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TDMS Study 93020-07 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                             DIISOPROPYLCARBODIIMIDE                                DATE: 01/03/05       
EXPERIMENT: 93020 TEST: 07                                                                                     TIME: 09:20:08       
TEST TYPE:  CHRONIC                                                                                            PAGE:       1        
CONT: N01-ES 05451                              ROUTE: SKIN APPLICATION                                        NTP C#: 93020D       
PATHOLOGIST: HEATH, JAMES                                                                                      CAS: 693-13-0        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                       25018 Dosing Accident                                                                        
                                       25023 Missing                                                                                
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25017 Scheduled Sacrifice                                                                    
                                       25021 Terminal Sacrifice                                                                     
                                       25007 Wrong Sex                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                             DIISOPROPYLCARBODIIMIDE                                DATE: 01/03/05       
EXPERIMENT: 93020 TEST: 07                                                                                     TIME: 09:20:08       
TEST TYPE:  CHRONIC                                                                                                                 
CONT: N01-ES 05451                              ROUTE: SKIN APPLICATION                                        NTP C#: 93020D       
PATHOLOGIST: HEATH, JAMES                                                                                      CAS: 693-13-0        
Rats(FISCHER 344)                                                                                                                   
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Brain                                                                              
                                                 Clitoral/Preputial Gland                                                           
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Nose                                                                               
                                                 Pancreas                                                                           
                                                 Parathyroid Gland                                                                  
                                                 Pituitary Gland                                                                    
                                                 Prostate                                                                           
                                                 Salivary Glands                                                                    
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                             DIISOPROPYLCARBODIIMIDE                                DATE: 01/03/05       
EXPERIMENT: 93020 TEST: 07                                                                                     TIME: 09:20:08       
TEST TYPE:  CHRONIC                                                                                                                 
CONT: N01-ES 05451                              ROUTE: SKIN APPLICATION                                        NTP C#: 93020D       
PATHOLOGIST: HEATH, JAMES                                                                                      CAS: 693-13-0        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                DIISOPROPYLCARBODIIMIDE                                                                           
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Medulla                        Pheochromocytoma Benign                                                                      
                                       Pheochromocytoma: Benign, Complex, Malignant, NOS                                            
Bone                                   Osteosarcoma or Osteoma                                                                      
Clitoral/Preputial Gland               Adenoma                                                                                      
Pituitary Gland: Pars Distalis or Unspecified Site                                                                                  
                                       Adenoma                                                                                      
                                       Carcinoma                                                                                    
                                       Carcinoma or Adenoma                                                                         
Pituitary Gland: Pars Intermedia       Carcinoma or Adenoma                                                                         
Testes                                 Adenoma                                                                                      
Thyroid Gland: C-Cell                  Carcinoma                                                                                    
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                           
                                       Osteosarcoma or Osteoma                                                                      
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Adenoma                                                                                      
Islets, Pancreatic                     Adenoma                                                                                      
                                       Carcinoma or Adenoma                                                                         
Liver                                  Hepatocellular Adenoma                                                                       
Mammary Gland                          Carcinoma                                                                                    
                                       Fibroadenoma                                                                                 
                                       Fibroma, Fibroadenoma or Adenoma                                                             
Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                          
                                       Squamous Cell Carcinoma, Papilloma Squamous,                                                 
                                       or Papilloma                                                                                 
Skin                                   Fibroma                                                                                      
                                       Schwannoma Malignant                                                                         
Thyroid Gland: C-Cell                  Carcinoma or Adenoma                                                                         
Uterus                                 Carcinoma                                                                                    
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                           
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 1       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -                 DIISOPROPYLCARBODIIMIDE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    0/50 (0%)    0/50 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/40.18      0/40.75      0/44.41      0/28.31     |3/41.69      0/42.03      0/43.75      1/41.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |7.2%         0.0%         0.0%         2.4%         | 
|TERMINAL (d)       |     0/20 (0%)    0/30 (0%)    0/32 (0%)    0/17 (0%)   |2/30 (7%)    0/32 (0%)    0/32 (0%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |710          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.285N     P=0.110N     P=0.112N     P=0.372N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.248N     P=0.117N     P=0.110N     P=0.310N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.248N     P=0.118N     P=0.113N     P=0.308N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.248N     P=0.114N     P=0.108N     P=0.319N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.264N     P=0.111N     P=0.106N     P=0.339N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.251N     P=0.121N     P=0.121N     P=0.316N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.038N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/48 (4%)    8/50 (16%)   7/50 (14%)  |0/49 (0%)    1/50 (2%)    1/50 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     3/40.23      2/39.75      8/44.41      7/28.90     |0/40.61      1/42.03      1/43.75      1/41.08      | 
|POLY-3 PERCENT (g) |     7.5%         5.0%         18.0%        24.2%       |0.0%         2.4%         2.3%         2.4%         | 
|TERMINAL (d)       |     2/20 (10%)   2/29 (7%)    8/32 (25%)   4/17 (24%)  |0/29 (0%)    1/32 (3%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     716          729 (T)      729 (T)      630         |---          729 (T)      729 (T)      725          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.012 *    P=0.337N     P=0.307      P=0.089     |P=0.338      P=0.520      P=0.520      P=0.471      | 
|POLY 3             |     P=0.012 *    P=0.506N     P=0.130      P=0.055     |P=0.387      P=0.507      P=0.515      P=0.502      | 
|POLY 1.5           |     P=0.016 *    P=0.513N     P=0.115      P=0.070     |P=0.389      P=0.505      P=0.512      P=0.503      | 
|POLY 6             |     P=0.013 *    P=0.489N     P=0.157      P=0.056     |P=0.378      P=0.510      P=0.518      P=0.498      | 
|LOGISTIC REGRESSION|     P=0.009 **   P=0.393N     P=0.269      P=0.052     |P=0.346      P=0.520      P=0.520      P=0.485      | 
|COCH-ARM / FISHERS |     P=0.059      P=0.520N     P=0.100      P=0.159     |P=0.382      P=0.505      P=0.505      P=0.500      | 
|ORDER RESTRICTED   |     P=0.027 *    (e)          (e)          (e)         |P=0.329      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 2       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    4/48 (8%)    4/50 (8%)    2/50 (4%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     4/40.50      4/39.75      4/45.23      2/28.31     |0/40.61      0/42.03      0/43.75      1/41.08      | 
|POLY-3 PERCENT (g) |     9.9%         10.1%        8.8%         7.1%        |0.0%         0.0%         0.0%         2.4%         | 
|TERMINAL (d)       |     0/20 (0%)    4/29 (14%)   2/32 (6%)    2/17 (12%)  |0/29 (0%)    0/32 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     688          729 (T)      563          729 (T)     |---          ---          ---          725          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.365N     P=0.461N     P=0.459N     P=0.459N    |P=0.172      (e)          (e)          P=0.471      | 
