TDMS Study 97013-10 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus WATER DISINFECTION MODEL (SODIUM BROMATE) DATE: 06/18/04
EXPERIMENT: 97013 TEST: 10 TIME: 09:12:18
TEST TYPE: SUBCHRON 26-WEEK CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-65406 ROUTE: DOSED WATER NTP C#: 97013A
PATHOLOGIST: TOFT, JOHN CAS: 7789-38-0
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1 MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus WATER DISINFECTION MODEL (SODIUM BROMATE) DATE: 06/18/04
EXPERIMENT: 97013 TEST: 10 TIME: 09:12:18
TEST TYPE: SUBCHRON 26-WEEK CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-65406 ROUTE: DOSED WATER NTP C#: 97013A
PATHOLOGIST: TOFT, JOHN CAS: 7789-38-0
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF WATER DISINFECTION MODEL (SODIUM BR
===============================================================
Male Mice
------------
Organ Morphology
----- ----------
Pituitary Gland: Pars Distalis Hyperplasia
Thymus Cyst
===============================================================
Female Mice
------------
Organ Morphology
----- ----------
Cyst
Ectopic Thyroid
Thyroid Gland: Follicle Depletion Secretory
Thyroid Gland: Follicular Cell Hypertrophy
===============================================================
Date: 06/18/04 EXPERIMENT: 97013 TEST: 10 Page 1
Statistical Analysis of Non-neoplastic Lesions in Mice(P53 Heterozygous Transgenic) - WATER DISINFECTION MODEL (SODI
UM BR
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/14 (7%) 0/15 (0%) 2/15 (13%) 0/15 (0%) |0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 1/14.00 0/14.47 2/14.34 0/14.22 |0/14.58 0/15.00 0/15.00 0/14.32 |
|POLY-3 PERCENT (g) | 7.1% 0.0% 14.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/14 (7%) 0/14 (0%) 2/14 (14%) 0/14 (0%) |0/14 (0%) 0/15 (0%) 0/15 (0%) 0/14 (0%) |
|FIRST INCIDENCE | 184 (T) --- 184 (T) --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.530N P=0.500N P=0.500 P=0.500N |(e) (e) (e) (e) |
|POLY 3 | P=0.528N P=0.493N P=0.508 P=0.497N |(e) (e) (e) (e) |
|POLY 1.5 | P=0.526N P=0.490N P=0.514 P=0.493N |(e) (e) (e) (e) |
|POLY 6 | P=0.528N P=0.497N P=0.503 P=0.499N |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.530N (e) P=0.500 (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.518N P=0.483N P=0.527 P=0.483N |(e) (e) (e) (e) |
|ORDER RESTRICTED | P=0.315N (e) (e) (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex: Subcapsular |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/14 (7%) 2/15 (13%) 2/15 (13%) 3/15 (20%) |13/15 (87%) 12/15 (80%) 13/15 (87%) 14/15 (93%) |
|POLY-3 RATE (b) | 1/14.00 2/14.47 2/14.34 3/14.22 |13/15.00 12/15.00 13/15.00 14/15.00 |
|POLY-3 PERCENT (g) | 7.1% 13.8% 14.0% 21.1% |86.7% 80.0% 86.7% 93.3% |
|TERMINAL (d) | 1/14 (7%) 2/14 (14%) 2/14 (14%) 3/14 (21%) |12/14 (86%) 12/15 (80%) 13/15 (87%) 13/14 (93%) |
|FIRST INCIDENCE | 184 (T) 184 (T) 184 (T) 184 (T) |154 185 (T) 185 (T) 127 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.235 P=0.500 P=0.500 P=0.298 |P=0.238 P=0.359N P=0.526N P=0.494 |
|POLY 3 | P=0.237 P=0.512 P=0.508 P=0.303 |P=0.270 P=0.500N P=0.698 P=0.500 |
|POLY 1.5 | P=0.243 P=0.517 P=0.514 P=0.310 |P=0.270 P=0.500N P=0.698 P=0.500 |
|POLY 6 | P=0.234 P=0.506 P=0.503 P=0.299 |P=0.270 P=0.500N P=0.698 P=0.500 |
|LOGISTIC REGRESSION| P=0.235 P=0.500 P=0.500 P=0.298 |(e) P=0.359N P=0.526N (e) |
