P=0.345N     | 
|COCH-ARM / FISHERS |     P=0.248N     P=0.122N     P=0.379N     P=0.194N    |P=0.322N     P=0.500      P=0.402      P=0.393N     | 
|ORDER RESTRICTED   |     P=0.174N     (e)          (e)          (e)         |P=0.443N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    2/50 (4%)    6/50 (12%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/42.15      1/45.65      0/44.07      1/45.01     |2/43.34      2/44.06      6/45.50      3/39.24      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         2.2%        |4.6%         4.5%         13.2%        7.6%         | 
|TERMINAL (d)       |     0/30 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          654          ---          710         |501          642          500          525          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.408      P=0.529      (e)          P=0.512     |P=0.246      P=0.670N     P=0.161      P=0.472      | 
|POLY 3             |     P=0.421      P=0.516      (e)          P=0.513     |P=0.260      P=0.688N     P=0.149      P=0.455      | 
|POLY 1.5           |     P=0.417      P=0.509      (e)          P=0.510     |P=0.291      P=0.689N     P=0.143      P=0.476      | 
|POLY 6             |     P=0.426      P=0.525      (e)          P=0.517     |P=0.213      P=0.692N     P=0.154      P=0.418      | 
|LOGISTIC REGRESSION|     P=0.405      P=0.505      (e)          P=0.514     |P=0.428      P=0.649      P=0.103      P=0.591      | 
|COCH-ARM / FISHERS |     P=0.408      P=0.505      (e)          P=0.505     |P=0.331      P=0.691N     P=0.134      P=0.500      | 
|ORDER RESTRICTED   |     P=0.265      (e)          (e)          (e)         |P=0.246      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/50 (6%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |3/42.30      0/43.50      1/43.91      0/37.73      | 
|POLY-3 PERCENT (g) |                                                        |7.1%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |                                                        |3/33 (9%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |                                                        |731 (T)      ---          715          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.121N     P=0.138N     P=0.304N     P=0.200N     | 
|POLY 3             |                                                        |P=0.091N     P=0.113N     P=0.292N     P=0.140N     | 
|POLY 1.5           |                                                        |P=0.089N     P=0.115N     P=0.297N     P=0.130N     | 
|POLY 6             |                                                        |P=0.093N     P=0.114N     P=0.288N     P=0.160N     | 
|LOGISTIC REGRESSION|                                                        |P=0.114N     (e)          P=0.290N     (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.086N     P=0.121N     P=0.309N     P=0.121N     | 
|ORDER RESTRICTED   |                                                        |P=0.029N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    3/50 (6%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |1/42.30      3/43.50      2/43.84      2/37.82      | 
|POLY-3 PERCENT (g) |                                                        |2.4%         6.9%         4.6%         5.3%         | 
|TERMINAL (d)       |                                                        |1/33 (3%)    3/30 (10%)   2/33 (6%)    1/22 (5%)    | 
|FIRST INCIDENCE    |                                                        |731 (T)      731 (T)      731 (T)      708          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.347      P=0.271      P=0.500      P=0.366      | 
|POLY 3             |                                                        |P=0.441      P=0.315      P=0.512      P=0.461      | 
|POLY 1.5           |                                                        |P=0.468      P=0.313      P=0.508      P=0.479      | 
|POLY 6             |                                                        |P=0.397      P=0.312      P=0.515      P=0.429      | 
|LOGISTIC REGRESSION|                                                        |P=0.346      P=0.271      P=0.500      P=0.385      | 
|COCH-ARM / FISHERS |                                                        |P=0.500      P=0.309      P=0.500      P=0.500      | 
|ORDER RESTRICTED   |                                                        |P=0.405      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |2/42.30      1/43.50      1/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |                                                        |4.7%         2.3%         2.3%         0.0%         | 
|TERMINAL (d)       |                                                        |2/33 (6%)    1/30 (3%)    1/33 (3%)    0/22 (0%)    | 
|FIRST INCIDENCE    |                                                        |731 (T)      731 (T)      731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.207N     P=0.533N     P=0.500N     P=0.331N     | 
|POLY 3             |                                                        |P=0.168N     P=0.490N     P=0.488N     P=0.263N     | 
|POLY 1.5           |                                                        |P=0.162N     P=0.493N     P=0.492N     P=0.251N     | 
|POLY 6             |                                                        |P=0.177N     P=0.493N     P=0.485N     P=0.287N     | 
|LOGISTIC REGRESSION|                                                        |P=0.207N     P=0.533N     P=0.500N     (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.153N     P=0.500N     P=0.500N     P=0.247N     | 
|ORDER RESTRICTED   |                                                        |P=0.139N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Lens                                                                                                                        | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/48 (2%)    3/48 (6%)    1/49 (2%)   |1/50 (2%)    3/48 (6%)    4/49 (8%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     2/43.52      1/44.87      3/43.35      1/43.97     |1/42.30      3/42.33      4/43.73      1/37.33      | 
|POLY-3 PERCENT (g) |     4.6%         2.2%         6.9%         2.3%        |2.4%         7.1%         9.2%         2.7%         | 
|TERMINAL (d)       |     1/31 (3%)    1/35 (3%)    2/32 (6%)    0/32 (0%)   |1/33 (3%)    3/30 (10%)   3/33 (9%)    1/22 (5%)    | 
|FIRST INCIDENCE    |     623          729 (T)      544          724         |731 (T)      731 (T)      614          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.471N     P=0.461N     P=0.515      P=0.485N    |P=0.511      P=0.271      P=0.184      P=0.669      | 
|POLY 3             |     P=0.478N     P=0.489N     P=0.498      P=0.496N    |P=0.575      P=0.305      P=0.188      P=0.732      | 
|POLY 1.5           |     P=0.477N     P=0.500N     P=0.489      P=0.500N    |P=0.563N     P=0.301      P=0.182      P=0.744      | 
|POLY 6             |     P=0.483N     P=0.476N     P=0.510      P=0.494N    |P=0.511      P=0.305      P=0.194      P=0.711      | 
|LOGISTIC REGRESSION|     P=0.483N     P=0.520N     P=0.482      P=0.508N    |P=0.565      P=0.271      P=0.183      P=0.669      | 
|COCH-ARM / FISHERS |     P=0.479N     P=0.515N     P=0.480      P=0.508N    |P=0.527N     P=0.293      P=0.175      P=0.747      | 
|ORDER RESTRICTED   |     P=0.458N     (e)          (e)          (e)         |P=0.341      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   5/50 (10%)   1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     7/43.15      5/45.38      1/44.07      1/44.93     |0/42.30      0/43.50      0/43.84      3/38.21      | 
|POLY-3 PERCENT (g) |     16.2%        11.0%        2.3%         2.2%        |0.0%         0.0%         0.0%         7.9%         | 
|TERMINAL (d)       |     7/31 (23%)   5/35 (14%)   1/32 (3%)    1/32 (3%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    2/22 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          ---          ---          589          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.008N**   P=0.292N     P=0.027N*    P=0.027N*   |P=0.005 **   (e)          (e)          P=0.076      | 
|POLY 3             |     P=0.008N**   P=0.343N     P=0.027N*    P=0.025N*   |P=0.010 *    (e)          (e)          P=0.101      | 
|POLY 1.5           |     P=0.008N**   P=0.364N     P=0.029N*    P=0.027N*   |P=0.010 *    (e)          (e)          P=0.109      | 
|POLY 6             |     P=0.008N**   P=0.317N     P=0.025N*    P=0.024N*   |P=0.009 **   (e)          (e)          P=0.088      | 
|LOGISTIC REGRESSION|     P=0.008N**   P=0.292N     P=0.027N*    P=0.027N*   |P=0.011 *    (e)          (e)          P=0.107      | 
|COCH-ARM / FISHERS |     P=0.010N*    P=0.380N     P=0.030N*    P=0.030N*   |P=0.012 *    (e)          (e)          P=0.121      | 
|ORDER RESTRICTED   |     P=0.009N**   (e)          (e)          (e)         |P=0.005 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Atrium                                                                                                                    | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/43.71      1/45.38      2/44.60      1/45.47     |0/42.30      1/43.50      2/43.88      0/37.73      | 
|POLY-3 PERCENT (g) |     4.6%         2.2%         4.5%         2.2%        |0.0%         2.3%         4.6%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    1/32 (3%)    0/32 (0%)   |0/33 (0%)    1/30 (3%)    1/33 (3%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     561          728          568          562         |---          731 (T)      722          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.440N     P=0.464N     P=0.683N     P=0.483N    |P=0.610      P=0.481      P=0.243      (e)          | 
|POLY 3             |     P=0.437N     P=0.487N     P=0.687N     P=0.486N    |P=0.621      P=0.506      P=0.245      (e)          | 
|POLY 1.5           |     P=0.438N     P=0.495N     P=0.692N     P=0.491N    |P=0.641N     P=0.504      P=0.242      (e)          | 
|POLY 6             |     P=0.438N     P=0.476N     P=0.681N     P=0.482N    |P=0.563      P=0.504      P=0.247      (e)          | 
|LOGISTIC REGRESSION|     P=0.469N     P=0.501N     P=0.686N     P=0.614N    |P=0.615      P=0.481      P=0.246      (e)          | 
|COCH-ARM / FISHERS |     P=0.444N     P=0.500N     P=0.691N     P=0.500N    |P=0.616N     P=0.500      P=0.247      (e)          | 
|ORDER RESTRICTED   |     P=0.425N     (e)          (e)          (e)         |P=0.334      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/48 (2%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.38      1/44.37      2/44.07      2/44.93     |0/42.30      0/43.50      0/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     2.3%         2.3%         4.5%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    1/34 (3%)    2/32 (6%)    2/32 (6%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     666          729 (T)      729 (T)      729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.341      P=0.742N     P=0.510      P=0.516     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.349      P=0.756N     P=0.506      P=0.512     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.348      P=0.760      P=0.501      P=0.508     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.348      P=0.748N     P=0.510      P=0.515     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.348      P=0.757      P=0.508      P=0.514     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.342      P=0.742      P=0.500      P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.449      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy Chronic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     37/50 (74%)  41/49 (84%)  41/50 (82%)  45/49 (92%) |19/50 (38%)  21/50 (42%)  19/49 (39%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |     37/46.60     41/47.56     41/47.29     45/48.00    |19/45.20     21/44.85     19/44.49     10/39.39     | 
|POLY-3 PERCENT (g) |     79.4%        86.2%        86.7%        93.8%       |42.0%        46.8%        42.7%        25.4%        | 
|TERMINAL (d)       |     27/31 (87%)  31/35 (89%)  29/32 (91%)  31/32 (97%) |13/33 (39%)  15/30 (50%)  16/33 (49%)  5/22 (23%)   | 
|FIRST INCIDENCE    |     506          569          544          513         |437          543          374          535          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.092      P=0.532N     P=0.381      P=0.160     |P=0.173N     P=0.331      P=0.570N     P=0.225N     | 
