NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: DOSED WATER Time: 10:01:33
FINAL #1/TGAC MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 79-43-6
Lock Date: 07/31/01
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 MG/L
Include 002 0 MG/L
Include 003 500 MG/L
Include 004 500 MG/L
Include 005 1000MG/L
Include 006 1000MG/L
Include 007 2000MG/L
Include 008 2000MG/L
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: DOSED WATER Time: 10:01:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 4 1 4
Natural Death 3 1 1
Survivors
Terminal Sacrifice 15 8 13 10
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 2 (13%)
Inflammation, Chronic Active 14 (93%) 10 (67%) 12 (80%) 12 (80%)
Hepatocyte, Fatty Change 2 (13%) 3 (20%)
Hepatocyte, Necrosis 1 (7%) 5 (33%) 1 (7%) 3 (20%)
Hepatocyte, Vacuolization Cytoplasmic 6 (40%) 10 (67%) 14 (93%) 14 (93%)
Stomach, Forestomach (15) (15) (15) (15)
Epithelium, Hyperkeratosis 5 (33%) 1 (7%) 1 (7%)
Epithelium, Hyperplasia 2 (13%) 5 (33%) 2 (13%) 2 (13%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Accessory Adrenal Cortical Nodule 2 (13%) 5 (33%) 4 (27%) 7 (47%)
Subcapsular, Hyperplasia 10 (67%) 7 (47%) 3 (20%) 9 (60%)
Pituitary Gland (15) (14) (15) (15)
Pars Distalis, Cyst 1 (7%) 3 (20%) 4 (27%)
Thyroid Gland (15) (15) (15) (15)
Follicle, Degeneration 4 (27%) 4 (27%) 4 (27%) 3 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: DOSED WATER Time: 10:01:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15)
Cyst 1 (7%) 1 (7%) 1 (7%) 2 (13%)
Inflammation, Chronic Active 1 (7%)
Pigmentation, Hemosiderin 1 (7%)
Uterus (15) (15) (15) (15)
Endometrium, Hyperplasia, Cystic 9 (60%) 8 (53%) 10 (67%) 5 (33%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (14) (15) (15)
Hyperplasia, Lymphoid 3 (20%) 2 (14%) 3 (20%) 2 (13%)
Spleen (15) (15) (15) (15)
Atrophy 1 (7%) 1 (7%)
Hematopoietic Cell Proliferation 1 (7%) 1 (7%)
Necrosis 1 (7%)
Thymus (15) (15) (15) (15)
Atrophy 1 (7%) 4 (27%) 3 (20%) 3 (20%)
Cyst 4 (27%) 3 (20%) 4 (27%) 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (4) (4) (2) (8)
Hyperkeratosis 1 (50%)
Epidermis, Hyperplasia 1 (50%) 4 (50%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: DOSED WATER Time: 10:01:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Chronic Active 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Inflammation, Chronic Active 1 (7%) 1 (7%)
Necrosis 1 (7%)
Nephropathy 5 (33%) 6 (40%) 5 (33%) 7 (47%)
Cortex, Cyst 1 (7%)
Papilla, Necrosis 1 (7%)
Renal Tubule, Dilatation 3 (20%) 1 (7%) 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: DOSED WATER Time: 10:01:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 1 2 4 1
Survivors
Terminal Sacrifice 14 13 11 14
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 3 (20%) 2 (13%) 1 (7%)
Inflammation, Chronic Active 9 (60%) 13 (87%) 12 (80%) 11 (73%)
Hepatocyte, Fatty Change 3 (20%) 1 (7%)
Hepatocyte, Necrosis 1 (7%) 1 (7%)
Hepatocyte, Vacuolization Cytoplasmic 7 (47%) 13 (87%) 15 (100%) 15 (100%)
Mesentery (1) (1) (2)
Fat, Fibrosis 1 (100%) 1 (50%)
Fat, Hemorrhage 1 (100%) 1 (100%) 2 (100%)
Fat, Inflammation, Chronic Active 1 (100%) 1 (100%) 2 (100%)
Fat, Necrosis 1 (100%) 1 (100%) 2 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Inflammation, Chronic Active 1 (7%)
Epithelium, Hyperkeratosis 1 (7%) 1 (7%)
Epithelium, Hyperplasia 2 (13%) 4 (27%) 3 (20%) 6 (40%)
Stomach, Glandular (1)
Glands, Ectasia 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Accessory Adrenal Cortical Nodule 1 (7%) 1 (7%) 2 (13%)
Hypertrophy 8 (53%) 9 (60%) 8 (53%) 8 (53%)
Subcapsular, Hyperplasia 2 (13%) 2 (13%)
Pituitary Gland (14) (15) (15) (15)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: DOSED WATER Time: 10:01:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Cyst 1 (7%) 1 (7%) 1 (7%) 1 (7%)
Thyroid Gland (15) (15) (15) (15)
Infiltration Cellular, Lymphocyte 1 (7%)
Follicle, Degeneration 7 (47%) 8 (53%) 5 (33%) 5 (33%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
Degeneration 2 (13%) 2 (13%) 2 (13%) 2 (13%)
Preputial Gland (2) (1)
Duct, Ectasia 2 (100%) 1 (100%)
Seminal Vesicle (1)
Inflammation, Chronic Active 1 (100%)
Testes (15) (15) (15) (15)
Cyst 1 (7%) 1 (7%) 1 (7%) 1 (7%)
Germinal Epithelium, Degeneration 2 (13%) 2 (13%) 1 (7%) 2 (13%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (14) (15) (14)
Hyperplasia, Lymphoid 1 (7%) 3 (21%) 2 (13%)
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 2 (13%) 1 (7%)
Thymus (15) (15) (14) (14)
Atrophy 1 (7%) 3 (20%) 4 (29%)
Cyst 1 (7%) 2 (13%) 1 (7%) 2 (14%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (4) (4) (4) (6)
Inflammation, Chronic Active 1 (17%)
Epidermis, Hyperplasia 1 (25%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: DOSED WATER Time: 10:01:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Inflammation, Chronic Active 4 (27%) 2 (13%) 1 (7%)
Alveolar Epithelium, Hyperplasia 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Inflammation, Chronic Active 1 (7%)
Necrosis 1 (7%)
Nephropathy 10 (67%) 9 (60%) 12 (80%) 14 (93%)
Renal Tubule, Dilatation 1 (7%) 2 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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