|COCH-ARM / FISHERS | P=0.251 P=0.527 P=0.527 P=0.326 |P=0.265 P=0.500N P=0.701N P=0.500 |
|ORDER RESTRICTED | P=0.237 (e) (e) (e) |P=0.343 (e) (e) (e) |
|=================================================================================================================================|
Date: 06/18/04 EXPERIMENT: 97013 TEST: 10 Page 2
Statistical Analysis of Non-neoplastic Lesions in Mice(P53 Heterozygous Transgenic) - WATER DISINFECTION MODEL (SODIU
M BR
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 5/15 (33%) 7/15 (47%) 3/15 (20%) 3/15 (20%) |0/15 (0%) 0/15 (0%) 2/15 (13%) 2/15 (13%) |
|POLY-3 RATE (b) | 5/14.83 7/14.47 3/14.34 3/14.22 |0/14.58 0/15.00 2/15.00 2/14.32 |
|POLY-3 PERCENT (g) | 33.7% 48.4% 20.9% 21.1% |0.0% 0.0% 13.3% 14.0% |
|TERMINAL (d) | 5/14 (36%) 7/14 (50%) 3/14 (21%) 3/14 (21%) |0/14 (0%) 0/15 (0%) 2/15 (13%) 2/14 (14%) |
|FIRST INCIDENCE | 184 (T) 184 (T) 184 (T) 184 (T) |--- --- 185 (T) 185 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.104N P=0.354 P=0.341N P=0.341N |P=0.062 (e) P=0.251 P=0.236 |
|POLY 3 | P=0.117N P=0.336 P=0.363N P=0.368N |P=0.060 (e) P=0.238 P=0.227 |
|POLY 1.5 | P=0.114N P=0.344 P=0.356N P=0.361N |P=0.061 (e) P=0.235 P=0.228 |
|POLY 6 | P=0.117N P=0.329 P=0.366N P=0.369N |P=0.059 (e) P=0.242 P=0.227 |
|LOGISTIC REGRESSION| P=0.104N P=0.354 P=0.341N P=0.341N |(e) (e) P=0.251 P=0.236 |
|COCH-ARM / FISHERS | P=0.105N P=0.355 P=0.341N P=0.341N |P=0.065 (e) P=0.241 P=0.241 |
|ORDER RESTRICTED | P=0.191N (e) (e) (e) |P=0.105 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 12/15 (80%) 12/15 (80%) 10/15 (67%) 14/15 (93%) |14/15 (93%) 13/15 (87%) 14/15 (93%) 14/15 (93%) |
|POLY-3 RATE (b) | 12/14.83 12/14.47 10/15.00 14/14.22 |14/14.58 13/15.00 14/15.00 14/15.00 |
|POLY-3 PERCENT (g) | 80.9% 82.9% 66.7% 98.5% |96.0% 86.7% 93.3% 93.3% |
|TERMINAL (d) | 12/14 (86%) 12/14 (86%) 9/14 (64%) 14/14 (100%)|14/14 (100%) 13/15 (87%) 14/15 (93%) 13/14 (93%) |
|FIRST INCIDENCE | 184 (T) 184 (T) 128 184 (T) |185 (T) 185 (T) 185 (T) 127 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.256 P=0.702 P=0.347N P=0.236 |P=0.391 P=0.251N P=0.514N P=0.760 |
|POLY 3 | P=0.204 P=0.632 P=0.322N P=0.160 |P=0.550 P=0.398N P=0.696N P=0.696N |
|POLY 1.5 | P=0.220 P=0.647 P=0.332N P=0.200 |P=0.517 P=0.445N P=0.730N P=0.730N |
|POLY 6 | P=0.204 P=0.619 P=0.305N P=0.143 |P=0.594 P=0.332N P=0.634N P=0.634N |
|LOGISTIC REGRESSION| P=0.182 P=0.702 P=0.325N P=0.236 |P=0.402 P=0.251N P=0.514N P=0.721 |
|COCH-ARM / FISHERS | P=0.269 P=0.674N P=0.341N P=0.299 |P=0.476 P=0.500N P=0.759N P=0.759N |
|ORDER RESTRICTED | P=0.088 (e) (e) (e) |P=0.486N (e) (e) (e) |
|=================================================================================================================================|
Date: 06/18/04 EXPERIMENT: 97013 TEST: 10 Page 3
Statistical Analysis of Non-neoplastic Lesions in Mice(P53 Heterozygous Transgenic) - WATER DISINFECTION MODEL (SODIU
M BR
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Fatty Change |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 10/15 (67%) 13/15 (87%) 10/15 (67%) 8/15 (53%) |1/15 (7%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 10/14.83 13/14.47 10/14.34 8/14.22 |1/15.00 0/15.00 0/15.00 0/14.32 |
|POLY-3 PERCENT (g) | 67.4% 89.8% 69.8% 56.3% |6.7% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 10/14 (71%) 13/14 (93%) 10/14 (71%) 8/14 (57%) |0/14 (0%) 0/15 (0%) 0/15 (0%) 0/14 (0%) |
