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TDMS Study 97013-11 Pathology Tables

NTP  EXP/TEST: 97013-11                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/21/04
ROUTE: SKIN APPLICATION                                                                                           TIME: 10:44:32

                                                         EIS REPORT 37


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  97013B

       CONTRACT NUMBER:  N01-ES-65406

       CAS NUMBER:  7789-38-0

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 97013-11                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 2
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/21/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 10:44:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 2                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: FEMALE                               TRT: 0 MG/KG            PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-11                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 3
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/21/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 10:44:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 4                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: FEMALE                               TRT: 64 MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-11                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 4
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/21/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 10:44:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 6                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: FEMALE                               TRT: 128     MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-11                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 5
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/21/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 10:44:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 8                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: FEMALE                               TRT: 256     MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-11                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 6
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/21/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 10:44:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 10                     ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: FEMALE                               TRT: TPA                PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

536         536   64 12/31/99    71 01/07/00   2/11  Papilloma Site Of Application Small 20
                  64 12/31/99    71 01/07/00   2/11  Papilloma Site Of Application Medium 4

  REMOVED  **  CID   536 **   REASON - Other
                                 74 01/10/00         Papilloma Site Of Application Small 20


537         537   78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Small 15
                  71 01/07/00    71 01/07/00   1/12  Papilloma Site Of Application Small 16
                  64 12/31/99    64 12/31/99   1/12  Papilloma Site Of Application Small 8
                  78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Medium 9

  REMOVED  **  CID   537 **   REASON - Other
                                 83 01/19/00         Papilloma Site Of Application Small 20


538         538   78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Medium 10
                  71 01/07/00    71 01/07/00   1/12  Papilloma Site Of Application Small 15
                  78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Small 19
                  64 12/31/99    64 12/31/99   1/12  Papilloma Site Of Application Small 6

  REMOVED  **  CID   538 **   REASON - Other
                                 83 01/19/00         Papilloma Site Of Application Small 20


539         539   64 12/31/99    71 01/07/00   2/12  Papilloma Site Of Application Small 12
                  78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Small 20
                  78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Medium 5

  REMOVED  **  CID   539 **   REASON - Other
                                 83 01/19/00         Papilloma Site Of Application Small 20


540         540   78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Small 20
                  64 12/31/99    71 01/07/00   2/12  Papilloma Site Of Application Small 9

  REMOVED  **  CID   540 **   REASON - Other
                                 83 01/19/00         Papilloma Site Of Application Small 20


541         541   64 12/31/99    64 12/31/99   1/18  Papilloma Site Of Application Small 10
                  71 01/07/00    71 01/07/00   1/18  Papilloma Site Of Application Small 15
                  99 02/04/00   106 02/11/00   2/18  Papilloma Site Of Application Small 2
                 120 02/25/00   120 02/25/00   1/18  Papilloma Site Of Application Small 20
                  85 01/21/00    92 01/28/00   2/18  Papilloma Site Of Application Small 5
                 113 02/18/00   113 02/18/00   1/18  Papilloma Site Of Application Small 6

  REMOVED  **  CID   541 **   REASON - Other

NTP  EXP/TEST: 97013-11                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 7
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/21/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 10:44:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 10                     ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: FEMALE                               TRT: TPA                PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
541         541                 120 02/25/00         Papilloma Site Of Application Small 20


542         542   57 12/24/99    57 12/24/99   1/11  Papilloma Site Of Application Small 12
                  64 12/31/99    64 12/31/99   1/11  Papilloma Site Of Application Small 15
                  50 12/17/99    50 12/17/99   1/11  Papilloma Site Of Application Medium 2
                  71 01/07/00    71 01/07/00   1/11  Papilloma Site Of Application Small 20
                  57 12/24/99    57 12/24/99   1/11  Papilloma Site Of Application Medium 3
                  50 12/17/99    50 12/17/99   1/11  Papilloma Site Of Application Small 6

  REMOVED  **  CID   542 **   REASON - Other
                                 74 01/10/00         Papilloma Site Of Application Small 20


