National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/20590

TDMS Study 93020-07 Pathology Tables

NTP Experiment-Test: 93020-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 06/30/04
Route: SKIN APPLICATION                                                                                           Time: 11:19:18

                                                         FINAL #1 RATS




       Facility:  Southern Research Institute

       Chemical CAS #:  693-13-0

       Lock Date:  03/14/03

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 93020-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 06/30/04  
Route: SKIN APPLICATION                                                                                           Time: 11:19:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13            9           10           14                                     
    Natural Death                                      7            9            8           10                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           32           32           25                                     
  Other                                                                                       1                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           49                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (49)         (49)                                   
   Intestine Large, Cecum                             (50)         (50)         (50)         (49)                                   
   Intestine Small, Duodenum                          (49)         (50)         (50)         (49)                                   
      Leiomyoma                                                                               1 (2%)                                
   Intestine Small, Jejunum                           (47)         (50)         (50)         (46)                                   
   Intestine Small, Ileum                             (48)         (49)         (50)         (49)                                   
   Liver                                              (50)         (50)         (50)         (49)                                   
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
      Hepatocellular Adenoma                           6 (12%)      1 (2%)       2 (4%)       1 (2%)                                
   Mesentery                                          (11)         (12)         (9)          (9)                                    
      Fibrosarcoma                                                               1 (11%)                                            
   Oral Mucosa                                        (1)                       (2)                                                 
      Squamous Cell Carcinoma                          1 (100%)                  1 (50%)                                            
   Pancreas                                           (50)         (50)         (50)         (49)                                   
   Salivary Glands                                    (50)         (50)         (50)         (48)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (49)                                   
   Tongue                                             (2)                       (1)                                                 
      Squamous Cell Papilloma                          2 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (49)                                   
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
      Schwannoma Malignant                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 06/30/04  
Route: SKIN APPLICATION                                                                                           Time: 11:19:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Adenoma                                          3 (6%)                                 1 (2%)                                
   Adrenal Medulla                                    (49)         (50)         (50)         (49)                                   
      Pheochromocytoma Malignant                                                              1 (2%)                                
      Pheochromocytoma Benign                                       1 (2%)       1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Adenoma                                                                                 2 (4%)                                
   Pituitary Gland                                    (50)         (50)         (50)         (49)                                   
      Pars Distalis, Adenoma                          28 (56%)     32 (64%)     30 (60%)     24 (49%)                               
      Pars Distalis, Adenoma, Multiple                 5 (10%)      2 (4%)       3 (6%)       3 (6%)                                
      Pars Distalis, Carcinoma                         3 (6%)       1 (2%)       1 (2%)       4 (8%)                                
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      C-Cell, Adenoma                                  3 (6%)       2 (4%)       6 (12%)      6 (12%)                               
      C-Cell, Carcinoma                                2 (4%)                    2 (4%)       3 (6%)                                
      Follicular Cell, Adenoma                                      2 (4%)                                                          
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (49)         (50)         (49)                                   
      Adenoma                                          2 (4%)       3 (6%)       5 (10%)      2 (4%)                                
      Carcinoma                                        2 (4%)       6 (12%)                   2 (4%)                                
      Carcinoma, Multiple                                                        1 (2%)                                             
   Ovary                                              (50)         (50)         (50)         (49)                                   
   Uterus                                             (50)         (50)         (50)         (49)                                   
      Carcinoma                                                                               2 (4%)                                
      Leiomyoma                                        1 (2%)                                 1 (2%)                                
      Polyp Stromal                                   10 (20%)     10 (20%)      9 (18%)      9 (18%)                               
      Polyp Stromal, Multiple                                                    1 (2%)       1 (2%)                                
      Sarcoma                                                                                 1 (2%)                                
   Vagina                                             (6)          (6)          (5)          (11)                                   
      Granular Cell Tumor Benign                                    1 (17%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 06/30/04  
Route: SKIN APPLICATION                                                                                           Time: 11:19:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (49)                                   
   Lymph Node                                         (13)         (10)         (14)         (8)                                    
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                1 (8%)                                 1 (13%)                               
      Mediastinal, Carcinoma, Metastatic, Thyroid                                                                                   
          Gland                                        1 (8%)                                 1 (13%)                               
      Renal, Carcinoma, Metastatic, Thyroid Gland                                             1 (13%)                               
   Lymph Node, Mandibular                             (3)          (7)          (1)          (2)                                    
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (48)                                   
   Spleen                                             (50)         (50)         (50)         (49)                                   
   Thymus                                             (50)         (48)         (49)         (46)                                   
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (48)                                   
