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TDMS Study 97013-09 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Battelle Columbus                      WATER DISINFECTION MODEL (SODIUM BROMATE)                               DATE: 06/18/04  
EXPERIMENT: 97013 TEST: 09                                                                                        TIME: 11:02:39    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: SUBCHRON 26-WEEK                         ROUTE: DOSED WATER                                            NTP:  C97013A     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BATTELLE COLUMBUS                                WATER DISINFECTION MODEL (SODIUM BROMATE)                   DATE: 06/18/04    
EXPERIMENT: 97013 TEST: 09                                                                                        TIME: 11:11:02    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: SUBCHRONIC (26-WEEK)                     ROUTE: DOSED WATER                                            NTP:  97013A      
CONT: N01-ES-65406                                                                                                CAS: 7789-38-0    
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                        
                          SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)                       
==================================================================================================================================  
           0 MG/L                     80 MG/L                            400 MG/L                           800 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     6.0    24.1                                          6.2     24.0    1.03      104      5.0     23.9    0.83      166       
  3     5.8    26.2       5.4     26.4    0.93       16      4.2     26.0    0.72       64      4.6     25.3    0.79      144       
  4     4.8    27.6                                          4.7     27.4    0.98       69      5.8     26.9    1.21      173       
  5     6.4    28.3       5.7     29.1    0.89       16      4.5     28.6    0.70       63      5.0     27.4    0.78      147       
  6     5.5    29.7       4.9     30.0    0.89       13      5.1     29.3    0.93       70      4.0     28.0    0.73      115       
  7                       5.5     30.7               14      4.9     29.9               65      5.8     28.6              161       
  8     6.2    31.7       4.3     31.3    0.69       11      5.5     30.4    0.89       72      5.2     28.7    0.84      144       
  9     5.3    32.6       4.7     32.4    0.89       12      5.0     31.4    0.94       63      5.3     29.6    1.00      144       
 10     7.3    33.3       5.8     33.0    0.79       14      5.0     31.7    0.68       63      4.7     29.2    0.64      129       
 11     5.4    34.9       5.8     34.5    1.07       13      5.2     32.3    0.96       64      5.6     30.1    1.04      150       
 12     5.4    35.9       5.0     35.0    0.93       11      6.7     33.1    1.24       81      4.7     30.8    0.87      121       
 13     4.5    36.5       4.8     35.9    1.07       11      6.2     34.2    1.38       73      4.9     31.1    1.09      126       
 14     4.6    36.5       5.3     36.2    1.15       12      4.8     33.6    1.04       57      4.2     30.6    0.91      109       
 15     5.0    36.3       5.7     35.8    1.14       13      5.4     35.0    1.08       62      4.8     31.7    0.96      121       
 16     5.2    35.7                                                                             4.9     31.7    0.94      124       
 17     4.8    35.8       6.6     35.6    1.38       15                                         3.9     31.0    0.81      100       
 18     5.4    36.2       5.7     35.8    1.06       13      5.1     33.0    0.94       62      4.5     30.8    0.83      116       
 19     5.5    36.2       4.6     35.4    0.84       10      3.7     33.3    0.67       44      4.0     30.6    0.73      105       
 20     4.9    36.4       6.9     36.0    1.41       15      4.1     33.1    0.84       50      3.4     31.2    0.69       87       
 21     5.0    36.6       5.7     36.6    1.14       13      4.1     33.6    0.82       48      5.5     31.4    1.10      140       
 22     4.7    37.1       5.5     37.0    1.17       12      5.7     33.9    1.21       68      5.4     31.5    1.15      136       
 23     4.7    36.4       5.2     37.2    1.11       11      5.6     33.3    1.19       67      4.5     30.9    0.96      115       
 24     5.2    37.0       5.0     37.6    0.96       11      4.7     34.3    0.90       54      4.2     31.1    0.81      108       
 25     5.1    36.2       4.4     37.6    0.86        9      3.6     33.9    0.71       42      4.4     31.7    0.86      111       
 26     4.9    38.0       4.0     37.1    0.82        9      4.0     34.0    0.82       48      4.4     32.1    0.90      111       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    5.7    31.0       5.2     31.8    0.91       13      5.3     29.9    0.95       71      5.0     28.3    0.89      143       
SD(D)   0.8               0.5             0.12        2      0.8             0.21       12      0.5             0.17       18       
CV(E)  13.8              10.3            13.1      15.2     14.3            22.6      16.4     10.6            19.0      12.6       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    5.0    36.5       5.4     36.5    1.09       12      4.6     33.7    0.93       55      4.5     31.3    0.90      114       
SD(D)   0.3               0.8             0.19        2      0.8             0.18        9      0.6             0.13       14       
CV(E)   5.5              15.3            17.7      16.5     16.7            19.7      16.5     13.1            14.6      12.5       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                                                  
SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)                                                 
==========================================                                                                                          
                      TPA                                                                                                           
