TDMS Study 97013-11 Pathology Tables
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7789-38-0
Lock Date: 07/30/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 001 0 MG/KG
Include 002 0 MG/KG
Include 003 64 MG/KG
Include 004 64 MG/KG
Include 005 128 MG/KG
Include 006 128 MG/KG
Include 007 256 MG/KG
Include 008 256 MG/KG
Page 1
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| | |
DAY ON TEST | 8| 6| 8| 8| 8| 8| 8| 8| 8| 4| 8| 5| 8| 8| 6| | |
| 2| 5| 2| 2| 2| 2| 2| 2| 2| 6| 2| 8| 2| 2| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 1 | 2 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 13 1.0|
Hepatocyte, Necrosis | 1 | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 2 1 | 3 1.3|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
Epithelium, Hyperkeratosis | 1 | 1 1.0|
Epithelium, Hyperplasia | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Tooth | + + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Accessory Adrenal Cortical Nodule | 1 1 1 | 3 1.0|
Subcapsular, Hyperplasia | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 2
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| | |
DAY ON TEST | 8| 6| 8| 8| 8| 8| 8| 8| 8| 4| 8| 5| 8| 8| 6| | |
| 2| 5| 2| 2| 2| 2| 2| 2| 2| 6| 2| 8| 2| 2| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Pars Distalis, Cyst | 1 1 | 2 1.0|
Pars Intermedia, Cyst | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Ectopic Thymus | 1 | 1 1.0|
Follicle, Cyst | 1 | 1 1.0|
Follicle, Depletion Secretory | 1 1 1 2 1 1 | 6 1.2|
Follicular Cell, Hypertrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
Endometrium, Hyperplasia, Cystic | 1 1 1 1 1 1 1 1 1 1 1 | 11 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
Hyperplasia, Lymphoid | 2 2 3 2 | 4 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + | 14 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 2 2 | 3 1.7|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 3
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| | |
DAY ON TEST | 8| 6| 8| 8| 8| 8| 8| 8| 8| 4| 8| 5| 8| 8| 6| | |
| 2| 5| 2| 2| 2| 2| 2| 2| 2| 6| 2| 8| 2| 2| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Atrophy | 3 | 1 3.0|
Cyst | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Epidermis, Hyperplasia, Focal | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Nephropathy | 1 1 1 1 1 1 1 1 | 8 1.0|
Renal Tubule, Dilatation | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 0| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| | |
DAY ON TEST | 8| 6| 8| 8| 8| 8| 8| 8| 6| 8| 8| 5| 8| 8| 7| | |
| 2| 7| 2| 2| 1| 2| 2| 2| 5| 2| 2| 2| 2| 2| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
64 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 2 |
Anus, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 1 | 2 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 | 12 1.0|
Hepatocyte, Degeneration | 2 | 1 2.0|
Hepatocyte, Fatty Change | 1 | 1 1.0|
Hepatocyte, Necrosis | 1 1 | 2 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 1 | 4 1.3|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
Epithelium, Hyperkeratosis | 2 2 | 2 2.0|
Epithelium, Hyperplasia | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Tooth | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 0| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| | |
DAY ON TEST | 8| 6| 8| 8| 8| 8| 8| 8| 6| 8| 8| 5| 8| 8| 7| | |
| 2| 7| 2| 2| 1| 2| 2| 2| 5| 2| 2| 2| 2| 2| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
64 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Accessory Adrenal Cortical Nodule | 1 1 1 | 3 1.0|
Subcapsular, Hyperplasia | 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Pars Distalis, Cyst | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 | 6 1.0|
Follicle, Depletion Secretory | 1 1 1 1 1 1 1 1 1 2 2 | 11 1.2|
Follicular Cell, Hypertrophy | 1 1 1 1 1 1 1 1 1 | 9 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
Endometrium, Hyperplasia, Cystic | 1 2 2 1 1 1 1 2 1 | 9 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + | 14 |
Hyperplasia, Lymphoid | 3 4 | 2 3.5|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 0| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| | |
DAY ON TEST | 8| 6| 8| 8| 8| 8| 8| 8| 6| 8| 8| 5| 8| 8| 7| | |
| 2| 7| 2| 2| 1| 2| 2| 2| 5| 2| 2| 2| 2| 2| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
64 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Atrophy | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 1 2 1 1 | 5 1.4|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + | 14 |
Atrophy | 4 3 2 | 3 3.0|
Cyst | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Hyperkeratosis | 4 | 1 4.0|
Inflammation, Chronic Active | 4 | 1 4.0|
Inflammation, Suppurative | 3 | 1 3.0|
Epidermis, Hyperplasia, Focal | 2 2 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + | 1 |
Fracture | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 0| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| | |
DAY ON TEST | 8| 6| 8| 8| 8| 8| 8| 8| 6| 8| 8| 5| 8| 8| 7| | |
| 2| 7| 2| 2| 1| 2| 2| 2| 5| 2| 2| 2| 2| 2| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
64 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Nephropathy | 1 1 1 1 1 1 1 | 7 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 8| 8| 8| 8| 8| 0| 8| 8| 8| 8| 3| 8| 8| | |
| 5| 0| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A |
128 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 1 | 2 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 | 12 1.0|
