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TDMS Study 97013-10 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Battelle Columbus                      WATER DISINFECTION MODEL (SODIUM BROMATE)                               DATE: 06/18/04  
EXPERIMENT: 97013 TEST: 10                                                                                        TIME: 08:48:00    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: SUBCHRON 26-WEEK                         ROUTE: DOSED WATER                                            NTP:  C97013A     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BATTELLE COLUMBUS                                WATER DISINFECTION MODEL (SODIUM BROMATE)                   DATE: 06/18/04    
EXPERIMENT: 97013 TEST: 10                                                                                        TIME:  8:54:47    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: SUBCHRONIC (26-WEEK)                     ROUTE: DOSED WATER                                            NTP:  97013A      
CONT: N01-ES-65406                                                                                                CAS: 7789-38-0    
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                        
                          SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)                       
==================================================================================================================================  
           0 MG/L                     80 MG/L                            400 MG/L                           800 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     3.6    25.0       3.6     25.7    1.00       11      3.3     25.6    0.92       52      3.4     24.6    0.94      110       
  3     3.6    26.2       3.5     26.8    0.97       10      3.4     27.0    0.94       50      3.2     25.9    0.89      100       
  5     3.7    28.4       3.7     29.3    1.00       10      3.5     29.5    0.95       47      3.4     28.2    0.92       97       
  6     3.5    29.7       3.4     30.9    0.97        9      3.4     31.1    0.97       44      3.2     29.6    0.91       87       
  7     3.7    31.3       3.7     32.8    1.00        9      3.6     32.7    0.97       44      3.3     30.9    0.89       86       
  8     3.7    32.2       3.5     33.8    0.95        8      3.4     34.2    0.92       40      3.3     31.8    0.89       82       
  9     4.0    33.5       3.8     34.9    0.95        9      3.7     35.4    0.93       42      3.5     33.3    0.88       84       
 10     3.8    35.1       3.5     36.4    0.92        8      3.5     36.7    0.92       38      3.1     34.5    0.82       73       
 11     3.9    36.4       3.5     37.7    0.90        8      3.6     37.9    0.92       38      3.2     35.5    0.82       72       
 12     4.1    37.7       3.6     38.9    0.88        7      3.6     39.1    0.88       37      3.2     36.4    0.78       70       
 13     4.1    38.7       3.6     40.0    0.88        7      3.7     39.9    0.90       37      3.3     37.4    0.80       70       
 14     4.0    39.9       3.5     40.9    0.88        7      3.5     40.1    0.88       35      3.2     38.0    0.80       68       
 15     4.1    41.2       3.5     42.2    0.85        7      3.5     41.3    0.85       34      3.2     38.8    0.78       67       
 16     4.2    41.6       3.7     43.0    0.88        7      3.7     41.6    0.88       36      3.3     39.0    0.79       67       
 17     4.1    42.2       3.9     43.3    0.95        7      3.7     42.2    0.90       35      3.2     40.7    0.78       62       
 18     4.2    43.1       3.9     44.9    0.93        7      3.8     42.9    0.90       36      3.4     41.5    0.81       66       
 19     4.1    43.6       3.6     44.9    0.88        6      3.7     43.3    0.90       34      3.2     42.0    0.78       61       
 20     4.2    44.0       3.9     45.1    0.93        7      3.8     45.4    0.90       33      3.4     42.6    0.81       63       
 21     4.1    44.4       3.6     45.7    0.88        6      4.1     45.8    1.00       36      3.3     42.8    0.80       62       
 22     4.3    44.5       3.9     46.6    0.91        7      3.9     46.1    0.91       34      3.5     43.7    0.81       64       
 23     4.3    45.3       3.8     47.4    0.88        6      3.9     46.4    0.91       34      3.2     44.4    0.74       57       
 24     4.2    45.6       3.9     47.6    0.93        7      4.2     46.8    1.00       36      3.4     45.1    0.81       60       
 25     3.9    46.3       3.7     48.0    0.95        6      4.0     47.4    1.03       34      3.1     45.7    0.79       54       
 26     4.4    46.5       4.1     48.1    0.93        7      3.9     47.2    0.89       33      3.4     45.5    0.77       60       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    3.8    32.2       3.6     33.4    0.95        9      3.5     33.6    0.93       43      3.3     31.6    0.87       85       
