Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/15968

TDMS Study 97013-11 Pathology Tables

NTP Experiment-Test: 97013-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04
Route: SKIN APPLICATION                           WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 09:21:32

                                                          FINAL#1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7789-38-0

       Lock Date:  07/30/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 MG/KG
                               Include 002    0 MG/KG
                               Include 003    64 MG/KG
                               Include 004    64 MG/KG
                               Include 005    128     MG/KG
                               Include 006    128     MG/KG
                               Include 007    256     MG/KG
                               Include 008    256     MG/KG


























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 97013-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04    
Route: SKIN APPLICATION                           WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 09:21:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/KG      64 MG/KG     128          256                                    
                                                                                MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            4            1            3                                     
    Natural Death                                      2            1            3            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                11           10           11           11                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (1)          (2)          (1)                                                 
      Anus, Hyperplasia                                             1 [1.0]                                                         
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                 2 [1.0]      2 [1.0]      2 [1.0]      3 [1.0]                               
      Inflammation, Chronic Active                    13 [1.0]     12 [1.0]     12 [1.0]     12 [1.1]                               
      Thrombosis                                                                              1 [3.0]                               
      Hepatocyte, Degeneration                                      1 [2.0]                                                         
      Hepatocyte, Fatty Change                                      1 [1.0]                                                         
      Hepatocyte, Necrosis                             1 [1.0]      2 [1.0]      1 [1.0]      1 [2.0]                               
      Hepatocyte, Vacuolization Cytoplasmic            3 [1.3]      4 [1.3]      3 [1.3]      3 [1.0]                               
   Salivary Glands                                                                           (1)                                    
      Atrophy                                                                                 1 [1.0]                               
      Inflammation, Chronic Active                                                            1 [1.0]                               
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Epithelium, Hyperkeratosis                       1 [1.0]      2 [2.0]      1 [2.0]      1 [2.0]                               
      Epithelium, Hyperplasia                          2 [1.0]      2 [2.0]      1 [2.0]      2 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Accessory Adrenal Cortical Nodule                3 [1.0]      3 [1.0]      1 [1.0]      1 [1.0]                               
      Subcapsular, Hyperplasia                         4 [1.0]      3 [1.0]      5 [1.0]      3 [1.0]                               
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Pars Distalis, Cyst                              2 [1.0]      1 [1.0]      2 [1.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04    
Route: SKIN APPLICATION                           WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 09:21:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/KG      64 MG/KG     128          256                                    
                                                                                MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Intermedia, Cyst                            1 [1.0]                                                                      
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Ectopic Thymus                                   1 [1.0]                                                                      
      Infiltration Cellular, Lymphocyte                             6 [1.0]      3 [1.0]     12 [1.3]                               
      Follicle, Cyst                                   1 [1.0]                                1 [2.0]                               
      Follicle, Depletion Secretory                    6 [1.2]     11 [1.2]     13 [1.5]     14 [2.6]                               
      Follicular Cell, Hypertrophy                     1 [1.0]      9 [1.0]     12 [1.9]     13 [2.8]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (15)         (15)                                   
      Atrophy                                                                    1 [3.0]                                            
      Cyst                                                                       1 [2.0]      3 [1.0]                               
      Hemorrhage                                                                 1 [2.0]                                            
      Pigmentation                                                               1 [3.0]                                            
   Uterus                                             (15)         (15)         (15)         (15)                                   
      Endometrium, Hyperplasia, Cystic                11 [1.0]      9 [1.3]     10 [1.3]     10 [1.2]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                      (2)                       (2)                                    
      Mediastinal, Hyperplasia, Lymphoid                            1 [2.0]                                                         
   Lymph Node, Mandibular                             (15)         (14)         (14)         (15)                                   
      Hyperplasia, Lymphoid                            4 [2.3]      2 [3.5]      2 [2.0]      3 [3.0]                               
   Lymph Node, Mesenteric                             (14)         (14)         (13)         (15)                                   
      Hyperplasia, Lymphoid                                                                   1 [3.0]                               
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                                       1 [2.0]      1 [3.0]      1 [2.0]                               
      Hematopoietic Cell Proliferation                 3 [1.7]      5 [1.4]      9 [1.9]     10 [2.1]                               
   Thymus                                             (15)         (14)         (15)         (15)                                   
      Atrophy                                          1 [3.0]      3 [3.0]      4 [2.8]      2 [2.5]                               
      Cyst                                             2 [1.0]      4 [1.0]      2 [1.0]      3 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04    
Route: SKIN APPLICATION                           WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 09:21:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/KG      64 MG/KG     128          256                                    
                                                                                MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
   Skin                                               (15)         (15)         (15)         (15)                                   
      Hyperkeratosis                                                1 [4.0]                                                         
      Inflammation, Chronic Active                                  1 [4.0]      1 [2.0]      1 [4.0]                               
      Inflammation, Suppurative                                     1 [3.0]                                                         
      Ulcer                                                                                   1 [4.0]                               
