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TDMS Study 97013-09 Pathology Tables

NTP Experiment-Test: 97013-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK                    WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 06/18/04
Route: DOSED WATER                                                                                                Time: 11:02:42

                                                         FINAL #1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7789-38-0

       Lock Date:  07/30/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 MG/L
                               Include 002    0 MG/L
                               Include 003    80 MG/L
                               Include 004    80 MG/L
                               Include 005    400 MG/L
                               Include 006    400 MG/L
                               Include 007    800 MG/L
                               Include 008    800 MG/L



























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 97013-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                    WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 06/18/04    
Route: DOSED WATER                                                                                                Time: 11:02:42    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Natural Death                                      3            5            5            3                                     
    Moribund Sacrifice                                 2            1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                10            9           10           12                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                 1 (7%)       1 (7%)                    1 (7%)                                
      Inflammation, Chronic Active                    11 (73%)      9 (60%)     10 (67%)     12 (80%)                               
      Necrosis                                         1 (7%)                                 1 (7%)                                
      Hepatocyte, Vacuolization Cytoplasmic            5 (33%)                   5 (33%)      5 (33%)                               
   Mesentery                                          (1)                                                                           
      Fat, Congestion                                  1 (100%)                                                                     
      Fat, Hemorrhage                                  1 (100%)                                                                     
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Epithelium, Hyperkeratosis                       4 (27%)      3 (20%)      3 (20%)      7 (47%)                               
      Epithelium, Hyperplasia                          5 (33%)      3 (20%)      3 (20%)      8 (53%)                               
   Tooth                                              (1)          (3)          (2)          (4)                                    
      Inflammation, Chronic Active                                  1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                                           
      Inflammation, Chronic                            1 (100%)                                                                     
      Necrosis, Fibrinoid                              1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Mineralization                                                1 (7%)                                                          
      Necrosis                                                      1 (7%)                                                          
      Subcapsular, Hyperplasia                         4 (27%)      6 (40%)      2 (13%)      2 (13%)                               
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Pars Distalis, Cyst                              1 (7%)                                 2 (13%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                    WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 06/18/04    
Route: DOSED WATER                                                                                                Time: 11:02:42    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hypertrophy                                                              6 (40%)                               
   Thyroid Gland                                      (15)         (13)         (13)         (15)                                   
      Infiltration Cellular, Lymphocyte                                          5 (38%)     11 (73%)                               
      Inflammation, Chronic Active                     1 (7%)                                                                       
      Follicle, Depletion Secretory                    7 (47%)      7 (54%)     11 (85%)     14 (93%)                               
      Follicular Cell, Hypertrophy                     2 (13%)      2 (15%)     11 (85%)     13 (87%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (14)         (15)                                   
      Cyst                                             1 (7%)                    1 (7%)                                             
      Mineralization                                                             1 (7%)                                             
      Pigmentation, Hemosiderin                        1 (7%)                    1 (7%)                                             
   Uterus                                             (15)         (15)         (15)         (15)                                   
      Endometrium, Hyperplasia, Cystic                 4 (27%)      7 (47%)      6 (40%)      3 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                              1 (7%)                                                          
      Hyperplasia, Lymphoid                                         4 (27%)      2 (13%)      5 (33%)                               
      Necrosis, Lymphoid                                            1 (7%)                                                          
   Lymph Node, Mesenteric                             (15)         (15)         (14)         (14)                                   
      Hyperplasia, Lymphoid                                                      1 (7%)                                             
      Necrosis, Lymphoid                                                         1 (7%)                                             
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                          1 (7%)       1 (7%)       1 (7%)       2 (13%)                               
      Hematopoietic Cell Proliferation                 2 (13%)      3 (20%)      1 (7%)       4 (27%)                               
      Necrosis                                                                                1 (7%)                                
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                          3 (20%)      3 (20%)      3 (20%)      4 (27%)                               
      Cyst                                                                                    1 (7%)                                
      Thymocyte, Necrosis                              2 (13%)                                2 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                    WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 06/18/04    
Route: DOSED WATER                                                                                                Time: 11:02:42    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (6)          (5)          (2)          (7)                                    
      Epidermis, Hyperkeratosis                                                               2 (29%)                               
      Epidermis, Hyperplasia, Focal                                                           2 (29%)                               
      Subcutaneous Tissue, Edema                                    1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Hemorrhage                                                                 1 (7%)                                             
      Inflammation, Chronic Active                                  3 (20%)                   1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Mineralization                                                                          1 (7%)                                