|POLY 3             |     P=0.025 *    P=0.263      P=0.238      P=0.027 *   |P=0.052N     P=0.402      P=0.560      P=0.080N     | 
|POLY 1.5           |     P=0.021 *    P=0.216      P=0.212      P=0.022 *   |P=0.033N*    P=0.413      P=0.560      P=0.057N     | 
|POLY 6             |     P=0.031 *    P=0.355      P=0.294      P=0.035 *   |P=0.099N     P=0.378      P=0.550      P=0.133N     | 
|LOGISTIC REGRESSION|     P=0.024 *    P=0.305      P=0.249      P=0.030 *   |P=0.033N*    P=0.446      P=0.572      P=0.050N     | 
|COCH-ARM / FISHERS |     P=0.019 *    P=0.176      P=0.235      P=0.017 *   |P=0.019N*    P=0.419      P=0.551      P=0.038N*    | 
|ORDER RESTRICTED   |     P=0.019 *    (e)          (e)          (e)         |P=0.052N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Cortex                                                                                                                   | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/49 (2%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/43.16      1/45.90      0/44.07      0/43.95     |0/42.30      0/43.50      0/43.33      2/38.38      | 
|POLY-3 PERCENT (g) |     2.3%         2.2%         0.0%         0.0%        |0.0%         0.0%         0.0%         5.2%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    1/22 (5%)    | 
|FIRST INCIDENCE    |     725          569          ---          ---         |---          ---          ---          516          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.237N     P=0.740N     P=0.500N     P=0.500N    |P=0.037 *    (e)          (e)          P=0.209      | 
|POLY 3             |     P=0.237N     P=0.747N     P=0.496N     P=0.496N    |P=0.042 *    (e)          (e)          P=0.216      | 
|POLY 1.5           |     P=0.238N     P=0.754N     P=0.499N     P=0.499N    |P=0.043 *    (e)          (e)          P=0.226      | 
|POLY 6             |     P=0.237N     P=0.737N     P=0.492N     P=0.494N    |P=0.040 *    (e)          (e)          P=0.198      | 
|LOGISTIC REGRESSION|     P=0.241N     P=0.725      P=0.488N     P=0.493N    |P=0.060      (e)          (e)          P=0.256      | 
|COCH-ARM / FISHERS |     P=0.237N     P=0.747      P=0.500N     P=0.505N    |P=0.047 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.247N     (e)          (e)          (e)         |P=0.023 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Cortex, Renal Tubule                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/49 (4%)    0/50 (0%)    2/49 (4%)   |1/50 (2%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.15      2/45.37      0/44.07      2/44.25     |1/42.30      1/43.64      0/43.33      0/37.73      | 
|POLY-3 PERCENT (g) |     2.3%         4.4%         0.0%         4.5%        |2.4%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    2/35 (6%)    0/32 (0%)    0/32 (0%)   |1/33 (3%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          674         |731 (T)      696          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.476      P=0.543      P=0.494N     P=0.528     |P=0.283N     P=0.750      P=0.500N     P=0.581N     | 
|POLY 3             |     P=0.476      P=0.518      P=0.496N     P=0.509     |P=0.237N     P=0.754N     P=0.495N     P=0.523N     | 
|POLY 1.5           |     P=0.472      P=0.507      P=0.499N     P=0.503     |P=0.238N     P=0.756N     P=0.498N     P=0.512N     | 
|POLY 6             |     P=0.480      P=0.531      P=0.492N     P=0.515     |P=0.234N     P=0.755N     P=0.493N     P=0.542N     | 
|LOGISTIC REGRESSION|     P=0.470      P=0.543      (e)          P=0.503     |P=0.256N     P=0.758N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.465      P=0.492      P=0.500N     P=0.492     |P=0.236N     P=0.753N     P=0.505N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.418      (e)          (e)          (e)         |P=0.274N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    2/49 (4%)    3/50 (6%)    2/49 (4%)   |0/50 (0%)    1/50 (2%)    3/49 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.69      2/45.37      3/44.21      2/43.95     |0/42.30      1/43.58      3/43.39      0/37.73      | 
|POLY-3 PERCENT (g) |     2.3%         4.4%         6.8%         4.6%        |0.0%         2.3%         6.9%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    2/35 (6%)    2/32 (6%)    2/32 (6%)   |0/33 (0%)    0/30 (0%)    2/33 (6%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      694          729 (T)     |---          711          715          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.400      P=0.543      P=0.322      P=0.511     |P=0.531      P=0.488      P=0.125      (e)          | 
|POLY 3             |     P=0.413      P=0.521      P=0.318      P=0.510     |P=0.549      P=0.506      P=0.123      (e)          | 
|POLY 1.5           |     P=0.411      P=0.512      P=0.314      P=0.507     |P=0.589      P=0.504      P=0.120      (e)          | 
|POLY 6             |     P=0.412      P=0.533      P=0.323      P=0.513     |P=0.477      P=0.505      P=0.125      (e)          | 
|LOGISTIC REGRESSION|     P=0.400      P=0.543      P=0.323      P=0.511     |P=0.560      P=0.505      P=0.126      (e)          | 
|COCH-ARM / FISHERS |     P=0.404      P=0.500      P=0.316      P=0.500     |P=0.633      P=0.500      P=0.117      (e)          | 
|ORDER RESTRICTED   |     P=0.367      (e)          (e)          (e)         |P=0.228      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    1/50 (2%)    1/49 (2%)   |0/50 (0%)    2/50 (4%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.69      1/45.37      1/44.07      1/43.95     |0/42.30      2/43.58      1/43.39      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         2.3%         2.3%        |0.0%         4.6%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    1/35 (3%)    1/32 (3%)    1/32 (3%)   |0/33 (0%)    1/30 (3%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      729 (T)     |---          711          715          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.381      P=0.524      P=0.506      P=0.506     |P=0.558N     P=0.223      P=0.506      (e)          | 
|POLY 3             |     P=0.393      P=0.512      P=0.506      P=0.506     |P=0.494N     P=0.244      P=0.505      (e)          | 
|POLY 1.5           |     P=0.391      P=0.507      P=0.504      P=0.504     |P=0.479N     P=0.242      P=0.502      (e)          | 
|POLY 6             |     P=0.394      P=0.519      P=0.509      P=0.507     |P=0.522N     P=0.242      P=0.508      (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.524      P=0.506      P=0.506     |P=0.523N     P=0.239      P=0.505      (e)          | 
|COCH-ARM / FISHERS |     P=0.384      P=0.500      P=0.505      P=0.500     |P=0.462N     P=0.247      P=0.495      (e)          | 
|ORDER RESTRICTED   |     P=0.332      (e)          (e)          (e)         |P=0.341      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    5/49 (10%)   1/50 (2%)    1/50 (2%)   |5/50 (10%)   7/50 (14%)   6/50 (12%)   0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/43.15      5/45.65      1/44.07      1/44.93     |5/42.68      7/43.90      6/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     4.6%         11.0%        2.3%         2.2%        |11.7%        15.9%        13.7%        0.0%         | 
|TERMINAL (d)       |     2/31 (7%)    4/35 (11%)   1/32 (3%)    1/32 (3%)   |4/33 (12%)   6/30 (20%)   6/33 (18%)   0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      654          729 (T)      729 (T)     |625          617          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.192N     P=0.270      P=0.489N     P=0.489N    |P=0.069N     P=0.331      P=0.502      P=0.075N     | 
|POLY 3             |     P=0.177N     P=0.239      P=0.493N     P=0.486N    |P=0.045N*    P=0.398      P=0.519      P=0.042N*    | 
|POLY 1.5           |     P=0.182N     P=0.226      P=0.498N     P=0.491N    |P=0.035N*    P=0.394      P=0.513      P=0.036N*    | 
|POLY 6             |     P=0.172N     P=0.258      P=0.486N     P=0.481N    |P=0.067N     P=0.393      P=0.519      P=0.054N     | 
|LOGISTIC REGRESSION|     P=0.183N     P=0.252      P=0.489N     P=0.489N    |P=0.050N     P=0.396      P=0.529      P=0.049N*    | 
|COCH-ARM / FISHERS |     P=0.192N     P=0.210      P=0.500N     P=0.500N    |P=0.027N*    P=0.380      P=0.500      P=0.028N*    | 
|ORDER RESTRICTED   |     P=0.175N     (e)          (e)          (e)         |P=0.033N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/49 (4%)    4/50 (8%)    8/50 (16%)  |5/50 (10%)   7/50 (14%)   6/50 (12%)   9/50 (18%)   | 
|POLY-3 RATE (b)    |     2/43.15      2/45.37      4/45.35      8/45.45     |5/42.68      7/43.67      6/44.06      9/40.10      | 
|POLY-3 PERCENT (g) |     4.6%         4.4%         8.8%         17.6%       |11.7%        16.0%        13.6%        22.4%        | 
|TERMINAL (d)       |     2/31 (7%)    2/35 (6%)    2/32 (6%)    7/32 (22%)  |4/33 (12%)   6/30 (20%)   5/33 (15%)   3/22 (14%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      460          569         |625          688          673          523          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.011 *    P=0.651N     P=0.352      P=0.052     |P=0.053      P=0.327      P=0.503      P=0.086      | 
|POLY 3             |     P=0.012 *    P=0.676N     P=0.360      P=0.053     |P=0.137      P=0.395      P=0.522      P=0.155      | 
|POLY 1.5           |     P=0.011 *    P=0.686N     P=0.348      P=0.051     |P=0.153      P=0.392      P=0.515      P=0.173      | 
|POLY 6             |     P=0.012 *    P=0.662N     P=0.374      P=0.056     |P=0.115      P=0.387      P=0.526      P=0.126      | 
|LOGISTIC REGRESSION|     P=0.011 *    P=0.651N     P=0.343      P=0.055     |P=0.127      P=0.391      P=0.527      P=0.180      | 
|COCH-ARM / FISHERS |     P=0.011 *    P=0.684      P=0.339      P=0.046 *   |P=0.172      P=0.380      P=0.500      P=0.194      | 
|ORDER RESTRICTED   |     P=0.020 *    (e)          (e)          (e)         |P=0.145      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/49 (2%)    3/50 (6%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.17      1/45.90      3/44.85      2/45.50     |0/42.30      0/43.50      1/43.88      0/37.73      | 
|POLY-3 PERCENT (g) |     2.3%         2.2%         6.7%         4.4%        |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    1/32 (3%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     722          569          460          562         |---          ---          722          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.333      P=0.740N     P=0.321      P=0.520     |P=0.655      (e)          P=0.506      (e)          | 
|POLY 3             |     P=0.341      P=0.747N     P=0.319      P=0.518     |P=0.635      (e)          P=0.507      (e)          | 
|POLY 1.5           |     P=0.337      P=0.754N     P=0.312      P=0.511     |P=0.663      (e)          P=0.505      (e)          | 
|POLY 6             |     P=0.342      P=0.737N     P=0.327      P=0.525     |P=0.584      (e)          P=0.509      (e)          | 
|LOGISTIC REGRESSION|     P=0.303      P=0.724      P=0.310      P=0.471     |P=0.669      (e)          P=0.508      (e)          | 
|COCH-ARM / FISHERS |     P=0.327      P=0.747      P=0.309      P=0.500     |P=0.694      (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.340      (e)          (e)          (e)         |P=0.389      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/49 (4%)    3/50 (6%)    3/50 (6%)   |4/50 (8%)    3/50 (6%)    0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/43.35      2/45.64      3/44.58      3/45.44     |4/43.26      3/43.78      0/43.84      3/38.90      | 
|POLY-3 PERCENT (g) |     2.3%         4.4%         6.7%         6.6%        |9.3%         6.9%         0.0%         7.7%         | 
|TERMINAL (d)       |     0/31 (0%)    1/35 (3%)    0/32 (0%)    1/32 (3%)   |1/33 (3%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     675          659          661          638         |477          703          ---          529          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.242      P=0.540      P=0.337      P=0.334     |P=0.488N     P=0.524N     P=0.065N     P=0.624N     | 
|POLY 3             |     P=0.243      P=0.518      P=0.315      P=0.322     |P=0.388N     P=0.493N     P=0.058N     P=0.558N     | 
