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TDMS Study 97013-07 Pathology Tables

NTP Experiment-Test: 97013-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 06/11/04
Route: GAVAGE                                                                                                     Time: 08:42:48

                                                          FINAL#1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  75-27-4

       Lock Date:  07/19/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 97013-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 06/11/04    
Route: GAVAGE                                                                                                     Time: 08:42:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/KG      25 MG/KG     50 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                              1                         1                                     
    Dosing Accident                                                              1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           14           14           14                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                                                    (1)                                                 
      Hyperkeratosis                                                             1 (100%)                                           
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                                                        2 (13%)                               
      Infiltration Cellular, Lymphocyte                5 (33%)      4 (27%)      3 (20%)                                            
      Inflammation                                    14 (93%)     15 (100%)    14 (93%)     14 (93%)                               
      Hepatocyte, Fatty Change                         2 (13%)      2 (13%)      3 (20%)     11 (73%)                               
      Hepatocyte, Vacuolization Cytoplasmic           10 (67%)      9 (60%)     10 (67%)     13 (87%)                               
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Inflammation                                                               1 (7%)       1 (7%)                                
      Epithelium, Hyperplasia                                                                 1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Subcapsular, Hyperplasia                        14 (93%)     15 (100%)    12 (80%)     14 (93%)                               
   Parathyroid Gland                                                            (2)                                                 
      Cyst                                                                       2 (100%)                                           
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Cyst                                                                       1 (7%)                                             
      Hyperplasia                                                   1 (7%)                                                          
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Ectopic Thymus                                   1 (7%)                                 1 (7%)                                
      Inflammation                                     3 (20%)      1 (7%)       1 (7%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 06/11/04    
Route: GAVAGE                                                                                                     Time: 08:42:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/KG      25 MG/KG     50 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                                                (1)                                    
      Inflammation                                                                            1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (15)         (15)                                   
      Cyst                                             2 (13%)      1 (7%)       2 (13%)      2 (13%)                               
   Uterus                                             (15)         (15)         (15)         (15)                                   
      Inflammation                                     2 (13%)      2 (13%)                                                         
      Necrosis                                                                                1 (7%)                                
      Thrombosis                                                                              1 (7%)                                
      Endometrium, Hyperplasia, Cystic                 9 (60%)      9 (60%)     12 (80%)     10 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                                                (2)                                    
      Mediastinal, Atrophy                                                                    1 (50%)                               
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)                                   
      Atrophy                                                                                 1 (7%)                                
   Lymph Node, Mesenteric                             (15)         (15)         (15)         (14)                                   
      Atrophy                                                                                 1 (7%)                                
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                                           2 (13%)      2 (13%)                               
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                                                                 2 (13%)                               
      Cyst                                             6 (40%)      5 (33%)      9 (60%)      7 (47%)                               
      Hyperplasia, Atypical                                                                   1 (7%)                                
      Necrosis                                                                   1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                                                                      (2)                                    
      Subcutaneous Tissue, Edema                                                              1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 06/11/04    
Route: GAVAGE                                                                                                     Time: 08:42:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/KG      25 MG/KG     50 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                                                                     (1)                                    
      Hydrocephalus                                                                           1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Infiltration Cellular, Lymphocyte                3 (20%)                   2 (13%)      1 (7%)                                
      Infiltration Cellular, Histiocyte                1 (7%)                                 1 (7%)                                
      Inflammation                                     1 (7%)                                                                       
   Pleura                                                                       (1)                                                 
      Inflammation, Suppurative                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Casts Protein                                   12 (80%)     11 (73%)      7 (47%)      7 (47%)                               
      Hydronephrosis                                                                          1 (7%)                                
      Inflammation                                                  1 (7%)                                                          
      Nephropathy                                      1 (7%)       3 (20%)      1 (7%)                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 06/11/04    
Route: GAVAGE                                                                                                     Time: 08:42:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/KG      25 MG/KG     50 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           15           15           15                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Infiltration Cellular, Lymphocyte                                          2 (13%)                                            
      Inflammation                                    13 (87%)     14 (93%)     13 (87%)     15 (100%)                              
      Necrosis                                                                                1 (7%)                                
      Hepatocyte, Fatty Change                        10 (67%)      9 (60%)      4 (27%)     11 (73%)                               
      Hepatocyte, Vacuolization Cytoplasmic           15 (100%)    15 (100%)    13 (87%)     15 (100%)                              
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Hyperkeratosis                                                                          1 (7%)                                
      Inflammation                                                  1 (7%)       1 (7%)       1 (7%)                                
      Epithelium, Hyperplasia                                       2 (13%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Hypertrophy                                      6 (40%)      2 (13%)                                                         
      Subcapsular, Hyperplasia                         2 (13%)      6 (40%)      6 (40%)      3 (20%)                               
   Pituitary Gland                                    (14)         (15)         (15)         (15)                                   
      Cyst                                             1 (7%)       4 (27%)                   2 (13%)                               
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Inflammation                                     1 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 06/11/04    
Route: GAVAGE                                                                                                     Time: 08:42:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/KG      25 MG/KG     50 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (15)         (15)         (15)         (15)                                   
      Granuloma Sperm                                  2 (13%)                                                                      
      Inflammation                                     1 (7%)                                 1 (7%)                                
   Testes                                             (15)         (15)         (15)         (15)                                   
      Inflammation, Granulomatous                                   1 (7%)                                                          
      Mineralization                                                1 (7%)                                                          
      Germinal Epithelium, Degeneration                3 (20%)      2 (13%)      1 (7%)       1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Lymphoid Follicle, Hyperplasia                                                          1 (7%)                                
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Cyst                                            11 (73%)      9 (60%)      9 (60%)     11 (73%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                                                                     (1)                                    
      Hydrocephalus                                                                           1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Inflammation                                                                            1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 06/11/04    
Route: GAVAGE                                                                                                     Time: 08:42:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/KG      25 MG/KG     50 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Casts Protein                                    2 (13%)                   5 (33%)      2 (13%)                               
      Hydronephrosis                                                1 (7%)                                                          
      Nephropathy                                      8 (53%)      9 (60%)      8 (53%)      8 (53%)                               
      Renal Tubule, Degeneration                                                              4 (27%)                               
      Renal Tubule, Vacuolization Cytoplasmic         12 (80%)      5 (33%)                                                         
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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