National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/20685

TDMS Study 97013-07 Pathology Tables

NTP Experiment-Test: 97013-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04
Route: GAVAGE                                  WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:45:25

                                                          FINAL#1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  75-27-4

       Lock Date:  07/19/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 97013-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04    
Route: GAVAGE                                  WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:45:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/KG      25 MG/KG     50 MG/KG     100                                    
                                                                                             MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                              1                         1                                     
    Dosing Accident                                                              1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           14           14           14                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                                                    (1)                                                 
      Hyperkeratosis                                                             1 [1.0]                                            
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                                                        2 [1.0]                               
      Infiltration Cellular, Lymphocyte                5 [1.2]      4 [1.0]      3 [1.0]                                            
      Inflammation                                    14 [1.0]     15 [1.0]     14 [1.0]     14 [1.1]                               
      Hepatocyte, Fatty Change                         2 [1.0]      2 [1.0]      3 [1.0]     11 [1.3]                               
      Hepatocyte, Vacuolization Cytoplasmic           10 [1.0]      9 [1.0]     10 [1.0]     13 [1.5]                               
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Inflammation                                                               1 [1.0]      1 [1.0]                               
      Epithelium, Hyperplasia                                                                 1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Subcapsular, Hyperplasia                        14 [1.0]     15 [1.0]     12 [1.0]     14 [1.0]                               
   Parathyroid Gland                                                            (2)                                                 
      Cyst                                                                       2 [2.0]                                            
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Cyst                                                                       1 [1.0]                                            
      Hyperplasia                                                   1 [2.0]                                                         
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Ectopic Thymus                                   1 [1.0]                                1 [1.0]                               
      Inflammation                                     3 [1.3]      1 [1.0]      1 [1.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04    
Route: GAVAGE                                  WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:45:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/KG      25 MG/KG     50 MG/KG     100                                    
                                                                                             MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                                                (1)                                    
      Inflammation                                                                            1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (15)         (15)                                   
      Cyst                                             2 [1.0]      1 [2.0]      2 [1.0]      2 [1.0]                               
   Uterus                                             (15)         (15)         (15)         (15)                                   
      Inflammation                                     2 [1.0]      2 [1.0]                                                         
      Necrosis                                                                                1 [3.0]                               
      Thrombosis                                                                              1 [2.0]                               
      Endometrium, Hyperplasia, Cystic                 9 [1.3]      9 [1.3]     12 [1.2]     10 [1.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                                                (2)                                    
      Mediastinal, Atrophy                                                                    1 [3.0]                               
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)                                   
      Atrophy                                                                                 1 [3.0]                               
   Lymph Node, Mesenteric                             (15)         (15)         (15)         (14)                                   
      Atrophy                                                                                 1 [2.0]                               
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                                           2 [1.0]      2 [1.5]                               
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                                                                 2 [2.5]                               
      Cyst                                             6 [1.0]      5 [1.0]      9 [1.0]      7 [1.0]                               
      Hyperplasia, Atypical                                                                   1 [2.0]                               
      Necrosis                                                                   1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                                                                      (2)                                    
      Subcutaneous Tissue, Edema                                                              1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04    
Route: GAVAGE                                  WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:45:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/KG      25 MG/KG     50 MG/KG     100                                    
                                                                                             MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                                                                     (1)                                    
      Hydrocephalus                                                                           1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Infiltration Cellular, Lymphocyte                3 [1.0]                   2 [1.0]      1 [1.0]                               
      Infiltration Cellular, Histiocyte                1 [1.0]                                1 [1.0]                               
      Inflammation                                     1 [1.0]                                                                      
   Pleura                                                                       (1)                                                 
      Inflammation, Suppurative                                                  1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Casts Protein                                   12 [1.0]     11 [1.0]      7 [1.0]      7 [1.0]                               
      Hydronephrosis                                                                          1 [3.0]                               
      Inflammation                                                  1 [1.0]                                                         
      Nephropathy                                      1 [1.0]      3 [1.0]      1 [1.0]                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04    
Route: GAVAGE                                  WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:45:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/KG      25 MG/KG     50 MG/KG     100                                    
                                                                                             MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           15           15           15                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Infiltration Cellular, Lymphocyte                                          2 [1.0]                                            
      Inflammation                                    13 [1.0]     14 [1.0]     13 [1.0]     15 [1.0]                               
      Necrosis                                                                                1 [1.0]                               
      Hepatocyte, Fatty Change                        10 [1.0]      9 [1.1]      4 [1.0]     11 [1.3]                               
      Hepatocyte, Vacuolization Cytoplasmic           15 [1.9]     15 [1.9]     13 [1.2]     15 [1.5]                               
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Hyperkeratosis                                                                          1 [1.0]                               
      Inflammation                                                  1 [1.0]      1 [1.0]      1 [1.0]                               
      Epithelium, Hyperplasia                                       2 [1.5]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Hypertrophy                                      6 [1.0]      2 [1.0]                                                         
      Subcapsular, Hyperplasia                         2 [1.0]      6 [1.0]      6 [1.0]      3 [1.0]                               
   Pituitary Gland                                    (14)         (15)         (15)         (15)                                   
      Cyst                                             1 [1.0]      4 [1.0]                   2 [1.0]                               
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Inflammation                                     1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04    
Route: GAVAGE                                  WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:45:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/KG      25 MG/KG     50 MG/KG     100                                    
                                                                                             MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (15)         (15)         (15)         (15)                                   
      Granuloma Sperm                                  2 [2.0]                                                                      
      Inflammation                                     1 [1.0]                                1 [1.0]                               
   Testes                                             (15)         (15)         (15)         (15)                                   
      Inflammation, Granulomatous                                   1 [2.0]                                                         
      Mineralization                                                1 [1.0]                                                         
      Germinal Epithelium, Degeneration                3 [1.3]      2 [1.5]      1 [1.0]      1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Lymphoid Follicle, Hyperplasia                                                          1 [2.0]                               
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Cyst                                            11 [1.1]      9 [1.2]      9 [1.2]     11 [1.1]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                                                                     (1)                                    
      Hydrocephalus                                                                           1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Inflammation                                                                            1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04    
Route: GAVAGE                                  WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:45:25    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/KG      25 MG/KG     50 MG/KG     100                                    
                                                                                             MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Casts Protein                                    2 [1.0]                   5 [1.0]      2 [1.0]                               
      Hydronephrosis                                                1 [2.0]                                                         
      Nephropathy                                      8 [1.0]      9 [1.0]      8 [1.0]      8 [1.1]                               
      Renal Tubule, Degeneration                                                              4 [1.3]                               
      Renal Tubule, Vacuolization Cytoplasmic         12 [1.2]      5 [1.0]                                                         
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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