|POLY 1.5           |     P=0.239      P=0.507      P=0.309      P=0.316     |P=0.381N     P=0.494N     P=0.059N     P=0.531N     | 
|POLY 6             |     P=0.246      P=0.531      P=0.324      P=0.329     |P=0.396N     P=0.500N     P=0.059N     P=0.604N     | 
|LOGISTIC REGRESSION|     P=0.225      P=0.481      P=0.305      P=0.290     |P=0.339N     P=0.507N     P=0.068N     P=0.460N     | 
|COCH-ARM / FISHERS |     P=0.230      P=0.492      P=0.309      P=0.309     |P=0.371N     P=0.500N     P=0.059N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.280      (e)          (e)          (e)         |P=0.227N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      0/45.37      3/44.07      0/44.93     |0/42.30      0/43.50      1/43.92      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         6.8%         0.0%        |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    3/32 (9%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          711          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.538      (e)          P=0.126      (e)         |P=0.659      (e)          P=0.516      (e)          | 
|POLY 3             |     P=0.554      (e)          P=0.122      (e)         |P=0.635      (e)          P=0.507      (e)          | 
|POLY 1.5           |     P=0.551      (e)          P=0.120      (e)         |P=0.663      (e)          P=0.505      (e)          | 
|POLY 6             |     P=0.554      (e)          P=0.125      (e)         |P=0.584      (e)          P=0.509      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.126      (e)         |P=0.680      (e)          P=0.507      (e)          | 
|COCH-ARM / FISHERS |     P=0.541      (e)          P=0.121      (e)         |P=0.694      (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.166      (e)          (e)          (e)         |P=0.390      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Periportal                                                                                                                | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    2/50 (4%)    0/50 (0%)   |3/50 (6%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.15      0/45.37      2/44.07      0/44.93     |3/43.09      2/43.61      1/43.84      2/38.18      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         0.0%        |7.0%         4.6%         2.3%         5.2%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    2/32 (6%)    0/32 (0%)   |2/33 (6%)    1/30 (3%)    1/33 (3%)    1/22 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |436          703          731 (T)      600          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.594      (e)          P=0.245      (e)         |P=0.522N     P=0.530N     P=0.308N     P=0.619N     | 
|POLY 3             |     P=0.608      (e)          P=0.242      (e)         |P=0.431N     P=0.495N     P=0.299N     P=0.555N     | 
|POLY 1.5           |     P=0.605      (e)          P=0.239      (e)         |P=0.421N     P=0.495N     P=0.301N     P=0.530N     | 
|POLY 6             |     P=0.608      (e)          P=0.246      (e)         |P=0.445N     P=0.499N     P=0.298N     P=0.596N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.245      (e)         |P=0.398N     P=0.513N     P=0.319N     P=0.478N     | 
|COCH-ARM / FISHERS |     P=0.596      (e)          P=0.247      (e)         |P=0.404N     P=0.500N     P=0.309N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.252      (e)          (e)          (e)         |P=0.394N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Portal                                                                                                                    | 
|     Bile Stasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    3/50 (6%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.15      0/45.37      0/44.07      0/44.93     |1/42.88      3/43.61      2/43.84      1/38.18      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         6.9%         4.6%         2.6%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)   |0/33 (0%)    2/30 (7%)    2/33 (6%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |549          703          731 (T)      600          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.583N     P=0.295      P=0.508      P=0.749      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.523N     P=0.311      P=0.508      P=0.734      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.501N     P=0.310      P=0.505      P=0.747      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.559N     P=0.307      P=0.508      P=0.712      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.481N     P=0.301      P=0.493      P=0.722N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.474N     P=0.309      P=0.500      P=0.753N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.467      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    4/50 (8%)    4/50 (8%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/43.58      1/45.38      4/45.21      4/45.50     |1/43.09      1/43.50      1/44.53      1/38.72      | 
|POLY-3 PERCENT (g) |     4.6%         2.2%         8.9%         8.8%        |2.3%         2.3%         2.3%         2.6%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    2/32 (6%)    2/32 (6%)   |0/33 (0%)    1/30 (3%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     612          728          114          562         |437          731 (T)      497          151          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.166      P=0.464N     P=0.358      P=0.363     |P=0.614      P=0.750      P=0.755N     P=0.760      | 
|POLY 3             |     P=0.169      P=0.486N     P=0.354      P=0.357     |P=0.595      P=0.759N     P=0.753N     P=0.737      | 
|POLY 1.5           |     P=0.168      P=0.494N     P=0.348      P=0.350     |P=0.614      P=0.759N     P=0.756N     P=0.749      | 
|POLY 6             |     P=0.168      P=0.475N     P=0.361      P=0.363     |P=0.563      P=0.760      P=0.752N     P=0.713      | 
|LOGISTIC REGRESSION|     P=0.132      P=0.501N     P=0.370      P=0.315     |P=0.432N     P=0.725      P=0.725      (e)          | 
|COCH-ARM / FISHERS |     P=0.160      P=0.500N     P=0.339      P=0.339     |P=0.634      P=0.753N     P=0.753N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.226      (e)          (e)          (e)         |P=0.707      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic Focal                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    5/50 (10%)   14/50 (28%) |27/50 (54%)  22/50 (44%)  26/50 (52%)  33/50 (66%)  | 
|POLY-3 RATE (b)    |     4/44.22      4/45.38      5/44.07      14/45.09    |27/43.93     22/44.39     26/45.99     33/43.70     | 
|POLY-3 PERCENT (g) |     9.1%         8.8%         11.3%        31.1%       |61.5%        49.6%        56.5%        75.5%        | 
|TERMINAL (d)       |     2/31 (7%)    3/35 (9%)    5/32 (16%)   13/32 (41%) |22/33 (67%)  14/30 (47%)  20/33 (61%)  17/22 (77%)  | 
|FIRST INCIDENCE    |     536          728          729 (T)      687         |437          670          374          535          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.587N     P=0.514      P=0.011 *   |P<0.001 **   P=0.349N     P=0.485N     P=0.004 **   | 
|POLY 3             |     P<0.001 **   P=0.629N     P=0.498      P=0.008 **  |P=0.039 *    P=0.174N     P=0.395N     P=0.104      | 
|POLY 1.5           |     P<0.001 **   P=0.639N     P=0.495      P=0.008 **  |P=0.045 *    P=0.185N     P=0.432N     P=0.118      | 
|POLY 6             |     P<0.001 **   P=0.616N     P=0.501      P=0.008 **  |P=0.032 *    P=0.174N     P=0.369N     P=0.083      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.643      P=0.501      P=0.012 *   |P=0.016 *    P=0.153N     P=0.432N     P=0.055      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.643N     P=0.500      P=0.009 **  |P=0.062      P=0.212N     P=0.500N     P=0.154      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.031 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    8/50 (16%)   6/50 (12%)   6/50 (12%)  |4/50 (8%)    2/50 (4%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/43.49      8/45.41      6/44.21      6/46.31     |4/42.30      2/43.64      3/43.84      1/37.73      | 
|POLY-3 PERCENT (g) |     9.2%         17.6%        13.6%        13.0%       |9.5%         4.6%         6.8%         2.7%         | 
|TERMINAL (d)       |     2/31 (7%)    6/35 (17%)   5/32 (16%)   3/32 (9%)   |4/33 (12%)   1/30 (3%)    3/33 (9%)    1/22 (5%)    | 
|FIRST INCIDENCE    |     638          722          694          513         |731 (T)      696          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.445      P=0.248      P=0.394      P=0.404     |P=0.271N     P=0.374N     P=0.500N     P=0.318N     | 
|POLY 3             |     P=0.491      P=0.197      P=0.379      P=0.409     |P=0.196N     P=0.322N     P=0.480N     P=0.214N     | 
|POLY 1.5           |     P=0.474      P=0.185      P=0.372      P=0.395     |P=0.181N     P=0.327N     P=0.487N     P=0.197N     | 
|POLY 6             |     P=0.507      P=0.213      P=0.388      P=0.424     |P=0.221N     P=0.324N     P=0.477N     P=0.248N     | 
|LOGISTIC REGRESSION|     P=0.456      P=0.228      P=0.393      P=0.334     |P=0.263N     P=0.339N     P=0.500N     P=0.318N     | 
|COCH-ARM / FISHERS |     P=0.442      P=0.178      P=0.370      P=0.370     |P=0.162N     P=0.339N     P=0.500N     P=0.181N     | 
|ORDER RESTRICTED   |     P=0.353      (e)          (e)          (e)         |P=0.165N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.15      1/45.38      1/44.10      2/44.93     |1/42.92      1/43.50      0/43.84      1/38.36      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         2.3%         4.5%        |2.3%         2.3%         0.0%         2.6%         | 
|TERMINAL (d)       |     0/31 (0%)    1/35 (3%)    0/32 (0%)    2/32 (6%)   |0/33 (0%)    1/30 (3%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      722          729 (T)     |533          731 (T)      ---          523          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.150      P=0.524      P=0.512      P=0.245     |P=0.637N     P=0.760      P=0.491N     P=0.743N     | 
|POLY 3             |     P=0.161      P=0.510      P=0.504      P=0.246     |P=0.618N     P=0.758N     P=0.496N     P=0.735      | 
|POLY 1.5           |     P=0.159      P=0.504      P=0.501      P=0.243     |P=0.617N     P=0.758N     P=0.497N     P=0.747      | 
|POLY 6             |     P=0.162      P=0.518      P=0.508      P=0.249     |P=0.616N     P=0.761      P=0.496N     P=0.713      | 
|LOGISTIC REGRESSION|     P=0.150      P=0.524      P=0.511      P=0.245     |P=0.544N     P=0.744      P=0.540N     P=0.701N     | 
|COCH-ARM / FISHERS |     P=0.153      P=0.500      P=0.500      P=0.247     |P=0.616N     P=0.753N     P=0.500N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.126      (e)          (e)          (e)         |P=0.559N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Infiltration Cellular Focal Histiocyte                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   12/50 (24%)  11/50 (22%)  4/50 (8%)   |8/50 (16%)   3/50 (6%)    6/50 (12%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     9/43.15      12/46.68     11/45.21     4/45.58     |8/43.80      3/43.67      6/44.56      5/38.52      | 
|POLY-3 PERCENT (g) |     20.9%        25.7%        24.3%        8.8%        |18.3%        6.9%         13.5%        13.0%        | 
|TERMINAL (d)       |     9/31 (29%)   9/35 (26%)   9/32 (28%)   3/32 (9%)   |5/33 (15%)   2/30 (7%)    5/33 (15%)   2/22 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      106          114          513         |437          688          481          535          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.066N     P=0.423      P=0.431      P=0.101N    |P=0.552N     P=0.128N     P=0.383N     P=0.488N     | 
|POLY 3             |     P=0.050N     P=0.385      P=0.446      P=0.094N    |P=0.423N     P=0.098N     P=0.373N     P=0.362N     | 
|POLY 1.5           |     P=0.056N     P=0.353      P=0.428      P=0.102N    |P=0.393N     P=0.097N     P=0.377N     P=0.322N     | 
|POLY 6             |     P=0.046N*    P=0.430      P=0.469      P=0.085N    |P=0.467N     P=0.102N     P=0.372N     P=0.433N     | 
|LOGISTIC REGRESSION|     P=0.070N     P=0.317      P=0.406      P=0.098N    |P=0.363N     P=0.102N     P=0.397N     P=0.287N     | 