      Nephropathy                                      2 (13%)      2 (13%)     10 (67%)     13 (87%)                               
      Artery, Inflammation, Chronic                    2 (13%)                                                                      
      Renal Tubule, Degeneration                                                 2 (13%)      8 (53%)                               
      Renal Tubule, Dilatation                         1 (7%)       2 (13%)                   1 (7%)                                
      Renal Tubule, Hypertrophy                                     1 (7%)       5 (33%)     12 (80%)                               
      Renal Tubule, Necrosis                                                                  1 (7%)                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                    WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 06/18/04    
Route: DOSED WATER                                                                                                Time: 11:02:42    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Natural Death                                      2            2                         1                                     
    Moribund Sacrifice                                                           1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                13           13           14           14                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                     9 (60%)      4 (27%)     10 (67%)      7 (47%)                               
      Necrosis                                                                                1 (7%)                                
      Hepatocyte, Vacuolization Cytoplasmic            6 (40%)      4 (27%)      7 (47%)      4 (27%)                               
   Mesentery                                          (1)                       (1)                                                 
      Fat, Fibrosis                                    1 (100%)                                                                     
      Fat, Inflammation, Chronic                                                 1 (100%)                                           
      Fat, Necrosis                                    1 (100%)                                                                     
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Epithelium, Hyperkeratosis                       1 (7%)       1 (7%)       2 (13%)                                            
      Epithelium, Hyperplasia                          1 (7%)       1 (7%)       2 (13%)      2 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Hypertrophy                                      4 (27%)      6 (40%)      6 (40%)      4 (27%)                               
      Subcapsular, Hyperplasia                         1 (7%)       1 (7%)                    1 (7%)                                
   Parathyroid Gland                                  (1)                       (2)                                                 
      Cyst                                             1 (100%)                  2 (100%)                                           
   Pituitary Gland                                    (15)         (14)         (15)         (15)                                   
      Pars Distalis, Cyst                                                        4 (27%)                                            
   Thyroid Gland                                      (15)         (14)         (15)         (15)                                   
      Infiltration Cellular, Lymphocyte                             1 (7%)       1 (7%)       2 (13%)                               
      Follicle, Depletion Secretory                    4 (27%)      6 (43%)     15 (100%)    15 (100%)                              
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                    WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 06/18/04    
Route: DOSED WATER                                                                                                Time: 11:02:42    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicular Cell, Hypertrophy                     1 (7%)       2 (14%)     12 (80%)     15 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (15)         (15)         (15)         (15)                                   
      Degeneration                                                               2 (13%)      2 (13%)                               
   Preputial Gland                                    (1)                       (1)                                                 
      Duct, Ectasia                                    1 (100%)                  1 (100%)                                           
   Testes                                             (15)         (15)         (15)         (15)                                   
      Cyst                                                                       3 (20%)                                            
      Germinal Epithelium, Degeneration                1 (7%)                    3 (20%)      2 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                                                (1)                                    
      Mediastinal, Necrosis, Lymphoid                                                         1 (100%)                              
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)                                   
      Hyperplasia, Lymphoid                            3 (20%)      1 (7%)       3 (20%)      1 (7%)                                
      Necrosis, Lymphoid                                                                      1 (7%)                                
   Lymph Node, Mesenteric                             (15)         (15)         (15)         (15)                                   
      Necrosis, Lymphoid                                                                      1 (7%)                                
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                          1 (7%)       1 (7%)                    1 (7%)                                
      Hematopoietic Cell Proliferation                 1 (7%)                                 3 (20%)                               
      Lymphoid Follicle, Necrosis, Lymphoid                                                   1 (7%)                                
   Thymus                                             (15)         (15)         (14)         (15)                                   
      Atrophy                                          2 (13%)      1 (7%)       1 (7%)       2 (13%)                               
      Cyst                                             2 (13%)                                                                      
      Ectopic Parathyroid Gland                                                               1 (7%)                                
      Thymocyte, Necrosis                                                                     1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                                            (2)          (4)          (3)                                    
      Epidermis, Hyperkeratosis                                                               1 (33%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                    WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 06/18/04    
Route: DOSED WATER                                                                                                Time: 11:02:42    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Epidermis, Hyperplasia, Focal                                              1 (25%)      2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                                               1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Mineralization                                   1 (7%)                                                                       
      Nephropathy                                      1 (7%)       7 (47%)     10 (67%)     14 (93%)                               
      Renal Tubule, Degeneration                                                             10 (67%)                               
      Renal Tubule, Dilatation                                                   1 (7%)                                             
      Renal Tubule, Hypertrophy                                                               2 (13%)                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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