      Adenoma                                                       1 (2%)       1 (2%)       1 (2%)                                
      Carcinoma                                        4 (8%)                    2 (4%)                                             
      Fibroadenoma                                    10 (20%)      9 (18%)     20 (40%)     13 (27%)                               
      Fibroadenoma, Multiple                           2 (4%)       2 (4%)       1 (2%)       3 (6%)                                
   Skin                                               (50)         (50)         (50)         (49)                                   
      Keratoacanthoma                                  1 (2%)                                                                       
      Sebaceous Gland, Adenoma                                      1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                                               1 (2%)       3 (6%)                                
      Subcutaneous Tissue, Fibrosarcoma                             2 (4%)                                                          
      Subcutaneous Tissue, Schwannoma Malignant        2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (49)                                   
      Carcinoma, Metastatic, Pituitary Gland           3 (6%)                                 2 (4%)                                
      Glioma Malignant, Mixed Cell                                               2 (4%)       1 (2%)                                
      Granular Cell Tumor Benign                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 06/30/04  
Route: SKIN APPLICATION                                                                                           Time: 11:19:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (49)                                   
      Alveolar/Bronchiolar Adenoma                                  1 (2%)                                                          
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (49)                                   
      Iris, Amelanotic Melanoma, Benign                1 (2%)                                                                       
   Harderian Gland                                    (50)         (50)         (50)         (49)                                   
      Adenoma                                                                                 1 (2%)                                
   Zymbal's Gland                                                  (1)                                                              
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)                                   
      Renal Tubule, Adenoma                                                                   1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (50)         (49)                                   
      Papilloma                                                                  1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(49)                                   
      Leukemia Mononuclear                             9 (18%)      9 (18%)      7 (14%)     15 (31%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 06/30/04  
Route: SKIN APPLICATION                                                                                           Time: 11:19:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          45          44          45                                       
     Total Primary Neoplasms                           99          89         100         103                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 44          41          41          39                                       
     Total Benign Neoplasms                            74          70          83          74                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          14          16          23                                       
     Total Malignant Neoplasms                         25          19          17          29                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4                                   3                                       
     Total Metastatic Neoplasm                          6                                   9                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 06/30/04  
Route: SKIN APPLICATION                                                                                           Time: 11:19:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     12            8            8           10                                     
    Moribund Sacrifice                                18           12           10           23                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                20           30           32           17                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                                     1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Mesentery                   1 (2%)                                                          
   Intestine Large, Cecum                             (50)         (50)         (50)         (49)                                   
   Intestine Small, Duodenum                          (49)         (49)         (49)         (49)                                   
      Schwannoma Malignant, Metastatic, Mesentery                   1 (2%)                                                          
   Intestine Small, Jejunum                           (49)         (49)         (48)         (49)                                   
   Intestine Small, Ileum                             (49)         (49)         (50)         (48)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Adenoma                                        2 (4%)       1 (2%)                                             
   Mesentery                                          (9)          (9)          (12)         (6)                                    
      Schwannoma Malignant                                          1 (11%)                   1 (17%)                               
   Oral Mucosa                                                                  (2)                                                 
      Squamous Cell Carcinoma                                                    2 (100%)                                           
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Mixed Tumor Malignant                                         1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (2%)                                             
      Acinus, Adenoma                                  3 (6%)       1 (2%)       2 (4%)                                             
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
      Sarcoma                                          1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)       1 (2%)                    1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (49)                                   
   Tongue                                             (1)          (1)          (1)          (1)                                    
      Squamous Cell Papilloma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 06/30/04  
Route: SKIN APPLICATION                                                                                           Time: 11:19:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant                             1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)         (50)                                   
   Adrenal Medulla                                    (50)         (48)         (50)         (50)                                   
      Ganglioneuroma                                                1 (2%)                                                          
      Pheochromocytoma Malignant                       3 (6%)       4 (8%)       4 (8%)       2 (4%)                                
      Pheochromocytoma Malignant, Multiple             1 (2%)                                                                       
      Pheochromocytoma Complex                                                                1 (2%)                                
      Pheochromocytoma Benign                          3 (6%)       2 (4%)       8 (16%)      7 (14%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                          4 (8%)      12 (24%)      9 (18%)      5 (10%)                               
      Adenoma, Multiple                                1 (2%)                    1 (2%)                                             