|COCH-ARM / FISHERS |     P=0.068N     P=0.312      P=0.402      P=0.117N    |P=0.351N     P=0.100N     P=0.387N     P=0.277N     | 
|ORDER RESTRICTED   |     P=0.057N     (e)          (e)          (e)         |P=0.269N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/19 (0%)    0/23 (0%)    0/25 (0%)    0/38 (0%)   |2/32 (6%)    1/37 (3%)    0/44 (0%)    0/34 (0%)    | 
|POLY-3 RATE (b)    |     0/16.52      0/21.53      0/22.26      0/33.09     |2/27.90      1/31.37      0/39.22      0/24.83      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |7.2%         3.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/11 (0%)    0/14 (0%)    0/17 (0%)    0/22 (0%)   |0/19 (0%)    1/19 (5%)    0/29 (0%)    0/13 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |437          731 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.099N     P=0.488N     P=0.233N     P=0.223N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.080N     P=0.459N     P=0.164N     P=0.263N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.083N     P=0.454N     P=0.166N     P=0.245N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.075N     P=0.467N     P=0.162N     P=0.292N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.052N     P=0.501N     P=0.228N     P=0.112N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.085N     P=0.445N     P=0.174N     P=0.231N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.091N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/49 (0%)    1/50 (2%)    3/50 (6%)   |2/50 (4%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.15      0/45.37      1/44.07      3/44.93     |2/42.30      1/43.50      2/44.09      0/37.73      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         2.3%         6.7%        |4.7%         2.3%         4.5%         0.0%         | 
|TERMINAL (d)       |     1/30 (3%)    0/35 (0%)    1/32 (3%)    3/32 (9%)   |2/33 (6%)    1/30 (3%)    1/33 (3%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      729 (T)     |731 (T)      731 (T)      666          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.096      P=0.469N     P=0.748N     P=0.327     |P=0.280N     P=0.533N     P=0.689N     P=0.331N     | 
|POLY 3             |     P=0.099      P=0.485N     P=0.751N     P=0.328     |P=0.230N     P=0.490N     P=0.679N     P=0.263N     | 
|POLY 1.5           |     P=0.100      P=0.491N     P=0.754N     P=0.323     |P=0.217N     P=0.493N     P=0.684N     P=0.251N     | 
|POLY 6             |     P=0.097      P=0.477N     P=0.746N     P=0.334     |P=0.252N     P=0.493N     P=0.675N     P=0.287N     | 
|LOGISTIC REGRESSION|     P=0.096      (e)          P=0.748N     P=0.327     |P=0.244N     P=0.533N     P=0.682N     (e)          | 
|COCH-ARM / FISHERS |     P=0.100      P=0.500N     P=0.747N     P=0.316     |P=0.200N     P=0.500N     P=0.691N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.093      (e)          (e)          (e)         |P=0.177N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Deep Cervical                                                                                                        | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/11 (0%)    0/5 (0%)     0/11 (0%)    0/6 (0%)    |0/6 (0%)     3/10 (30%)   0/9 (0%)     1/8 (13%)    | 
|POLY-3 RATE (b)    |     0/8.29       0/3.96       0/9.61       0/4.98      |0/4.78       3/8.77       0/7.24       1/5.96       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         34.2%        0.0%         16.8%        | 
|TERMINAL (d)       |     0/3 (0%)     0/2 (0%)     0/6 (0%)     0/3 (0%)    |0/2 (0%)     1/5 (20%)    0/3 (0%)     1/1 (100%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          703          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.475      P=0.168      (e)          P=0.362      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.619N     P=0.222      (e)          P=0.545      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.616N     P=0.208      (e)          P=0.552      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.622N     P=0.251      (e)          P=0.530      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.558      P=0.249      (e)          P=0.362      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.609N     P=0.214      (e)          P=0.571      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.356      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Galactocele                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/35 (9%)    2/43 (5%)    6/47 (13%)   3/48 (6%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/29.94      2/39.40      6/41.77      3/43.14     |1/42.30      2/44.29      0/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     10.0%        5.1%         14.4%        7.0%        |2.4%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/21 (10%)   2/30 (7%)    4/30 (13%)   1/30 (3%)   |1/33 (3%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     704          729 (T)      586          680         |731 (T)      487          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.561      P=0.355N     P=0.381      P=0.560N    |P=0.218N     P=0.492      P=0.500N     P=0.581N     | 
|POLY 3             |     P=0.518N     P=0.376N     P=0.427      P=0.486N    |P=0.194N     P=0.516      P=0.493N     P=0.523N     | 
|POLY 1.5           |     P=0.520N     P=0.388N     P=0.414      P=0.494N    |P=0.191N     P=0.511      P=0.495N     P=0.512N     | 
|POLY 6             |     P=0.520N     P=0.362N     P=0.442      P=0.479N    |P=0.199N     P=0.516      P=0.491N     P=0.542N     | 
|LOGISTIC REGRESSION|     P=0.516N     P=0.343N     P=0.422      P=0.480N    |P=0.171N     P=0.475      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.528N     P=0.402N     P=0.410      P=0.502N    |P=0.188N     P=0.500      P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.503      (e)          (e)          (e)         |P=0.200N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/12 (58%)   13/13 (100%) 18/18 (100%) 9/11 (82%)  |14/15 (93%)  20/20 (100%) 16/17 (94%)  6/6 (100%)   | 
|POLY-3 RATE (b)    |     7/11.61      13/13.00     18/18.00     9/10.61     |14/14.32     20/20.00     16/16.92     6/6.00       | 
|POLY-3 PERCENT (g) |     60.3%        100.0%       100.0%       84.8%       |97.8%        100.0%       94.6%        100.0%       | 
|TERMINAL (d)       |     5/8 (63%)    10/10 (100%) 11/11 (100%) 6/6 (100%)  |10/10 (100%) 13/13 (100%) 13/13 (100%) 4/4 (100%)   | 
|FIRST INCIDENCE    |     704          393          544          633         |437          543          497          535          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.152      P=0.132      P=0.018 *    P=0.192     |P=0.223N     P=0.305      P=0.481N     P=0.386N     | 
|POLY 3             |     P=0.117      P=0.010 *    P=0.002 **   P=0.200     |P=0.774N     P=0.973      P=0.696N     P=0.996      | 
|POLY 1.5           |     P=0.136      P=0.010 *    P=0.002 **   P=0.211     |P=0.745      P=0.728      P=0.740N     P=0.896      | 
|POLY 6             |     P=0.088      P=0.013 *    P=0.003 **   P=0.180     |P=0.735N     P=1.000      P=0.654N     P=1.000      | 
|LOGISTIC REGRESSION|     P=0.180      P=0.017 *    P=0.006 **   P=0.110     |P=0.655      P=0.826      P=0.681N     P=0.859      | 
|COCH-ARM / FISHERS |     P=0.182      P=0.015 *    P=0.006 **   P=0.222     |P=0.576      P=0.429      P=0.726      P=0.714      | 
|ORDER RESTRICTED   |     P=0.004 **   (e)          (e)          (e)         |P=0.570N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   1/48 (2%)    3/50 (6%)    0/49 (0%)   |1/50 (2%)    5/50 (10%)   1/49 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     5/43.83      1/44.87      3/44.12      0/43.95     |1/42.30      5/43.57      1/43.33      0/37.33      | 
|POLY-3 PERCENT (g) |     11.4%        2.2%         6.8%         0.0%        |2.4%         11.5%        2.3%         0.0%         | 
|TERMINAL (d)       |     3/31 (10%)   1/35 (3%)    2/32 (6%)    0/32 (0%)   |1/33 (3%)    4/30 (13%)   1/33 (3%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     543          729 (T)      717          ---         |731 (T)      715          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.037N*    P=0.082N     P=0.337N     P=0.032N*   |P=0.211N     P=0.084      P=0.762      P=0.581N     | 
|POLY 3             |     P=0.038N*    P=0.096N     P=0.352N     P=0.030N*   |P=0.158N     P=0.107      P=0.755N     P=0.525N     | 
|POLY 1.5           |     P=0.037N*    P=0.102N     P=0.357N     P=0.031N*   |P=0.147N     P=0.106      P=0.759N     P=0.515N     | 
|POLY 6             |     P=0.039N*    P=0.088N     P=0.346N     P=0.029N*   |P=0.179N     P=0.105      P=0.753N     P=0.543N     | 
|LOGISTIC REGRESSION|     P=0.037N*    P=0.113N     P=0.350N     P=0.036N*   |P=0.205N     P=0.091      P=0.762      (e)          | 
|COCH-ARM / FISHERS |     P=0.038N*    P=0.112N     P=0.357N     P=0.030N*   |P=0.139N     P=0.102      P=0.747      P=0.505N     | 
|ORDER RESTRICTED   |     P=0.010N*    (e)          (e)          (e)         |P=0.095N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   9/48 (19%)   17/50 (34%)  10/49 (20%) |5/50 (10%)   12/50 (24%)  8/49 (16%)   7/49 (14%)   | 
|POLY-3 RATE (b)    |     5/43.83      9/44.87      17/45.47     10/44.79    |5/43.26      12/43.84     8/43.82      7/38.50      | 
|POLY-3 PERCENT (g) |     11.4%        20.1%        37.4%        22.3%       |11.6%        27.4%        18.3%        18.2%        | 
|TERMINAL (d)       |     3/31 (10%)   9/35 (26%)   9/32 (28%)   8/32 (25%)  |3/33 (9%)    9/30 (30%)   7/33 (21%)   4/22 (18%)   | 
|FIRST INCIDENCE    |     543          729 (T)      586          513         |437          688          582          523          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.118      P=0.265      P=0.009 **   P=0.153     |P=0.273      P=0.042 *    P=0.283      P=0.198      | 
|POLY 3             |     P=0.119      P=0.204      P=0.003 **   P=0.137     |P=0.432      P=0.053      P=0.283      P=0.298      | 
|POLY 1.5           |     P=0.115      P=0.190      P=0.003 **   P=0.132     |P=0.476      P=0.054      P=0.275      P=0.328      | 
|POLY 6             |     P=0.120      P=0.223      P=0.004 **   P=0.141     |P=0.359      P=0.050      P=0.288      P=0.247      | 
|LOGISTIC REGRESSION|     P=0.113      P=0.219      P=0.004 **   P=0.127     |P=0.446      P=0.060      P=0.271      P=0.352      | 
|COCH-ARM / FISHERS |     P=0.109      P=0.172      P=0.004 **   P=0.122     |P=0.531      P=0.054      P=0.264      P=0.365      | 
|ORDER RESTRICTED   |     P=0.024 *    (e)          (e)          (e)         |P=0.206      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Glands                                                                                                                     | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    30/48 (63%)  48/50 (96%)  46/49 (94%) |0/50 (0%)    17/50 (34%)  38/49 (78%)  44/49 (90%)  | 
|POLY-3 RATE (b)    |     3/43.15      30/46.54     48/48.52     46/48.18    |0/42.30      17/44.95     38/46.70     44/46.60     | 
|POLY-3 PERCENT (g) |     7.0%         64.5%        98.9%        95.5%       |0.0%         37.8%        81.4%        94.4%        | 
|TERMINAL (d)       |     3/31 (10%)   22/35 (63%)  32/32 (100%) 32/32 (100%)|0/33 (0%)    11/30 (37%)  28/33 (85%)  21/22 (96%)  | 
|FIRST INCIDENCE    |     729 (T)      569          460          513         |---          561          493          523          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Goblet Cell                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/48 (6%)    7/50 (14%)   16/49 (33%) |1/50 (2%)    3/50 (6%)    1/49 (2%)    4/49 (8%)    | 
|POLY-3 RATE (b)    |     1/43.15      3/44.87      7/44.07      16/44.30    |1/42.66      3/44.37      1/43.33      4/37.71      | 
|POLY-3 PERCENT (g) |     2.3%         6.7%         15.9%        36.1%       |2.3%         6.8%         2.3%         10.6%        | 
|TERMINAL (d)       |     1/31 (3%)    3/35 (9%)    7/32 (22%)   15/32 (47%) |0/33 (0%)    2/30 (7%)    1/33 (3%)    2/22 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      633         |631          374          731 (T)      653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.349      P=0.034 *    P<0.001 **  |P=0.086      P=0.297      P=0.755N     P=0.098      | 
|POLY 3             |     P<0.001 **   P=0.319      P=0.032 *    P<0.001 **  |P=0.132      P=0.319      P=0.757N     P=0.142      | 