|FIRST INCIDENCE | 184 (T) 184 (T) 184 (T) 184 (T) |154 --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.080N P=0.166 P=0.659 P=0.349N |P=0.360N P=0.500N P=0.500N P=0.514N |
|POLY 3 | P=0.113N P=0.145 P=0.602 P=0.408N |P=0.347N P=0.500N P=0.500N P=0.509N |
|POLY 1.5 | P=0.109N P=0.164 P=0.617 P=0.393N |P=0.349N P=0.500N P=0.500N P=0.506N |
|POLY 6 | P=0.111N P=0.128 P=0.594 P=0.411N |P=0.346N P=0.500N P=0.500N P=0.512N |
|LOGISTIC REGRESSION| P=0.080N P=0.166 P=0.659 P=0.349N |P=0.101N (e) (e) P=0.325N |
|COCH-ARM / FISHERS | P=0.096N P=0.195 P=0.650N P=0.355N |P=0.350N P=0.500N P=0.500N P=0.500N |
|ORDER RESTRICTED | P=0.138N (e) (e) (e) |P=0.129N (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 13/15 (87%) 14/15 (93%) 12/15 (80%) 14/15 (93%) |13/15 (87%) 14/15 (93%) 12/15 (80%) 12/15 (80%) |
|POLY-3 RATE (b) | 13/14.83 14/14.47 12/14.34 14/14.22 |13/14.58 14/15.00 12/15.00 12/14.32 |
|POLY-3 PERCENT (g) | 87.7% 96.8% 83.7% 98.5% |89.2% 93.3% 80.0% 83.8% |
|TERMINAL (d) | 13/14 (93%) 14/14 (100%) 12/14 (86%) 14/14 (100%)|13/14 (93%) 14/15 (93%) 12/15 (80%) 12/14 (86%) |
|FIRST INCIDENCE | 184 (T) 184 (T) 184 (T) 184 (T) |185 (T) 185 (T) 185 (T) 185 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.530 P=0.500 P=0.500N P=0.500 |P=0.278N P=0.749 P=0.324N P=0.500N |
|POLY 3 | P=0.381 P=0.403 P=0.589N P=0.330 |P=0.292N P=0.601 P=0.428N P=0.549N |
|POLY 1.5 | P=0.425 P=0.445 P=0.557N P=0.386 |P=0.278N P=0.555 P=0.460N P=0.534N |
|POLY 6 | P=0.371 P=0.359 P=0.609N P=0.306 |P=0.297N P=0.664 P=0.384N P=0.546N |
|LOGISTIC REGRESSION| P=0.530 P=0.500 P=0.500N P=0.500 |P=0.278N P=0.749 P=0.324N P=0.500N |
|COCH-ARM / FISHERS | P=0.520 P=0.500 P=0.500N P=0.500 |P=0.245N P=0.500 P=0.500N P=0.500N |
|ORDER RESTRICTED | P=0.202 (e) (e) (e) |P=0.364N (e) (e) (e) |
|=================================================================================================================================|
Date: 06/18/04 EXPERIMENT: 97013 TEST: 10 Page 4
Statistical Analysis of Non-neoplastic Lesions in Mice(P53 Heterozygous Transgenic) - WATER DISINFECTION MODEL (SODIU
M BR
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/15 (13%) 1/15 (7%) 0/15 (0%) 0/15 (0%) |1/15 (7%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 2/14.83 1/15.00 0/14.34 0/14.22 |1/14.58 0/15.00 0/15.00 0/14.32 |
|POLY-3 PERCENT (g) | 13.5% 6.7% 0.0% 0.0% |6.9% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/14 (14%) 0/14 (0%) 0/14 (0%) 0/14 (0%) |1/14 (7%) 0/15 (0%) 0/15 (0%) 0/14 (0%) |
|FIRST INCIDENCE | 184 (T) 143 --- --- |185 (T) --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.108N P=0.500N P=0.236N P=0.236N |P=0.353N P=0.486N P=0.486N P=0.500N |
|POLY 3 | P=0.105N P=0.496N P=0.239N P=0.241N |P=0.352N P=0.494N P=0.494N P=0.503N |
|POLY 1.5 | P=0.103N P=0.498N P=0.237N P=0.238N |P=0.352N P=0.497N P=0.497N P=0.503N |
|POLY 6 | P=0.106N P=0.493N P=0.241N P=0.242N |P=0.353N P=0.491N P=0.491N P=0.503N |
|LOGISTIC REGRESSION| P=0.057N P=0.305N (e) (e) |P=0.353N (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.100N P=0.500N P=0.241N P=0.241N |P=0.350N P=0.500N P=0.500N P=0.500N |
|ORDER RESTRICTED | P=0.076N (e) (e) (e) |P=0.123N (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/15 (7%) 2/15 (13%) 1/15 (7%) 0/15 (0%) |0/15 (0%) 2/15 (13%) 1/15 (7%) 1/15 (7%) |
|POLY-3 RATE (b) | 1/14.83 2/14.47 1/14.34 0/14.22 |0/14.58 2/15.00 1/15.00 1/14.32 |