|POLY 3             |     P=0.396N     P=0.634      P=0.582N     P=0.511N    |P=0.198      (e)          (e)          P=0.502      | 
|POLY 1.5           |     P=0.376N     P=0.627      P=0.610N     P=0.473N    |P=0.199      (e)          (e)          P=0.503      | 
|POLY 6             |     P=0.384N     P=0.641N     P=0.539N     P=0.516N    |P=0.195      (e)          (e)          P=0.498      | 
|LOGISTIC REGRESSION|     P=0.399N     P=0.591N     P=0.629N     P=0.491N    |P=0.181      (e)          (e)          P=0.485      | 
|COCH-ARM / FISHERS |     P=0.250N     P=0.619      P=0.643N     P=0.339N    |P=0.197      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.554N     (e)          (e)          (e)         |P=0.122      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   6/48 (13%)   12/50 (24%)  9/50 (18%)  |0/49 (0%)    1/50 (2%)    1/50 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     6/40.50      6/39.75      12/45.23     9/28.90     |0/40.61      1/42.03      1/43.75      1/41.08      | 
|POLY-3 PERCENT (g) |     14.8%        15.1%        26.5%        31.1%       |0.0%         2.4%         2.3%         2.4%         | 
|TERMINAL (d)       |     2/20 (10%)   6/29 (21%)   10/32 (31%)  6/17 (35%)  |0/29 (0%)    1/32 (3%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     688          729 (T)      563          630         |---          729 (T)      729 (T)      725          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.049 *    P=0.378N     P=0.357      P=0.155     |P=0.338      P=0.520      P=0.520      P=0.471      | 
|POLY 3             |     P=0.038 *    P=0.609      P=0.142      P=0.093     |P=0.387      P=0.507      P=0.515      P=0.502      | 
|POLY 1.5           |     P=0.052      P=0.599      P=0.119      P=0.123     |P=0.389      P=0.505      P=0.512      P=0.503      | 
|POLY 6             |     P=0.040 *    P=0.618N     P=0.182      P=0.091     |P=0.378      P=0.510      P=0.518      P=0.498      | 
|LOGISTIC REGRESSION|     P=0.034 *    P=0.525N     P=0.182      P=0.090     |P=0.346      P=0.520      P=0.520      P=0.485      | 
|COCH-ARM / FISHERS |     P=0.184      P=0.591      P=0.096      P=0.288     |P=0.382      P=0.505      P=0.505      P=0.500      | 
|ORDER RESTRICTED   |     P=0.095      (e)          (e)          (e)         |P=0.329      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 3       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Osteosarcoma or Osteoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/40.18      0/41.64      0/44.41      2/28.51     |0/41.61      0/42.03      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         7.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/30 (0%)    0/32 (0%)    1/17 (6%)   |0/30 (0%)    0/32 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          676         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.020 *    (e)          (e)          P=0.180     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.038 *    (e)          (e)          P=0.170     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.038 *    (e)          (e)          P=0.182     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.039 *    (e)          (e)          P=0.171     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.022 *    (e)          (e)          P=0.165     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.012 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Glioma Malignant                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/40.18      0/41.64      0/44.41      0/28.31     |0/41.61      0/42.03      2/44.49      1/41.82      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.5%         2.4%         | 
|TERMINAL (d)       |     0/20 (0%)    0/30 (0%)    0/32 (0%)    0/17 (0%)   |0/30 (0%)    0/32 (0%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          465          456          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.235      (e)          P=0.254      P=0.508      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.248      (e)          P=0.252      P=0.501      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.249      (e)          P=0.248      P=0.501      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.239      (e)          P=0.257      P=0.498      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.152      (e)          P=0.182      P=0.315      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.241      (e)          P=0.247      P=0.495      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.180      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 4       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     1/40.18      0/41.64      0/44.41      0/28.31     |0/41.61      0/42.03      2/44.49      1/41.82      | 
|POLY-3 PERCENT (g) |     2.5%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.5%         2.4%         | 
|TERMINAL (d)       |     1/20 (5%)    0/30 (0%)    0/32 (0%)    0/17 (0%)   |0/30 (0%)    0/32 (0%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          465          456          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.311N     P=0.419N     P=0.406N     P=0.532N    |P=0.235      (e)          P=0.254      P=0.508      | 
|POLY 3             |     P=0.240N     P=0.493N     P=0.480N     P=0.568N    |P=0.248      (e)          P=0.252      P=0.501      | 
|POLY 1.5           |     P=0.260N     P=0.497N     P=0.489N     P=0.554N    |P=0.249      (e)          P=0.248      P=0.501      | 
|POLY 6             |     P=0.233N     P=0.485N     P=0.466N     P=0.568N    |P=0.239      (e)          P=0.257      P=0.498      | 
|LOGISTIC REGRESSION|     P=0.311N     (e)          (e)          (e)         |P=0.152      (e)          P=0.182      P=0.315      | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.241      (e)          P=0.247      P=0.495      | 
|ORDER RESTRICTED   |     P=0.193N     (e)          (e)          (e)         |P=0.180      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    4/50 (8%)   |2/50 (4%)    3/49 (6%)    5/50 (10%)   2/49 (4%)    | 
|POLY-3 RATE (b)    |     1/40.18      1/41.64      1/44.41      4/29.07     |2/41.61      3/41.03      5/44.17      2/41.28      | 
|POLY-3 PERCENT (g) |     2.5%         2.4%         2.3%         13.8%       |4.8%         7.3%         11.3%        4.8%         | 
|TERMINAL (d)       |     1/20 (5%)    1/30 (3%)    1/32 (3%)    2/17 (12%)  |2/30 (7%)    3/31 (10%)   4/32 (13%)   1/25 (4%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      607         |729 (T)      729 (T)      606          673          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.026 *    P=0.669N     P=0.654N     P=0.118     |P=0.497      P=0.515      P=0.241      P=0.636      | 
|POLY 3             |     P=0.046 *    P=0.753N     P=0.738N     P=0.097     |P=0.578N     P=0.494      P=0.240      P=0.692      | 
|POLY 1.5           |     P=0.047 *    P=0.757N     P=0.749N     P=0.110     |P=0.575N     P=0.491      P=0.233      P=0.693      | 
|POLY 6             |     P=0.048 *    P=0.744N     P=0.721N     P=0.100     |P=0.567      P=0.499      P=0.248      P=0.686      | 
|LOGISTIC REGRESSION|     P=0.026 *    P=0.669N     P=0.654N     P=0.094     |P=0.566      P=0.515      P=0.239      P=0.679      | 
|COCH-ARM / FISHERS |     P=0.067      P=0.753N     P=0.753N     P=0.181     |P=0.573      P=0.490      P=0.218      P=0.684      | 
|ORDER RESTRICTED   |     P=0.025 *    (e)          (e)          (e)         |P=0.438      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 5       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    6/49 (12%)   1/50 (2%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     1/40.24      2/42.08      0/44.41      0/28.31     |2/42.17      6/41.68      1/43.75      2/41.07      | 
|POLY-3 PERCENT (g) |     2.5%         4.8%         0.0%         0.0%        |4.7%         14.4%        2.3%         4.9%         | 
|TERMINAL (d)       |     0/20 (0%)    0/30 (0%)    0/32 (0%)    0/17 (0%)   |1/30 (3%)    4/31 (13%)   1/32 (3%)    2/25 (8%)    | 
|FIRST INCIDENCE    |     714          621          ---          ---         |556          513          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.215N     P=0.573      P=0.428N     P=0.560N    |P=0.382N     P=0.150      P=0.482N     P=0.648      | 
|POLY 3             |     P=0.195N     P=0.516      P=0.480N     P=0.568N    |P=0.321N     P=0.127      P=0.487N     P=0.685      | 
|POLY 1.5           |     P=0.201N     P=0.507      P=0.489N     P=0.554N    |P=0.317N     P=0.127      P=0.490N     P=0.689      | 
|POLY 6             |     P=0.183N     P=0.532      P=0.467N     P=0.569N    |P=0.331N     P=0.130      P=0.485N     P=0.674      | 
|LOGISTIC REGRESSION|     P=0.217N     P=0.505      P=0.457N     P=0.565N    |P=0.319N     P=0.128      P=0.507N     P=0.691      | 
|COCH-ARM / FISHERS |     P=0.188N     P=0.500      P=0.500N     P=0.500N    |P=0.324N     P=0.128      P=0.500N     P=0.684      | 
|ORDER RESTRICTED   |     P=0.258N     (e)          (e)          (e)         |P=0.209N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    1/50 (2%)    4/50 (8%)   |4/50 (8%)    9/49 (18%)   6/50 (12%)   4/49 (8%)    | 
|POLY-3 RATE (b)    |     2/40.24      3/42.08      1/44.41      4/29.07     |4/42.17      9/41.68      6/44.17      4/41.28      | 
|POLY-3 PERCENT (g) |     5.0%         7.1%         2.3%         13.8%       |9.5%         21.6%        13.6%        9.7%         | 
|TERMINAL (d)       |     1/20 (5%)    1/30 (3%)    1/32 (3%)    2/17 (12%)  |3/30 (10%)   7/31 (23%)   5/32 (16%)   3/25 (12%)   | 
|FIRST INCIDENCE    |     714          621          729 (T)      607         |556          513          606          673          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.176      P=0.628      P=0.352N     P=0.234     |P=0.478N     P=0.132      P=0.406      P=0.563      | 
|POLY 3             |     P=0.220      P=0.520      P=0.466N     P=0.203     |P=0.373N     P=0.107      P=0.398      P=0.632      | 
|POLY 1.5           |     P=0.224      P=0.510      P=0.481N     P=0.225     |P=0.366N     P=0.107      P=0.390      P=0.637      | 
|POLY 6             |     P=0.232      P=0.542      P=0.442N     P=0.207     |P=0.393N     P=0.110      P=0.406      P=0.619      | 
|LOGISTIC REGRESSION|     P=0.167      P=0.527      P=0.385N     P=0.195     |P=0.372N     P=0.110      P=0.393      P=0.635      | 
|COCH-ARM / FISHERS |     P=0.292      P=0.500      P=0.500N     P=0.339     |P=0.378N     P=0.109      P=0.370      P=0.631      | 
|ORDER RESTRICTED   |     P=0.126      (e)          (e)          (e)         |P=0.350N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 6       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   12/50 (24%)  10/50 (20%)  5/50 (10%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     5/41.01      12/42.04     10/45.45     5/29.34     |0/41.61      0/42.03      0/43.75      2/41.51      | 
|POLY-3 PERCENT (g) |     12.2%        28.6%        22.0%        17.0%       |0.0%         0.0%         0.0%         4.8%         | 