|POLY 1.5           |     P<0.001 **   P=0.307      P=0.031 *    P<0.001 **  |P=0.143      P=0.316      P=0.760N     P=0.156      | 
|POLY 6             |     P<0.001 **   P=0.335      P=0.033 *    P<0.001 **  |P=0.117      P=0.316      P=0.756N     P=0.120      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.349      P=0.034 *    P<0.001 **  |P=0.166      P=0.258      P=0.757      P=0.148      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.293      P=0.030 *    P<0.001 **  |P=0.157      P=0.309      P=0.747      P=0.175      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.082      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    6/48 (13%)   1/50 (2%)    4/49 (8%)   |3/50 (6%)    1/50 (2%)    3/49 (6%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     2/43.15      6/45.76      1/44.07      4/44.56     |3/42.96      1/44.37      3/44.30      1/37.70      | 
|POLY-3 PERCENT (g) |     4.6%         13.1%        2.3%         9.0%        |7.0%         2.3%         6.8%         2.7%         | 
|TERMINAL (d)       |     2/31 (7%)    3/35 (9%)    1/32 (3%)    2/32 (6%)   |2/33 (6%)    0/30 (0%)    1/33 (3%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      393          729 (T)      569         |515          374          374          626          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.480      P=0.178      P=0.489N     P=0.357     |P=0.385N     P=0.319N     P=0.652N     P=0.388N     | 
|POLY 3             |     P=0.504      P=0.152      P=0.493N     P=0.352     |P=0.367N     P=0.293N     P=0.648N     P=0.353N     | 
|POLY 1.5           |     P=0.493      P=0.139      P=0.498N     P=0.343     |P=0.348N     P=0.296N     P=0.656N     P=0.334N     | 
|POLY 6             |     P=0.514      P=0.170      P=0.486N     P=0.361     |P=0.395N     P=0.296N     P=0.643N     P=0.387N     | 
|LOGISTIC REGRESSION|     P=0.473      P=0.103      P=0.489N     P=0.335     |P=0.239N     P=0.368N     P=0.612      P=0.298N     | 
|COCH-ARM / FISHERS |     P=0.477      P=0.121      P=0.500N     P=0.329     |P=0.321N     P=0.309N     P=0.651      P=0.316N     | 
|ORDER RESTRICTED   |     P=0.346      (e)          (e)          (e)         |P=0.297N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    47/48 (98%)  49/50 (98%)  49/49 (100%)|0/50 (0%)    50/50 (100%) 49/49 (100%) 48/49 (98%)  | 
|POLY-3 RATE (b)    |     0/43.15      47/48.00     49/49.00     49/49.00    |0/42.30      50/50.00     49/49.00     48/48.01     | 
|POLY-3 PERCENT (g) |     0.0%         97.9%        100.0%       100.0%      |0.0%         100.0%       100.0%       100.0%       | 
|TERMINAL (d)       |     0/31 (0%)    34/35 (97%)  32/32 (100%) 32/32 (100%)|0/33 (0%)    30/30 (100%) 33/33 (100%) 22/22 (100%) | 
|FIRST INCIDENCE    |     ---          393          460          513         |---          374          374          516          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    0/48 (0%)    2/50 (4%)    1/49 (2%)   |10/50 (20%)  14/50 (28%)  15/49 (31%)  4/49 (8%)    | 
|POLY-3 RATE (b)    |     4/43.66      0/44.87      2/44.46      1/44.16     |10/44.20     14/44.13     15/44.55     4/38.51      | 
|POLY-3 PERCENT (g) |     9.2%         0.0%         4.5%         2.3%        |22.6%        31.7%        33.7%        10.4%        | 
|TERMINAL (d)       |     2/31 (7%)    0/35 (0%)    1/32 (3%)    0/32 (0%)   |6/33 (18%)   10/30 (33%)  11/33 (33%)  1/22 (5%)    | 
|FIRST INCIDENCE    |     612          ---          619          674         |437          617          493          525          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.196N     P=0.053N     P=0.326N     P=0.169N    |P=0.196N     P=0.199      P=0.198      P=0.197N     | 
|POLY 3             |     P=0.207N     P=0.057N     P=0.329N     P=0.175N    |P=0.104N     P=0.234      P=0.177      P=0.116N     | 
|POLY 1.5           |     P=0.204N     P=0.060N     P=0.335N     P=0.178N    |P=0.078N     P=0.240      P=0.171      P=0.098N     | 
|POLY 6             |     P=0.213N     P=0.052N     P=0.321N     P=0.172N    |P=0.161N     P=0.219      P=0.182      P=0.154N     | 
|LOGISTIC REGRESSION|     P=0.203N     P=0.068N     P=0.337N     P=0.187N    |P=0.070N     P=0.255      P=0.167      P=0.074N     | 
|COCH-ARM / FISHERS |     P=0.201N     P=0.064N     P=0.339N     P=0.187N    |P=0.055N     P=0.241      P=0.163      P=0.080N     | 
|ORDER RESTRICTED   |     P=0.072N     (e)          (e)          (e)         |P=0.033N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Hyperplasia Basal Cell                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    21/48 (44%)  44/50 (88%)  48/49 (98%) |0/50 (0%)    25/50 (50%)  42/49 (86%)  45/49 (92%)  | 
|POLY-3 RATE (b)    |     0/43.15      21/45.70     44/47.74     48/48.84    |0/42.30      25/47.06     42/47.42     45/47.52     | 
|POLY-3 PERCENT (g) |     0.0%         46.0%        92.2%        98.3%       |0.0%         53.1%        88.6%        94.7%        | 
|TERMINAL (d)       |     0/31 (0%)    16/35 (46%)  30/32 (94%)  32/32 (100%)|0/33 (0%)    16/30 (53%)  31/33 (94%)  20/22 (91%)  | 
|FIRST INCIDENCE    |     ---          654          460          513         |---          374          374          516          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/48 (2%)    0/50 (0%)    2/49 (4%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      1/44.87      0/44.07      2/44.54     |0/42.30      0/43.50      0/43.33      0/37.33      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    1/35 (3%)    0/32 (0%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          614         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.144      P=0.524      (e)          P=0.259     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.145      P=0.508      (e)          P=0.244     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.143      P=0.501      (e)          P=0.240     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.148      P=0.516      (e)          P=0.249     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.135      P=0.524      (e)          P=0.192     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.139      P=0.490      (e)          P=0.242     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.079      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/48 (0%)    0/50 (0%)    0/49 (0%)   |5/50 (10%)   3/50 (6%)    4/49 (8%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      0/44.87      0/44.07      0/43.95     |5/42.53      3/44.18      4/43.82      0/37.33      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |11.8%        6.8%         9.1%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)   |3/33 (9%)    1/30 (3%)    3/33 (9%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |687          542          582          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.070N     P=0.392N     P=0.494N     P=0.086N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.051N     P=0.335N     P=0.481N     P=0.042N*    | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.044N*    P=0.341N     P=0.493N     P=0.037N*    | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.065N     P=0.337N     P=0.473N     P=0.054N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.041N*    P=0.347N     P=0.490N     P=0.058N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.037N*    P=0.357N     P=0.513N     P=0.030N*    | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.032N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |6/50 (12%)   6/50 (12%)   11/50 (22%)  4/50 (8%)    | 
|POLY-3 RATE (b)    |                                                        |6/42.98      6/44.05      11/44.35     4/37.91      | 
|POLY-3 PERCENT (g) |                                                        |14.0%        13.6%        24.8%        10.6%        | 
|TERMINAL (d)       |                                                        |5/33 (15%)   5/30 (17%)   8/33 (24%)   3/22 (14%)   | 
|FIRST INCIDENCE    |                                                        |501          561          614          684          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.473      P=0.574      P=0.151      P=0.602N     | 
|POLY 3             |                                                        |P=0.508N     P=0.604N     P=0.155      P=0.450N     | 
|POLY 1.5           |                                                        |P=0.449N     P=0.608N     P=0.151      P=0.412N     | 
|POLY 6             |                                                        |P=0.496      P=0.609N     P=0.159      P=0.515N     | 
|LOGISTIC REGRESSION|                                                        |P=0.500N     P=0.609N     P=0.159      P=0.467N     | 
|COCH-ARM / FISHERS |                                                        |P=0.376N     P=0.620N     P=0.143      P=0.370N     | 
|ORDER RESTRICTED   |                                                        |P=0.319N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/50 (30%)  18/49 (37%)  27/50 (54%)  21/50 (42%) |3/50 (6%)    5/49 (10%)   2/50 (4%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     15/44.99     18/46.02     27/47.39     21/47.53    |3/42.47      5/43.90      2/43.84      4/38.91      | 
|POLY-3 PERCENT (g) |     33.3%        39.1%        57.0%        44.2%       |7.1%         11.4%        4.6%         10.3%        | 
|TERMINAL (d)       |     11/31 (36%)  13/35 (37%)  16/32 (50%)  12/32 (38%) |2/33 (6%)    3/30 (10%)   2/33 (6%)    2/22 (9%)    | 
|FIRST INCIDENCE    |     543          654          460          567         |687          374          731 (T)      535          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.127      P=0.497      P=0.032 *    P=0.212     |P=0.376      P=0.326      P=0.500N     P=0.352      | 
|POLY 3             |     P=0.141      P=0.361      P=0.016 *    P=0.194     |P=0.492      P=0.374      P=0.486N     P=0.452      | 
|POLY 1.5           |     P=0.125      P=0.339      P=0.013 *    P=0.176     |P=0.514      P=0.366      P=0.490N     P=0.475      | 
|POLY 6             |     P=0.163      P=0.393      P=0.022 *    P=0.219     |P=0.453      P=0.375      P=0.484N     P=0.408      | 
|LOGISTIC REGRESSION|     P=0.107      P=0.371      P=0.013 *    P=0.148     |P=0.552      P=0.337      P=0.481N     P=0.491      | 
|COCH-ARM / FISHERS |     P=0.104      P=0.310      P=0.013 *    P=0.149     |P=0.541      P=0.346      P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.066      (e)          (e)          (e)         |P=0.478      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Duct                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/49 (4%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.15      2/45.37      3/44.07      0/44.93     |0/42.30      0/42.90      0/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     2.3%         4.4%         6.8%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    2/35 (6%)    3/32 (9%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.337N     P=0.543      P=0.316      P=0.494N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.321N     P=0.518      P=0.313      P=0.492N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.326N     P=0.507      P=0.308      P=0.495N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.319N     P=0.531      P=0.319      P=0.489N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.337N     P=0.543      P=0.316      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.335N     P=0.492      P=0.309      P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.188N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    1/49 (2%)   |6/50 (12%)   6/50 (12%)   1/50 (2%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     1/43.15      1/45.65      1/44.07      1/43.95     |6/43.70      6/44.92      1/43.84      5/39.70      | 
|POLY-3 PERCENT (g) |     2.3%         2.2%         2.3%         2.3%        |13.7%        13.4%        2.3%         12.6%        | 
|TERMINAL (d)       |     1/31 (3%)    0/35 (0%)    1/32 (3%)    1/32 (3%)   |4/33 (12%)   3/30 (10%)   1/33 (3%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      654          729 (T)      729 (T)     |436          542          731 (T)      540          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.634N     P=0.731N     P=0.755N     P=0.755N    |P=0.486N     P=0.596      P=0.060N     P=0.590      | 
|POLY 3             |     P=0.635N     P=0.748N     P=0.756N     P=0.757N    |P=0.375N     P=0.602N     P=0.055N     P=0.567N     | 