      Epidermis, Hyperplasia, Focal                    2 [2.0]      3 [2.3]      3 [3.3]      1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                                            (1)                                                              
      Fracture                                                      1                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                                  2 [1.0]                                                         
      Thrombosis                                                                              1 [1.0]                               
      Alveolar Epithelium, Hyperplasia                                                        1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Nephropathy                                      8 [1.0]      7 [1.0]     13 [1.0]     15 [1.0]                               
      Renal Tubule, Dilatation                         1 [1.0]                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04    
Route: SKIN APPLICATION                           WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 09:21:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/KG      64 MG/KG     128          256                                    
                                                                                MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            1                                                               
    Natural Death                                      1            3            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                12           11           13           15                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                                           1 [1.0]      1 [1.0]                               
      Inflammation, Chronic Active                    10 [1.0]      6 [1.0]      9 [1.0]     11 [1.0]                               
      Hepatocyte, Necrosis                             1 [2.0]      2 [2.0]                                                         
      Hepatocyte, Vacuolization Cytoplasmic            6 [1.2]      4 [1.3]      3 [1.0]      6 [1.8]                               
   Mesentery                                                       (1)          (1)                                                 
      Fat, Necrosis                                                 1 [4.0]      1 [4.0]                                            
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Epithelium, Hyperplasia                          1 [2.0]      2 [1.5]      1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Accessory Adrenal Cortical Nodule                1 [1.0]                                                                      
      Hypertrophy                                      8 [1.5]      4 [1.5]      1 [1.0]      3 [1.3]                               
      Subcapsular, Hyperplasia                                                   1 [1.0]                                            
   Pituitary Gland                                    (15)         (14)         (15)         (15)                                   
      Pars Distalis, Cyst                                           3 [1.0]      4 [1.0]      3 [1.0]                               
      Pars Distalis, Hyperplasia                                                 1 [1.0]                                            
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Infiltration Cellular, Lymphocyte                                          1 [1.0]                                            
      Follicle, Depletion Secretory                    7 [1.0]      4 [1.0]      5 [1.0]     11 [1.1]                               
      Follicular Cell, Hypertrophy                                  7 [1.0]     10 [1.3]     14 [1.4]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04    
Route: SKIN APPLICATION                           WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 09:21:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/KG      64 MG/KG     128          256                                    
                                                                                MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (15)         (15)         (15)         (15)                                   
      Degeneration                                     1 [4.0]                                2 [4.0]                               
   Testes                                             (15)         (15)         (15)         (15)                                   
      Cyst                                             1 [3.0]                                1 [2.0]                               
      Germinal Epithelium, Degeneration                2 [2.0]                   2 [2.0]      3 [1.7]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)                                   
      Necrosis, Lymphoid                               1 [2.0]      1 [1.0]                                                         
   Lymph Node, Mesenteric                             (15)         (15)         (15)         (15)                                   
      Necrosis, Lymphoid                               1 [2.0]                                                                      
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                          1 [3.0]                                                                      
      Hematopoietic Cell Proliferation                                           1 [2.0]      2 [2.0]                               
   Thymus                                             (14)         (15)         (15)         (15)                                   
      Atrophy                                          1 [2.0]      4 [2.5]      1 [3.0]      4 [2.5]                               
      Cyst                                             2 [1.0]      2 [1.5]      2 [1.0]      5 [1.0]                               
      Ectopic Parathyroid Gland                                     1 [1.0]                                                         
      Ectopic Thyroid                                               1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)                                   
      Hyperkeratosis                                   2 [2.0]                   3 [1.7]      4 [2.0]                               
      Hyperkeratosis, Focal                            1 [2.0]                                                                      
      Inflammation, Chronic Active                                  1 [1.0]                                                         
      Epidermis, Hyperplasia, Focal                    3 [2.0]      2 [1.5]      3 [1.3]      4 [1.8]                               
      Site of Application - Epidermis, Hyperplasia,                                                                                 
         Focal                                                                                1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/18/04    
Route: SKIN APPLICATION                           WATER DISINFECTION MODEL (SODIUM BROMATE)                       Time: 09:21:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/KG      64 MG/KG     128          256                                    
                                                                                MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                                  1 [1.0]                                                         
      Pigmentation                                                  1 [1.0]                                                         
      Thrombosis                                                                              1 [3.0]                               
      Alveolar Epithelium, Hyperplasia                 1 [1.0]                                                                      
      Alveolus, Infiltration Cellular, Histiocyte                   1 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Nephropathy                                      8 [1.0]      8 [1.1]     14 [1.0]     14 [1.1]                               
      Artery, Inflammation, Chronic Active             1 [2.0]                                                                      
      Renal Tubule, Dilatation                         1 [2.0]                                2 [1.5]                               
   Urethra                                                                                   (1)                                    
      Bulbourethral Gland, Cyst                                                               1 [4.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------