|POLY-3 PERCENT (g) | 6.7% 13.8% 7.0% 0.0% |0.0% 13.3% 6.7% 7.0% |
|TERMINAL (d) | 1/14 (7%) 2/14 (14%) 1/14 (7%) 0/14 (0%) |0/14 (0%) 2/15 (13%) 1/15 (7%) 1/14 (7%) |
|FIRST INCIDENCE | 184 (T) 184 (T) 184 (T) --- |--- 185 (T) 185 (T) 185 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.198N P=0.500 P=0.764 P=0.500N |P=0.571 P=0.251 P=0.514 P=0.500 |
|POLY 3 | P=0.209N P=0.491 P=0.753 P=0.508N |P=0.570 P=0.238 P=0.506 P=0.496 |
|POLY 1.5 | P=0.206N P=0.495 P=0.755 P=0.506N |P=0.572 P=0.235 P=0.503 P=0.497 |
|POLY 6 | P=0.209N P=0.488 P=0.752 P=0.509N |P=0.571 P=0.242 P=0.509 P=0.497 |
|LOGISTIC REGRESSION| P=0.198N P=0.500 P=0.764 (e) |(e) P=0.251 P=0.514 P=0.500 |
|COCH-ARM / FISHERS | P=0.196N P=0.500 P=0.759N P=0.500N |P=0.578 P=0.241 P=0.500 P=0.500 |
|ORDER RESTRICTED | P=0.223N (e) (e) (e) |P=0.276 (e) (e) (e) |
|=================================================================================================================================|
Date: 06/18/04 EXPERIMENT: 97013 TEST: 10 Page 5
Statistical Analysis of Non-neoplastic Lesions in Mice(P53 Heterozygous Transgenic) - WATER DISINFECTION MODEL (SODIU
M BR
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Ovary |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | |1/15 (7%) 1/15 (7%) 2/15 (13%) 1/15 (7%) |
|POLY-3 RATE (b) | |1/14.58 1/15.00 2/15.00 1/14.32 |
|POLY-3 PERCENT (g) | |6.9% 6.7% 13.3% 7.0% |
|TERMINAL (d) | |1/14 (7%) 1/15 (7%) 2/15 (13%) 1/14 (7%) |
|FIRST INCIDENCE | |185 (T) 185 (T) 185 (T) 185 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.563 P=0.749N P=0.525 P=0.764 |
|POLY 3 | |P=0.554 P=0.754N P=0.510 P=0.757 |
|POLY 1.5 | |P=0.559 P=0.757N P=0.506 P=0.758 |
|POLY 6 | |P=0.551 P=0.750N P=0.516 P=0.757 |
|LOGISTIC REGRESSION| |P=0.563 P=0.749N P=0.525 P=0.764 |
|COCH-ARM / FISHERS | |P=0.571 P=0.759N P=0.500 P=0.759N |
|ORDER RESTRICTED | |P=0.584 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 4/15 (27%) 1/15 (7%) 3/15 (20%) 3/15 (20%) |0/15 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) |
|POLY-3 RATE (b) | 4/14.83 1/14.47 3/15.00 3/14.22 |0/14.58 0/15.00 0/15.00 1/14.32 |
|POLY-3 PERCENT (g) | 27.0% 6.9% 20.0% 21.1% |0.0% 0.0% 0.0% 7.0% |
|TERMINAL (d) | 4/14 (29%) 1/14 (7%) 2/14 (14%) 3/14 (21%) |0/14 (0%) 0/15 (0%) 0/15 (0%) 1/14 (7%) |
|FIRST INCIDENCE | 184 (T) 184 (T) 128 184 (T) |--- --- --- 185 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.513 P=0.166N P=0.500N P=0.500N |P=0.182 (e) (e) P=0.500 |
|POLY 3 | P=0.504 P=0.170N P=0.493N P=0.525N |P=0.183 (e) (e) P=0.496 |
|POLY 1.5 | P=0.506 P=0.167N P=0.497N P=0.518N |P=0.184 (e) (e) P=0.497 |
|POLY 6 | P=0.507 P=0.172N P=0.488N P=0.526N |P=0.182 (e) (e) P=0.497 |
|LOGISTIC REGRESSION| P=0.546 P=0.166N P=0.397N P=0.500N |(e) (e) (e) P=0.500 |
|COCH-ARM / FISHERS | P=0.517 P=0.165N P=0.500N P=0.500N |P=0.185 (e) (e) P=0.500 |
|ORDER RESTRICTED | P=0.364N (e) (e) (e) |P=0.116 (e) (e) (e) |
|=================================================================================================================================|
Date: 06/18/04 EXPERIMENT: 97013 TEST: 10 Page 6
Statistical Analysis of Non-neoplastic Lesions in Mice(P53 Heterozygous Transgenic) - WATER DISINFECTION MODEL (SODIU
M BR
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/15 (13%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |0/15 (0%) 0/15 (0%) 1/15 (7%) 1/15 (7%) |
