National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/17655

TDMS Study 88004-05 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                      DIVINYLBENZENE                                    DATE: 12/17/03       
EXPERIMENT: 88004 TEST: 05                                                                                     TIME: 11:48:38       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 88004B       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 1321-74-0       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           FINAL #1 RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                      DIVINYLBENZENE                                    DATE: 12/17/03       
EXPERIMENT: 88004 TEST: 05                                                                                     TIME: 11:48:38       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 88004B       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 1321-74-0       
                                                                                                                                   
                                  DIVINYLBENZENE                                                                                    
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE RATS                                                                                      
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = CONTROL                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 19     CENSORED DEATHS 0    TERMINAL 31        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      355   506   536   543   561   589   589   612   612   623                 |                                                 
 |      638   666   670   675   682   701   704   722   725                       |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 100 PPM                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      106   393   569   582   605   654   654   659   682   704                 |                                                 
 |      708   710   717   722   728                                               |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 200 PPM                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      114   460   544   568   578   586   617   619   653   661                 |                                                 
 |      676   687   694   694   717   722   722   723                             |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                  DIVINYLBENZENE                                                                                    
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE RATS                                                                                      
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = 400 PPM                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      513   562   567   569   589   614   633   638   674   680                 |                                                 
 |      680   682   687   694   708   710   723   724                             |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                  DIVINYLBENZENE                                                                                    
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE RATS                                                                                      
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |CONTROL    |   100.0 100.0 100.0  98.0  98.0  98.0  92.0  86.0  78.0  62.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |100 PPM    |   100.0  98.0  98.0  98.0  96.0  96.0  96.0  90.0  84.0  70.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |200 PPM    |   100.0  98.0  98.0  98.0  98.0  96.0  94.0  88.0  80.0  64.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |400 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  90.0  84.0  64.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
 ==================================================================================                                                 
 |                           SURVIVAL SUMMARY STATISTICS                          |                                                 
 |                                                                                |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                                  DOSE                          |                                                 
 |                                                                                |                                                 
 |                                CONTROL      100 PPM      200 PPM      400 PPM  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |SURVIVAL AT END OF STUDY|       62.0%        70.0%        64.0%        64.0%    |                                                 
 |(KAPLAN-MEIER)          |                                                       |                                                 
 |                        |                                                       |                                                 
 |SIGNIFICANCE (B)        |       P=1.000N     P=0.435N     P=0.907N     P=0.853N |                                                 
 |(LIFE TABLE)            |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN DAY OF             |       616.3        612.9        613.1        647.1    |                                                 
 |NATURAL DEATHS (C)      |       (20.8)       (42.6)       (34.0)       (15.1)   |                                                 
 |(STANDARD ERROR)        |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN LIFE SPAN (D)      |       686.2        694.2        687.3        699.5    |                                                 
 |(STANDARD ERROR)        |       (11.0)       (14.6)       (14.4)       ( 7.7)   |                                                 
 |                        |                                                       |                                                 
 ==================================================================================                                                 
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                                  DIVINYLBENZENE                                                                                    
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE RATS                                                                                     
                       FIRST TERMINAL SACRIFICE AT 731 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = CONTROL                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      436   437   437   455   477   501   515   533   549   625                 |                                                 
 |      631   687   694   703   710   716   722                                   |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 100 PPM                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 19     CENSORED DEATHS 1    TERMINAL 30        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      374   487   542   543   561   617   638   642   666   670                 |                                                 
 |      670   688   696   703   703   708   711   715   729                       |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      506                                                                       |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 200 PPM                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      374   481   493   497   500   582   586   614   654   666                 |                                                 
 |      673   704   711   712   715   722   726                                   |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                  DIVINYLBENZENE                                                                                    
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE RATS                                                                                     
                       FIRST TERMINAL SACRIFICE AT 731 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = 400 PPM                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 28     CENSORED DEATHS 0    TERMINAL 22        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      151   516   523   525   529   535   535   540   551   563                 |                                                 
 |      586   586   589   600   600   613   617   626   626   631                 |                                                 
 |      653   653   656   656   684   708   708   712                             |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                  DIVINYLBENZENE                                                                                    
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE RATS                                                                                     
                       FIRST TERMINAL SACRIFICE AT 731 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 90   180   270   365   425   485   545   605   665   731 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |CONTROL    |   100.0 100.0 100.0 100.0 100.0  90.0  84.0  82.0  78.0  66.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |100 PPM    |   100.0 100.0 100.0 100.0  98.0  98.0  91.9  89.9  83.7  61.3      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |200 PPM    |   100.0 100.0 100.0 100.0  98.0  96.0  90.0  86.0  82.0  66.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |400 PPM    |   100.0  98.0  98.0  98.0  98.0  98.0  84.0  70.0  52.0  44.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
 ==================================================================================                                                 
 |                           SURVIVAL SUMMARY STATISTICS                          |                                                 
 |                                                                                |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                                  DOSE                          |                                                 
 |                                                                                |                                                 
 |                                CONTROL      100 PPM      200 PPM      400 PPM  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |SURVIVAL AT END OF STUDY|       66.0%        61.3%        66.0%        44.0%    |                                                 
 |(KAPLAN-MEIER)          |                                                       |                                                 
 |                        |                                                       |                                                 
 |SIGNIFICANCE (B)        |       P=0.019      P=0.901      P=1.000N     P=0.049  |                                                 
 |(LIFE TABLE)            |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN DAY OF             |       578.1        634.9        612.4        588.3    |                                                 
 |NATURAL DEATHS (C)      |       (27.2)       (21.5)       (26.3)       (19.8)   |                                                 
 |(STANDARD ERROR)        |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN LIFE SPAN (D)      |       679.0        690.0        690.7        651.1    |                                                 
 |(STANDARD ERROR)        |       (13.8)       (11.1)       (11.9)       (14.9)   |                                                 
 |                        |                                                       |                                                 
 ==================================================================================                                                 
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                                                           DIVINYLBENZENE                                                           
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        CONTROL          = 1                                                        
                                                        100 PPM          = 2                                                        
                                                        200 PPM          = 3                                                        
                                                        400 PPM          = 4                                                        
                                                                                                                                    