       ---------------------------------                                                                                            
                         DOSE/                                                                                                      
       GRAMS    BODY    CONTROL                                                                                                     
       WATER/   WEIGHT  WATER (B)  DOSE/                                                                                            
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                                                            
==========================================                                                                                          
  2     6.6     22.5     1.10     368                                                                                               
  3     5.2     24.2     0.90     267                                                                                               
  4     5.6     26.1     1.17     268                                                                                               
  5     5.0     26.8     0.78     232                                                                                               
  6                                                                                                                                 
  7     5.5     28.0              245                                                                                               
  8                                                                                                                                 
  9     5.9     28.9     1.11     253                                                                                               
 10                                                                                                                                 
 11     6.8     30.2     1.26     282                                                                                               
 12     6.8     30.3     1.26     278                                                                                               
 13     6.7     30.6     1.49     276                                                                                               
 14     6.4     30.8     1.39     261                                                                                               
 15     6.3     31.7     1.26     247                                                                                               
 16     4.8     30.8     0.92     195                                                                                               
 17     4.8     29.6     1.00     203                                                                                               
 18     5.3     28.9     0.98     229                                                                                               
 19     5.9     29.6     1.07     248                                                                                               
 20     5.9     29.7     1.20     248                                                                                               
 21     5.9     29.6     1.18     251                                                                                               
 22                                                                                                                                 
 23     6.1     30.4     1.30     253                                                                                               
 24     5.9     30.6     1.13     239                                                                                               
 25     5.3     29.2     1.04     227                                                                                               
 26     5.2     30.1     1.06     216                                                                                               
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    6.0     27.5     1.13     274                                                                                               
SD(D)   0.7              0.22      39                                                                                               
CV(E)  12.3             19.5     14.1                                                                                               
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    5.7     30.1     1.13     235                                                                                               
SD(D)   0.6              0.14      21                                                                                               
CV(E)   9.8             12.5      8.9                                                                                               
==========================================                                                                                          
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                      
                          SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)                       
==================================================================================================================================  
           0 MG/L                     80 MG/L                            400 MG/L                           800 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2                                                          5.5     20.0              111                                          
  3     5.3    20.3                                          5.4     21.4     1.02     101      4.7     21.0     0.89     179       
  4     6.1    22.6       5.2     22.9     0.85      18      4.4     23.2     0.72      75      4.5     22.4     0.74     160       
  5     6.2    23.5       4.5     23.6     0.73      15      4.8     24.1     0.77      80      4.3     22.8     0.69     149       
  6     5.8    23.8       5.5     24.0     0.95      18      5.7     23.8     0.98      95      4.2     22.4     0.72     148       