|TERMINAL (d)       |     2/20 (10%)   11/30 (37%)  6/32 (19%)   3/17 (18%)  |0/30 (0%)    0/32 (0%)    0/32 (0%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     608          617          563          513         |---          ---          ---          601          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.552      P=0.183      P=0.359      P=0.461     |P=0.039 *    (e)          (e)          P=0.217      | 
|POLY 3             |     P=0.414      P=0.054      P=0.178      P=0.412     |P=0.044 *    (e)          (e)          P=0.236      | 
|POLY 1.5           |     P=0.468      P=0.053      P=0.155      P=0.455     |P=0.045 *    (e)          (e)          P=0.237      | 
|POLY 6             |     P=0.435      P=0.058      P=0.217      P=0.413     |P=0.043 *    (e)          (e)          P=0.232      | 
|LOGISTIC REGRESSION|     P=0.483      P=0.073      P=0.156      P=0.439     |P=0.043 *    (e)          (e)          P=0.229      | 
|COCH-ARM / FISHERS |     P=0.348N     P=0.054      P=0.131      P=0.630N    |P=0.045 *    (e)          (e)          P=0.242      | 
|ORDER RESTRICTED   |     P=0.236      (e)          (e)          (e)         |P=0.029 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/40.18      1/41.64      1/44.41      0/28.31     |0/41.61      0/42.03      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     5.0%         2.4%         2.3%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/20 (10%)   1/30 (3%)    1/32 (3%)    0/17 (0%)   |0/30 (0%)    0/32 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.158N     P=0.359N     P=0.338N     P=0.273N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.184N     P=0.487N     P=0.465N     P=0.322N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.182N     P=0.494N     P=0.481N     P=0.304N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.179N     P=0.474N     P=0.441N     P=0.322N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.158N     P=0.359N     P=0.338N     (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.153N     P=0.500N     P=0.500N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.191N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 7       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   13/50 (26%)  11/50 (22%)  5/50 (10%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     7/41.01      13/42.04     11/45.45     5/29.34     |0/41.61      0/42.03      0/43.75      2/41.51      | 
|POLY-3 PERCENT (g) |     17.1%        30.9%        24.2%        17.0%       |0.0%         0.0%         0.0%         4.8%         | 
|TERMINAL (d)       |     4/20 (20%)   12/30 (40%)  7/32 (22%)   3/17 (18%)  |0/30 (0%)    0/32 (0%)    0/32 (0%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     608          617          563          513         |---          ---          ---          601          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.365N     P=0.327      P=0.537      P=0.556N    |P=0.039 *    (e)          (e)          P=0.217      | 
|POLY 3             |     P=0.484N     P=0.107      P=0.291      P=0.622N    |P=0.044 *    (e)          (e)          P=0.236      | 
|POLY 1.5           |     P=0.436N     P=0.105      P=0.256      P=0.575N    |P=0.045 *    (e)          (e)          P=0.237      | 
|POLY 6             |     P=0.457N     P=0.116      P=0.347      P=0.621N    |P=0.043 *    (e)          (e)          P=0.232      | 
|LOGISTIC REGRESSION|     P=0.449N     P=0.146      P=0.286      P=0.613N    |P=0.043 *    (e)          (e)          P=0.229      | 
|COCH-ARM / FISHERS |     P=0.192N     P=0.105      P=0.218      P=0.380N    |P=0.045 *    (e)          (e)          P=0.242      | 
|ORDER RESTRICTED   |     P=0.380      (e)          (e)          (e)         |P=0.029 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |6/50 (12%)   1/50 (2%)    2/50 (4%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/40.18      2/41.83      1/44.41      0/28.31     |6/42.04      1/42.03      2/43.75      1/41.07      | 
|POLY-3 PERCENT (g) |     0.0%         4.8%         2.3%         0.0%        |14.3%        2.4%         4.6%         2.4%         | 
|TERMINAL (d)       |     0/20 (0%)    1/30 (3%)    1/32 (3%)    0/17 (0%)   |4/30 (13%)   1/32 (3%)    2/32 (6%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     ---          682          729 (T)      ---         |632          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.526N     P=0.295      P=0.594      (e)         |P=0.067N     P=0.052N     P=0.117N     P=0.090N     | 
|POLY 3             |     P=0.550N     P=0.246      P=0.520      (e)         |P=0.049N*    P=0.055N     P=0.119N     P=0.058N     | 
|POLY 1.5           |     P=0.539N     P=0.241      P=0.511      (e)         |P=0.048N*    P=0.056N     P=0.123N     P=0.057N     | 
|POLY 6             |     P=0.538N     P=0.256      P=0.534      (e)         |P=0.051N     P=0.053N     P=0.117N     P=0.063N     | 
|LOGISTIC REGRESSION|     P=0.542N     P=0.253      P=0.594      (e)         |P=0.052N     P=0.054N     P=0.114N     P=0.063N     | 
|COCH-ARM / FISHERS |     P=0.461N     P=0.247      P=0.500      (e)         |P=0.052N     P=0.056N     P=0.134N     P=0.059N     | 
|ORDER RESTRICTED   |     P=0.381      (e)          (e)          (e)         |P=0.014N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 8       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/40.24      2/41.64      0/44.41      0/28.31     |0/41.61      1/42.03      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     2.5%         4.8%         0.0%         0.0%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    2/30 (7%)    0/32 (0%)    0/17 (0%)   |0/30 (0%)    1/32 (3%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     714          729 (T)      ---          ---         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.202N     P=0.627      P=0.428N     P=0.560N    |P=0.599N     P=0.513      (e)          (e)          | 
|POLY 3             |     P=0.196N     P=0.512      P=0.480N     P=0.568N    |P=0.566N     P=0.502      (e)          (e)          | 
|POLY 1.5           |     P=0.202N     P=0.506      P=0.489N     P=0.554N    |P=0.567N     P=0.501      (e)          (e)          | 
|POLY 6             |     P=0.183N     P=0.525      P=0.467N     P=0.569N    |P=0.563N     P=0.505      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.212N     P=0.578      P=0.457N     P=0.565N    |(e)          P=0.513      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.188N     P=0.500      P=0.500N     P=0.500N    |P=0.571N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.256N     (e)          (e)          (e)         |P=0.385N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |4/50 (8%)    0/50 (0%)    2/50 (4%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/40.18      0/41.64      1/44.72      0/28.31     |4/41.69      0/42.03      2/43.91      0/41.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |9.6%         0.0%         4.6%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/30 (0%)    0/32 (0%)    0/17 (0%)   |3/30 (10%)   0/32 (0%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          645          ---         |710          ---          686          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.670      (e)          P=0.550      (e)         |P=0.074N     P=0.056N     P=0.305N     P=0.089N     | 
|POLY 3             |     P=0.495      (e)          P=0.521      (e)         |P=0.060N     P=0.059N     P=0.313N     P=0.061N     | 
|POLY 1.5           |     P=0.546      (e)          P=0.511      (e)         |P=0.060N     P=0.060N     P=0.320N     P=0.061N     | 
|POLY 6             |     P=0.479      (e)          P=0.536      (e)         |P=0.063N     P=0.057N     P=0.305N     P=0.064N     | 
|LOGISTIC REGRESSION|     P=0.709      (e)          P=0.468      (e)         |P=0.063N     P=0.055N     P=0.304N     P=0.074N     | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.063N     P=0.059N     P=0.339N     P=0.061N     | 
|ORDER RESTRICTED   |     P=0.416      (e)          (e)          (e)         |P=0.012N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 9       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |4/50 (8%)    1/50 (2%)    2/50 (4%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/40.18      0/41.64      1/44.72      0/28.31     |4/41.69      1/42.23      2/43.91      1/41.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |9.6%         2.4%         4.6%         2.4%         | 
|TERMINAL (d)       |     0/20 (0%)    0/30 (0%)    0/32 (0%)    0/17 (0%)   |3/30 (10%)   0/32 (0%)    1/32 (3%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     ---          ---          645          ---         |710          677          686          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.670      (e)          P=0.550      (e)         |P=0.201N     P=0.162N     P=0.305N     P=0.238N     | 
|POLY 3             |     P=0.495      (e)          P=0.521      (e)         |P=0.167N     P=0.174N     P=0.313N     P=0.182N     | 
|POLY 1.5           |     P=0.546      (e)          P=0.511      (e)         |P=0.166N     P=0.177N     P=0.320N     P=0.180N     | 
|POLY 6             |     P=0.479      (e)          P=0.536      (e)         |P=0.173N     P=0.168N     P=0.305N     P=0.189N     | 
|LOGISTIC REGRESSION|     P=0.709      (e)          P=0.468      (e)         |P=0.170N     P=0.171N     P=0.304N     P=0.209N     | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.169N     P=0.181N     P=0.339N     P=0.187N     | 
|ORDER RESTRICTED   |     P=0.416      (e)          (e)          (e)         |P=0.098N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroadenoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/50 (8%)    1/50 (2%)    1/50 (2%)   |12/50 (24%)  11/50 (22%)  21/50 (42%)  16/49 (33%)  | 
|POLY-3 RATE (b)    |     0/40.18      4/41.83      1/44.41      1/28.31     |12/42.74     11/42.03     21/45.13     16/42.85     | 
|POLY-3 PERCENT (g) |     0.0%         9.6%         2.3%         3.5%        |28.1%        26.2%        46.5%        37.3%        | 
|TERMINAL (d)       |     0/20 (0%)    3/30 (10%)   1/32 (3%)    1/17 (6%)   |8/30 (27%)   10/32 (31%)  17/32 (53%)  9/25 (36%)   | 
|FIRST INCIDENCE    |     ---          682          729 (T)      729 (T)     |606          728          465          559          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.597      P=0.113      P=0.594      P=0.468     |P=0.044 *    P=0.441N     P=0.073      P=0.154      | 
|POLY 3             |     P=0.509      P=0.065      P=0.520      P=0.432     |P=0.124      P=0.519N     P=0.055      P=0.245      | 
|POLY 1.5           |     P=0.534      P=0.062      P=0.511      P=0.446     |P=0.125      P=0.512N     P=0.052      P=0.248      | 
|POLY 6             |     P=0.523      P=0.070      P=0.534      P=0.432     |P=0.113      P=0.526N     P=0.055      P=0.231      | 
|LOGISTIC REGRESSION|     P=0.572      P=0.078      P=0.594      P=0.468     |P=0.106      P=0.475N     P=0.059      P=0.235      | 
|COCH-ARM / FISHERS |     P=0.556N     P=0.059      P=0.500      P=0.500     |P=0.111      P=0.500N     P=0.044 *    P=0.232      | 