543         543   64 12/31/99    64 12/31/99   1/11  Papilloma Site Of Application Small 16
                  71 01/07/00    71 01/07/00   1/11  Papilloma Site Of Application Small 20

  REMOVED  **  CID   543 **   REASON - Other
                                 74 01/10/00         Papilloma Site Of Application Small 20


544         544   50 12/17/99    50 12/17/99   1/8   Papilloma Site Of Application Small 15
                  50 12/17/99    50 12/17/99   1/8   Papilloma Site Of Application Medium 7

  REMOVED  **  CID   544 **   REASON - Other
                                 54 12/21/99         Papilloma Site Of Application Small 20


545         545   64 12/31/99    64 12/31/99   1/11  Papilloma Site Of Application Small 19
                  71 01/07/00    71 01/07/00   1/11  Papilloma Site Of Application Small 20

  REMOVED  **  CID   545 **   REASON - Other
                                 74 01/10/00         Papilloma Site Of Application Small 20


546         546   50 12/17/99    64 12/31/99   3/11  Papilloma Site Of Application Small 13
                  71 01/07/00    71 01/07/00   1/11  Papilloma Site Of Application Small 20

  REMOVED  **  CID   546 **   REASON - Other
                                 74 01/10/00         Papilloma Site Of Application Small 20


547         547   64 12/31/99    64 12/31/99   1/11  Papilloma Site Of Application Small 12
                  71 01/07/00    71 01/07/00   1/11  Papilloma Site Of Application Small 20

  REMOVED  **  CID   547 **   REASON - Other
                                 74 01/10/00         Papilloma Site Of Application Small 20

NTP  EXP/TEST: 97013-11                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 8
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/21/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 10:44:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 10                     ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: FEMALE                               TRT: TPA                PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------



548         548   78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Medium 13
                  78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Small 15
                  71 01/07/00    71 01/07/00   1/12  Papilloma Site Of Application Small 17
                  64 12/31/99    64 12/31/99   1/12  Papilloma Site Of Application Small 5

  REMOVED  **  CID   548 **   REASON - Other
                                 83 01/19/00         Papilloma Site Of Application Small 20


549         549   50 12/17/99    50 12/17/99   1/8   Papilloma Site Of Application Small 17
                  50 12/17/99    50 12/17/99   1/8   Papilloma Site Of Application Medium 2
                  50 12/17/99    50 12/17/99   1/8   Papilloma Site Of Application Large 2

  REMOVED  **  CID   549 **   REASON - Other
                                 54 12/21/99         Papilloma Site Of Application Small 20


550         550   78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Small 15
                  78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Medium 16
                  71 01/07/00    71 01/07/00   1/12  Papilloma Site Of Application Small 18
                  78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Large 6
                  64 12/31/99    64 12/31/99   1/12  Papilloma Site Of Application Small 8

  REMOVED  **  CID   550 **   REASON - Other
                                 83 01/19/00         Papilloma Site Of Application Small 20

NTP  EXP/TEST: 97013-11                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 9
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/21/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 10:44:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 1                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: MALE                                 TRT: 0 MG/KG            PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-11                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 10
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/21/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 10:44:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 3                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: MALE                                 TRT: 64 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-11                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 11
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/21/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 10:44:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 5                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: MALE                                 TRT: 128     MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-11                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 12
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/21/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 10:44:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 7                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: MALE                                 TRT: 256     MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-11                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 13
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/21/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 10:44:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 9                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: MALE                                 TRT: TPA                PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

521         521   50 12/17/99    57 12/24/99   2/12  Papilloma Site Of Application Medium 2
                  78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Small 20
                  50 12/17/99    57 12/24/99   2/12  Papilloma Site Of Application Small 3
                  64 12/31/99    64 12/31/99   1/12  Papilloma Site Of Application Small 5
                  78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Medium 6
                  71 01/07/00    71 01/07/00   1/12  Papilloma Site Of Application Small 8

