National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/20731

TDMS Study 97013-09 Pathology Tables

NTP Experiment-Test: 97013-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04
Route: DOSED WATER                                WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 11:10:54

                                                         FINAL #1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7789-38-0

       Lock Date:  07/30/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 MG/L
                               Include 002    0 MG/L
                               Include 003    80 MG/L
                               Include 004    80 MG/L
                               Include 005    400 MG/L
                               Include 006    400 MG/L
                               Include 007    800 MG/L
                               Include 008    800 MG/L


























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 97013-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04    
Route: DOSED WATER                                WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 11:10:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       80 MG/L      400 MG/L     800 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Natural Death                                      3            5            5            3                                     
    Moribund Sacrifice                                 2            1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                10            9           10           12                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                 1 [1.0]      1 [1.0]                   1 [1.0]                               
      Inflammation, Chronic Active                    11 [1.1]      9 [1.4]     10 [1.2]     12 [1.1]                               
      Necrosis                                         1 [2.0]                                1 [1.0]                               
      Hepatocyte, Vacuolization Cytoplasmic            5 [1.8]                   5 [1.0]      5 [1.4]                               
   Mesentery                                          (1)                                                                           
      Fat, Congestion                                  1 [3.0]                                                                      
      Fat, Hemorrhage                                  1 [2.0]                                                                      
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Epithelium, Hyperkeratosis                       4 [1.3]      3 [1.0]      3 [1.3]      7 [1.3]                               
      Epithelium, Hyperplasia                          5 [2.0]      3 [1.3]      3 [1.3]      8 [1.9]                               
   Tooth                                              (1)          (3)          (2)          (4)                                    
      Inflammation, Chronic Active                                  1 [4.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                                           
      Inflammation, Chronic                            1 [4.0]                                                                      
      Necrosis, Fibrinoid                              1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Mineralization                                                1 [2.0]                                                         
      Necrosis                                                      1 [2.0]                                                         
      Subcapsular, Hyperplasia                         4 [1.0]      6 [1.2]      2 [1.0]      2 [1.0]                               
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Pars Distalis, Cyst                              1 [1.0]                                2 [1.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04    
Route: DOSED WATER                                WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 11:10:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       80 MG/L      400 MG/L     800 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hypertrophy                                                              6 [2.2]                               
   Thyroid Gland                                      (15)         (13)         (13)         (15)                                   
      Infiltration Cellular, Lymphocyte                                          5 [1.0]     11 [1.5]                               
      Inflammation, Chronic Active                     1 [1.0]                                                                      
      Follicle, Depletion Secretory                    7 [1.1]      7 [1.6]     11 [1.8]     14 [3.1]                               
      Follicular Cell, Hypertrophy                     2 [1.0]      2 [1.0]     11 [1.9]     13 [3.2]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (14)         (15)                                   
      Cyst                                             1 [2.0]                   1 [2.0]                                            
      Mineralization                                                             1 [2.0]                                            
      Pigmentation, Hemosiderin                        1 [2.0]                   1 [2.0]                                            
   Uterus                                             (15)         (15)         (15)         (15)                                   
      Endometrium, Hyperplasia, Cystic                 4 [1.5]      7 [1.1]      6 [1.3]      3 [1.7]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                              1 [2.0]                                                         
      Hyperplasia, Lymphoid                                         4 [2.0]      2 [3.0]      5 [2.8]                               
      Necrosis, Lymphoid                                            1 [1.0]                                                         
   Lymph Node, Mesenteric                             (15)         (15)         (14)         (14)                                   
      Hyperplasia, Lymphoid                                                      1 [3.0]                                            
      Necrosis, Lymphoid                                                         1 [2.0]                                            
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                          1 [2.0]      1 [3.0]      1 [3.0]      2 [3.0]                               
      Hematopoietic Cell Proliferation                 2 [2.0]      3 [2.0]      1 [2.0]      4 [2.5]                               
      Necrosis                                                                                1 [3.0]                               
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                          3 [2.7]      3 [3.0]      3 [3.0]      4 [2.3]                               
      Cyst                                                                                    1 [1.0]                               
      Thymocyte, Necrosis                              2 [4.0]                                2 [3.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04    
Route: DOSED WATER                                WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 11:10:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       80 MG/L      400 MG/L     800 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (6)          (5)          (2)          (7)                                    
      Epidermis, Hyperkeratosis                                                               2 [2.0]                               
      Epidermis, Hyperplasia, Focal                                                           2 [3.0]                               
      Subcutaneous Tissue, Edema                                    1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Hemorrhage                                                                 1 [3.0]                                            
      Inflammation, Chronic Active                                  3 [1.0]                   1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Mineralization                                                                          1 [3.0]                               