|ORDER RESTRICTED   |     P=0.245      (e)          (e)          (e)         |P=0.106      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 10      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma or Adenoma                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/50 (8%)    1/50 (2%)    1/50 (2%)   |12/50 (24%)  12/50 (24%)  21/50 (42%)  16/49 (33%)  | 
|POLY-3 RATE (b)    |     0/40.18      4/41.83      1/44.41      1/28.31     |12/42.74     12/42.23     21/45.13     16/42.85     | 
|POLY-3 PERCENT (g) |     0.0%         9.6%         2.3%         3.5%        |28.1%        28.4%        46.5%        37.3%        | 
|TERMINAL (d)       |     0/20 (0%)    3/30 (10%)   1/32 (3%)    1/17 (6%)   |8/30 (27%)   10/32 (31%)  17/32 (53%)  9/25 (36%)   | 
|FIRST INCIDENCE    |     ---          682          729 (T)      729 (T)     |606          677          465          559          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.597      P=0.113      P=0.594      P=0.468     |P=0.053      P=0.530N     P=0.073      P=0.154      | 
|POLY 3             |     P=0.509      P=0.065      P=0.520      P=0.432     |P=0.142      P=0.582      P=0.055      P=0.245      | 
|POLY 1.5           |     P=0.534      P=0.062      P=0.511      P=0.446     |P=0.143      P=0.585      P=0.052      P=0.248      | 
|POLY 6             |     P=0.523      P=0.070      P=0.534      P=0.432     |P=0.129      P=0.581      P=0.055      P=0.231      | 
|LOGISTIC REGRESSION|     P=0.572      P=0.078      P=0.594      P=0.468     |P=0.123      P=0.573N     P=0.059      P=0.235      | 
|COCH-ARM / FISHERS |     P=0.556N     P=0.059      P=0.500      P=0.500     |P=0.127      P=0.592N     P=0.044 *    P=0.232      | 
|ORDER RESTRICTED   |     P=0.245      (e)          (e)          (e)         |P=0.131      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/50 (8%)    2/50 (4%)    1/50 (2%)   |14/50 (28%)  12/50 (24%)  22/50 (44%)  16/49 (33%)  | 
|POLY-3 RATE (b)    |     0/40.18      4/41.83      2/44.72      1/28.31     |14/42.81     12/42.23     22/45.29     16/42.85     | 
|POLY-3 PERCENT (g) |     0.0%         9.6%         4.5%         3.5%        |32.7%        28.4%        48.6%        37.3%        | 
|TERMINAL (d)       |     0/20 (0%)    3/30 (10%)   1/32 (3%)    1/17 (6%)   |9/30 (30%)   10/32 (31%)  17/32 (53%)  9/25 (36%)   | 
|FIRST INCIDENCE    |     ---          682          645          729 (T)     |606          677          465          559          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.541      P=0.113      P=0.321      P=0.468     |P=0.103      P=0.350N     P=0.123      P=0.268      | 
|POLY 3             |     P=0.432      P=0.065      P=0.262      P=0.432     |P=0.239      P=0.423N     P=0.093      P=0.411      | 
|POLY 1.5           |     P=0.466      P=0.062      P=0.250      P=0.446     |P=0.240      P=0.418N     P=0.087      P=0.413      | 
|POLY 6             |     P=0.443      P=0.070      P=0.280      P=0.432     |P=0.222      P=0.427N     P=0.096      P=0.393      | 
|LOGISTIC REGRESSION|     P=0.509      P=0.078      P=0.239      P=0.468     |P=0.211      P=0.383N     P=0.095      P=0.393      | 
|COCH-ARM / FISHERS |     P=0.577N     P=0.059      P=0.247      P=0.500     |P=0.213      P=0.410N     P=0.072      P=0.388      | 
|ORDER RESTRICTED   |     P=0.214      (e)          (e)          (e)         |P=0.172      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 11      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Papilloma Squamous or Papilloma                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/40.18      0/41.64      1/44.41      0/28.31     |2/41.61      0/42.03      1/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         0.0%        |4.8%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/30 (0%)    1/32 (3%)    0/17 (0%)   |2/30 (7%)    0/32 (0%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.689      (e)          P=0.594      (e)         |P=0.212N     P=0.224N     P=0.477N     P=0.279N     | 
|POLY 3             |     P=0.496      (e)          P=0.520      (e)         |P=0.190N     P=0.235N     P=0.483N     P=0.240N     | 
|POLY 1.5           |     P=0.547      (e)          P=0.511      (e)         |P=0.189N     P=0.236N     P=0.488N     P=0.238N     | 
|POLY 6             |     P=0.481      (e)          P=0.534      (e)         |P=0.193N     P=0.231N     P=0.478N     P=0.245N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.594      (e)         |P=0.212N     (e)          P=0.477N     (e)          | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.191N     P=0.247N     P=0.500N     P=0.253N     | 
|ORDER RESTRICTED   |     P=0.415      (e)          (e)          (e)         |P=0.076N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Squamous Cell Carcinoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/40.18      0/41.64      2/44.85      0/28.31     |1/42.46      0/42.03      1/43.90      0/41.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         0.0%        |2.4%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/30 (0%)    0/32 (0%)    0/17 (0%)   |0/30 (0%)    0/32 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          645          ---         |394          ---          690          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.537      (e)          P=0.302      (e)         |P=0.406N     P=0.504N     P=0.745N     P=0.496N     | 
|POLY 3             |     P=0.357      (e)          P=0.262      (e)         |P=0.409N     P=0.502N     P=0.753N     P=0.507N     | 
|POLY 1.5           |     P=0.413      (e)          P=0.251      (e)         |P=0.407N     P=0.502N     P=0.755N     P=0.504N     | 
|POLY 6             |     P=0.341      (e)          P=0.281      (e)         |P=0.414N     P=0.500N     P=0.751N     P=0.512N     | 
|LOGISTIC REGRESSION|     P=0.564      (e)          P=0.220      (e)         |P=0.498N     P=0.487N     P=0.681      P=0.783N     | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |P=0.409N     P=0.500N     P=0.753N     P=0.505N     | 
|ORDER RESTRICTED   |     P=0.290      (e)          (e)          (e)         |P=0.257N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 12      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/50 (6%)    0/50 (0%)   |3/50 (6%)    0/50 (0%)    2/50 (4%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/40.18      0/41.64      3/44.85      0/28.31     |3/42.46      0/42.03      2/43.90      0/41.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         6.7%         0.0%        |7.1%         0.0%         4.6%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/30 (0%)    1/32 (3%)    0/17 (0%)   |2/30 (7%)    0/32 (0%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          645          ---         |394          ---          690          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.467      (e)          P=0.190      (e)         |P=0.141N     P=0.116N     P=0.470N     P=0.143N     | 
|POLY 3             |     P=0.275      (e)          P=0.139      (e)         |P=0.127N     P=0.120N     P=0.485N     P=0.124N     | 
|POLY 1.5           |     P=0.333      (e)          P=0.130      (e)         |P=0.125N     P=0.120N     P=0.489N     P=0.122N     | 
|POLY 6             |     P=0.260      (e)          P=0.156      (e)         |P=0.131N     P=0.118N     P=0.479N     P=0.129N     | 
|LOGISTIC REGRESSION|     P=0.467      (e)          P=0.123      (e)         |P=0.135N     P=0.119N     P=0.528N     P=0.140N     | 
|COCH-ARM / FISHERS |     P=0.539      (e)          P=0.121      (e)         |P=0.128N     P=0.121N     P=0.500N     P=0.125N     | 
|ORDER RESTRICTED   |     P=0.206      (e)          (e)          (e)         |P=0.039N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa                                                                                                                      | 
|     Squamous Cell Carcinoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/40.18      0/41.64      2/44.85      0/28.31     |1/42.46      0/42.03      1/43.90      0/41.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         0.0%        |2.4%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/30 (0%)    0/32 (0%)    0/17 (0%)   |0/30 (0%)    0/32 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          645          ---         |394          ---          690          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.537      (e)          P=0.302      (e)         |P=0.406N     P=0.504N     P=0.745N     P=0.496N     | 
|POLY 3             |     P=0.357      (e)          P=0.262      (e)         |P=0.409N     P=0.502N     P=0.753N     P=0.507N     | 
|POLY 1.5           |     P=0.413      (e)          P=0.251      (e)         |P=0.407N     P=0.502N     P=0.755N     P=0.504N     | 
|POLY 6             |     P=0.341      (e)          P=0.281      (e)         |P=0.414N     P=0.500N     P=0.751N     P=0.512N     | 
|LOGISTIC REGRESSION|     P=0.564      (e)          P=0.220      (e)         |P=0.498N     P=0.487N     P=0.681      P=0.783N     | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |P=0.409N     P=0.500N     P=0.753N     P=0.505N     | 
|ORDER RESTRICTED   |     P=0.290      (e)          (e)          (e)         |P=0.257N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 13      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     3/40.18      1/41.64      2/44.95      0/28.31     |0/41.61      0/42.03      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     7.5%         2.4%         4.5%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/20 (15%)   1/30 (3%)    1/32 (3%)    0/17 (0%)   |0/30 (0%)    0/32 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      563          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.117N     P=0.172N     P=0.327N     P=0.148N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.150N     P=0.292N     P=0.449N     P=0.194N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.144N     P=0.299N     P=0.472N     P=0.176N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.147N     P=0.277N     P=0.414N     P=0.193N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.142N     P=0.172N     P=0.465N     (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.104N     P=0.309N     P=0.500N     P=0.121N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.115N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     29/50 (58%)  33/50 (66%)  42/50 (84%)  20/50 (40%) |33/50 (66%)  34/50 (68%)  33/50 (66%)  27/49 (55%)  | 
|POLY-3 RATE (b)    |     29/45.46     33/47.21     42/49.46     20/31.56    |33/44.47     34/46.41     33/47.67     27/43.85     | 
|POLY-3 PERCENT (g) |     63.8%        69.9%        84.9%        63.4%       |74.2%        73.3%        69.2%        61.6%        | 
|TERMINAL (d)       |     14/20 (70%)  19/30 (63%)  27/32 (84%)  12/17 (71%) |24/30 (80%)  22/32 (69%)  22/32 (69%)  17/25 (68%)  | 
|FIRST INCIDENCE    |     522          444          444          290         |437          522          465          469          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.435N     P=0.355N     P=0.498      P=0.370N    |P=0.383N     P=0.522N     P=0.419N     P=0.443N     | 
|POLY 3             |     P=0.262      P=0.338      P=0.011 *    P=0.582N    |P=0.090N     P=0.555N     P=0.379N     P=0.135N     | 
|POLY 1.5           |     P=0.475      P=0.301      P=0.006 **   P=0.402N    |P=0.086N     P=0.569      P=0.449N     P=0.139N     | 