|POLY 1.5           |     P=0.634      P=0.755N     P=0.759N     P=0.759N    |P=0.360N     P=0.607N     P=0.055N     P=0.538N     | 
|POLY 6             |     P=0.635      P=0.738N     P=0.752N     P=0.754N    |P=0.396N     P=0.603N     P=0.055N     P=0.614N     | 
|LOGISTIC REGRESSION|     P=0.634N     P=0.762N     P=0.755N     P=0.755N    |P=0.281N     P=0.585      P=0.063N     P=0.448N     | 
|COCH-ARM / FISHERS |     P=0.628      P=0.753N     P=0.753N     P=0.747     |P=0.338N     P=0.620N     P=0.056N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.737N     (e)          (e)          (e)         |P=0.266N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   8/50 (16%)   9/50 (18%)   8/49 (16%)  |4/50 (8%)    8/50 (16%)   4/50 (8%)    7/50 (14%)   | 
|POLY-3 RATE (b)    |     5/44.04      8/45.48      9/45.32      8/44.74     |4/42.92      8/44.28      4/44.25      7/39.50      | 
|POLY-3 PERCENT (g) |     11.4%        17.6%        19.9%        17.9%       |9.3%         18.1%        9.0%         17.7%        | 
|TERMINAL (d)       |     2/31 (7%)    7/35 (20%)   7/32 (22%)   6/32 (19%)  |3/33 (9%)    5/30 (17%)   3/33 (9%)    2/22 (9%)    | 
|FIRST INCIDENCE    |     589          704          460          513         |533          561          614          563          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.274      P=0.356      P=0.214      P=0.303     |P=0.164      P=0.158      P=0.636N     P=0.136      | 
|POLY 3             |     P=0.282      P=0.296      P=0.207      P=0.285     |P=0.284      P=0.191      P=0.627N     P=0.213      | 
|POLY 1.5           |     P=0.276      P=0.283      P=0.199      P=0.278     |P=0.308      P=0.187      P=0.632N     P=0.234      | 
|POLY 6             |     P=0.281      P=0.313      P=0.215      P=0.289     |P=0.248      P=0.188      P=0.623N     P=0.179      | 
|LOGISTIC REGRESSION|     P=0.263      P=0.298      P=0.194      P=0.257     |P=0.318      P=0.184      P=0.639N     P=0.257      | 
|COCH-ARM / FISHERS |     P=0.258      P=0.277      P=0.194      P=0.264     |P=0.340      P=0.178      P=0.643N     P=0.262      | 
|ORDER RESTRICTED   |     P=0.274      (e)          (e)          (e)         |P=0.213      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    1/50 (2%)    2/50 (4%)    1/49 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     1/41.16      1/46.37      2/45.57      1/43.93     |                                                    | 
|POLY-3 PERCENT (g) |     2.4%         2.2%         4.4%         2.3%        |                                                    | 
|TERMINAL (d)       |     1/30 (3%)    0/35 (0%)    0/32 (0%)    1/31 (3%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      106          114          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.590      P=0.743N     P=0.510      P=0.755N    |                                                    | 
|POLY 3             |     P=0.603      P=0.734N     P=0.535      P=0.746N    |                                                    | 
|POLY 1.5           |     P=0.601      P=0.741N     P=0.527      P=0.750N    |                                                    | 
|POLY 6             |     P=0.603      P=0.724N     P=0.546      P=0.743N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.461      P=0.663N     P=0.629      P=0.755N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.595      P=0.742N     P=0.515      P=0.747N    |                                                    | 
|ORDER RESTRICTED   |     P=0.602      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    4/50 (8%)    1/50 (2%)    1/49 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     1/41.16      4/45.43      1/44.58      1/43.93     |                                                    | 
|POLY-3 PERCENT (g) |     2.4%         8.8%         2.2%         2.3%        |                                                    | 
|TERMINAL (d)       |     1/30 (3%)    3/35 (9%)    0/32 (0%)    1/31 (3%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      717          578          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.375N     P=0.229      P=0.751N     P=0.755N    |                                                    | 
|POLY 3             |     P=0.347N     P=0.210      P=0.743N     P=0.746N    |                                                    | 
|POLY 1.5           |     P=0.355N     P=0.200      P=0.748N     P=0.750N    |                                                    | 
|POLY 6             |     P=0.339N     P=0.224      P=0.736N     P=0.743N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.359N     P=0.241      P=0.751N     P=0.755N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.367N     P=0.194      P=0.742N     P=0.747N    |                                                    | 
|ORDER RESTRICTED   |     P=0.329N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   1/50 (2%)    4/50 (8%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     5/43.70      1/45.38      4/44.79      2/45.01     |                                                    | 
|POLY-3 PERCENT (g) |     11.4%        2.2%         8.9%         4.4%        |                                                    | 
|TERMINAL (d)       |     3/31 (10%)   1/35 (3%)    0/32 (0%)    1/32 (3%)   |                                                    | 
|FIRST INCIDENCE    |     623          729 (T)      578          710         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.272N     P=0.081N     P=0.472N     P=0.203N    |                                                    | 
|POLY 3             |     P=0.269N     P=0.093N     P=0.485N     P=0.204N    |                                                    | 
|POLY 1.5           |     P=0.268N     P=0.098N     P=0.494N     P=0.208N    |                                                    | 
|POLY 6             |     P=0.274N     P=0.086N     P=0.472N     P=0.201N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.269N     P=0.097N     P=0.500N     P=0.204N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.273N     P=0.102N     P=0.500N     P=0.218N    |                                                    | 
|ORDER RESTRICTED   |     P=0.146N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Cyst Epithelial Inclusion                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    3/50 (6%)    2/50 (4%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/43.45      1/45.38      3/44.58      2/45.07     |0/42.30      2/43.50      0/43.84      1/37.73      | 
|POLY-3 PERCENT (g) |     9.2%         2.2%         6.7%         4.4%        |0.0%         4.6%         0.0%         2.7%         | 
|TERMINAL (d)       |     2/31 (7%)    1/35 (3%)    2/32 (6%)    1/32 (3%)   |0/33 (0%)    2/30 (7%)    0/33 (0%)    1/22 (5%)    | 
|FIRST INCIDENCE    |     675          729 (T)      578          694         |---          731 (T)      ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.370N     P=0.145N     P=0.478N     P=0.317N    |P=0.446      P=0.217      (e)          P=0.419      | 
|POLY 3             |     P=0.367N     P=0.165N     P=0.486N     P=0.320N    |P=0.506      P=0.243      (e)          P=0.477      | 
|POLY 1.5           |     P=0.366N     P=0.173N     P=0.495N     P=0.326N    |P=0.522      P=0.242      (e)          P=0.488      | 
|POLY 6             |     P=0.371N     P=0.156N     P=0.476N     P=0.315N    |P=0.478      P=0.241      (e)          P=0.458      | 
|LOGISTIC REGRESSION|     P=0.364N     P=0.159N     P=0.498N     P=0.317N    |(e)          P=0.217      (e)          P=0.419      | 
|COCH-ARM / FISHERS |     P=0.371N     P=0.181N     P=0.500N     P=0.339N    |P=0.539      P=0.247      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.264N     (e)          (e)          (e)         |P=0.304      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/43.16      1/45.38      2/44.07      0/44.93     |0/42.30      1/43.50      0/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     4.6%         2.2%         4.5%         0.0%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    1/35 (3%)    2/32 (6%)    0/32 (0%)   |0/33 (0%)    1/30 (3%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     725          729 (T)      729 (T)      ---         |---          731 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.201N     P=0.458N     P=0.685N     P=0.236N    |P=0.625N     P=0.481      (e)          (e)          | 
|POLY 3             |     P=0.196N     P=0.483N     P=0.687N     P=0.228N    |P=0.563N     P=0.506      (e)          (e)          | 
|POLY 1.5           |     P=0.196N     P=0.492N     P=0.691N     P=0.231N    |P=0.565N     P=0.504      (e)          (e)          | 
|POLY 6             |     P=0.197N     P=0.469N     P=0.680N     P=0.225N    |P=0.561N     P=0.504      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.196N     P=0.450N     P=0.676N     P=0.226N    |(e)          P=0.481      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.200N     P=0.500N     P=0.691N     P=0.247N    |P=0.567N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.148N     (e)          (e)          (e)         |P=0.405N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Inflammation Acute                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      0/45.38      2/44.36      0/44.93     |0/42.30      0/43.50      0/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    1/32 (3%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          653          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.598      (e)          P=0.251      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.609      (e)          P=0.243      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.607      (e)          P=0.239      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.609      (e)          P=0.248      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.595      (e)          P=0.238      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.253      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      0/45.38      2/44.33      0/44.93     |1/43.09      0/43.50      1/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         0.0%        |2.3%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    1/32 (3%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    1/33 (3%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          661          ---         |436          ---          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.600      (e)          P=0.249      (e)         |P=0.441N     P=0.504N     P=0.758      P=0.504N     | 
|POLY 3             |     P=0.609      (e)          P=0.243      (e)         |P=0.425N     P=0.498N     P=0.757N     P=0.526N     | 
|POLY 1.5           |     P=0.607      (e)          P=0.239      (e)         |P=0.417N     P=0.498N     P=0.758N     P=0.514N     | 
|POLY 6             |     P=0.609      (e)          P=0.248      (e)         |P=0.434N     P=0.501N     P=0.757N     P=0.546N     | 
|LOGISTIC REGRESSION|     P=0.596      (e)          P=0.238      (e)         |P=0.342N     P=0.541N     P=0.733      P=0.369N     | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |P=0.405N     P=0.500N     P=0.753N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.253      (e)          (e)          (e)         |P=0.279N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Accessory Spleen                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/49 (6%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      3/45.90      0/44.07      1/45.40     |2/42.42      1/43.67      1/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         6.5%         0.0%         2.2%        |4.7%         2.3%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    2/35 (6%)    0/32 (0%)    0/32 (0%)   |1/33 (3%)    0/30 (0%)    1/33 (3%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          569          ---          589         |703          688          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.632N     P=0.142      (e)          P=0.504     |P=0.209N     P=0.514N     P=0.494N     P=0.331N     | 
|POLY 3             |     P=0.610N     P=0.130      (e)          P=0.510     |P=0.169N     P=0.490N     P=0.488N     P=0.264N     | 
|POLY 1.5           |     P=0.619N     P=0.124      (e)          P=0.506     |P=0.162N     P=0.492N     P=0.492N     P=0.251N     | 
|POLY 6             |     P=0.600N     P=0.139      (e)          P=0.514     |P=0.178N     P=0.492N     P=0.487N     P=0.288N     | 