  REMOVED  **  CID   521 **   REASON - Other
                                 83 01/19/00         Papilloma Site Of Application Small 20


522         522   50 12/17/99    57 12/24/99   2/11  Papilloma Site Of Application Medium 1
                  71 01/07/00    71 01/07/00   1/11  Papilloma Site Of Application Small 11
                  50 12/17/99    71 01/07/00   4/11  Papilloma Site Of Application Large 4
                  64 12/31/99    64 12/31/99   1/11  Papilloma Site Of Application Small 4
                  71 01/07/00    71 01/07/00   1/11  Papilloma Site Of Application Medium 5
                  50 12/17/99    57 12/24/99   2/11  Papilloma Site Of Application Small 6

  REMOVED  **  CID   522 **   REASON - Other
                                 74 01/10/00         Papilloma Site Of Application Small 20
                                 74 01/10/00         Papilloma Site Of Application Medium 4


523         523   64 12/31/99    64 12/31/99   1/12  Papilloma Site Of Application Small 1
                  78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Small 14
                  71 01/07/00    71 01/07/00   1/12  Papilloma Site Of Application Small 4
                  78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Medium 8
                  78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Large 9

  REMOVED  **  CID   523 **   REASON - Other
                                 83 01/19/00         Papilloma Site Of Application Small 20


524         524   50 12/17/99    50 12/17/99   1/8   Papilloma Site Of Application Large 2
                  50 12/17/99    50 12/17/99   1/8   Papilloma Site Of Application Small 20

  REMOVED  **  CID   524 **   REASON - Other
                                 54 12/21/99         Papilloma Site Of Application Small 20


525         525   99 02/04/00    99 02/04/00   1/16  Papilloma Site Of Application Small 14
                 106 02/11/00   106 02/11/00   1/16  Papilloma Site Of Application Small 15
                  71 01/07/00    71 01/07/00   1/16  Papilloma Site Of Application Medium 2
                  85 01/21/00    85 01/21/00   1/16  Papilloma Site Of Application Small 4
                  78 01/14/00    78 01/14/00   1/16  Papilloma Site Of Application Large 4
                  92 01/28/00    99 02/04/00   2/16  Papilloma Site Of Application Medium 5
                  78 01/14/00    78 01/14/00   1/16  Papilloma Site Of Application Small 5
                  71 01/07/00    71 01/07/00   1/16  Papilloma Site Of Application Small 6

NTP  EXP/TEST: 97013-11                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 14
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/21/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 10:44:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 9                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: MALE                                 TRT: TPA                PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS ANIMAL DATA -
525         525   85 01/21/00    85 01/21/00   1/16  Papilloma Site Of Application Large 6
                  64 12/31/99    64 12/31/99   1/16  Papilloma Site Of Application Small 7
                  78 01/14/00    85 01/21/00   2/16  Papilloma Site Of Application Medium 7
                 106 02/11/00   106 02/11/00   1/16  Papilloma Site Of Application Medium 8

  REMOVED  **  CID   525 **   REASON - Other
                                109 02/14/00         Papilloma Site Of Application Small 15
                                109 02/14/00         Papilloma Site Of Application Medium 7


526         526   71 01/07/00    71 01/07/00   1/11  Papilloma Site Of Application Small 20
                  50 12/17/99    57 12/24/99   2/11  Papilloma Site Of Application Large 3
                  64 12/31/99    64 12/31/99   1/11  Papilloma Site Of Application Small 4
                  50 12/17/99    71 01/07/00   3/11  Papilloma Site Of Application Medium 4
                  57 12/24/99    57 12/24/99   1/11  Papilloma Site Of Application Medium 8
                  50 12/17/99    57 12/24/99   2/11  Papilloma Site Of Application Small 9

  REMOVED  **  CID   526 **   REASON - Other
                                 74 01/10/00         Papilloma Site Of Application Small 20


527         527   64 12/31/99    64 12/31/99   1/11  Papilloma Site Of Application Small 12
                  71 01/07/00    71 01/07/00   1/11  Papilloma Site Of Application Small 20