|POLY-3 RATE (b) | 2/14.83 0/14.47 0/14.34 0/14.22 |0/14.58 0/15.00 1/15.00 1/14.32 |
|POLY-3 PERCENT (g) | 13.5% 0.0% 0.0% 0.0% |0.0% 0.0% 6.7% 7.0% |
|TERMINAL (d) | 2/14 (14%) 0/14 (0%) 0/14 (0%) 0/14 (0%) |0/14 (0%) 0/15 (0%) 1/15 (7%) 1/14 (7%) |
|FIRST INCIDENCE | 184 (T) --- --- --- |--- --- 185 (T) 185 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.159N P=0.236N P=0.236N P=0.236N |P=0.201 (e) P=0.514 P=0.500 |
|POLY 3 | P=0.150N P=0.237N P=0.239N P=0.241N |P=0.200 (e) P=0.506 P=0.496 |
|POLY 1.5 | P=0.151N P=0.235N P=0.237N P=0.238N |P=0.203 (e) P=0.503 P=0.497 |
|POLY 6 | P=0.150N P=0.239N P=0.241N P=0.242N |P=0.198 (e) P=0.509 P=0.497 |
|LOGISTIC REGRESSION| P=0.159N (e) (e) (e) |(e) (e) P=0.514 P=0.500 |
|COCH-ARM / FISHERS | P=0.158N P=0.241N P=0.241N P=0.241N |P=0.206 (e) P=0.500 P=0.500 |
|ORDER RESTRICTED | P=0.029N* (e) (e) (e) |P=0.248 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/15 (0%) 1/15 (7%) 0/15 (0%) 1/15 (7%) |1/15 (7%) 0/15 (0%) 2/15 (13%) 1/15 (7%) |
|POLY-3 RATE (b) | 0/14.83 1/15.00 0/14.34 1/14.22 |1/15.00 0/15.00 2/15.00 1/15.00 |
|POLY-3 PERCENT (g) | 0.0% 6.7% 0.0% 7.0% |6.7% 0.0% 13.3% 6.7% |
|TERMINAL (d) | 0/14 (0%) 0/14 (0%) 0/14 (0%) 1/14 (7%) |0/14 (0%) 0/15 (0%) 2/15 (13%) 0/14 (0%) |
|FIRST INCIDENCE | --- 143 --- 184 (T) |154 --- 185 (T) 127 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.456 P=0.500 (e) P=0.500 |P=0.415 P=0.500N P=0.516 P=0.753 |
|POLY 3 | P=0.453 P=0.502 (e) P=0.492 |P=0.423 P=0.500N P=0.500 P=0.760 |
|POLY 1.5 | P=0.456 P=0.501 (e) P=0.494 |P=0.423 P=0.500N P=0.500 P=0.760 |
|POLY 6 | P=0.452 P=0.504 (e) P=0.491 |P=0.423 P=0.500N P=0.500 P=0.760 |
|LOGISTIC REGRESSION| P=0.597 (e) (e) P=0.500 |(e) (e) P=0.516 (e) |
|COCH-ARM / FISHERS | P=0.464 P=0.500 (e) P=0.500 |P=0.422 P=0.500N P=0.500 P=0.759N |
|ORDER RESTRICTED | P=0.243 (e) (e) (e) |P=0.374 (e) (e) (e) |
|=================================================================================================================================|
Date: 06/18/04 EXPERIMENT: 97013 TEST: 10 Page 7
Statistical Analysis of Non-neoplastic Lesions in Mice(P53 Heterozygous Transgenic) - WATER DISINFECTION MODEL (SODIU
M BR
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 3/15 (20%) 3/15 (20%) 1/15 (7%) 3/14 (21%) |4/15 (27%) 1/15 (7%) 2/15 (13%) 2/15 (13%) |
|POLY-3 RATE (b) | 3/14.83 3/15.00 1/15.00 3/14.00 |4/15.00 1/15.00 2/15.00 2/14.32 |
|POLY-3 PERCENT (g) | 20.2% 20.0% 6.7% 21.4% |26.7% 6.7% 13.3% 14.0% |
|TERMINAL (d) | 3/14 (21%) 2/14 (14%) 0/14 (0%) 3/14 (21%) |3/14 (21%) 1/15 (7%) 2/15 (13%) 2/14 (14%) |
|FIRST INCIDENCE | 184 (T) 143 128 184 (T) |154 185 (T) 185 (T) 185 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.524N P=0.669 P=0.303N P=0.674 |P=0.424N P=0.159N P=0.305N P=0.337N |
|POLY 3 | P=0.550N P=0.665N P=0.294N P=0.643 |P=0.427N P=0.163N P=0.327N P=0.350N |
|POLY 1.5 | P=0.551N P=0.668N P=0.296N P=0.640 |P=0.421N P=0.163N P=0.327N P=0.341N |
|POLY 6 | P=0.547N P=0.661N P=0.290N P=0.648 |P=0.432N P=0.163N P=0.327N P=0.357N |
|LOGISTIC REGRESSION| P=0.551 P=0.588N P=0.150N P=0.674 |P=0.371N P=0.159N P=0.305N P=0.306N |
|COCH-ARM / FISHERS | P=0.554N P=0.674N P=0.299N P=0.639 |P=0.409N P=0.165N P=0.326N P=0.326N |
|ORDER RESTRICTED | P=0.516N (e) (e) (e) |P=0.199N (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Testes: Germinal Epithelium |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 6/15 (40%) 3/15 (20%) 3/15 (20%) 2/15 (13%) | |