  7     4.5    25.0       5.0     24.5     1.11      16      4.2     24.5     0.93      69      4.6     23.7     1.02     157       
  8     5.7    25.3       5.4     25.3     0.95      17      5.3     25.1     0.93      85      4.6     24.1     0.81     154       
  9     5.1    26.4       5.4     26.0     1.06      17      5.6     25.8     1.10      87      4.7     25.0     0.92     149       
 10     5.5    27.6       5.1     26.4     0.93      15      5.6     26.2     1.02      85      4.7     24.3     0.85     155       
 11     4.9    28.0       4.8     26.2     0.98      15      5.1     26.0     1.04      78      5.0     25.5     1.02     156       
 12     5.0    28.4       5.0     27.2     1.00      15      5.8     26.7     1.16      86      4.1     25.5     0.82     128       
 13     5.3    28.3       5.4     27.6     1.02      16      4.6     26.9     0.87      69      4.8     25.5     0.91     150       
 14     5.2    28.4       4.8     27.7     0.92      14      4.2     27.3     0.81      61      4.2     25.6     0.81     133       
 15     3.8    28.9       4.3     27.4     1.13      12      5.0     27.7     1.32      72      4.3     26.0     1.13     132       
 16     3.5    28.7       5.8     27.7     1.66      17      4.6     27.2     1.31      68      5.8     26.2     1.66     178       
 17     5.4    29.0       4.6     27.7     0.85      13      5.1     27.2     0.94      75      4.4     25.2     0.81     138       
 18     4.3    28.7       3.3     27.4     0.77      10      5.0     27.8     1.16      71      5.0     26.1     1.16     152       
 19     3.4    28.2       4.8     28.0     1.41      14      4.2     28.9     1.24      58      4.2     25.4     1.24     134       
 20     4.7    29.1       5.3     29.0     1.13      15      4.4     29.2     0.94      61      5.1     25.8     1.09     159       
 21     4.6    29.6       4.9     29.3     1.07      13      3.9     29.5     0.85      53      4.0     25.8     0.87     125       
 22     4.5    30.9       5.5     29.7     1.22      15      4.5     30.3     1.00      59      5.3     26.6     1.18     159       
 23     3.5    29.8       4.5     29.4     1.29      12      3.7     30.1     1.06      49      4.6     26.6     1.31     138       
 24     3.2    30.6       4.3     29.4     1.34      12      3.4     31.0     1.06      44      4.4     26.2     1.38     136       
 25     3.3    31.4       3.6     29.8     1.09      10      4.0     31.2     1.21      51      4.3     26.6     1.30     130       
 26     3.8    31.2       4.3     30.5     1.13      11      3.1     31.8     0.82      39      4.3     26.5     1.13     129       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    5.4    25.4       5.1     25.4     0.96      16      5.2     24.5     0.96      85      4.6     23.8     0.85     153       
SD(D)   0.5               0.3              0.11       1      0.5              0.13      12      0.3              0.11      12       
CV(E)   9.3               6.3             11.3      8.1     10.3             13.8     14.7      6.1             13.0      7.9       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.1    29.6       4.6     28.7     1.15      13      4.2     29.2     1.05      59      4.6     26.0     1.16     142       
SD(D)   0.7               0.7              0.24       2      0.6              0.18      11      0.5              0.24      16       
CV(E)  18.1              15.4             20.7     16.0     14.4             17.2     18.9     11.5             20.5     11.0       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                                
SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)                                                 
==========================================                                                                                          
                      TPA                                                                                                           
       ---------------------------------                                                                                            
                         DOSE/                                                                                                      
       GRAMS    BODY    CONTROL                                                                                                     
       WATER/   WEIGHT  WATER (B)  DOSE/                                                                                            
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                                                            
==========================================                                                                                          
  2     6.4     19.3              412                                                                                               
  3     6.9     20.7     1.30     419                                                                                               
  4     6.3     22.4     1.03     349                                                                                               
  5     6.5     22.9     1.05     358                                                                                               
  6     5.9     22.7     1.02     326                                                                                               
  7     5.9     23.0     1.31     318                                                                                               
  8     6.6     24.0     1.16     343                                                                                               
  9     6.3     24.4     1.24     322                                                                                               
 10     6.7     24.6     1.22     340                                                                                               
 11     5.6     24.5     1.14     285                                                                                               
 12     6.2     24.9     1.24     309                                                                                               
 13     5.6     25.9     1.06     271                                                                                               