Hepatocyte, Necrosis | 1 | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 | 3 1.3|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
Epithelium, Hyperkeratosis | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Accessory Adrenal Cortical Nodule | 1 | 1 1.0|
Subcapsular, Hyperplasia | 1 1 1 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 8| 8| 8| 8| 8| 0| 8| 8| 8| 8| 3| 8| 8| | |
| 5| 0| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A |
128 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Pars Distalis, Cyst | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Infiltration Cellular, Lymphocyte | 1 1 1 | 3 1.0|
Follicle, Depletion Secretory | 1 3 1 2 1 2 1 1 2 2 1 1 2 | 13 1.5|
Follicular Cell, Hypertrophy | 1 3 2 2 2 2 2 2 2 1 2 2 | 12 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
Atrophy | 3 | 1 3.0|
Cyst | 2 | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
Endometrium, Hyperplasia, Cystic | 1 1 1 1 2 1 2 2 1 1 | 10 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + | 14 |
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + + + + M + + | 13 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Atrophy | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 1 3 2 2 2 1 2 2 2 | 9 1.9|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 8| 8| 8| 8| 8| 0| 8| 8| 8| 8| 3| 8| 8| | |
| 5| 0| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | A |
128 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 2 2 3 4 | 4 2.8|
Cyst | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 2 | 1 2.0|
Epidermis, Hyperplasia, Focal | 4 3 3 | 3 3.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 13 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 0| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 1| 1| 9| 8| 8| 8| 8| 8| 6| 8| | |
| 2| 2| 2| 2| 2| 6| 3| 9| 2| 2| 2| 2| 2| 9| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
256 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 1 1 | 3 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 2 1 | 12 1.1|
Thrombosis | 3 | 1 3.0|
Hepatocyte, Necrosis | 2 | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
Atrophy | 1 | 1 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
Epithelium, Hyperkeratosis | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Tooth | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 0| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 1| 1| 9| 8| 8| 8| 8| 8| 6| 8| | |
| 2| 2| 2| 2| 2| 6| 3| 9| 2| 2| 2| 2| 2| 9| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
256 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Accessory Adrenal Cortical Nodule | 1 | 1 1.0|
Subcapsular, Hyperplasia | 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 1 1 1 2 2 1 1 | 12 1.3|
Follicle, Cyst | 2 | 1 2.0|
Follicle, Depletion Secretory | 3 3 3 3 3 2 1 3 3 3 3 2 2 3 | 14 2.6|
Follicular Cell, Hypertrophy | 3 3 3 3 3 2 3 3 3 3 2 3 3 | 13 2.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
Cyst | 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
Endometrium, Hyperplasia, Cystic | 1 2 1 1 2 1 1 1 1 1 | 10 1.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
Hyperplasia, Lymphoid | 3 3 3 | 3 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 0| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 1| 1| 9| 8| 8| 8| 8| 8| 6| 8| | |
| 2| 2| 2| 2| 2| 6| 3| 9| 2| 2| 2| 2| 2| 9| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
256 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Spleen | + + + + + + + + + + + + + + + | 15 |
Atrophy | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 2 2 1 2 2 2 2 3 2 | 10 2.1|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 3 2 | 2 2.5|
Cyst | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 4 | 1 4.0|
Ulcer | 4 | 1 4.0|
Epidermis, Hyperplasia, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Thrombosis | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 0| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 1| 1| 9| 8| 8| 8| 8| 8| 6| 8| | |
| 2| 2| 2| 2| 2| 6| 3| 9| 2| 2| 2| 2| 2| 9| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
256 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 15 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 0| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 4| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 8| 4| | |
| 1| 2| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Hepatocyte, Necrosis | 2 | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 2 1 1 | 6 1.2|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Accessory Adrenal Cortical Nodule | 1 | 1 1.0|
Hypertrophy | 1 2 2 2 1 1 1 2 | 8 1.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 0| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 4| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 8| 4| | |
| 1| 2| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Follicle, Depletion Secretory | 1 1 1 1 1 1 1 | 7 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
Degeneration | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
Cyst | 3 | 1 3.0|
Germinal Epithelium, Degeneration | 1 3 | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
Necrosis, Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
Necrosis, Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Atrophy | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + + + | 14 |
Atrophy | 2 | 1 2.0|
