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TDMS Study 97013-13 Pathology Tables

NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05
Route: DOSED WATER                                                                                                Time: 10:01:33

                                                       FINAL #1/TGAC MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  79-43-6

       Lock Date:  07/31/01

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 MG/L
                               Include 002    0 MG/L
                               Include 003    500 MG/L
                               Include 004    500 MG/L
                               Include 005    1000MG/L
                               Include 006    1000MG/L
                               Include 007    2000MG/L
                               Include 008    2000MG/L


























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05    
Route: DOSED WATER                                                                                                Time: 10:01:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                              4            1            4                                     
    Natural Death                                                   3            1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                15            8           13           10                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                 2 (13%)                                                                      
      Inflammation, Chronic Active                    14 (93%)     10 (67%)     12 (80%)     12 (80%)                               
      Hepatocyte, Fatty Change                         2 (13%)      3 (20%)                                                         
      Hepatocyte, Necrosis                             1 (7%)       5 (33%)      1 (7%)       3 (20%)                               
      Hepatocyte, Vacuolization Cytoplasmic            6 (40%)     10 (67%)     14 (93%)     14 (93%)                               
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Epithelium, Hyperkeratosis                                    5 (33%)      1 (7%)       1 (7%)                                
      Epithelium, Hyperplasia                          2 (13%)      5 (33%)      2 (13%)      2 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Accessory Adrenal Cortical Nodule                2 (13%)      5 (33%)      4 (27%)      7 (47%)                               
      Subcapsular, Hyperplasia                        10 (67%)      7 (47%)      3 (20%)      9 (60%)                               
   Pituitary Gland                                    (15)         (14)         (15)         (15)                                   
      Pars Distalis, Cyst                              1 (7%)                    3 (20%)      4 (27%)                               
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Follicle, Degeneration                           4 (27%)      4 (27%)      4 (27%)      3 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05    
Route: DOSED WATER                                                                                                Time: 10:01:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (15)         (15)                                   
      Cyst                                             1 (7%)       1 (7%)       1 (7%)       2 (13%)                               
      Inflammation, Chronic Active                                  1 (7%)                                                          
      Pigmentation, Hemosiderin                                                               1 (7%)                                
   Uterus                                             (15)         (15)         (15)         (15)                                   
      Endometrium, Hyperplasia, Cystic                 9 (60%)      8 (53%)     10 (67%)      5 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (14)         (15)         (15)                                   
      Hyperplasia, Lymphoid                            3 (20%)      2 (14%)      3 (20%)      2 (13%)                               
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                                       1 (7%)       1 (7%)                                             
      Hematopoietic Cell Proliferation                 1 (7%)       1 (7%)                                                          
      Necrosis                                                                                1 (7%)                                
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                          1 (7%)       4 (27%)      3 (20%)      3 (20%)                               
      Cyst                                             4 (27%)      3 (20%)      4 (27%)      1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (4)          (4)          (2)          (8)                                    
      Hyperkeratosis                                                             1 (50%)                                            
      Epidermis, Hyperplasia                                                     1 (50%)      4 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05    
Route: DOSED WATER                                                                                                Time: 10:01:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Chronic Active                                  1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                     1 (7%)                                 1 (7%)                                
      Necrosis                                                                   1 (7%)                                             
      Nephropathy                                      5 (33%)      6 (40%)      5 (33%)      7 (47%)                               
      Cortex, Cyst                                     1 (7%)                                                                       
      Papilla, Necrosis                                                                       1 (7%)                                
      Renal Tubule, Dilatation                         3 (20%)      1 (7%)       1 (7%)                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05    
Route: DOSED WATER                                                                                                Time: 10:01:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1            2            4            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                14           13           11           14                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                              3 (20%)      2 (13%)      1 (7%)                                
      Inflammation, Chronic Active                     9 (60%)     13 (87%)     12 (80%)     11 (73%)                               
      Hepatocyte, Fatty Change                                      3 (20%)      1 (7%)                                             
      Hepatocyte, Necrosis                                          1 (7%)       1 (7%)                                             
      Hepatocyte, Vacuolization Cytoplasmic            7 (47%)     13 (87%)     15 (100%)    15 (100%)                              
   Mesentery                                          (1)          (1)          (2)                                                 
      Fat, Fibrosis                                                 1 (100%)     1 (50%)                                            
      Fat, Hemorrhage                                  1 (100%)     1 (100%)     2 (100%)                                           
      Fat, Inflammation, Chronic Active                1 (100%)     1 (100%)     2 (100%)                                           
      Fat, Necrosis                                    1 (100%)     1 (100%)     2 (100%)                                           
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                                                            1 (7%)                                
      Epithelium, Hyperkeratosis                                                 1 (7%)       1 (7%)                                
      Epithelium, Hyperplasia                          2 (13%)      4 (27%)      3 (20%)      6 (40%)                               
   Stomach, Glandular                                                                        (1)                                    
      Glands, Ectasia                                                                         1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Accessory Adrenal Cortical Nodule                1 (7%)                    1 (7%)       2 (13%)                               
      Hypertrophy                                      8 (53%)      9 (60%)      8 (53%)      8 (53%)                               
      Subcapsular, Hyperplasia                         2 (13%)                   2 (13%)                                            
   Pituitary Gland                                    (14)         (15)         (15)         (15)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05    
Route: DOSED WATER                                                                                                Time: 10:01:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Cyst                              1 (7%)       1 (7%)       1 (7%)       1 (7%)                                
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Infiltration Cellular, Lymphocyte                             1 (7%)                                                          
      Follicle, Degeneration                           7 (47%)      8 (53%)      5 (33%)      5 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (15)         (15)         (15)         (15)                                   
      Degeneration                                     2 (13%)      2 (13%)      2 (13%)      2 (13%)                               
   Preputial Gland                                                 (2)          (1)                                                 
      Duct, Ectasia                                                 2 (100%)     1 (100%)                                           
   Seminal Vesicle                                    (1)                                                                           
      Inflammation, Chronic Active                     1 (100%)                                                                     
   Testes                                             (15)         (15)         (15)         (15)                                   
      Cyst                                             1 (7%)       1 (7%)       1 (7%)       1 (7%)                                
      Germinal Epithelium, Degeneration                2 (13%)      2 (13%)      1 (7%)       2 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (14)         (15)         (14)                                   
      Hyperplasia, Lymphoid                            1 (7%)       3 (21%)      2 (13%)                                            
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                                           2 (13%)      1 (7%)                                
   Thymus                                             (15)         (15)         (14)         (14)                                   
      Atrophy                                          1 (7%)       3 (20%)      4 (29%)                                            
      Cyst                                             1 (7%)       2 (13%)      1 (7%)       2 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (4)          (4)          (4)          (6)                                    
      Inflammation, Chronic Active                                                            1 (17%)                               
      Epidermis, Hyperplasia                           1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05    
Route: DOSED WATER                                                                                                Time: 10:01:33    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                                  4 (27%)      2 (13%)      1 (7%)                                
      Alveolar Epithelium, Hyperplasia                                           1 (7%)       1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                                  1 (7%)                                                          
      Necrosis                                                      1 (7%)                                                          
      Nephropathy                                     10 (67%)      9 (60%)     12 (80%)     14 (93%)                               
      Renal Tubule, Dilatation                         1 (7%)                                 2 (13%)                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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