TDMS Study 97013-08 Pathology Tables
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:47:29
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 MG/KG
Include 004 25 MG/KG
Include 006 50 MG/KG
Include 008 100 MG/KG
Include 001 0 MG/KG
Include 003 25 MG/KG
Include 005 50 MG/KG
Include 007 100 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:47:29
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15
Early Deaths
Moribund Sacrifice 1 1
Dosing Accident 1 1
Natural Death 2 1 2
Survivors
Terminal Sacrifice 11 14 13 13
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Salivary Glands (1) (1)
Duct, Carcinoma 1 (100%) 1 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Squamous Cell Papilloma 3 (20%) 3 (20%) 4 (27%)
Squamous Cell Papilloma, Multiple 3 (20%) 5 (33%) 6 (40%) 11 (73%)
Tooth (4) (3) (2)
Odontogenic Tumor 4 (100%) 3 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Adrenal Medulla (15) (15) (15) (15)
Pituitary Gland (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:47:29
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15)
Uterus (15) (15) (15) (15)
Polyp Stromal 1 (7%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Lymph Node, Mandibular (14) (15) (15) (15)
Lymph Node, Mesenteric (14) (15) (15) (15)
Spleen (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (1) (3) (6) (2)
Squamous Cell Papilloma 1 (100%) 1 (33%) 5 (83%) 2 (100%)
Squamous Cell Papilloma, Multiple 2 (67%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Adenoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:47:29
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15)
Leukemia Erythrocytic 2 (13%) 2 (13%) 1 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:47:29
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 10 10 12 13
Total Primary Neoplasms 14 14 20 16
Total Animals with Benign Neoplasms 7 9 12 12
Total Benign Neoplasms 7 12 16 13
Total Animals with Malignant Neoplasms 3 2 1 1
Total Malignant Neoplasms 3 2 1 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 4 3 2
Total Uncertain Neoplasms 4 3 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:47:29
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15
Early Deaths
Dosing Accident 1
Moribund Sacrifice 1 1 3
Survivors
Terminal Sacrifice 13 14 12 14
Natural Death 1
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Stomach, Forestomach (15) (15) (15) (15)
Squamous Cell Papilloma 4 (27%) 2 (13%) 2 (13%) 5 (33%)
Squamous Cell Papilloma, Multiple 5 (33%) 3 (20%) 9 (60%) 7 (47%)
Tooth (3) (2) (3) (3)
Odontogenic Tumor 2 (67%) 2 (100%) 3 (100%) 2 (67%)
Sarcoma 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Adrenal Medulla (15) (15) (15) (15)
Pituitary Gland (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:47:29
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (1) (1) (1) (5)
Squamous Cell Papilloma 1 (100%) 4 (80%)
Squamous Cell Papilloma, Multiple 1 (100%) 1 (20%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Alveolar/Bronchiolar Adenoma 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Page 7
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:47:29
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15)
Leukemia Erythrocytic 1 (7%) 1 (7%)
Lymphoma Malignant 1 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 8
NTP Experiment-Test: 97013-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:47:29
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 11 6 13 14
Total Primary Neoplasms 14 9 15 21
Total Animals with Benign Neoplasms 9 5 11 13
Total Benign Neoplasms 10 6 12 18
Total Animals with Malignant Neoplasms 2 1 1
Total Malignant Neoplasms 2 1 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 2 2 3 2
Total Uncertain Neoplasms 2 2 3 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 9
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------