 14     6.2     26.2     1.19     295                                                                                               
 15     6.2     26.5     1.63     292                                                                                               
 16     5.2     26.3     1.49     247                                                                                               
 17                                                                                                                                 
 18                                                                                                                                 
 19                                                                                                                                 
 20                                                                                                                                 
 21     7.6     28.0     1.65     337                                                                                               
 22                                                                                                                                 
 23     5.9     28.9     1.69     254                                                                                               
 24     6.9     29.3     2.16     293                                                                                               
 25     6.8     27.6     2.06     308                                                                                               
 26     6.1     29.9     1.61     255                                                                                               
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    6.2     23.3     1.16     338                                                                                               
SD(D)   0.4              0.11      44                                                                                               
CV(E)   6.8              9.4     13.1                                                                                               
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    6.3     27.8     1.68     285                                                                                               
SD(D)   0.7              0.31      31                                                                                               
CV(E)  11.3             18.2     10.8                                                                                               
==========================================                                                                                          
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                         DIAGNOSTIC TRAILER REPORT                                                                                  
                         WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                         
                         SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)                        
==================================================================================================================================  
           0 MG/L                  80 MG/L                  400 MG/L                 800 MG/L                   TPA                 
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM     
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS    
=================================================================================================================================== 
  B               23.6  15                 23.9  15                 23.6  15                 23.8  15                 21.8  15      
  1               23.6  15                 23.9  15                 23.6  15                 23.8  15                 21.8  15      
  2   6.0   400   24.1  15                 24.8  15     6.2   357   24.0  15     5.0   332   23.9  15     6.6   191   22.5  15      
  3   5.8   782   26.2  15     5.4   118   26.4  15     4.2   262   26.0  15     4.6   747   25.3  15     5.2   433   24.2  15      
  4   4.8   194   27.6  15     6.8   118   27.9  15     4.7   263   27.4  15     5.8   336   26.9  15     5.6   183   26.1  15      
  5   6.4   427   28.3  15     5.7   455   29.1  15     4.5   527   28.6  15     5.0   813   27.4  15     5.0   217   26.8  15      
  6   5.5   760   29.7  14     4.9   514   30.0  15     5.1   587   29.3  15     4.0   759   28.0  15                 27.0  15      
  7   5.4   121   30.8  14     5.5   715   30.7  15     4.9   690   29.9  15     5.8  1148   28.6  15     5.5   358   28.0  15      
  8   6.2   219   31.7  14     4.3   404   31.3  15     5.5   782   30.4  15     5.2  1059   28.7  15     4.1    71   28.4  15      
  9   5.3   836   32.6  14     4.7  1072   32.4  15     5.0   658   31.4  15     5.3  1206   29.6  15     5.9   366   28.9  15      
 10   7.3   668   33.3  14     5.8  1182   33.0  15     5.0   488   31.7  15     4.7   696   29.2  15     6.5   170   29.5  15      
 11   5.4   885   34.9  14     5.8   949   34.5  15     5.2   896   32.3  15     5.6  1171   30.1  15     6.8   877   30.2  15      
 12   5.4  1233   35.9  14     5.0   924   35.0  15     6.7   945   33.1  15     4.7  1174   30.8  15     6.8   883   30.3  13      
 13   4.5   874   36.5  14     4.8   861   35.9  15     6.2   693   34.2  15     4.9  1207   31.1  15     6.7   812   30.6   9      
 14   4.6   988   36.5  14     5.3   994   36.2  15     4.8   964   33.6  15     4.2  1576   30.6  15     6.4   532   30.8   7      
 15   5.0  1246   36.3  14     5.7  1472   35.8  15     5.4  1526   35.0  15     4.8  2006   31.7  15     6.3   404   31.7   7      
 16   5.2   539   35.7  14     6.3   202   35.3  15     4.9    19   34.1  15     4.9  1008   31.7  15     4.8   169   30.8   4      
 17   4.8   678   35.8  14     6.6   666   35.6  15     5.9   194   33.4  15     3.9   856   31.0  15     4.8   171   29.6   3      
 18   5.4   744   36.2  14     5.7   942   35.8  15     5.1   413   33.0  15     4.5  1017   30.8  15     5.3   170   28.9   3      