|POLY 6             |     P=0.229      P=0.416      P=0.026 *    P=0.572     |P=0.117N     P=0.454N     P=0.309N     P=0.148N     | 
|LOGISTIC REGRESSION|     P=0.441N     P=0.274      P=0.005 **   P=0.467N    |P=0.088N     P=0.506      P=0.487N     P=0.147N     | 
|COCH-ARM / FISHERS |     P=0.031N*    P=0.268      P=0.004 **   P=0.055N    |P=0.119N     P=0.500      P=0.583N     P=0.183N     | 
|ORDER RESTRICTED   |     P=0.186      (e)          (e)          (e)         |P=0.146N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 14      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   1/50 (2%)    0/50 (0%)    2/50 (4%)   |3/50 (6%)    1/50 (2%)    1/50 (2%)    4/49 (8%)    | 
|POLY-3 RATE (b)    |     5/41.63      1/42.23      0/44.41      2/28.31     |3/42.21      1/42.10      1/43.75      4/42.10      | 
|POLY-3 PERCENT (g) |     12.0%        2.4%         0.0%         7.1%        |7.1%         2.4%         2.3%         9.5%         | 
|TERMINAL (d)       |     1/20 (5%)    0/30 (0%)    0/32 (0%)    2/17 (12%)  |1/30 (3%)    0/32 (0%)    1/32 (3%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     463          542          ---          729 (T)     |626          712          729 (T)      593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.232N     P=0.080N     P=0.020N*    P=0.347N    |P=0.264      P=0.294N     P=0.286N     P=0.460      | 
|POLY 3             |     P=0.143N     P=0.097N     P=0.025N*    P=0.397N    |P=0.300      P=0.306N     P=0.292N     P=0.498      | 
|POLY 1.5           |     P=0.156N     P=0.100N     P=0.028N*    P=0.353N    |P=0.301      P=0.306N     P=0.295N     P=0.500      | 
|POLY 6             |     P=0.133N     P=0.090N     P=0.021N*    P=0.408N    |P=0.294      P=0.304N     P=0.291N     P=0.490      | 
|LOGISTIC REGRESSION|     P=0.149N     P=0.105N     P=0.049N*    P=0.323N    |P=0.292      P=0.304N     P=0.299N     P=0.480      | 
|COCH-ARM / FISHERS |     P=0.165N     P=0.102N     P=0.028N*    P=0.218N    |P=0.293      P=0.309N     P=0.309N     P=0.489      | 
|ORDER RESTRICTED   |     P=0.079N     (e)          (e)          (e)         |P=0.198      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     34/50 (68%)  34/50 (68%)  42/50 (84%)  22/50 (44%) |36/50 (72%)  35/50 (70%)  34/50 (68%)  30/49 (61%)  | 
|POLY-3 RATE (b)    |     34/46.91     34/47.80     42/49.46     22/31.56    |36/45.07     35/46.48     34/47.67     30/44.75     | 
|POLY-3 PERCENT (g) |     72.5%        71.1%        84.9%        69.7%       |79.9%        75.3%        71.3%        67.0%        | 
|TERMINAL (d)       |     15/20 (75%)  19/30 (63%)  27/32 (84%)  14/17 (82%) |25/30 (83%)  22/32 (69%)  23/32 (72%)  18/25 (72%)  | 
|FIRST INCIDENCE    |     463          444          444          290         |437          522          465          469          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.315N     P=0.155N     P=0.292N     P=0.250N    |P=0.432N     P=0.383N     P=0.284N     P=0.462N     | 
|POLY 3             |     P=0.376      P=0.534N     P=0.095      P=0.496N    |P=0.090N     P=0.389N     P=0.229N     P=0.113N     | 
|POLY 1.5           |     P=0.434N     P=0.564N     P=0.070      P=0.265N    |P=0.090N     P=0.446N     P=0.282N     P=0.122N     | 
|POLY 6             |     P=0.299      P=0.468N     P=0.150      P=0.603N    |P=0.114N     P=0.308N     P=0.189N     P=0.123N     | 
|LOGISTIC REGRESSION|     P=0.252N     P=0.573      P=0.042 *    P=0.298N    |P=0.099N     P=0.496N     P=0.309N     P=0.134N     | 
|COCH-ARM / FISHERS |     P=0.008N**   P=0.585N     P=0.050      P=0.013N*   |P=0.135N     P=0.500N     P=0.414N     P=0.178N     | 
|ORDER RESTRICTED   |     P=0.388      (e)          (e)          (e)         |P=0.122N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 15      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/41.05      0/41.64      0/44.41      0/28.31     |0/41.61      1/42.03      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     4.9%         0.0%         0.0%         0.0%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/30 (0%)    0/32 (0%)    0/17 (0%)   |0/30 (0%)    1/32 (3%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     533          ---          ---          ---         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.136N     P=0.242N     P=0.222N     P=0.333N    |P=0.599N     P=0.513      (e)          (e)          | 
|POLY 3             |     P=0.086N     P=0.234N     P=0.220N     P=0.328N    |P=0.566N     P=0.502      (e)          (e)          | 
|POLY 1.5           |     P=0.095N     P=0.236N     P=0.228N     P=0.307N    |P=0.567N     P=0.501      (e)          (e)          | 
|POLY 6             |     P=0.081N     P=0.228N     P=0.208N     P=0.332N    |P=0.563N     P=0.505      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.056N     P=0.236N     P=0.296N     P=0.205N    |(e)          P=0.513      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |P=0.571N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.078N     (e)          (e)          (e)         |P=0.385N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     3/41.05      0/41.64      0/44.41      0/28.31     |0/41.61      1/42.03      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     7.3%         0.0%         0.0%         0.0%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    0/30 (0%)    0/32 (0%)    0/17 (0%)   |0/30 (0%)    1/32 (3%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     533          ---          ---          ---         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.053N     P=0.102N     P=0.089N     P=0.187N    |P=0.599N     P=0.513      (e)          (e)          | 
|POLY 3             |     P=0.033N*    P=0.115N     P=0.105N     P=0.199N    |P=0.566N     P=0.502      (e)          (e)          | 
|POLY 1.5           |     P=0.038N*    P=0.118N     P=0.111N     P=0.179N    |P=0.567N     P=0.501      (e)          (e)          | 
|POLY 6             |     P=0.031N*    P=0.111N     P=0.096N     P=0.203N    |P=0.563N     P=0.505      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.033N*    P=0.124N     P=0.150N     P=0.139N    |(e)          P=0.513      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.047N*    P=0.121N     P=0.121N     P=0.121N    |P=0.571N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.030N*    (e)          (e)          (e)         |P=0.385N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 16      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     1/40.18      2/41.64      1/44.41      0/28.31     |                                                    | 
|POLY-3 PERCENT (g) |     2.5%         4.8%         2.3%         0.0%        |                                                    | 
|TERMINAL (d)       |     1/20 (5%)    2/30 (7%)    1/32 (3%)    0/17 (0%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.272N     P=0.641      P=0.654N     P=0.532N    |                                                    | 
|POLY 3             |     P=0.312N     P=0.513      P=0.738N     P=0.568N    |                                                    | 
|POLY 1.5           |     P=0.305N     P=0.506      P=0.749N     P=0.554N    |                                                    | 
|POLY 6             |     P=0.301N     P=0.526      P=0.721N     P=0.568N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.272N     P=0.641      P=0.654N     (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.247N     P=0.500      P=0.753N     P=0.500N    |                                                    | 
|ORDER RESTRICTED   |     P=0.311N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    4/50 (8%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     4/40.64      2/41.64      4/44.41      1/28.31     |1/41.61      0/42.03      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     9.8%         4.8%         9.0%         3.5%        |2.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    2/30 (7%)    4/32 (13%)   1/17 (6%)   |1/30 (3%)    0/32 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     662          729 (T)      729 (T)      729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.249N     P=0.224N     P=0.421N     P=0.272N    |P=0.323N     P=0.487N     P=0.487N     P=0.536N     | 
|POLY 3             |     P=0.314N     P=0.325N     P=0.594N     P=0.307N    |P=0.307N     P=0.498N     P=0.490N     P=0.503N     | 
|POLY 1.5           |     P=0.291N     P=0.332N     P=0.617N     P=0.276N    |P=0.308N     P=0.499N     P=0.493N     P=0.501N     | 
|POLY 6             |     P=0.313N     P=0.312N     P=0.561N     P=0.311N    |P=0.304N     P=0.495N     P=0.487N     P=0.507N     | 
|LOGISTIC REGRESSION|     P=0.278N     P=0.296N     P=0.526N     P=0.293N    |P=0.323N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.186N     P=0.339N     P=0.643N     P=0.181N    |P=0.308N     P=0.500N     P=0.500N     P=0.505N     | 
|ORDER RESTRICTED   |     P=0.285N     (e)          (e)          (e)         |P=0.122N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 17      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   4/50 (8%)    2/50 (4%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     5/40.89      4/41.83      2/44.41      3/29.23     |0/41.61      0/42.03      1/43.75      3/41.55      | 
|POLY-3 PERCENT (g) |     12.2%        9.6%         4.5%         10.3%       |0.0%         0.0%         2.3%         7.2%         | 
|TERMINAL (d)       |     2/20 (10%)   3/30 (10%)   2/32 (6%)    0/17 (0%)   |0/30 (0%)    0/32 (0%)    1/32 (3%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     608          682          729 (T)      606         |---          ---          729 (T)      662          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.367N     P=0.342N     P=0.102N     P=0.511N    |P=0.015 *    (e)          P=0.513      P=0.110      | 
|POLY 3             |     P=0.330N     P=0.486N     P=0.183N     P=0.549N    |P=0.019 *    (e)          P=0.510      P=0.118      | 
|POLY 1.5           |     P=0.328N     P=0.494N     P=0.198N     P=0.511N    |P=0.019 *    (e)          P=0.507      P=0.118      | 
|POLY 6             |     P=0.315N     P=0.468N     P=0.162N     P=0.543N    |P=0.018 *    (e)          P=0.513      P=0.115      | 
|LOGISTIC REGRESSION|     P=0.393N     P=0.463N     P=0.171N     P=0.520N    |P=0.019 *    (e)          P=0.513      P=0.118      | 
|COCH-ARM / FISHERS |     P=0.256N     P=0.500N     P=0.218N     P=0.357N    |P=0.019 *    (e)          P=0.500      P=0.117      | 
|ORDER RESTRICTED   |     P=0.372N     (e)          (e)          (e)         |P=0.020 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   4/50 (8%)    3/50 (6%)    3/50 (6%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     5/40.89      4/41.83      3/44.70      3/29.23     |0/41.61      2/42.13      1/43.75      3/41.55      | 
|POLY-3 PERCENT (g) |     12.2%        9.6%         6.7%         10.3%       |0.0%         4.8%         2.3%         7.2%         | 
|TERMINAL (d)       |     2/20 (10%)   3/30 (10%)   2/32 (6%)    0/17 (0%)   |0/30 (0%)    1/32 (3%)    1/32 (3%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     608          682          649          606         |---          703          729 (T)      662          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.404N     P=0.342N     P=0.195N     P=0.511N    |P=0.080      P=0.257      P=0.513      P=0.110      | 