Cyst | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 0| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 4| 8| 8| 8| 7| 8| 8| 8| 8| 8| 8| 8| 8| 4| | |
| 1| 2| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Hyperkeratosis, Focal | 2 | 1 2.0|
Hyperkeratosis | 2 2 | 2 2.0|
Epidermis, Hyperplasia, Focal | 2 1 3 | 3 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Nephropathy | 1 1 1 1 1 1 1 1 | 8 1.0|
Artery, Inflammation, Chronic Active | 2 | 1 2.0|
Renal Tubule, Dilatation | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| | |
DAY ON TEST | 8| 7| 8| 7| 8| 8| 3| 8| 8| 8| 8| 4| 8| 8| 8| | |
| 1| 4| 1| 6| 1| 1| 6| 1| 1| 1| 1| 8| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
64 MG/KG | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 1 1 1 1 1 1 | 6 1.0|
Hepatocyte, Necrosis | 3 1 | 2 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 2 1 | 4 1.3|
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
Epithelium, Hyperplasia | 2 1 | 2 1.5|
|__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Hypertrophy | 2 1 2 1 | 4 1.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| | |
DAY ON TEST | 8| 7| 8| 7| 8| 8| 3| 8| 8| 8| 8| 4| 8| 8| 8| | |
| 1| 4| 1| 6| 1| 1| 6| 1| 1| 1| 1| 8| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
64 MG/KG | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Pituitary Gland | + + + + + + + + + + + M + + + | 14 |
Pars Distalis, Cyst | 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Follicle, Depletion Secretory | 1 1 1 1 | 4 1.0|
Follicular Cell, Hypertrophy | 1 1 1 1 1 1 1 | 7 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
Necrosis, Lymphoid | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 4 3 2 1 | 4 2.5|
Cyst | 2 1 | 2 1.5|
Ectopic Parathyroid Gland | 1 | 1 1.0|
Ectopic Thyroid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| | |
DAY ON TEST | 8| 7| 8| 7| 8| 8| 3| 8| 8| 8| 8| 4| 8| 8| 8| | |
| 1| 4| 1| 6| 1| 1| 6| 1| 1| 1| 1| 8| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
64 MG/KG | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 1 | 1 1.0|
Epidermis, Hyperplasia, Focal | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 1 | 1 1.0|
Pigmentation | 1 | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Nephropathy | 1 1 2 1 1 1 1 1 | 8 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 6| 8| 8| 4| 8| 8| 8| 8| 8| 8| | |
| 1| 1| 1| 1| 1| 8| 1| 1| 6| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
128 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 | 9 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
Epithelium, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Hypertrophy | 1 | 1 1.0|
Subcapsular, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 6| 8| 8| 4| 8| 8| 8| 8| 8| 8| | |
| 1| 1| 1| 1| 1| 8| 1| 1| 6| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
128 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Pars Distalis, Cyst | 1 1 1 1 | 4 1.0|
Pars Distalis, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Follicle, Depletion Secretory | 1 1 1 1 1 | 5 1.0|
Follicular Cell, Hypertrophy | 1 1 1 1 1 2 2 2 1 1 | 10 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
Germinal Epithelium, Degeneration | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 3 | 1 3.0|
Cyst | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 6| 8| 8| 4| 8| 8| 8| 8| 8| 8| | |
| 1| 1| 1| 1| 1| 8| 1| 1| 6| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
128 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Hyperkeratosis | 2 2 1 | 3 1.7|
Epidermis, Hyperplasia, Focal | 1 2 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 14 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
256 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 | 11 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 1 1 2 1 3 | 6 1.8|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
|__________________________________________________________________________|____________|
Tooth | + + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Hypertrophy | 1 2 1 | 3 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Pars Distalis, Cyst | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
256 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Follicle, Depletion Secretory | 1 1 1 1 1 1 1 1 2 1 1 | 11 1.1|
Follicular Cell, Hypertrophy | 1 1 1 1 2 2 1 2 1 2 1 2 1 2 | 14 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
Degeneration | 4 4 | 2 4.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
Cyst | 2 | 1 2.0|
Germinal Epithelium, Degeneration | 1 2 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
Atrophy | 3 2 2 3 | 4 2.5|
Cyst | 1 1 1 1 1 | 5 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 97013-11 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: SKIN APPLICATION Time: 09:19:13
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
256 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Skin | + + + + + + + + + + + + + + + | 15 |
Hyperkeratosis | 2 2 2 2 | 4 2.0|
Epidermis, Hyperplasia, Focal | 2 1 2 2 | 4 1.8|
Site of Application - Epidermis, | | |
Hyperplasia, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Nephropathy | 1 1 1 1 1 1 1 2 1 1 1 1 1 2 | 14 1.1|
Renal Tubule, Dilatation | 2 1 | 2 1.5|
|__________________________________________________________________________|____________|
Urethra | + | 1 |
Bulbourethral Gland, Cyst | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
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