|LOGISTIC REGRESSION|     P=0.625      P=0.101      (e)          P=0.401     |P=0.175N     P=0.492N     P=0.486N     P=0.292N     | 
|COCH-ARM / FISHERS |     P=0.631N     P=0.117      (e)          P=0.500     |P=0.153N     P=0.500N     P=0.500N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.275      (e)          (e)          (e)         |P=0.139N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    6/49 (12%)   4/50 (8%)    1/50 (2%)   |3/50 (6%)    1/50 (2%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/43.33      6/46.11      4/44.41      1/45.40     |3/42.30      1/43.50      3/43.86      1/37.82      | 
|POLY-3 PERCENT (g) |     4.6%         13.0%        9.0%         2.2%        |7.1%         2.3%         6.8%         2.6%         | 
|TERMINAL (d)       |     1/31 (3%)    2/35 (6%)    2/32 (6%)    0/32 (0%)   |3/33 (9%)    1/30 (3%)    2/33 (6%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     682          605          676          589         |731 (T)      731 (T)      726          708          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.232N     P=0.188      P=0.368      P=0.485N    |P=0.449N     P=0.339N     P=0.660N     P=0.455N     | 
|POLY 3             |     P=0.207N     P=0.154      P=0.348      P=0.484N    |P=0.359N     P=0.295N     P=0.646N     P=0.346N     | 
|POLY 1.5           |     P=0.215N     P=0.142      P=0.341      P=0.490N    |P=0.339N     P=0.298N     P=0.651N     P=0.327N     | 
|POLY 6             |     P=0.201N     P=0.170      P=0.358      P=0.478N    |P=0.389N     P=0.297N     P=0.643N     P=0.382N     | 
|LOGISTIC REGRESSION|     P=0.232N     P=0.128      P=0.345      P=0.532N    |P=0.444N     P=0.339N     P=0.653N     P=0.435N     | 
|COCH-ARM / FISHERS |     P=0.231N     P=0.128      P=0.339      P=0.500N    |P=0.313N     P=0.309N     P=0.661N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.170N     (e)          (e)          (e)         |P=0.290N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    1/50 (2%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.15      2/45.46      1/44.60      1/45.45     |2/42.39      1/44.10      1/44.09      2/39.01      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         2.2%         2.2%        |4.7%         2.3%         2.3%         5.1%         | 
|TERMINAL (d)       |     0/31 (0%)    1/35 (3%)    0/32 (0%)    0/32 (0%)   |1/33 (3%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          708          568          569         |710          542          666          516          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.505      P=0.275      P=0.509      P=0.509     |P=0.497      P=0.508N     P=0.488N     P=0.636      | 
|POLY 3             |     P=0.526      P=0.249      P=0.507      P=0.510     |P=0.524      P=0.486N     P=0.486N     P=0.664      | 
|POLY 1.5           |     P=0.517      P=0.242      P=0.503      P=0.507     |P=0.538      P=0.490N     P=0.491N     P=0.679      | 
|POLY 6             |     P=0.535      P=0.258      P=0.512      P=0.514     |P=0.503      P=0.487N     P=0.483N     P=0.634      | 
|LOGISTIC REGRESSION|     P=0.487      P=0.257      P=0.540      P=0.374     |P=0.590N     P=0.513N     P=0.492N     P=0.660N     | 
|COCH-ARM / FISHERS |     P=0.502      P=0.242      P=0.500      P=0.500     |P=0.556      P=0.500N     P=0.500N     P=0.691N     | 
|ORDER RESTRICTED   |     P=0.280      (e)          (e)          (e)         |P=0.493      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hyperplasia Focal Lymphoid                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/49 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      1/45.37      0/44.07      0/44.93     |0/42.30      2/43.50      0/43.84      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |0.0%         4.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    1/35 (3%)    0/32 (0%)    0/32 (0%)   |0/33 (0%)    2/30 (7%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          731 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.569N     P=0.524      (e)          (e)         |P=0.476N     P=0.217      (e)          (e)          | 
|POLY 3             |     P=0.555N     P=0.510      (e)          (e)         |P=0.414N     P=0.243      (e)          (e)          | 
|POLY 1.5           |     P=0.560N     P=0.504      (e)          (e)         |P=0.409N     P=0.242      (e)          (e)          | 
|POLY 6             |     P=0.550N     P=0.518      (e)          (e)         |P=0.424N     P=0.241      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.524      (e)          (e)         |(e)          P=0.217      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.566N     P=0.495      (e)          (e)         |P=0.405N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.383N     (e)          (e)          (e)         |P=0.276N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/49 (2%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/43.58      1/45.90      1/44.07      1/45.07     |0/42.30      0/43.50      0/43.84      1/38.33      | 
|POLY-3 PERCENT (g) |     6.9%         2.2%         2.3%         2.2%        |0.0%         0.0%         0.0%         2.6%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    1/32 (3%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     666          569          729 (T)      694         |---          ---          ---          540          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.240N     P=0.273N     P=0.297N     P=0.290N    |P=0.195      (e)          (e)          P=0.505      | 
|POLY 3             |     P=0.245N     P=0.287N     P=0.301N     P=0.293N    |P=0.185      (e)          (e)          P=0.480      | 
|POLY 1.5           |     P=0.243N     P=0.297N     P=0.305N     P=0.297N    |P=0.191      (e)          (e)          P=0.490      | 
|POLY 6             |     P=0.249N     P=0.275N     P=0.297N     P=0.290N    |P=0.176      (e)          (e)          P=0.463      | 
|LOGISTIC REGRESSION|     P=0.245N     P=0.356N     P=0.301N     P=0.305N    |P=0.262      (e)          (e)          P=0.560      | 
|COCH-ARM / FISHERS |     P=0.240N     P=0.316N     P=0.309N     P=0.309N    |P=0.198      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.175N     (e)          (e)          (e)         |P=0.104      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/48 (2%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    1/49 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     4/43.82      1/44.95      1/44.12      0/44.93     |1/43.03      1/43.67      1/43.43      1/37.93      | 
|POLY-3 PERCENT (g) |     9.1%         2.2%         2.3%         0.0%        |2.3%         2.3%         2.3%         2.6%         | 
|TERMINAL (d)       |     1/31 (3%)    0/35 (0%)    0/32 (0%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     589          708          717          ---         |477          688          704          551          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.035N*    P=0.151N     P=0.175N     P=0.063N    |P=0.591      P=0.753N     P=0.744N     P=0.751N     | 
|POLY 3             |     P=0.034N*    P=0.171N     P=0.176N     P=0.057N    |P=0.588      P=0.757N     P=0.759N     P=0.732      | 
|POLY 1.5           |     P=0.034N*    P=0.179N     P=0.179N     P=0.058N    |P=0.605      P=0.758N     P=0.760      P=0.743      | 
|POLY 6             |     P=0.035N*    P=0.161N     P=0.173N     P=0.056N    |P=0.559      P=0.760N     P=0.757N     P=0.711      | 
|LOGISTIC REGRESSION|     P=0.034N*    P=0.203N     P=0.179N     P=0.066N    |P=0.572N     P=0.724      P=0.727      P=0.703N     | 
|COCH-ARM / FISHERS |     P=0.034N*    P=0.194N     P=0.181N     P=0.059N    |P=0.627      P=0.753N     P=0.747      P=0.747      | 
|ORDER RESTRICTED   |     P=0.011N*    (e)          (e)          (e)         |P=0.702      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/48 (4%)    2/50 (4%)    2/49 (4%)   |0/50 (0%)    0/50 (0%)    1/49 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/43.15      2/45.49      2/44.13      2/44.06     |0/42.30      0/43.50      1/43.36      1/37.96      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         4.5%         4.5%        |0.0%         0.0%         2.3%         2.6%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          569          722          708         |---          ---          722          540          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.244      P=0.268      P=0.250      P=0.253     |P=0.197      (e)          P=0.506      P=0.505      | 
|POLY 3             |     P=0.253      P=0.249      P=0.242      P=0.242     |P=0.204      (e)          P=0.505      P=0.478      | 
|POLY 1.5           |     P=0.249      P=0.240      P=0.239      P=0.239     |P=0.217      (e)          P=0.502      P=0.487      | 
|POLY 6             |     P=0.256      P=0.261      P=0.246      P=0.245     |P=0.184      (e)          P=0.508      P=0.462      | 
|LOGISTIC REGRESSION|     P=0.239      P=0.177      P=0.249      P=0.244     |P=0.260      (e)          P=0.507      P=0.554      | 
|COCH-ARM / FISHERS |     P=0.240      P=0.237      P=0.247      P=0.242     |P=0.232      (e)          P=0.495      P=0.495      | 
|ORDER RESTRICTED   |     P=0.192      (e)          (e)          (e)         |P=0.230      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/48 (4%)    1/50 (2%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    1/49 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/43.38      2/44.95      1/44.33      0/43.95     |0/42.30      0/43.50      1/43.35      0/37.36      | 
|POLY-3 PERCENT (g) |     2.3%         4.5%         2.3%         0.0%        |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    0/32 (0%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     666          710          661          ---         |---          ---          726          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.242N     P=0.545      P=0.752N     P=0.485N    |P=0.657      (e)          P=0.506      (e)          | 
|POLY 3             |     P=0.242N     P=0.512      P=0.756N     P=0.497N    |P=0.636      (e)          P=0.505      (e)          | 
|POLY 1.5           |     P=0.245N     P=0.501      P=0.759N     P=0.500N    |P=0.662      (e)          P=0.502      (e)          | 
|POLY 6             |     P=0.240N     P=0.526      P=0.752N     P=0.496N    |P=0.587      (e)          P=0.507      (e)          | 
|LOGISTIC REGRESSION|     P=0.250N     P=0.493      P=0.761N     P=0.522N    |P=0.663      (e)          P=0.507      (e)          | 
|COCH-ARM / FISHERS |     P=0.249N     P=0.485      P=0.753N     P=0.505N    |P=0.692      (e)          P=0.495      (e)          | 
|ORDER RESTRICTED   |     P=0.230N     (e)          (e)          (e)         |P=0.388      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Artery                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     0/43.15      0/45.38      2/44.28      0/44.93     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    1/32 (3%)    0/32 (0%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          676          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.604      (e)          P=0.255      (e)         |                                                    | 
|POLY 3             |     P=0.609      (e)          P=0.243      (e)         |                                                    | 
|POLY 1.5           |     P=0.607      (e)          P=0.239      (e)         |                                                    | 
|POLY 6             |     P=0.609      (e)          P=0.248      (e)         |                                                    | 
|LOGISTIC REGRESSION|     P=0.598      (e)          P=0.240      (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |                                                    | 
|ORDER RESTRICTED   |     P=0.252      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/50 (32%)  12/50 (24%)  11/50 (22%)  9/50 (18%)  |                                                    | 
|POLY-3 RATE (b)    |     16/44.05     12/45.85     11/45.18     9/45.47     |                                                    | 
|POLY-3 PERCENT (g) |     36.3%        26.2%        24.3%        19.8%       |                                                    | 
|TERMINAL (d)       |     10/31 (32%)  10/35 (29%)  5/32 (16%)   8/32 (25%)  |                                                    | 