|POLY 3             |     P=0.382N     P=0.486N     P=0.308N     P=0.549N    |P=0.103      P=0.240      P=0.510      P=0.118      | 
|POLY 1.5           |     P=0.374N     P=0.494N     P=0.330N     P=0.511N    |P=0.103      P=0.238      P=0.507      P=0.118      | 
|POLY 6             |     P=0.366N     P=0.468N     P=0.276N     P=0.543N    |P=0.100      P=0.243      P=0.513      P=0.115      | 
|LOGISTIC REGRESSION|     P=0.421N     P=0.463N     P=0.318N     P=0.520N    |P=0.099      P=0.243      P=0.513      P=0.118      | 
|COCH-ARM / FISHERS |     P=0.278N     P=0.500N     P=0.357N     P=0.357N    |P=0.099      P=0.247      P=0.500      P=0.117      | 
|ORDER RESTRICTED   |     P=0.470N     (e)          (e)          (e)         |P=0.056      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 18      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/40.18      0/41.64      1/44.70      0/28.31     |0/41.61      2/42.13      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |0.0%         4.8%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/30 (0%)    0/32 (0%)    0/17 (0%)   |0/30 (0%)    1/32 (3%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          649          ---         |---          703          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.667      (e)          P=0.541      (e)         |P=0.434N     P=0.257      (e)          (e)          | 
|POLY 3             |     P=0.495      (e)          P=0.521      (e)         |P=0.402N     P=0.240      (e)          (e)          | 
|POLY 1.5           |     P=0.546      (e)          P=0.511      (e)         |P=0.403N     P=0.238      (e)          (e)          | 
|POLY 6             |     P=0.479      (e)          P=0.536      (e)         |P=0.402N     P=0.243      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.704      (e)          P=0.470      (e)         |P=0.413N     P=0.243      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.409N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.416      (e)          (e)          (e)         |P=0.252N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Keratoacanthoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    3/50 (6%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     3/40.48      1/41.64      3/44.41      1/28.31     |1/41.61      0/42.03      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     7.4%         2.4%         6.8%         3.5%        |2.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    1/30 (3%)    3/32 (9%)    1/17 (6%)   |1/30 (3%)    0/32 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     662          729 (T)      729 (T)      729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.390N     P=0.210N     P=0.465N     P=0.393N    |P=0.323N     P=0.487N     P=0.487N     P=0.536N     | 
|POLY 3             |     P=0.430N     P=0.294N     P=0.619N     P=0.441N    |P=0.307N     P=0.498N     P=0.490N     P=0.503N     | 
|POLY 1.5           |     P=0.411N     P=0.300N     P=0.639N     P=0.411N    |P=0.308N     P=0.499N     P=0.493N     P=0.501N     | 
|POLY 6             |     P=0.428N     P=0.283N     P=0.589N     P=0.444N    |P=0.304N     P=0.495N     P=0.487N     P=0.507N     | 
|LOGISTIC REGRESSION|     P=0.420N     P=0.272N     P=0.556N     P=0.430N    |P=0.323N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.313N     P=0.309N     P=0.661N     P=0.309N    |P=0.308N     P=0.500N     P=0.500N     P=0.505N     | 
|ORDER RESTRICTED   |     P=0.407N     (e)          (e)          (e)         |P=0.122N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 19      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Lipoma                                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/40.18      3/41.64      1/44.41      0/28.31     |0/41.61      0/42.03      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     0.0%         7.2%         2.3%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    3/30 (10%)   1/32 (3%)    0/17 (0%)   |0/30 (0%)    0/32 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.415N     P=0.200      P=0.594      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.466N     P=0.124      P=0.520      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.454N     P=0.121      P=0.511      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.450N     P=0.131      P=0.534      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.200      P=0.594      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.366N     P=0.121      P=0.500      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.306N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Schwannoma Malignant                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/40.60      0/41.64      2/44.41      2/28.31     |2/41.89      0/42.03      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     4.9%         0.0%         4.5%         7.1%        |4.8%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    0/30 (0%)    2/32 (6%)    2/17 (12%)  |1/30 (3%)    0/32 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     606          ---          729 (T)      729 (T)     |654          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.352      P=0.201N     P=0.549N     P=0.624     |P=0.120N     P=0.233N     P=0.227N     P=0.263N     | 
|POLY 3             |     P=0.326      P=0.231N     P=0.662N     P=0.557     |P=0.113N     P=0.236N     P=0.227N     P=0.241N     | 
|POLY 1.5           |     P=0.346      P=0.234N     P=0.676N     P=0.588     |P=0.114N     P=0.237N     P=0.230N     P=0.239N     | 
|POLY 6             |     P=0.323      P=0.224N     P=0.638N     P=0.554     |P=0.112N     P=0.234N     P=0.225N     P=0.247N     | 
|LOGISTIC REGRESSION|     P=0.321      P=0.239N     P=0.665N     P=0.567     |P=0.115N     P=0.237N     P=0.232N     P=0.240N     | 
|COCH-ARM / FISHERS |     P=0.444      P=0.247N     P=0.691N     P=0.691N    |P=0.116N     P=0.247N     P=0.247N     P=0.253N     | 
|ORDER RESTRICTED   |     P=0.294      (e)          (e)          (e)         |P=0.031N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 20      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           | 
|     Carcinoma or Keratoacanthoma                                                                                                | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    4/50 (8%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     4/40.64      2/41.64      4/44.41      1/28.31     |1/41.61      0/42.03      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     9.8%         4.8%         9.0%         3.5%        |2.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    2/30 (7%)    4/32 (13%)   1/17 (6%)   |1/30 (3%)    0/32 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     662          729 (T)      729 (T)      729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.249N     P=0.224N     P=0.421N     P=0.272N    |P=0.323N     P=0.487N     P=0.487N     P=0.536N     | 
|POLY 3             |     P=0.314N     P=0.325N     P=0.594N     P=0.307N    |P=0.307N     P=0.498N     P=0.490N     P=0.503N     | 
|POLY 1.5           |     P=0.291N     P=0.332N     P=0.617N     P=0.276N    |P=0.308N     P=0.499N     P=0.493N     P=0.501N     | 
|POLY 6             |     P=0.313N     P=0.312N     P=0.561N     P=0.311N    |P=0.304N     P=0.495N     P=0.487N     P=0.507N     | 
|LOGISTIC REGRESSION|     P=0.278N     P=0.296N     P=0.526N     P=0.293N    |P=0.323N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.186N     P=0.339N     P=0.643N     P=0.181N    |P=0.308N     P=0.500N     P=0.500N     P=0.505N     | 
|ORDER RESTRICTED   |     P=0.285N     (e)          (e)          (e)         |P=0.122N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    4/50 (8%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     4/40.64      2/41.64      4/44.41      1/28.31     |1/41.61      0/42.03      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     9.8%         4.8%         9.0%         3.5%        |2.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    2/30 (7%)    4/32 (13%)   1/17 (6%)   |1/30 (3%)    0/32 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     662          729 (T)      729 (T)      729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.249N     P=0.224N     P=0.421N     P=0.272N    |P=0.323N     P=0.487N     P=0.487N     P=0.536N     | 
|POLY 3             |     P=0.314N     P=0.325N     P=0.594N     P=0.307N    |P=0.307N     P=0.498N     P=0.490N     P=0.503N     | 
|POLY 1.5           |     P=0.291N     P=0.332N     P=0.617N     P=0.276N    |P=0.308N     P=0.499N     P=0.493N     P=0.501N     | 
|POLY 6             |     P=0.313N     P=0.312N     P=0.561N     P=0.311N    |P=0.304N     P=0.495N     P=0.487N     P=0.507N     | 
|LOGISTIC REGRESSION|     P=0.278N     P=0.296N     P=0.526N     P=0.293N    |P=0.323N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.186N     P=0.339N     P=0.643N     P=0.181N    |P=0.308N     P=0.500N     P=0.500N     P=0.505N     | 
|ORDER RESTRICTED   |     P=0.285N     (e)          (e)          (e)         |P=0.122N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 21      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     36/50 (72%)  37/50 (74%)  31/50 (62%)  22/50 (44%) |                                                    | 
|POLY-3 RATE (b)    |     36/45.13     37/44.91     31/46.60     22/30.15    |                                                    | 
|POLY-3 PERCENT (g) |     79.8%        82.4%        66.5%        73.0%       |                                                    | 
|TERMINAL (d)       |     18/20 (90%)  26/30 (87%)  22/32 (69%)  15/17 (88%) |                                                    | 
|FIRST INCIDENCE    |     533          571          444          606         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.060N     P=0.087N     P=0.003N**   P=0.123N    |                                                    | 
|POLY 3             |     P=0.111N     P=0.479      P=0.101N     P=0.330N    |                                                    | 
|POLY 1.5           |     P=0.051N     P=0.483      P=0.137N     P=0.134N    |                                                    | 
|POLY 6             |     P=0.124N     P=0.497      P=0.069N     P=0.444N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.106N     P=0.583      P=0.062N     P=0.256N    |                                                    | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.500      P=0.198N     P=0.004N**  |                                                    | 
|ORDER RESTRICTED   |     P=0.182N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   9/50 (18%)   8/50 (16%)   4/50 (8%)   |3/50 (6%)    2/50 (4%)    6/50 (12%)   6/49 (12%)   | 
|POLY-3 RATE (b)    |     5/40.29      9/43.03      8/44.95      4/28.73     |3/41.61      2/42.13      6/43.92      6/41.99      | 
|POLY-3 PERCENT (g) |     12.4%        20.9%        17.8%        13.9%       |7.2%         4.8%         13.7%        14.3%        | 
|TERMINAL (d)       |     4/20 (20%)   4/30 (13%)   5/32 (16%)   3/17 (18%)  |3/30 (10%)   1/32 (3%)    4/32 (13%)   3/25 (12%)   | 
