National Toxicology Program

National Toxicology Program
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TDMS Study 97013-06 Pathology Tables

NTP  EXP/TEST: 97013-06                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK                     INITIAL AND CURRENT BODY WEIGHT                                   DATE: 06/11/04
ROUTE: SKIN APPLICATION                                                                                           TIME: 08:06:41

                                                         EIS REPORT 03


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  97013F

       CONTRACT NUMBER:  NO1-ES-65406

       CAS NUMBER:  75-27-4

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 97013-06                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 2
TEST TYPE: SUBCHRON 26-WEEK                     INITIAL AND CURRENT BODY WEIGHT                                   DATE: 06/11/04
ROUTE: SKIN APPLICATION                                     EISRPT03                                              TIME: 08:06:41
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 SPECIES-STRAIN: TG.AC HEMI-MICE            SEX: FEMALE      WEEK ON DOSE: 27     FIRST DOSE: 08/19/99
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            15     20.1    0.9        11     28.3    2.7                     11      8.3    2.6

 64 MG/KG           15     20.0    1.0        10     28.1    3.1        99.2         10      8.2    2.5

 128     MG/KG      15     20.2    0.7        12     28.7    3.4       101.4         12      8.5    3.1

 256     MG/KG      15     20.5    0.8        10     29.5    2.8       104.2         10      9.3    2.5

 TPA                15     19.0    1.8         0      0.0    0.0                      0      0.0    0.0




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 SPECIES-STRAIN: TG.AC HEMI-MICE            SEX: MALE        WEEK ON DOSE: 27     FIRST DOSE: 08/19/99
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            15     24.0    1.3        13     35.1    4.4                     13     11.0    4.1

 64 MG/KG           15     23.9    1.2        14     34.5    3.3        98.2         14     10.4    2.7

 128     MG/KG      15     23.9    1.1        15     36.0    3.6       102.5         15     12.0    3.2

 256     MG/KG      15     24.3    0.8        13     34.4    2.9        98.0         13     10.3    2.7

 TPA                15     22.9    1.7         0      0.0    0.0                      0      0.0    0.0

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