SD(D)   0.2               0.1             0.05        1      0.1             0.03        5      0.1             0.05       13       
CV(E)   5.7               3.3             5.0      15.0      3.4             3.0      12.8      3.4             6.2      15.8       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.2    43.7       3.8     45.2    0.91        7      3.8     44.3    0.92       35      3.3     42.3    0.79       62       
SD(D)   0.1               0.2             0.03        0      0.2             0.05        1      0.1             0.02        4       
CV(E)   3.3               4.7             3.6       4.7      5.7             5.8       3.0      3.5             2.5       6.5       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                      
                          SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)                       
==================================================================================================================================  
           0 MG/L                     80 MG/L                            400 MG/L                           800 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     4.0    20.8       3.9     20.5     0.98      15      4.0     20.3     1.00      79      3.9     20.4     0.98     154       
  3     4.3    21.4       3.9     21.2     0.91      15      4.0     21.1     0.93      77      3.9     21.0     0.91     148       
  5     4.5    22.6       4.4     22.3     0.98      16      4.5     21.7     1.00      82      4.3     22.1     0.96     156       
  6     4.6    23.0       4.0     22.8     0.87      14      4.1     22.2     0.89      75      4.2     22.4     0.91     148       
  7     4.3    23.8       4.1     23.4     0.95      14      4.3     22.7     1.00      75      4.1     23.1     0.95     142       
  8     4.6    24.2       4.3     23.8     0.93      14      4.1     22.9     0.89      72      4.4     23.1     0.96     153       
  9     4.8    24.9       4.2     24.4     0.88      14      4.6     23.5     0.96      78      4.3     23.4     0.90     148       
 10     4.6    25.6       3.9     25.2     0.85      12      4.3     24.2     0.93      72      3.8     24.0     0.83     128       
 11     4.9    26.2       3.9     25.5     0.80      12      4.4     24.3     0.90      72      4.2     24.0     0.86     141       
 12     4.9    26.2       4.2     26.0     0.86      13      4.6     24.8     0.94      74      4.6     24.2     0.94     152       
 13     4.8    27.4       4.4     26.9     0.92      13      4.8     24.8     1.00      77      4.6     24.6     0.96     148       
 14     4.6    28.0       4.3     27.1     0.93      13      4.8     25.9     1.04      75      4.4     25.1     0.96     141       
 15     4.6    28.4       4.2     27.6     0.91      12      4.9     26.4     1.07      73      4.7     25.5     1.02     147       
 16     4.9    29.3       4.3     28.4     0.88      12      4.5     26.9     0.92      67      4.4     26.1     0.90     135       
 17     4.6    30.4       4.1     29.2     0.89      11      4.7     27.5     1.02      69      4.2     26.8     0.91     124       
 18     4.5    30.2       4.3     28.9     0.96      12      4.6     27.7     1.02      67      4.2     27.0     0.93     126       
 19     4.6    30.5       4.1     28.8     0.89      11      4.1     28.0     0.89      59      4.5     27.0     0.98     133       
 20     4.7    30.8       4.5     29.7     0.96      12      4.6     28.5     0.98      65      4.4     27.2     0.94     128       
 21     4.5    31.3       4.2     30.3     0.93      11      4.7     29.0     1.04      65      4.4     27.5     0.98     128       
 22     4.7    31.3       4.4     31.0     0.94      11      4.8     30.1     1.02      64      4.4     28.4     0.94     123       
 23     4.4    32.4       4.0     31.9     0.91      10      4.6     31.1     1.05      59      3.8     29.6     0.86     102       
 24     4.3    32.8       4.5     33.0     1.05      11      4.5     31.8     1.05      57      3.8     29.3     0.88     104       
 25     4.3    33.6       4.2     33.8     0.98      10      4.4     32.6     1.02      54      3.9     29.9     0.91     104       
 26     4.5    34.3       4.1     33.7     0.91      10      4.7     33.2     1.04      56      4.2     30.3     0.93     111       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.6    24.2       4.1     23.8     0.90      14      4.3     23.0     0.95      76      4.2     22.9     0.92     147       
SD(D)   0.3               0.2              0.06       1      0.2              0.05       3      0.3              0.05       8       