|FIRST INCIDENCE    |     701          593          645          607         |729 (T)      703          703          593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.491N     P=0.380      P=0.580      P=0.620N    |P=0.065      P=0.469N     P=0.278      P=0.186      | 
|POLY 3             |     P=0.508      P=0.227      P=0.349      P=0.569     |P=0.107      P=0.494N     P=0.268      P=0.245      | 
|POLY 1.5           |     P=0.535N     P=0.209      P=0.314      P=0.609     |P=0.107      P=0.498N     P=0.260      P=0.244      | 
|POLY 6             |     P=0.526      P=0.266      P=0.406      P=0.575     |P=0.102      P=0.487N     P=0.277      P=0.241      | 
|LOGISTIC REGRESSION|     P=0.555N     P=0.219      P=0.435      P=0.577     |P=0.095      P=0.475N     P=0.279      P=0.233      | 
|COCH-ARM / FISHERS |     P=0.309N     P=0.194      P=0.277      P=0.500N    |P=0.100      P=0.500N     P=0.243      P=0.233      | 
|ORDER RESTRICTED   |     P=0.454      (e)          (e)          (e)         |P=0.160      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 22      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   1/50 (2%)    2/50 (4%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    2/50 (4%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     5/40.69      1/41.64      2/44.41      0/28.31     |2/41.79      0/42.03      2/43.75      3/41.89      | 
|POLY-3 PERCENT (g) |     12.3%        2.4%         4.5%         0.0%        |4.8%         0.0%         4.6%         7.2%         | 
|TERMINAL (d)       |     3/20 (15%)   1/30 (3%)    2/32 (6%)    0/17 (0%)   |1/30 (3%)    0/32 (0%)    2/32 (6%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     593          729 (T)      729 (T)      ---         |682          ---          729 (T)      617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.026N*    P=0.046N*    P=0.089N     P=0.057N    |P=0.203      P=0.226N     P=0.662N     P=0.471      | 
|POLY 3             |     P=0.038N*    P=0.094N     P=0.181N     P=0.075N    |P=0.236      P=0.236N     P=0.678N     P=0.501      | 
|POLY 1.5           |     P=0.036N*    P=0.098N     P=0.197N     P=0.063N    |P=0.237      P=0.237N     P=0.682N     P=0.501      | 
|POLY 6             |     P=0.036N*    P=0.087N     P=0.159N     P=0.076N    |P=0.231      P=0.233N     P=0.675N     P=0.496      | 
|LOGISTIC REGRESSION|     P=0.036N*    P=0.087N     P=0.153N     P=0.069N    |P=0.233      P=0.235N     P=0.672N     P=0.490      | 
|COCH-ARM / FISHERS |     P=0.025N*    P=0.102N     P=0.218N     P=0.028N*   |P=0.230      P=0.247N     P=0.691N     P=0.490      | 
|ORDER RESTRICTED   |     P=0.024N*    (e)          (e)          (e)         |P=0.216      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  10/50 (20%)  9/50 (18%)   4/50 (8%)   |5/50 (10%)   2/50 (4%)    8/50 (16%)   9/49 (18%)   | 
|POLY-3 RATE (b)    |     10/40.80     10/43.03     9/44.95      4/28.73     |5/41.79      2/42.13      8/43.92      9/42.81      | 
|POLY-3 PERCENT (g) |     24.5%        23.2%        20.0%        13.9%       |12.0%        4.8%         18.2%        21.0%        | 
|TERMINAL (d)       |     7/20 (35%)   5/30 (17%)   6/32 (19%)   3/17 (18%)  |4/30 (13%)   1/32 (3%)    6/32 (19%)   3/25 (12%)   | 
|FIRST INCIDENCE    |     593          593          645          607         |682          703          703          593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.113N     P=0.323N     P=0.164N     P=0.143N    |P=0.029 *    P=0.193N     P=0.327      P=0.150      | 
|POLY 3             |     P=0.172N     P=0.548N     P=0.405N     P=0.222N    |P=0.054      P=0.212N     P=0.307      P=0.203      | 
|POLY 1.5           |     P=0.147N     P=0.575N     P=0.449N     P=0.183N    |P=0.053      P=0.215N     P=0.298      P=0.198      | 
|POLY 6             |     P=0.160N     P=0.495N     P=0.339N     P=0.218N    |P=0.053      P=0.206N     P=0.315      P=0.205      | 
|LOGISTIC REGRESSION|     P=0.153N     P=0.548N     P=0.314N     P=0.210N    |P=0.047 *    P=0.201N     P=0.323      P=0.187      | 
|COCH-ARM / FISHERS |     P=0.050N     P=0.598N     P=0.500N     P=0.074N    |P=0.048 *    P=0.218N     P=0.277      P=0.183      | 
|ORDER RESTRICTED   |     P=0.259N     (e)          (e)          (e)         |P=0.067      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 23      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/40.18      0/41.64      0/44.41      0/28.31     |0/41.61      2/42.03      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     2.5%         0.0%         0.0%         0.0%        |0.0%         4.8%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    0/30 (0%)    0/32 (0%)    0/17 (0%)   |0/30 (0%)    2/32 (6%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.311N     P=0.419N     P=0.406N     P=0.532N    |P=0.441N     P=0.252      (e)          (e)          | 
|POLY 3             |     P=0.240N     P=0.493N     P=0.480N     P=0.568N    |P=0.402N     P=0.239      (e)          (e)          | 
|POLY 1.5           |     P=0.260N     P=0.497N     P=0.489N     P=0.554N    |P=0.403N     P=0.238      (e)          (e)          | 
|POLY 6             |     P=0.233N     P=0.485N     P=0.466N     P=0.568N    |P=0.402N     P=0.242      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.311N     (e)          (e)          (e)         |(e)          P=0.252      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.409N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.193N     (e)          (e)          (e)         |P=0.252N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/40.18      0/41.64      0/44.41      0/28.31     |1/41.61      2/42.03      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     2.5%         0.0%         0.0%         0.0%        |2.4%         4.8%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    0/30 (0%)    0/32 (0%)    0/17 (0%)   |1/30 (3%)    2/32 (6%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.311N     P=0.419N     P=0.406N     P=0.532N    |P=0.212N     P=0.523      P=0.487N     P=0.536N     | 
|POLY 3             |     P=0.240N     P=0.493N     P=0.480N     P=0.568N    |P=0.187N     P=0.503      P=0.490N     P=0.503N     | 
|POLY 1.5           |     P=0.260N     P=0.497N     P=0.489N     P=0.554N    |P=0.187N     P=0.501      P=0.493N     P=0.501N     | 
|POLY 6             |     P=0.233N     P=0.485N     P=0.466N     P=0.568N    |P=0.187N     P=0.508      P=0.487N     P=0.507N     | 
|LOGISTIC REGRESSION|     P=0.311N     (e)          (e)          (e)         |P=0.212N     P=0.523      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.191N     P=0.500      P=0.500N     P=0.505N     | 
|ORDER RESTRICTED   |     P=0.193N     (e)          (e)          (e)         |P=0.171N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 24      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tongue                                                                                                                           | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/40.18      0/41.64      1/44.41      0/28.31     |2/41.61      0/42.03      1/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         0.0%        |4.8%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/30 (0%)    1/32 (3%)    0/17 (0%)   |2/30 (7%)    0/32 (0%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.689      (e)          P=0.594      (e)         |P=0.212N     P=0.224N     P=0.477N     P=0.279N     | 
|POLY 3             |     P=0.496      (e)          P=0.520      (e)         |P=0.190N     P=0.235N     P=0.483N     P=0.240N     | 
|POLY 1.5           |     P=0.547      (e)          P=0.511      (e)         |P=0.189N     P=0.236N     P=0.488N     P=0.238N     | 
|POLY 6             |     P=0.481      (e)          P=0.534      (e)         |P=0.193N     P=0.231N     P=0.478N     P=0.245N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.594      (e)         |P=0.212N     (e)          P=0.477N     (e)          | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.191N     P=0.247N     P=0.500N     P=0.253N     | 
|ORDER RESTRICTED   |     P=0.415      (e)          (e)          (e)         |P=0.076N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |                                                        |0/41.61      0/42.03      0/43.75      2/41.07      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         0.0%         4.9%         | 
|TERMINAL (d)       |                                                        |0/30 (0%)    0/32 (0%)    0/32 (0%)    2/25 (8%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.031 *    (e)          (e)          P=0.198      | 
|POLY 3             |                                                        |P=0.044 *    (e)          (e)          P=0.234      | 
|POLY 1.5           |                                                        |P=0.044 *    (e)          (e)          P=0.236      | 
|POLY 6             |                                                        |P=0.043 *    (e)          (e)          P=0.228      | 
|LOGISTIC REGRESSION|                                                        |(e)          (e)          (e)          P=0.198      | 
|COCH-ARM / FISHERS |                                                        |P=0.045 *    (e)          (e)          P=0.242      | 
|ORDER RESTRICTED   |                                                        |P=0.028 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 25      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |10/50 (20%)  10/50 (20%)  10/50 (20%)  10/49 (20%)  | 
|POLY-3 RATE (b)    |                                                        |10/43.56     10/42.41     10/44.90     10/42.91     | 
|POLY-3 PERCENT (g) |                                                        |23.0%        23.6%        22.3%        23.3%        | 
|TERMINAL (d)       |                                                        |6/30 (20%)   9/32 (28%)   6/32 (19%)   4/25 (16%)   | 
|FIRST INCIDENCE    |                                                        |394          621          465          456          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.412      P=0.554N     P=0.524N     P=0.494      | 
|POLY 3             |                                                        |P=0.545      P=0.574      P=0.570N     P=0.586      | 
|POLY 1.5           |                                                        |P=0.548      P=0.581      P=0.577N     P=0.591      | 
|POLY 6             |                                                        |P=0.530      P=0.573      P=0.566N     P=0.571      | 
|LOGISTIC REGRESSION|                                                        |P=0.535      P=0.596N     P=0.594      P=0.571      | 
|COCH-ARM / FISHERS |                                                        |P=0.526      P=0.598N     P=0.598N     P=0.579      | 
|ORDER RESTRICTED   |                                                        |P=0.723N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           | 
|     Undifferentiated                                                                                                            | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  22/50 (44%)  13/50 (26%)  6/50 (12%)  |9/50 (18%)   9/50 (18%)   7/50 (14%)   15/49 (31%)  | 