|POLY-3 RATE (b) | 6/14.83 3/14.47 3/14.34 2/14.22 | |
|POLY-3 PERCENT (g) | 40.5% 20.7% 20.9% 14.1% | |
|TERMINAL (d) | 6/14 (43%) 3/14 (21%) 3/14 (21%) 2/14 (14%) | |
|FIRST INCIDENCE | 184 (T) 184 (T) 184 (T) 184 (T) | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.114N P=0.213N P=0.213N P=0.109N | |
|POLY 3 | P=0.123N P=0.227N P=0.232N P=0.117N | |
|POLY 1.5 | P=0.122N P=0.222N P=0.226N P=0.113N | |
|POLY 6 | P=0.122N P=0.230N P=0.235N P=0.118N | |
|LOGISTIC REGRESSION| P=0.114N P=0.213N P=0.213N P=0.109N | |
|COCH-ARM / FISHERS | P=0.115N P=0.213N P=0.213N P=0.107N | |
|ORDER RESTRICTED | P=0.073N (e) (e) (e) | |
|=================================================================================================================================|
Date: 06/18/04 EXPERIMENT: 97013 TEST: 10 Page 8
Statistical Analysis of Non-neoplastic Lesions in Mice(P53 Heterozygous Transgenic) - WATER DISINFECTION MODEL (SODIU
M BR
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Thymus |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 7/14 (50%) 6/15 (40%) 2/15 (13%) 2/15 (13%) |4/15 (27%) 7/15 (47%) 12/15 (80%) 3/15 (20%) |
|POLY-3 RATE (b) | 7/14.00 6/14.47 2/14.34 2/14.22 |4/14.58 7/15.00 12/15.00 3/14.32 |
|POLY-3 PERCENT (g) | 50.0% 41.5% 14.0% 14.1% |27.4% 46.7% 80.0% 20.9% |
|TERMINAL (d) | 7/14 (50%) 6/14 (43%) 2/14 (14%) 2/14 (14%) |4/14 (29%) 7/15 (47%) 12/15 (80%) 3/14 (21%) |
|FIRST INCIDENCE | 184 (T) 184 (T) 184 (T) 184 (T) |185 (T) 185 (T) 185 (T) 185 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.015N* P=0.500N P=0.056N P=0.056N |P=0.404N P=0.271 P=0.009 ** P=0.500N |
|POLY 3 | P=0.012N* P=0.469N P=0.041N* P=0.043N* |P=0.412N P=0.244 P=0.002 ** P=0.510N |
|POLY 1.5 | P=0.011N* P=0.455N P=0.039N* P=0.040N* |P=0.399N P=0.237 P=0.002 ** P=0.508N |
|POLY 6 | P=0.012N* P=0.485N P=0.044N* P=0.045N* |P=0.418N P=0.255 P=0.003 ** P=0.509N |
|LOGISTIC REGRESSION| P=0.015N* P=0.500N P=0.056N P=0.056N |P=0.404N P=0.271 P=0.009 ** P=0.500N |
|COCH-ARM / FISHERS | P=0.013N* P=0.434N P=0.041N* P=0.041N* |P=0.383N P=0.225 P=0.005 ** P=0.500N |
|ORDER RESTRICTED | P=0.021N* (e) (e) (e) |P=0.051N (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Thymus |
| Ectopic Parathyroid Gland |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/14 (7%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |0/15 (0%) 2/15 (13%) 1/15 (7%) 2/15 (13%) |
|POLY-3 RATE (b) | 1/14.00 0/14.47 0/14.34 0/14.22 |0/14.58 2/15.00 1/15.00 2/14.32 |
|POLY-3 PERCENT (g) | 7.1% 0.0% 0.0% 0.0% |0.0% 13.3% 6.7% 14.0% |
|TERMINAL (d) | 1/14 (7%) 0/14 (0%) 0/14 (0%) 0/14 (0%) |0/14 (0%) 2/15 (13%) 1/15 (7%) 2/14 (14%) |
|FIRST INCIDENCE | 184 (T) --- --- --- |--- 185 (T) 185 (T) 185 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.352N P=0.500N P=0.500N P=0.500N |P=0.289 P=0.251 P=0.514 P=0.236 |
|POLY 3 | P=0.339N P=0.493N P=0.495N P=0.497N |P=0.293 P=0.238 P=0.506 P=0.227 |
|POLY 1.5 | P=0.341N P=0.490N P=0.492N P=0.493N |P=0.295 P=0.235 P=0.503 P=0.228 |
|POLY 6 | P=0.336N P=0.497N P=0.498N P=0.499N |P=0.294 P=0.242 P=0.509 P=0.227 |
|LOGISTIC REGRESSION| P=0.352N (e) (e) (e) |(e) P=0.251 P=0.514 P=0.236 |
|COCH-ARM / FISHERS | P=0.344N P=0.483N P=0.483N P=0.483N |P=0.297 P=0.241 P=0.500 P=0.241 |
|ORDER RESTRICTED | P=0.117N (e) (e) (e) |P=0.146 (e) (e) (e) |