CV(E)   6.1               4.7              6.4      8.0      5.7              4.8      4.5      6.2              5.1      5.4       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.5    31.0       4.2     30.3     0.93      11      4.6     29.1     1.01      64      4.2     27.7     0.93     124       
SD(D)   0.2               0.2              0.04       1      0.2              0.05       6      0.3              0.04      14       
CV(E)   3.8               3.8              4.8      8.3      4.3              5.2     10.2      6.5              4.6     11.6       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
             DIAGNOSTIC TRAILER REPORT                                                                                              
             WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                                     
             SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)                                    
=========================================================================================================                           
           0 MG/L                  80 MG/L                  400 MG/L                 800 MG/L                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               24.2  15                 24.8  15                 24.8  15                 24.6  15                               
  1               24.2  15                 24.8  15                 24.8  15                 24.6  15                               
  2   3.6  2450   25.0  15     3.6  2470   25.7  15     3.3  2455   25.6  15     3.4  2461   24.6  15                               
  3   3.6  4305   26.2  15     3.5  4285   26.8  15     3.4  4305   27.0  15     3.2  4305   25.9  15                               
  4   3.6   750   27.2  15     3.6   760   27.7  15     3.2   760   28.0  15     3.2   705   26.5  15                               
  5   3.7  2540   28.4  15     3.7  2530   29.3  15     3.5  2530   29.5  15     3.4  2540   28.2  15                               
  6   3.5  2535   29.7  15     3.4  2505   30.9  15     3.4  2520   31.1  15     3.2  2505   29.6  15                               
  7   3.7  2510   31.3  15     3.7  2539   32.8  15     3.6  2530   32.7  15     3.3  2545   30.9  15                               
  8   3.7  2525   32.2  15     3.5  2535   33.8  15     3.4  2530   34.2  15     3.3  2535   31.8  15                               
  9   4.0  2482   33.5  15     3.8  2450   34.9  15     3.7  2466   35.4  15     3.5  2442   33.3  15                               
 10   3.8  2520   35.1  15     3.5  2525   36.4  15     3.5  2520   36.7  15     3.1  2518   34.5  15                               
 11   3.9  2515   36.4  15     3.5  2304   37.7  15     3.6  2525   37.9  15     3.2  2535   35.5  15                               
 12   4.1  2171   37.7  15     3.6  2144   38.9  15     3.6  2500   39.1  15     3.2  2338   36.4  15                               
 13   4.1  2520   38.7  15     3.6  2520   40.0  15     3.7  2520   39.9  15     3.3  2520   37.4  15                               
 14   4.0  2540   39.9  15     3.5  2516   40.9  15     3.5  2531   40.1  15     3.2  2536   38.0  15                               
 15   4.1  3280   41.2  15     3.5  3280   42.2  15     3.5  3275   41.3  15     3.2  3221   38.8  15                               
 16   4.2  1785   41.6  15     3.7  1785   43.0  15     3.7  1783   41.6  15     3.3  1904   39.0  15                               
 17   4.1  2525   42.2  15     3.9  2325   43.3  15     3.7  2508   42.2  15     3.2  2330   40.7  14                               
 18   4.2  2510   43.1  15     3.9  2479   44.9  15     3.8  2510   42.9  15     3.4  2334   41.5  14                               
 19   4.1  2564   43.6  15     3.6  2595   44.9  15     3.7  2575   43.3  15     3.2  2422   42.0  14                               
 20   4.2  2540   44.0  15     3.9  2530   45.1  15     3.8  2365   45.4  14     3.4  2370   42.6  14                               
 21   4.1  2535   44.4  15     3.6  2535   45.7  15     4.1  2366   45.8  14     3.3  2366   42.8  14                               
 22   4.3  2515   44.5  15     3.9  2342   46.6  14     3.9  2340   46.1  14     3.5  2334   43.7  14                               
 23   4.3  2480   45.3  15     3.8  2147   47.4  14     3.9  2313   46.4  14     3.2  2323   44.4  14                               
 24   4.2  2510   45.6  15     3.9  2347   47.6  14     4.2  2343   46.8  14     3.4  2343   45.1  14                               
 25   3.9  2515   46.3  15     3.7  2191   48.0  14     4.0  2353   47.4  14     3.1  2348   45.7  14                               
 26   4.4  2394   46.5  14     4.1  2380   48.1  14     3.9  2215   47.2  14     3.4  2143   45.5  14                               
 27   4.3  2315                4.1  2038                3.8  2153                3.2  2158                                          
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           31.2                     32.3                     32.5                     30.7                                   
