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TDMS Study 97013-10 Pathology Tables

NTP Experiment-Test: 97013-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04
Route: DOSED WATER                                WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 09:14:57

                                                         FINAL #1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7789-38-0

       Lock Date:  07/30/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 97013-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04    
Route: DOSED WATER                                WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 09:14:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/L       80 MG/L      400 MG/L     800 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Natural Death                                      1                                      1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                14           15           15           14                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (15)         (15)         (15)         (15)                                   
      Diverticulum                                                               1                                                  
   Liver                                              (15)         (15)         (15)         (15)                                   
      Angiectasis                                                                             1 [3.0]                               
      Hematopoietic Cell Proliferation                                                        1 [1.0]                               
      Inflammation, Chronic Active                    14 [1.0]     13 [1.0]     14 [1.0]     14 [1.0]                               
      Hepatocyte, Fatty Change                         1 [1.0]                                                                      
      Hepatocyte, Vacuolization Cytoplasmic           13 [1.1]     14 [1.1]     12 [1.1]     12 [1.0]                               
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Inflammation                                                                            1 [1.0]                               
      Inflammation, Chronic Active                     1 [1.0]                                                                      
      Epithelium, Hyperplasia                          4 [1.3]      1 [1.0]      2 [1.0]      2 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Accessory Adrenal Cortical Nodule                1 [1.0]                                                                      
      Subcapsular, Hyperplasia                        13 [1.0]     12 [1.0]     13 [1.0]     14 [1.0]                               
   Parathyroid Gland                                  (1)                       (1)                                                 
      Cyst                                             1 [2.0]                   1 [1.0]                                            
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Pars Distalis, Cyst                                                                     1 [1.0]                               
      Pars Distalis, Hyperplasia                                                 1 [1.0]      1 [1.0]                               
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Ectopic Thymus                                   1 [2.0]      2 [1.5]      2 [1.5]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04    
Route: DOSED WATER                                WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 09:14:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/L       80 MG/L      400 MG/L     800 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Infiltration Cellular, Lymphocyte                             1 [1.0]      2 [1.5]                                            
      Follicle, Depletion Secretory                                                           2 [1.0]                               
      Follicular Cell, Hypertrophy                                                            2 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (15)         (15)                                   
      Cyst                                             1 [2.0]      1 [2.0]      2 [1.5]      1 [2.0]                               
   Uterus                                             (15)         (15)         (15)         (15)                                   
      Inflammation, Suppurative                        1 [1.0]                   1 [1.0]                                            
      Endometrium, Hyperplasia, Cystic                11 [1.8]     10 [1.8]     10 [1.4]     10 [1.3]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)                                   
      Hyperplasia, Lymphoid                                         2 [2.0]      1 [2.0]      1 [2.0]                               
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                 1 [3.0]                   2 [2.0]      1 [4.0]                               
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                                                                 1 [2.0]                               
      Cyst                                             4 [1.0]      7 [1.0]     12 [1.0]      3 [1.0]                               
      Ectopic Parathyroid Gland                                     2 [1.0]      1 [1.0]      2 [1.0]                               
      Ectopic Thyroid                                                                         2 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04    
Route: DOSED WATER                                WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 09:14:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/L       80 MG/L      400 MG/L     800 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                     1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Hydronephrosis                                                                          1 [2.0]                               
      Nephropathy                                                                2 [1.0]      2 [1.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04    
Route: DOSED WATER                                WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 09:14:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/L       80 MG/L      400 MG/L     800 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Natural Death                                      1                                      1                                     
    Moribund Sacrifice                                              1            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                14           14           14           14                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                              1 [2.0]                                                         
      Inflammation, Chronic Active                    12 [1.2]     12 [1.0]     10 [1.0]     14 [1.0]                               
      Hepatocyte, Fatty Change                        10 [1.0]     13 [1.2]     10 [1.3]      8 [1.1]                               
      Hepatocyte, Vacuolization Cytoplasmic           13 [2.5]     14 [3.0]     12 [2.8]     14 [2.6]                               
   Stomach, Forestomach                               (15)         (15)         (15)         (14)                                   
      Epithelium, Hyperplasia                          3 [1.0]      3 [1.3]      1 [1.0]      3 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (14)         (15)         (15)         (15)                                   
      Accessory Adrenal Cortical Nodule                             1 [2.0]                                                         
      Hypertrophy                                      1 [1.0]                   2 [1.5]                                            
      Subcapsular, Hyperplasia                         1 [1.0]      2 [1.0]      2 [1.0]      3 [1.0]                               
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Pars Distalis, Cyst                              4 [1.3]      1 [1.0]      3 [1.0]      3 [1.0]                               
      Pars Distalis, Hyperplasia                       2 [1.0]                                                                      
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Ectopic Thymus                                                             1 [2.0]      1 [1.0]                               
      Infiltration Cellular, Lymphocyte                1 [1.0]      1 [2.0]      1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04    
Route: DOSED WATER                                WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 09:14:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/L       80 MG/L      400 MG/L     800 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (15)         (15)         (15)         (15)                                   
      Degeneration                                     1 [4.0]                                                                      
      Granuloma Sperm                                                            1 [3.0]                                            
   Testes                                             (15)         (15)         (15)         (15)                                   
      Cyst                                             1 [2.0]                                                                      
      Mineralization                                   1 [1.0]                                                                      
      Germinal Epithelium, Degeneration                6 [1.3]      3 [1.0]      3 [1.0]      2 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)                                   
      Hyperplasia, Lymphoid                            1 [2.0]      2 [2.0]      1 [3.0]                                            
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                              1 [3.0]                   1 [2.0]                               
   Thymus                                             (14)         (15)         (15)         (15)                                   
      Cyst                                             7 [1.6]      6 [1.8]      2 [1.5]      2 [2.0]                               
      Ectopic Parathyroid Gland                        1 [1.0]                                                                      
      Ectopic Thyroid                                  1 [2.0]                                                                      
      Hyperplasia, Lymphoid                                                      1 [4.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-10         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04    
Route: DOSED WATER                                WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 09:14:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/L       80 MG/L      400 MG/L     800 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Lung                                               (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                     2 [1.5]      1 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Nephropathy                                      5 [1.0]      7 [1.0]      3 [1.0]      3 [1.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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