National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/19300

TDMS Study 97013-04 Pathology Tables

NTP  EXP/TEST: 97013-04                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK                     INITIAL AND CURRENT BODY WEIGHT                                   DATE: 06/11/04
ROUTE: DOSED WATER                                                                                                TIME: 08:06:26

                                                         EIS REPORT 03


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  97013E

       CONTRACT NUMBER:  NO1-ES-65406

       CAS NUMBER:  75-27-4

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 97013-04                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 2
TEST TYPE: SUBCHRON 26-WEEK                     INITIAL AND CURRENT BODY WEIGHT                                   DATE: 06/11/04
ROUTE: DOSED WATER                                          EISRPT03                                              TIME: 08:06:26
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: P53(C57BL/6)-MICE          SEX: FEMALE      WEEK ON DOSE: 27     FIRST DOSE: 08/31/99
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/L             15     18.9    0.8        15     36.4    9.4                     15     17.5    8.9

 175 MG/L           15     18.9    0.8        15     33.2    4.7        91.2         15     14.3    4.5

 350 MG/L           15     18.8    1.0        14     34.0    7.3        93.4         14     15.1    6.8

 700 MG/L           15     18.6    0.9        15     31.7    6.7        87.0         15     13.1    6.4




----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: P53(C57BL/6)-MICE          SEX: MALE        WEEK ON DOSE: 27     FIRST DOSE: 08/31/99
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/L             15     22.8    1.1        15     47.8    4.2                     15     24.9    3.3

 175 MG/L           15     23.0    1.2        15     46.3    3.8        96.8         15     23.3    3.6

 350 MG/L           15     22.9    1.0        15     42.7    2.7        89.3         15     19.8    2.1

 700 MG/L           15     22.5    1.2        15     36.5    4.5        76.3         15     14.0    4.5

                                               -----------------------------------
                                               ---------- END-OF-REPORT ----------
                                               -----------------------------------
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.