14 TO 52          43.7                     45.2                     44.3                     42.3                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
             DIAGNOSTIC TRAILER REPORT                                                                                              
             WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                   
             SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)                                    
=========================================================================================================                           
           0 MG/L                  80 MG/L                  400 MG/L                 800 MG/L                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               20.1  15                 19.9  15                 19.6  15                 19.9  15                               
  1               20.1  15                 19.9  15                 19.6  15                 19.9  15                               
  2   4.0  2387   20.8  15     3.9  2460   20.5  15     4.0  2296   20.3  15     3.9  2460   20.4  15                               
  3   4.3  3789   21.4  15     3.9  4295   21.2  15     4.0  4300   21.1  15     3.9  4295   21.0  15                               
  4   4.5   755   22.3  15     3.9   755   21.9  15     4.0   708   21.3  15     4.1   765   21.6  15                               
  5   4.5  2535   22.6  15     4.4  2535   22.3  15     4.5  2520   21.7  15     4.3  2520   22.1  15                               
  6   4.6  2360   23.0  15     4.0  2520   22.8  15     4.1  2536   22.2  15     4.2  2346   22.4  15                               
  7   4.3  2340   23.8  15     4.1  2520   23.4  15     4.3  2515   22.7  15     4.1  2525   23.1  15                               
  8   4.6  2525   24.2  15     4.3  2525   23.8  15     4.1  2525   22.9  15     4.4  2357   23.1  15                               
  9   4.8  2491   24.9  15     4.2  2305   24.4  15     4.6  2491   23.5  15     4.3  2481   23.4  15                               
 10   4.6  2352   25.6  15     3.9  2357   25.2  15     4.3  2515   24.2  15     3.8  2520   24.0  15                               
 11   4.9  2341   26.2  15     3.9  2250   25.5  15     4.4  2346   24.3  15     4.2  2520   24.0  15                               
 12   4.9  1844   26.2  15     4.2  1915   26.0  15     4.6  2374   24.8  15     4.6  2334   24.2  15                               
 13   4.8  2395   27.4  15     4.4  2352   26.9  15     4.8  2184   24.8  15     4.6  2520   24.6  15                               
 14   4.6  2365   28.0  15     4.3  2468   27.1  15     4.8  2365   25.9  15     4.4  2530   25.1  15                               
 15   4.6  3107   28.4  15     4.2  2984   27.6  15     4.9  2963   26.4  15     4.7  2942   25.5  15                               
 16   4.9  1779   29.3  15     4.3  1662   28.4  15     4.5  1543   26.9  15     4.4  1785   26.1  15                               
 17   4.6  2350   30.4  15     4.1  2510   29.2  15     4.7  2519   27.5  15     4.2  2327   26.8  15                               
 18   4.5  2520   30.2  15     4.3  2341   28.9  15     4.6  2520   27.7  15     4.2  2520   27.0  15                               
 19   4.6  2391   30.5  15     4.1  2407   28.8  15     4.1  2391   28.0  15     4.5  2406   27.0  14                               
 20   4.7  2361   30.8  15     4.5  2386   29.7  15     4.6  2530   28.5  15     4.4  2356   27.2  14                               
 21   4.5  2535   31.3  15     4.2  2197   30.3  15     4.7  2366   29.0  15     4.4  2366   27.5  14                               
 22   4.7  2180   31.3  15     4.4  2342   31.0  15     4.8  2511   30.1  15     4.4  2348   28.4  14                               
 23   4.4  2142   32.4  14     4.0  2480   31.9  15     4.6  2470   31.1  15     3.8  2300   29.6  14                               
 24   4.3  2176   32.8  14     4.5  2510   33.0  15     4.5  2515   31.8  15     3.8  2348   29.3  14                               
 25   4.3  2189   33.6  14     4.2  2523   33.8  15     4.4  2525   32.6  15     3.9  2362   29.9  14                               
 26   4.5  2161   34.3  14     4.1  2047   33.7  15     4.7  2213   33.2  15     4.2  2379   30.3  14                               
 27   4.2  2149                4.2  2059                4.3  2194                3.9  1916                                          
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           23.7                     23.4                     22.6                     22.6                                   
14 TO 52          31.0                     30.3                     29.1                     27.7                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.