National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/20739

TDMS Study 97013-10 Pathology Tables

NTP Experiment-Test: 97013-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK                    WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 06/18/04
Route: DOSED WATER                                                                                                Time: 09:06:18

                                                         FINAL #1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7789-38-0

       Lock Date:  07/30/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 97013-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                    WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 06/18/04    
Route: DOSED WATER                                                                                                Time: 09:06:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Natural Death                                      1                                      1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                14           15           15           14                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (15)         (15)         (15)         (15)                                   
      Diverticulum                                                               1 (7%)                                             
   Liver                                              (15)         (15)         (15)         (15)                                   
      Angiectasis                                                                             1 (7%)                                
      Hematopoietic Cell Proliferation                                                        1 (7%)                                
      Inflammation, Chronic Active                    14 (93%)     13 (87%)     14 (93%)     14 (93%)                               
      Hepatocyte, Fatty Change                         1 (7%)                                                                       
      Hepatocyte, Vacuolization Cytoplasmic           13 (87%)     14 (93%)     12 (80%)     12 (80%)                               
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Inflammation                                                                            1 (7%)                                
      Inflammation, Chronic Active                     1 (7%)                                                                       
      Epithelium, Hyperplasia                          4 (27%)      1 (7%)       2 (13%)      2 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Accessory Adrenal Cortical Nodule                1 (7%)                                                                       
      Subcapsular, Hyperplasia                        13 (87%)     12 (80%)     13 (87%)     14 (93%)                               
   Parathyroid Gland                                  (1)                       (1)                                                 
      Cyst                                             1 (100%)                  1 (100%)                                           
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Pars Distalis, Cyst                                                                     1 (7%)                                
      Pars Distalis, Hyperplasia                                                 1 (7%)       1 (7%)                                
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Ectopic Thymus                                   1 (7%)       2 (13%)      2 (13%)                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                    WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 06/18/04    
Route: DOSED WATER                                                                                                Time: 09:06:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Infiltration Cellular, Lymphocyte                             1 (7%)       2 (13%)                                            
      Follicle, Depletion Secretory                                                           2 (13%)                               
      Follicular Cell, Hypertrophy                                                            2 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (15)         (15)                                   
      Cyst                                             1 (7%)       1 (7%)       2 (13%)      1 (7%)                                
   Uterus                                             (15)         (15)         (15)         (15)                                   
      Inflammation, Suppurative                        1 (7%)                    1 (7%)                                             
      Endometrium, Hyperplasia, Cystic                11 (73%)     10 (67%)     10 (67%)     10 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)                                   
      Hyperplasia, Lymphoid                                         2 (13%)      1 (7%)       1 (7%)                                
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                 1 (7%)                    2 (13%)      1 (7%)                                
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                                                                 1 (7%)                                
      Cyst                                             4 (27%)      7 (47%)     12 (80%)      3 (20%)                               
      Ectopic Parathyroid Gland                                     2 (13%)      1 (7%)       2 (13%)                               
      Ectopic Thyroid                                                                         2 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                    WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 06/18/04    
Route: DOSED WATER                                                                                                Time: 09:06:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                     1 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Hydronephrosis                                                                          1 (7%)                                
      Nephropathy                                                                2 (13%)      2 (13%)                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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NTP Experiment-Test: 97013-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                    WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 06/18/04    
Route: DOSED WATER                                                                                                Time: 09:06:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Natural Death                                      1                                      1                                     
    Moribund Sacrifice                                              1            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                14           14           14           14                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                              1 (7%)                                                          
      Inflammation, Chronic Active                    12 (80%)     12 (80%)     10 (67%)     14 (93%)                               
      Hepatocyte, Fatty Change                        10 (67%)     13 (87%)     10 (67%)      8 (53%)                               
      Hepatocyte, Vacuolization Cytoplasmic           13 (87%)     14 (93%)     12 (80%)     14 (93%)                               
   Stomach, Forestomach                               (15)         (15)         (15)         (14)                                   
      Epithelium, Hyperplasia                          3 (20%)      3 (20%)      1 (7%)       3 (21%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (14)         (15)         (15)         (15)                                   
      Accessory Adrenal Cortical Nodule                             1 (7%)                                                          
      Hypertrophy                                      1 (7%)                    2 (13%)                                            
      Subcapsular, Hyperplasia                         1 (7%)       2 (13%)      2 (13%)      3 (20%)                               
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Pars Distalis, Cyst                              4 (27%)      1 (7%)       3 (20%)      3 (20%)                               
      Pars Distalis, Hyperplasia                       2 (13%)                                                                      
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Ectopic Thymus                                                             1 (7%)       1 (7%)                                
      Infiltration Cellular, Lymphocyte                1 (7%)       1 (7%)       1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                    WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 06/18/04    
Route: DOSED WATER                                                                                                Time: 09:06:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (15)         (15)         (15)         (15)                                   
      Degeneration                                     1 (7%)                                                                       
      Granuloma Sperm                                                            1 (7%)                                             
   Testes                                             (15)         (15)         (15)         (15)                                   
      Cyst                                             1 (7%)                                                                       
      Mineralization                                   1 (7%)                                                                       
      Germinal Epithelium, Degeneration                6 (40%)      3 (20%)      3 (20%)      2 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)                                   
      Hyperplasia, Lymphoid                            1 (7%)       2 (13%)      1 (7%)                                             
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                              1 (7%)                    1 (7%)                                
   Thymus                                             (14)         (15)         (15)         (15)                                   
      Cyst                                             7 (50%)      6 (40%)      2 (13%)      2 (13%)                               
      Ectopic Parathyroid Gland                        1 (7%)                                                                       
      Ectopic Thyroid                                  1 (7%)                                                                       
      Hyperplasia, Lymphoid                                                      1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                    WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 06/18/04    
Route: DOSED WATER                                                                                                Time: 09:06:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Lung                                               (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                     2 (13%)      1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Nephropathy                                      5 (33%)      7 (47%)      3 (20%)      3 (20%)                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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