|=================================================================================================================================|
Date: 06/18/04 EXPERIMENT: 97013 TEST: 10 Page 9
Statistical Analysis of Non-neoplastic Lesions in Mice(P53 Heterozygous Transgenic) - WATER DISINFECTION MODEL (SODIU
M BR
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Thymus |
| Ectopic Thyroid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/14 (7%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) |
|POLY-3 RATE (b) | 1/14.00 0/14.47 0/14.34 0/14.22 |0/14.58 0/15.00 0/15.00 2/14.32 |
|POLY-3 PERCENT (g) | 7.1% 0.0% 0.0% 0.0% |0.0% 0.0% 0.0% 14.0% |
|TERMINAL (d) | 1/14 (7%) 0/14 (0%) 0/14 (0%) 0/14 (0%) |0/14 (0%) 0/15 (0%) 0/15 (0%) 2/14 (14%) |
|FIRST INCIDENCE | 184 (T) --- --- --- |--- --- --- 185 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.352N P=0.500N P=0.500N P=0.500N |P=0.040 * (e) (e) P=0.236 |
|POLY 3 | P=0.339N P=0.493N P=0.495N P=0.497N |P=0.037 * (e) (e) P=0.227 |
|POLY 1.5 | P=0.341N P=0.490N P=0.492N P=0.493N |P=0.037 * (e) (e) P=0.228 |
|POLY 6 | P=0.336N P=0.497N P=0.498N P=0.499N |P=0.037 * (e) (e) P=0.227 |
|LOGISTIC REGRESSION| P=0.352N (e) (e) (e) |(e) (e) (e) P=0.236 |
|COCH-ARM / FISHERS | P=0.344N P=0.483N P=0.483N P=0.483N |P=0.041 * (e) (e) P=0.241 |
|ORDER RESTRICTED | P=0.117N (e) (e) (e) |P=0.024 * (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland |
| Ectopic Thymus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 1/15 (7%) 1/15 (7%) |1/15 (7%) 2/15 (13%) 2/15 (13%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/14.83 0/14.47 1/14.34 1/14.22 |1/14.58 2/15.00 2/15.00 0/14.32 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 7.0% 7.0% |6.9% 13.3% 13.3% 0.0% |
|TERMINAL (d) | 0/14 (0%) 0/14 (0%) 1/14 (7%) 1/14 (7%) |1/14 (7%) 2/15 (13%) 2/15 (13%) 0/14 (0%) |
|FIRST INCIDENCE | --- --- 184 (T) 184 (T) |185 (T) 185 (T) 185 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.207 (e) P=0.500 P=0.500 |P=0.263N P=0.525 P=0.525 P=0.500N |
|POLY 3 | P=0.201 (e) P=0.493 P=0.492 |P=0.267N P=0.510 P=0.510 P=0.503N |
|POLY 1.5 | P=0.203 (e) P=0.496 P=0.494 |P=0.265N P=0.506 P=0.506 P=0.503N |
|POLY 6 | P=0.201 (e) P=0.492 P=0.491 |P=0.268N P=0.516 P=0.516 P=0.503N |
|LOGISTIC REGRESSION| (e) (e) P=0.500 P=0.500 |P=0.263N P=0.525 P=0.525 (e) |
|COCH-ARM / FISHERS | P=0.206 (e) P=0.500 P=0.500 |P=0.257N P=0.500 P=0.500 P=0.500N |
|ORDER RESTRICTED | P=0.242 (e) (e) (e) |P=0.230N (e) (e) (e) |
|=================================================================================================================================|
Date: 06/18/04 EXPERIMENT: 97013 TEST: 10 Page 10
Statistical Analysis of Non-neoplastic Lesions in Mice(P53 Heterozygous Transgenic) - WATER DISINFECTION MODEL (SODIU
M BR
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland |
| Infiltration Cellular Lymphocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/15 (7%) 1/15 (7%) 1/15 (7%) 0/15 (0%) |0/15 (0%) 1/15 (7%) 2/15 (13%) 0/15 (0%) |
|POLY-3 RATE (b) | 1/14.83 1/14.47 1/14.34 0/14.22 |0/14.58 1/15.00 2/15.00 0/14.32 |
|POLY-3 PERCENT (g) | 6.7% 6.9% 7.0% 0.0% |0.0% 6.7% 13.3% 0.0% |
|TERMINAL (d) | 1/14 (7%) 1/14 (7%) 1/14 (7%) 0/14 (0%) |0/14 (0%) 1/15 (7%) 2/15 (13%) 0/14 (0%) |
|FIRST INCIDENCE | 184 (T) 184 (T) 184 (T) --- |--- 185 (T) 185 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.301N P=0.764 P=0.764 P=0.500N |P=0.596N P=0.514 P=0.251 (e) |