  REMOVED  **  CID   527 **   REASON - Other
                                 74 01/10/00         Papilloma Site Of Application Small 20


528         528   50 12/17/99    57 12/24/99   2/11  Papilloma Site Of Application Large 1
                  64 12/31/99    64 12/31/99   1/11  Papilloma Site Of Application Small 10
                  50 12/17/99    57 12/24/99   2/11  Papilloma Site Of Application Small 11
                  71 01/07/00    71 01/07/00   1/11  Papilloma Site Of Application Small 20
                  50 12/17/99    57 12/24/99   2/11  Papilloma Site Of Application Medium 3
                  64 12/31/99    71 01/07/00   2/11  Papilloma Site Of Application Medium 6

  REMOVED  **  CID   528 **   REASON - Other
                                 74 01/10/00         Papilloma Site Of Application Small 20


529         529   50 12/17/99    57 12/24/99   2/12  Papilloma Site Of Application Large 1
                  78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Medium 13
                  64 12/31/99    71 01/07/00   2/12  Papilloma Site Of Application Medium 3
                  50 12/17/99    50 12/17/99   1/12  Papilloma Site Of Application Small 6
                  64 12/31/99    78 01/14/00   3/12  Papilloma Site Of Application Small 8
                  57 12/24/99    57 12/24/99   1/12  Papilloma Site Of Application Small 9
                  78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Large 9

  REMOVED  **  CID   529 **   REASON - Other

NTP  EXP/TEST: 97013-11                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 15
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/21/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 10:44:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 9                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: MALE                                 TRT: TPA                PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
529         529                  83 01/19/00         Papilloma Site Of Application Small 20


530         530   64 12/31/99    71 01/07/00   2/11  Papilloma Site Of Application Small 20

  REMOVED  **  CID   530 **   REASON - Other
                                 74 01/10/00         Papilloma Site Of Application Small 20


531         531   64 12/31/99    64 12/31/99   1/11  Papilloma Site Of Application Small 16
                  71 01/07/00    71 01/07/00   1/11  Papilloma Site Of Application Small 20

  REMOVED  **  CID   531 **   REASON - Other
                                 74 01/10/00         Papilloma Site Of Application Small 20


532         532   64 12/31/99    64 12/31/99   1/11  Papilloma Site Of Application Small 14
                  71 01/07/00    71 01/07/00   1/11  Papilloma Site Of Application Small 20

  REMOVED  **  CID   532 **   REASON - Other
                                 74 01/10/00         Papilloma Site Of Application Small 20


533         533   78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Large 10
                  78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Medium 10
                  50 12/17/99    57 12/24/99   2/12  Papilloma Site Of Application Medium 2
                  50 12/17/99    71 01/07/00   4/12  Papilloma Site Of Application Large 3
                  64 12/31/99    71 01/07/00   2/12  Papilloma Site Of Application Medium 6
                  50 12/17/99    71 01/07/00   3/12  Papilloma Site Of Application Small 6

  REMOVED  **  CID   533 **   REASON - Other
                                 83 01/19/00         Papilloma Site Of Application Small 20


534         534   64 12/31/99    78 01/14/00   2/12  Papilloma Site Of Application Small 10
                  78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Medium 13
                  71 01/07/00    71 01/07/00   1/12  Papilloma Site Of Application Small 15
                  78 01/14/00    78 01/14/00   1/12  Papilloma Site Of Application Large 6

  REMOVED  **  CID   534 **   REASON - Other
                                 83 01/19/00         Papilloma Site Of Application Small 20


535         535   71 01/07/00    71 01/07/00   1/11  Papilloma Site Of Application Small 20
                  64 12/31/99    64 12/31/99   1/11  Papilloma Site Of Application Small 5

  REMOVED  **  CID   535 **   REASON - Other

NTP  EXP/TEST: 97013-11                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 16
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/21/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 10:44:32
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 9                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: MALE                                 TRT: TPA                PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
535         535                  74 01/10/00         Papilloma Site Of Application Small 20



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