      Carcinoma                                        2 (4%)       1 (2%)       1 (2%)                                             
   Parathyroid Gland                                  (49)         (48)         (49)         (48)                                   
      Adenoma                                                                                 1 (2%)                                
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Pars Distalis, Adenoma                          28 (56%)     33 (66%)     38 (76%)     17 (34%)                               
      Pars Distalis, Adenoma, Multiple                 1 (2%)                    4 (8%)       3 (6%)                                
      Pars Distalis, Carcinoma                         5 (10%)      1 (2%)                    2 (4%)                                
      Pars Intermedia, Adenoma                         2 (4%)                                                                       
      Pars Intermedia, Carcinoma                       1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Sarcoma, Metastatic, Salivary Glands             1 (2%)                                                                       
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                  3 (6%)       8 (16%)      8 (16%)      4 (8%)                                
      C-Cell, Adenoma, Multiple                        1 (2%)       1 (2%)                                                          
      C-Cell, Carcinoma                                5 (10%)      1 (2%)       2 (4%)                                             
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)          (1)                                                 
      Hemangioma                                                    1 (100%)                                                        
      Lipoma                                                                     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 06/30/04  
Route: SKIN APPLICATION                                                                                           Time: 11:19:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)       4 (8%)                                
      Carcinoma                                        1 (2%)       2 (4%)                                                          
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)       2 (4%)       1 (2%)                                             
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           21 (42%)     27 (54%)     15 (30%)     14 (28%)                               
      Interstitial Cell, Adenoma                      15 (30%)     10 (20%)     16 (32%)      8 (16%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (18)         (14)         (16)         (13)                                   
      Mediastinal, Hemangiosarcoma                                               1 (6%)                                             
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant, Metastatic, Mesentery                   1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (50)                                   
   Thymus                                             (49)         (46)         (46)         (49)                                   
      Thymoma Benign                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (48)         (47)         (48)                                   
      Carcinoma                                                                  1 (2%)                                             
      Fibroadenoma                                                  4 (8%)       1 (2%)       1 (2%)                                
   Skin                                               (49)         (50)         (50)         (50)                                   
      Keratoacanthoma                                  3 (6%)       1 (2%)       3 (6%)       1 (2%)                                
      Squamous Cell Papilloma                          1 (2%)       1 (2%)       1 (2%)                                             
      Sebaceous Gland, Carcinoma                       1 (2%)       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     5 (10%)      4 (8%)       2 (4%)       3 (6%)                                
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                                             
      Subcutaneous Tissue, Lipoma                                   3 (6%)       1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant        2 (4%)                    2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 06/30/04  
Route: SKIN APPLICATION                                                                                           Time: 11:19:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
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 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteoma                                                                                 1 (2%)                                
      Osteosarcoma                                                                            1 (2%)                                
   Skeletal Muscle                                    (3)          (1)          (1)          (5)                                    
      Lipoma                                           1 (33%)                                                                      
      Sarcoma                                          1 (33%)                                                                      
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                            1 (2%)                                                                       
      Carcinoma, Metastatic, Pituitary Gland           5 (10%)      1 (2%)                    1 (2%)                                
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       2 (4%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                    2 (4%)                                             
      Schwannoma Malignant, Metastatic, Mesentery                   1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma                          1 (2%)                                                                       
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
   Zymbal's Gland                                                                            (1)                                    
      Carcinoma                                                                               1 (100%)                              
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 06/30/04  
Route: SKIN APPLICATION                                                                                           Time: 11:19:18  
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         FISCHER 344 RATS MALE                     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
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 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            13 (26%)     22 (44%)     13 (26%)      6 (12%)                               
      Lymphoma Malignant                               2 (4%)                                 1 (2%)                                
      Mesothelioma Malignant                           1 (2%)       2 (4%)       4 (8%)       1 (2%)                                
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 06/30/04  
Route: SKIN APPLICATION                                                                                           Time: 11:19:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          50          33                                       
     Total Primary Neoplasms                          141         154         148          89                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          48          50          32                                       
     Total Benign Neoplasms                            99         117         115          70                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              34          31          27          15                                       
     Total Malignant Neoplasms                         42          37          33          19                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              7           2           3           1                                       
     Total Metastatic Neoplasm                          7           5           4           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.