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
      |                                                                                                                             
  100 + 1                 23                                    1                        4                                          
      |                                                                                                                             
      |                   23                                    1      2         3      14       4                                  
      |                                                                                                                             
   96 +                                                                2         3      1    13   2                                 
      |                                                                                                                             
      |                                                                                      11  42 2                               
      |                                                                                                                             
   92 +                                                                                       1  1332 4 2                           
      |                                                                                                                             
      |                                                                                          1 33 1 24     2                    
      |                                                                                                                             
P  88 +                                                                                             3    43 4                       
E     |                                                                                                                             
R     |                                                                                               1  1  44 2 2                  
C     |                                                                                                                             
E  84 +                                                                                                   3  4 3 2 42               
N     |                                                                                                                             
T     |                                                                                                  11    3 3 42  2            
      |                                                                                                                             
S  80 +                                                                                                   1  1   3 3   22           
U     |                                                                                                                             
R     |                                                                                                      1    13 3              
V     |                                                                                                                             
I  76 +                                                                                                             433 22          
V     |                                                                                                                             
A     |                                                                                                           11 44  22         
L     |                                                                                                                             
   72 +                                                                                                            11 3 43          
      |                                                                                                                             
      |                                                                                                             1  1 32 2       
      |                                                                                                                             
   68 +                                                                                                                 4 4         
      |                                                                                                                             
      |                                                                                                                1  1         
      |                                                                                                                             
   64 +                                                                                                                   3 3       
      |                                                                                                                             
      |                                                                                                                   1 1       
      |                                                                                                                             
   60 +                                                                                                                             
      |                                                                                                                             
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110 
                                                                                                                                    
                                                                   WEEK                                                             
                                                                                                                                    
NOTE: 14 obs hidden.                                                                                                                
                                                                                                                                   
                                                           DIVINYLBENZENE                                                           
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        CONTROL          = 1                                                        
                                                        100 PPM          = 2                                                        
                                                        200 PPM          = 3                                                        
                                                        400 PPM          = 4                                                        
                                                                                                                                    
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
      |                                                                                                                             
      |                                                                                                                             
  100 + 1                       4                                  2         1                                                      
      |                         4                                  2                32   4                                          
      |                                                                      1  1   323  4 4  2                                     
      |                                                                         1   1 33   44 2  2                                  
P  90 +                                                                             1  1    44   2  3     2                         
E     |                                                                                1 1                2  2                      
R     |                                                                                  1   141    3    3     3                    
C     |                                                                                        1 4         1 2 3  2                 
E  80 +                                                                                          4  4      11     33                
N     |                                                                                                     1     23 1 3            
T     |                                                                                             4 44             1113           
      |                                                                                                               2113          
S  70 +                                                                                                4 4             2113         
U     |                                                                                                  44              11         
R     |                                                                                                   44            221 1       
V     |                                                                                                    44            2  2       
I  60 +                                                                                                     4  4                    
V     |                                                                                                                             
A     |                                                                                                                             
L     |                                                                                                        4    4               
   50 +                                                                                                             4   4           
      |                                                                                                                             
      |                                                                                                                 4   4       
      |                                                                                                                             
   40 +                                                                                                                             
      |                                                                                                                             
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110 
                                                                                                                                    
                                                                   WEEK                                                             
                                                                                                                                    
NOTE: 26 obs hidden.                                                                                                                
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.