|POLY-3 RATE (b)    |     13/42.99     22/45.56     13/46.15     6/29.00     |9/42.76      9/42.48      7/44.82      15/43.32     | 
|POLY-3 PERCENT (g) |     30.2%        48.3%        28.2%        20.7%       |21.1%        21.2%        15.6%        34.6%        | 
|TERMINAL (d)       |     3/20 (15%)   12/30 (40%)  6/32 (19%)   3/17 (18%)  |4/30 (13%)   7/32 (22%)   3/32 (9%)    8/25 (32%)   | 
|FIRST INCIDENCE    |     522          522          556          606         |535          621          535          593          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.068N     P=0.211      P=0.281N     P=0.219N    |P=0.042 *    P=0.549N     P=0.345N     P=0.083      | 
|POLY 3             |     P=0.112N     P=0.059      P=0.507N     P=0.270N    |P=0.075      P=0.598      P=0.352N     P=0.119      | 
|POLY 1.5           |     P=0.077N     P=0.051      P=0.546N     P=0.203N    |P=0.074      P=0.598      P=0.364N     P=0.119      | 
|POLY 6             |     P=0.114N     P=0.080      P=0.449N     P=0.292N    |P=0.073      P=0.602      P=0.343N     P=0.115      | 
|LOGISTIC REGRESSION|     P=0.043N*    P=0.046 *    P=0.564      P=0.199N    |P=0.071      P=0.595N     P=0.378N     P=0.114      | 
|COCH-ARM / FISHERS |     P=0.010N*    P=0.046 *    P=0.590N     P=0.062N    |P=0.068      P=0.602N     P=0.393N     P=0.109      | 
|ORDER RESTRICTED   |     P=0.093N     (e)          (e)          (e)         |P=0.064      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 26      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/40.59      0/41.64      0/44.41      1/28.31     |0/41.61      0/42.03      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     4.9%         0.0%         0.0%         3.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    0/30 (0%)    0/32 (0%)    1/17 (6%)   |0/30 (0%)    0/32 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     608          ---          ---          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.522N     P=0.198N     P=0.173N     P=0.576N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.401N     P=0.231N     P=0.217N     P=0.621N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.425N     P=0.234N     P=0.226N     P=0.596N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.389N     P=0.224N     P=0.204N     P=0.625N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.531N     P=0.239N     P=0.250N     P=0.615N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.461N     P=0.247N     P=0.247N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.213N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Benign, Malignant, NOS                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    4/50 (8%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/40.44      2/42.29      4/44.58      1/28.65     |0/41.61      0/42.03      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     2.5%         4.7%         9.0%         3.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/30 (0%)    2/32 (6%)    0/17 (0%)   |0/30 (0%)    0/32 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     657          601          694          634         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.483      P=0.503      P=0.315      P=0.672     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.358      P=0.516      P=0.209      P=0.678     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.404      P=0.507      P=0.195      P=0.696     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.356      P=0.531      P=0.232      P=0.679     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.502      P=0.492      P=0.221      P=0.729     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.596      P=0.500      P=0.181      P=0.753N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.365      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 27      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Malignant                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    4/50 (8%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/40.44      2/42.29      4/44.58      1/28.65     |0/41.61      0/42.03      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     2.5%         4.7%         9.0%         3.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/30 (0%)    2/32 (6%)    0/17 (0%)   |0/30 (0%)    0/32 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     657          601          694          634         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.483      P=0.503      P=0.315      P=0.672     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.358      P=0.516      P=0.209      P=0.678     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.404      P=0.507      P=0.195      P=0.696     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.356      P=0.531      P=0.232      P=0.679     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.502      P=0.492      P=0.221      P=0.729     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.596      P=0.500      P=0.181      P=0.753N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.365      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma or Osteoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/40.18      0/41.64      0/44.41      2/28.51     |0/41.61      0/42.03      0/43.75      0/41.07      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         7.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/30 (0%)    0/32 (0%)    1/17 (6%)   |0/30 (0%)    0/32 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          676         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.020 *    (e)          (e)          P=0.180     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.038 *    (e)          (e)          P=0.170     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.038 *    (e)          (e)          P=0.182     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.039 *    (e)          (e)          P=0.171     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.022 *    (e)          (e)          P=0.165     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.012 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 28      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     47/50 (94%)  48/50 (96%)  50/50 (100%) 32/50 (64%) |44/50 (88%)  41/50 (82%)  41/50 (82%)  39/49 (80%)  | 
|POLY-3 RATE (b)    |     47/48.36     48/48.71     50/50.00     32/33.39    |44/46.95     41/46.52     41/47.91     39/46.61     | 
|POLY-3 PERCENT (g) |     97.2%        98.6%        100.0%       95.8%       |93.7%        88.1%        85.6%        83.7%        | 
|TERMINAL (d)       |     20/20 (100%) 30/30 (100%) 32/32 (100%) 17/17 (100%)|29/30 (97%)  28/32 (88%)  28/32 (88%)  21/25 (84%)  | 
|FIRST INCIDENCE    |     522          444          444          290         |394          522          465          456          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.240N     P=0.077N     P=0.032N*    P=0.277N    |P=0.449      P=0.237N     P=0.200N     P=0.547      | 
|POLY 3             |     P=0.602N     P=0.637      P=0.321      P=0.677N    |P=0.084N     P=0.267N     P=0.148N     P=0.092N     | 
|POLY 1.5           |     P=0.021N*    P=0.552      P=0.191      P=0.059N    |P=0.096N     P=0.284N     P=0.179N     P=0.109N     | 
|POLY 6             |     P=0.464      P=0.881      P=0.758      P=0.934     |P=0.094N     P=0.222N     P=0.130N     P=0.091N     | 
|LOGISTIC REGRESSION|     P=0.364      P=0.477      P=0.160      P=0.570     |P=0.107N     P=0.267N     P=0.159N     P=0.122N     | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.500      P=0.121      P<0.001N**  |P=0.190N     P=0.288N     P=0.288N     P=0.194N     | 
|ORDER RESTRICTED   |     P=0.125N     (e)          (e)          (e)         |P=0.087N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     34/50 (68%)  31/50 (62%)  27/50 (54%)  15/50 (30%) |22/50 (44%)  14/50 (28%)  16/50 (32%)  23/49 (47%)  | 
|POLY-3 RATE (b)    |     34/47.18     31/48.18     27/47.46     15/30.62    |22/45.65     14/43.24     16/45.88     23/45.42     | 
|POLY-3 PERCENT (g) |     72.1%        64.3%        56.9%        49.0%       |48.2%        32.4%        34.9%        50.6%        | 
|TERMINAL (d)       |     12/20 (60%)  14/30 (47%)  15/32 (47%)  9/17 (53%)  |9/30 (30%)   9/32 (28%)   9/32 (28%)   9/25 (36%)   | 
|FIRST INCIDENCE    |     463          485          556          319         |394          513          465          456          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.015N*    P=0.117N     P=0.010N*    P=0.030N*   |P=0.178      P=0.079N     P=0.135N     P=0.357      | 
|POLY 3             |     P=0.020N*    P=0.274N     P=0.086N     P=0.032N*   |P=0.297      P=0.093N     P=0.137N     P=0.491      | 
|POLY 1.5           |     P=0.006N**   P=0.306N     P=0.097N     P=0.008N**  |P=0.290      P=0.083N     P=0.136N     P=0.493      | 
|POLY 6             |     P=0.033N*    P=0.223N     P=0.071N     P=0.060N    |P=0.292      P=0.108N     P=0.148N     P=0.471      | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.364N     P=0.120N     P=0.008N**  |P=0.261      P=0.071N     P=0.153N     P=0.459      | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.338N     P=0.109N     P<0.001N**  |P=0.256      P=0.072N     P=0.151N     P=0.463      | 
|ORDER RESTRICTED   |     P=0.038N*    (e)          (e)          (e)         |P=0.181      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/03/05                           EXPERIMENT: 93020 TEST: 07                                            Page 29      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 DIISOPROPYLCARBODIIMIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     50/50 (100%) 50/50 (100%) 50/50 (100%) 33/50 (66%) |48/50 (96%)  45/50 (90%)  44/50 (88%)  45/49 (92%)  | 
|POLY-3 RATE (b)    |     50/50.00     50/50.00     50/50.00     33/34.31    |48/48.16     45/47.24     44/48.97     45/47.75     | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       96.2%       |99.7%        95.3%        89.9%        94.2%        | 
|TERMINAL (d)       |     20/20 (100%) 30/30 (100%) 32/32 (100%) 17/17 (100%)|30/30 (100%) 30/32 (94%)  28/32 (88%)  23/25 (92%)  | 
|FIRST INCIDENCE    |     463          444          444          290         |394          513          465          456          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.170N     (e)          (e)          P=0.226N    |P=0.304      P=0.237N     P=0.162N     P=0.397      | 
|POLY 3             |     P<0.001N**   (e)          (e)          P=0.131N    |P=0.151N     P=0.217N     P=0.035N*    P=0.143N     | 
|POLY 1.5           |     P<0.001N**   (e)          (e)          P<0.001N**  |P=0.165N     P=0.195N     P=0.044N*    P=0.158N     | 
|POLY 6             |     P=0.737N     (e)          (e)          P=1.000N    |P=0.177N     P=0.231N     P=0.036N*    P=0.175N     | 
|LOGISTIC REGRESSION|     P=0.093N     (e)          (e)          P=0.364N    |P=0.165N     P=0.165N     P=0.052N     P=0.134N     | 
|COCH-ARM / FISHERS |     P<0.001N**   (e)          (e)          P<0.001N**  |P=0.337N     P=0.218N     P=0.134N     P=0.329N     | 
|ORDER RESTRICTED   |     P<0.001N**   (e)          (e)          (e)         |P=0.054N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).