|POLY 3 | P=0.312N P=0.755 P=0.753 P=0.508N |P=0.598N P=0.506 P=0.238 (e) |
|POLY 1.5 | P=0.309N P=0.757 P=0.755 P=0.506N |P=0.596N P=0.503 P=0.235 (e) |
|POLY 6 | P=0.312N P=0.753 P=0.752 P=0.509N |P=0.599N P=0.509 P=0.242 (e) |
|LOGISTIC REGRESSION| P=0.301N P=0.764 P=0.764 (e) |(e) P=0.514 P=0.251 (e) |
|COCH-ARM / FISHERS | P=0.299N P=0.759N P=0.759N P=0.500N |P=0.589N P=0.500 P=0.241 (e) |
|ORDER RESTRICTED | P=0.329N (e) (e) (e) |P=0.325 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicle |
| Depletion Secretory |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) |
|POLY-3 RATE (b) | 0/14.83 0/14.47 0/14.34 0/14.22 |0/14.58 0/15.00 0/15.00 2/14.32 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% |0.0% 0.0% 0.0% 14.0% |
|TERMINAL (d) | 0/14 (0%) 0/14 (0%) 0/14 (0%) 0/14 (0%) |0/14 (0%) 0/15 (0%) 0/15 (0%) 2/14 (14%) |
|FIRST INCIDENCE | --- --- --- --- |--- --- --- 185 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.040 * (e) (e) P=0.236 |
|POLY 3 | (e) (e) (e) (e) |P=0.037 * (e) (e) P=0.227 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.037 * (e) (e) P=0.228 |
|POLY 6 | (e) (e) (e) (e) |P=0.037 * (e) (e) P=0.227 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) P=0.236 |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.041 * (e) (e) P=0.241 |
|ORDER RESTRICTED | (e) (e) (e) (e) |P=0.024 * (e) (e) (e) |
|=================================================================================================================================|
Date: 06/18/04 EXPERIMENT: 97013 TEST: 10 Page 11
Statistical Analysis of Non-neoplastic Lesions in Mice(P53 Heterozygous Transgenic) - WATER DISINFECTION MODEL (SODIU
M BR
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) |
|POLY-3 RATE (b) | 0/14.83 0/14.47 0/14.34 0/14.22 |0/14.58 0/15.00 0/15.00 2/14.32 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% |0.0% 0.0% 0.0% 14.0% |
|TERMINAL (d) | 0/14 (0%) 0/14 (0%) 0/14 (0%) 0/14 (0%) |0/14 (0%) 0/15 (0%) 0/15 (0%) 2/14 (14%) |
|FIRST INCIDENCE | --- --- --- --- |--- --- --- 185 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.040 * (e) (e) P=0.236 |
|POLY 3 | (e) (e) (e) (e) |P=0.037 * (e) (e) P=0.227 |
|POLY 1.5 | (e) (e) (e) (e) |P=0.037 * (e) (e) P=0.228 |
|POLY 6 | (e) (e) (e) (e) |P=0.037 * (e) (e) P=0.227 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |(e) (e) (e) P=0.236 |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.041 * (e) (e) P=0.241 |
|ORDER RESTRICTED | (e) (e) (e) (e) |P=0.024 * (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Uterus: Endometrium |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | |11/15 (73%) 10/15 (67%) 10/15 (67%) 10/15 (67%) |
|POLY-3 RATE (b) | |11/14.58 10/15.00 10/15.00 10/14.32 |
|POLY-3 PERCENT (g) | |75.5% 66.7% 66.7% 69.8% |
|TERMINAL (d) | |11/14 (79%) 10/15 (67%) 10/15 (67%) 10/14 (71%) |
|FIRST INCIDENCE | |185 (T) 185 (T) 185 (T) 185 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.497N P=0.384N P=0.384N P=0.500N |
|POLY 3 | |P=0.503N P=0.452N P=0.452N P=0.530N |
|POLY 1.5 | |P=0.489N P=0.473N P=0.473N P=0.522N |
|POLY 6 | |P=0.510N P=0.424N P=0.424N P=0.528N |
|LOGISTIC REGRESSION| |P=0.497N P=0.384N P=0.384N P=0.500N |
|COCH-ARM / FISHERS | |P=0.458N P=0.500N P=0.500N P=0.500N |
|ORDER RESTRICTED | |P=0.519N (e) (e) (e) |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).