TDMS Study 97013-10 Pathology Tables
NTP Experiment-Test: 97013-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/18/04
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 09:14:57
FINAL #1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7789-38-0
Lock Date: 07/30/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97013-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/18/04
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 09:14:57
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Natural Death 1 1
Survivors
Terminal Sacrifice 14 15 15 14
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (15) (15) (15) (15)
Diverticulum 1
Liver (15) (15) (15) (15)
Angiectasis 1 [3.0]
Hematopoietic Cell Proliferation 1 [1.0]
Inflammation, Chronic Active 14 [1.0] 13 [1.0] 14 [1.0] 14 [1.0]
Hepatocyte, Fatty Change 1 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 13 [1.1] 14 [1.1] 12 [1.1] 12 [1.0]
Stomach, Forestomach (15) (15) (15) (15)
Inflammation 1 [1.0]
Inflammation, Chronic Active 1 [1.0]
Epithelium, Hyperplasia 4 [1.3] 1 [1.0] 2 [1.0] 2 [1.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Accessory Adrenal Cortical Nodule 1 [1.0]
Subcapsular, Hyperplasia 13 [1.0] 12 [1.0] 13 [1.0] 14 [1.0]
Parathyroid Gland (1) (1)
Cyst 1 [2.0] 1 [1.0]
Pituitary Gland (15) (15) (15) (15)
Pars Distalis, Cyst 1 [1.0]
Pars Distalis, Hyperplasia 1 [1.0] 1 [1.0]
Thyroid Gland (15) (15) (15) (15)
Ectopic Thymus 1 [2.0] 2 [1.5] 2 [1.5]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97013-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/18/04
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 09:14:57
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Infiltration Cellular, Lymphocyte 1 [1.0] 2 [1.5]
Follicle, Depletion Secretory 2 [1.0]
Follicular Cell, Hypertrophy 2 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15)
Cyst 1 [2.0] 1 [2.0] 2 [1.5] 1 [2.0]
Uterus (15) (15) (15) (15)
Inflammation, Suppurative 1 [1.0] 1 [1.0]
Endometrium, Hyperplasia, Cystic 11 [1.8] 10 [1.8] 10 [1.4] 10 [1.3]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (15)
Hyperplasia, Lymphoid 2 [2.0] 1 [2.0] 1 [2.0]
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 [3.0] 2 [2.0] 1 [4.0]
Thymus (15) (15) (15) (15)
Atrophy 1 [2.0]
Cyst 4 [1.0] 7 [1.0] 12 [1.0] 3 [1.0]
Ectopic Parathyroid Gland 2 [1.0] 1 [1.0] 2 [1.0]
Ectopic Thyroid 2 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97013-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/18/04
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 09:14:57
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Inflammation, Chronic Active 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Hydronephrosis 1 [2.0]
Nephropathy 2 [1.0] 2 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97013-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/18/04
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 09:14:57
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Natural Death 1 1
Moribund Sacrifice 1 1
Survivors
Terminal Sacrifice 14 14 14 14
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 [2.0]
Inflammation, Chronic Active 12 [1.2] 12 [1.0] 10 [1.0] 14 [1.0]
Hepatocyte, Fatty Change 10 [1.0] 13 [1.2] 10 [1.3] 8 [1.1]
Hepatocyte, Vacuolization Cytoplasmic 13 [2.5] 14 [3.0] 12 [2.8] 14 [2.6]
Stomach, Forestomach (15) (15) (15) (14)
Epithelium, Hyperplasia 3 [1.0] 3 [1.3] 1 [1.0] 3 [1.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (14) (15) (15) (15)
Accessory Adrenal Cortical Nodule 1 [2.0]
Hypertrophy 1 [1.0] 2 [1.5]
Subcapsular, Hyperplasia 1 [1.0] 2 [1.0] 2 [1.0] 3 [1.0]
Pituitary Gland (15) (15) (15) (15)
Pars Distalis, Cyst 4 [1.3] 1 [1.0] 3 [1.0] 3 [1.0]
Pars Distalis, Hyperplasia 2 [1.0]
Thyroid Gland (15) (15) (15) (15)
Ectopic Thymus 1 [2.0] 1 [1.0]
Infiltration Cellular, Lymphocyte 1 [1.0] 1 [2.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97013-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/18/04
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 09:14:57
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
Degeneration 1 [4.0]
Granuloma Sperm 1 [3.0]
Testes (15) (15) (15) (15)
Cyst 1 [2.0]
Mineralization 1 [1.0]
Germinal Epithelium, Degeneration 6 [1.3] 3 [1.0] 3 [1.0] 2 [1.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (15)
Hyperplasia, Lymphoid 1 [2.0] 2 [2.0] 1 [3.0]
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 [3.0] 1 [2.0]
Thymus (14) (15) (15) (15)
Cyst 7 [1.6] 6 [1.8] 2 [1.5] 2 [2.0]
Ectopic Parathyroid Gland 1 [1.0]
Ectopic Thyroid 1 [2.0]
Hyperplasia, Lymphoid 1 [4.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97013-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/18/04
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 09:14:57
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Lung (15) (15) (15) (15)
Inflammation, Chronic Active 2 [1.5] 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Nephropathy 5 [1.0] 7 [1.0] 3 [1.0] 3 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
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