      Nephropathy                                      2 [1.0]      2 [1.0]     10 [1.0]     13 [1.8]                               
      Artery, Inflammation, Chronic                    2 [1.5]                                                                      
      Renal Tubule, Degeneration                                                 2 [1.0]      8 [1.9]                               
      Renal Tubule, Dilatation                         1 [1.0]      2 [1.5]                   1 [1.0]                               
      Renal Tubule, Hypertrophy                                     1 [1.0]      5 [1.0]     12 [1.8]                               
      Renal Tubule, Necrosis                                                                  1 [3.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04    
Route: DOSED WATER                                WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 11:10:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       80 MG/L      400 MG/L     800 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Natural Death                                      2            2                         1                                     
    Moribund Sacrifice                                                           1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                13           13           14           14                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                     9 [1.0]      4 [1.0]     10 [1.0]      7 [1.0]                               
      Necrosis                                                                                1 [1.0]                               
      Hepatocyte, Vacuolization Cytoplasmic            6 [1.0]      4 [1.0]      7 [1.0]      4 [1.0]                               
   Mesentery                                          (1)                       (1)                                                 
      Fat, Fibrosis                                    1 [2.0]                                                                      
      Fat, Inflammation, Chronic                                                 1 [3.0]                                            
      Fat, Necrosis                                    1 [4.0]                                                                      
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Epithelium, Hyperkeratosis                       1 [1.0]      1 [2.0]      2 [1.5]                                            
      Epithelium, Hyperplasia                          1 [1.0]      1 [2.0]      2 [2.0]      2 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Hypertrophy                                      4 [1.3]      6 [1.5]      6 [1.3]      4 [1.0]                               
      Subcapsular, Hyperplasia                         1 [1.0]      1 [1.0]                   1 [1.0]                               
   Parathyroid Gland                                  (1)                       (2)                                                 
      Cyst                                             1 [1.0]                   2 [2.0]                                            
   Pituitary Gland                                    (15)         (14)         (15)         (15)                                   
      Pars Distalis, Cyst                                                        4 [1.0]                                            
   Thyroid Gland                                      (15)         (14)         (15)         (15)                                   
      Infiltration Cellular, Lymphocyte                             1 [1.0]      1 [1.0]      2 [1.0]                               
      Follicle, Depletion Secretory                    4 [1.0]      6 [1.0]     15 [1.1]     15 [1.3]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04    
Route: DOSED WATER                                WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 11:10:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       80 MG/L      400 MG/L     800 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicular Cell, Hypertrophy                     1 [2.0]      2 [1.5]     12 [1.6]     15 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (15)         (15)         (15)         (15)                                   
      Degeneration                                                               2 [4.0]      2 [4.0]                               
   Preputial Gland                                    (1)                       (1)                                                 
      Duct, Ectasia                                    1 [2.0]                   1 [2.0]                                            
   Testes                                             (15)         (15)         (15)         (15)                                   
      Cyst                                                                       3 [2.0]                                            
      Germinal Epithelium, Degeneration                1 [1.0]                   3 [2.0]      2 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                                                (1)                                    
      Mediastinal, Necrosis, Lymphoid                                                         1 [2.0]                               
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)                                   
      Hyperplasia, Lymphoid                            3 [2.3]      1 [2.0]      3 [3.0]      1 [3.0]                               
      Necrosis, Lymphoid                                                                      1 [2.0]                               
   Lymph Node, Mesenteric                             (15)         (15)         (15)         (15)                                   
      Necrosis, Lymphoid                                                                      1 [3.0]                               
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                          1 [2.0]      1 [3.0]                   1 [3.0]                               
      Hematopoietic Cell Proliferation                 1 [1.0]                                3 [2.0]                               
      Lymphoid Follicle, Necrosis, Lymphoid                                                   1 [2.0]                               
   Thymus                                             (15)         (15)         (14)         (15)                                   
      Atrophy                                          2 [2.0]      1 [3.0]      1 [3.0]      2 [3.0]                               
      Cyst                                             2 [1.0]                                                                      
      Ectopic Parathyroid Gland                                                               1 [2.0]                               
      Thymocyte, Necrosis                                                                     1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                                            (2)          (4)          (3)                                    
      Epidermis, Hyperkeratosis                                                               1 [2.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04    
Route: DOSED WATER                                WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 11:10:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       80 MG/L      400 MG/L     800 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Epidermis, Hyperplasia, Focal                                              1 [3.0]      2 [2.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                                               1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Mineralization                                   1 [1.0]                                                                      
      Nephropathy                                      1 [1.0]      7 [1.0]     10 [1.0]     14 [1.6]                               
      Renal Tubule, Degeneration                                                             10 [1.3]                               
      Renal Tubule, Dilatation                                                   1 [2.0]                                            
      Renal Tubule, Hypertrophy                                                               2 [1.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.