|FIRST INCIDENCE    |     589          605          578          562         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.080N     P=0.159N     P=0.176N     P=0.075N    |                                                    | 
|POLY 3             |     P=0.061N     P=0.207N     P=0.156N     P=0.063N    |                                                    | 
|POLY 1.5           |     P=0.064N     P=0.232N     P=0.172N     P=0.069N    |                                                    | 
|POLY 6             |     P=0.061N     P=0.179N     P=0.138N     P=0.059N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.061N     P=0.180N     P=0.164N     P=0.061N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.073N     P=0.252N     P=0.184N     P=0.083N    |                                                    | 
|ORDER RESTRICTED   |     P=0.054N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   6/50 (12%)   2/50 (4%)    3/50 (6%)   |                                                    | 
|POLY-3 RATE (b)    |     7/44.87      6/46.08      2/44.10      3/45.47     |                                                    | 
|POLY-3 PERCENT (g) |     15.6%        13.0%        4.5%         6.6%        |                                                    | 
|TERMINAL (d)       |     4/31 (13%)   4/35 (11%)   1/32 (3%)    2/32 (6%)   |                                                    | 
|FIRST INCIDENCE    |     506          605          722          562         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.080N     P=0.431N     P=0.082N     P=0.151N    |                                                    | 
|POLY 3             |     P=0.076N     P=0.479N     P=0.082N     P=0.151N    |                                                    | 
|POLY 1.5           |     P=0.076N     P=0.494N     P=0.082N     P=0.153N    |                                                    | 
|POLY 6             |     P=0.078N     P=0.457N     P=0.082N     P=0.150N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.082N     P=0.506N     P=0.079N     P=0.205N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.078N     P=0.500N     P=0.080N     P=0.159N    |                                                    | 
|ORDER RESTRICTED   |     P=0.083N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    9/50 (18%)   7/49 (14%)  |5/50 (10%)   8/50 (16%)   6/50 (12%)   1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/43.73      4/45.48      9/44.10      7/44.48     |5/42.30      8/43.99      6/44.03      1/38.34      | 
|POLY-3 PERCENT (g) |     4.6%         8.8%         20.4%        15.7%       |11.8%        18.2%        13.6%        2.6%         | 
|TERMINAL (d)       |     1/31 (3%)    3/35 (9%)    8/32 (25%)   6/32 (19%)  |5/33 (15%)   5/30 (17%)   4/33 (12%)   0/22 (0%)    | 
|FIRST INCIDENCE    |     543          704          722          569         |731 (T)      666          704          535          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.052      P=0.393      P=0.032 *    P=0.091     |P=0.141N     P=0.234      P=0.510      P=0.192N     | 
|POLY 3             |     P=0.054      P=0.355      P=0.025 *    P=0.082     |P=0.079N     P=0.300      P=0.528      P=0.124N     | 
|POLY 1.5           |     P=0.053      P=0.344      P=0.025 *    P=0.080     |P=0.067N     P=0.293      P=0.518      P=0.113N     | 
|POLY 6             |     P=0.053      P=0.371      P=0.026 *    P=0.084     |P=0.106N     P=0.301      P=0.536      P=0.148N     | 
|LOGISTIC REGRESSION|     P=0.053      P=0.339      P=0.030 *    P=0.074     |P=0.087N     P=0.282      P=0.527      P=0.129N     | 
|COCH-ARM / FISHERS |     P=0.050      P=0.339      P=0.026 *    P=0.075     |P=0.056N     P=0.277      P=0.500      P=0.102N     | 
|ORDER RESTRICTED   |     P=0.036 *    (e)          (e)          (e)         |P=0.066N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/50 (4%)    1/49 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.15      2/45.38      2/44.07      1/43.95     |0/42.30      1/43.50      0/43.84      1/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         4.5%         2.3%        |0.0%         2.3%         0.0%         2.7%         | 
|TERMINAL (d)       |     0/31 (0%)    2/35 (6%)    2/32 (6%)    1/32 (3%)   |0/33 (0%)    1/30 (3%)    0/33 (0%)    1/22 (5%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      729 (T)     |---          731 (T)      ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.467      P=0.265      P=0.245      P=0.506     |P=0.326      P=0.481      (e)          P=0.419      | 
|POLY 3             |     P=0.482      P=0.248      P=0.242      P=0.504     |P=0.378      P=0.506      (e)          P=0.477      | 
|POLY 1.5           |     P=0.476      P=0.242      P=0.239      P=0.501     |P=0.391      P=0.504      (e)          P=0.488      | 
|POLY 6             |     P=0.487      P=0.257      P=0.246      P=0.506     |P=0.357      P=0.504      (e)          P=0.458      | 
|LOGISTIC REGRESSION|     (e)          P=0.265      P=0.245      P=0.506     |(e)          P=0.481      (e)          P=0.419      | 
|COCH-ARM / FISHERS |     P=0.462      P=0.247      P=0.247      P=0.495     |P=0.405      P=0.500      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.236      (e)          (e)          (e)         |P=0.229      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tongue: Epithelium                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/1 (0%)     1/1 (100%)   0/0 (0%)     0/0 (0%)    |1/1 (100%)   0/1 (0%)     3/3 (100%)   2/3 (67%)    | 
|POLY-3 RATE (b)    |     0/1.00       1/1.00       0/0.00       0/0.00      |1/1.00       0/0.94       3/3.00       2/3.00       | 
|POLY-3 PERCENT (g) |     0.0%         100.0%       0.0%         0.0%        |100.0%       0.0%         100.0%       66.7%        | 
|TERMINAL (d)       |     0/1 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |1/1 (100%)   0/0 (0%)     2/2 (100%)   0/1 (0%)     | 
|FIRST INCIDENCE    |     ---          682          ---          ---         |731 (T)      ---          722          563          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.571N     P=0.530      (e)          (e)         |P=0.205      P=1.000N     (e)          P=0.418      | 
|POLY 3             |     (e)          P=1.000N     (e)          (e)         |P=0.649N     P=1.000N     (e)          P=0.691N     | 
|POLY 1.5           |     (e)          P=1.000N     (e)          (e)         |P=0.663N     P=1.000N     (e)          P=0.691N     | 
|POLY 6             |     (e)          P=1.000N     (e)          (e)         |P=0.623N     P=1.000N     (e)          P=0.691N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.486N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.921      P=0.500      (e)          (e)         |P=0.668N     P=0.500N     (e)          P=0.750N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.483N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Trachea: Glands                                                                                                                  | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    0/50 (0%)    5/49 (10%)  |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/43.15      0/45.37      0/44.07      5/44.36     |0/42.30      0/43.50      1/43.84      1/38.18      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         11.3%       |0.0%         0.0%         2.3%         2.6%         | 
|TERMINAL (d)       |     1/31 (3%)    0/35 (0%)    0/32 (0%)    4/32 (13%)  |0/33 (0%)    0/30 (0%)    1/33 (3%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          614         |---          ---          731 (T)      600          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.008 **   P=0.476N     P=0.494N     P=0.114     |P=0.189      (e)          P=0.500      P=0.480      | 
|POLY 3             |     P=0.007 **   P=0.490N     P=0.496N     P=0.107     |P=0.204      (e)          P=0.507      P=0.480      | 
|POLY 1.5           |     P=0.007 **   P=0.496N     P=0.499N     P=0.104     |P=0.218      (e)          P=0.505      P=0.489      | 
|POLY 6             |     P=0.007 **   P=0.482N     P=0.492N     P=0.111     |P=0.182      (e)          P=0.509      P=0.462      | 
|LOGISTIC REGRESSION|     P=0.008 **   (e)          (e)          P=0.107     |P=0.243      (e)          P=0.500      P=0.530      | 
|COCH-ARM / FISHERS |     P=0.008 **   P=0.505N     P=0.500N     P=0.098     |P=0.236      (e)          P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.003 **   (e)          (e)          (e)         |P=0.232      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Calculus Micro Observation Only                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/49 (4%)    4/50 (8%)    4/49 (8%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     4/44.03      2/45.42      4/44.60      4/44.28     |0/42.30      0/43.50      0/43.33      0/37.33      | 
|POLY-3 PERCENT (g) |     9.1%         4.4%         9.0%         9.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/31 (7%)    1/35 (3%)    2/32 (6%)    3/32 (9%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     589          717          578          638         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.464      P=0.298N     P=0.626N     P=0.621N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.457      P=0.323N     P=0.636N     P=0.640N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.458      P=0.333N     P=0.642N     P=0.642     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.452      P=0.311N     P=0.630N     P=0.638N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.453      P=0.366N     P=0.643N     P=0.622     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.455      P=0.349N     P=0.643N     P=0.631     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.539      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/49 (2%)    1/50 (2%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/43.75      1/45.87      1/44.10      0/43.95     |0/42.30      0/43.50      0/43.33      0/37.33      | 
|POLY-3 PERCENT (g) |     4.6%         2.2%         2.3%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    0/35 (0%)    0/32 (0%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     536          582          723          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.154N     P=0.481N     P=0.493N     P=0.234N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.157N     P=0.484N     P=0.497N     P=0.236N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.157N     P=0.493N     P=0.500N     P=0.238N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.159N     P=0.471N     P=0.493N     P=0.235N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.159N     P=0.597N     P=0.496N     P=0.286N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.155N     P=0.508N     P=0.500N     P=0.253N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.116N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/17/03                           EXPERIMENT: 88004 TEST: 05                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      DIVINYLBENZENE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |2/43.47      1/43.50      1/43.84      2/38.13      | 
|POLY-3 PERCENT (g) |                                                        |4.6%         2.3%         2.3%         5.3%         | 
|TERMINAL (d)       |                                                        |0/33 (0%)    1/30 (3%)    1/33 (3%)    1/22 (5%)    | 
|FIRST INCIDENCE    |                                                        |437          731 (T)      731 (T)      617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.465      P=0.505N     P=0.497N     P=0.619      | 
|POLY 3             |                                                        |P=0.514      P=0.500N     P=0.497N     P=0.646      | 
|POLY 1.5           |                                                        |P=0.532      P=0.498N     P=0.498N     P=0.668      | 
|POLY 6             |                                                        |P=0.489      P=0.506N     P=0.499N     P=0.608      | 
|LOGISTIC REGRESSION|                                                        |P=0.594      P=0.558N     P=0.546N     P=0.647N     | 
|COCH-ARM / FISHERS |                                                        |P=0.556      P=0.500N     P=0.500N     P=0.691N     | 
|ORDER RESTRICTED   |                                                        |P=0.476      (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).