 19   5.5   268   36.2  14     4.6   945   35.4  15     3.7   593   33.3  15     4.0   901   30.6  15     5.9   219   29.6   3      
 20   4.9   745   36.4  14     6.9   337   36.0  15     4.1   167   33.1  15     3.4   504   31.2  15     5.9   168   29.7   3      
 21   5.0   700   36.6  14     5.7   841   36.6  15     4.1   528   33.6  15     5.5  1275   31.4  15     5.9   215   29.6   3      
 22   4.7  1216   37.1  14     5.5  1008   37.0  15     5.7   496   33.9  14     5.4   824   31.5  15     7.7    18   28.2   3      
 23   4.7   742   36.4  14     5.2  1126   37.2  14     5.6   768   33.3  14     4.5   741   30.9  15     6.1   337   30.4   3      
 24   5.2  1407   37.0  14     5.0  1398   37.6  14     4.7   970   34.3  14     4.2  1129   31.1  14     5.9   338   30.6   3      
 25   5.1   896   36.2  14     4.4  1415   37.6  14     3.6   748   33.9  14     4.4  1058   31.7  14     5.3   335   29.2   3      
 26   4.9   715   38.0  13     4.0  1191   37.1  14     4.0   287   34.0  14     4.4   836   32.1  14     5.2   168   30.1   3      
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           30.4                     30.4                     29.4                     28.0                     27.2          
14 TO 52          36.5                     36.4                     33.7                     31.3                     29.9          
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                         DIAGNOSTIC TRAILER REPORT                                                                                  
                         WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                       
                         SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)                        
==================================================================================================================================  
           0 MG/L                  80 MG/L                  400 MG/L                 800 MG/L                   TPA                 
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM     
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS    
=================================================================================================================================== 
  B               19.2  15                 19.4  15                 19.7  15                 19.8  15                 18.3  15      
  1               19.2  15                 19.4  15                 19.7  15                 19.8  15                 18.3  15      
  2   4.8   237   19.6  15                 20.1  15     5.5   189   20.0  15     4.1   261   19.2  15     6.4   355   19.3  15      
  3   5.3  1306   20.3  15     5.3   156   21.5  15     5.4   263   21.4  15     4.7   746   21.0  14     6.9    91   20.7  15      
  4   6.1   503   22.6  15     5.2   524   22.9  15     4.4   214   23.2  15     4.5   860   22.4  14     6.3   186   22.4  15      
  5   6.2   456   23.5  14     4.5   408   23.6  15     4.8   655   24.1  14     4.3  1695   22.8  13     6.5   338   22.9  15      
  6   5.8   686   23.8  14     5.5   781   24.0  15     5.7   514   23.8  14     4.2  1716   22.4  13     5.9   415   22.7  15      
  7   4.5   403   25.0  14     5.0   746   24.5  15     4.2   786   24.5  14     4.6  1679   23.7  13     5.9   697   23.0  15      
  8   5.7   504   25.3  13     5.4   693   25.3  14     5.3   623   25.1  14     4.6  1185   24.1  13     6.6   526   24.0  15      
  9   5.1   482   26.4  13     5.4  1192   26.0  13     5.6   882   25.8  14     4.7  2038   25.0  13     6.3  1462   24.4  15      
 10   5.5   794   27.6  13     5.1   867   26.4  13     5.6  1041   26.2  14     4.7  1375   24.3  13     6.7   725   24.6  15      
 11   4.9  1052   28.0  13     4.8  1033   26.2  13     5.1  1441   26.0  14     5.0  1704   25.5  13     5.6   925   24.5  15      
 12   5.0  1101   28.4  13     5.0   952   27.2  13     5.8  1585   26.7  14     4.1  1496   25.5  13     6.2   889   24.9  14      
 13   5.3  1347   28.3  13     5.4  1054   27.6  13     4.6  1321   26.9  14     4.8  1461   25.5  13     5.6   690   25.9  10      
 14   5.2  1030   28.4  13     4.8   813   27.7  12     4.2  1284   27.3  13     4.2  1423   25.6  13     6.2   584   26.2   9      
 15   3.8   794   28.9  13     4.3   918   27.4  12     5.0  1174   27.7  13     4.3  2006   26.0  13     6.2   716   26.5   9      
 16   3.5   675   28.7  13     5.8   503   27.7  11     4.6   824   27.2  13     5.8  1282   26.2  13     5.2   188   26.3   7      
 17   5.4   828   29.0  13     4.6   343   27.7  11     5.1   614   27.2  13     4.4  1548   25.2  13     5.7    70   26.9   5      
 18   4.3  1251   28.7  13     3.3   272   27.4  11     5.0   880   27.8  13     5.0  1672   26.1  13                 26.2   4      
 19   3.4  1140   28.2  12     4.8   998   28.0  11     4.2   797   28.9  13     4.2  1909   25.4  13                 27.1   4      
 20   4.7   961   29.1  12     5.3   672   29.0  11     4.4   845   29.2  13     5.1  1708   25.8  13                 28.5   3      
 21   4.6  1192   29.6  12     4.9   623   29.3  10     3.9  1031   29.5  13     4.0  1218   25.8  13     7.6   189   28.0   3      
 22   4.5  1294   30.9  12     5.5   611   29.7   9     4.5  1076   30.3  13     5.3  1819   26.6  12                 29.4   3      
 23   3.5   829   29.8  12     4.5   476   29.4   9     3.7  1139   30.1  12     4.6  1434   26.6  12     5.9   117   28.9   3      
 24   3.2   916   30.6  12     4.3   795   29.4   9     3.4   985   31.0  11     4.4  1906   26.2  12     6.9   190   29.3   3      
 25   3.3  1257   31.4  12     3.6   599   29.8   9     4.0   962   31.2  11     4.3  1763   26.6  12                 27.6   3      
 26   3.8   959   31.2  11     4.3  1026   30.5   9     3.1  1078   31.8  11     4.3  1838   26.5  12     6.1   168   29.9   3      
 27   3.9  1034                3.9   836                3.8  1074                4.2  2018                6.8   168                 
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           24.5                     24.2                     24.1                     23.2                     22.9          
14 TO 52          29.6                     28.7                     29.2                     26.0                     27.8          
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.