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TDMS Study 97013-98 Pathology Tables

NTP Experiment-Test: 97013-98         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03
Route: GAVAGE                                                                                                     Time: 12:04:54

                                                          FINAL#1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  75-27-4

       Lock Date:  07/19/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 97013-98         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:04:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/KG      25 MG/KG     50 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      1                                                                            
    Moribund Sacrifice                                              1            1            1                                     
    Dosing Accident                                                              1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9            9            8            9                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                                                    (1)                                                 
      Perforation                                                                1 (100%)                                           
   Liver                                              (10)         (10)         (10)         (10)                                   
      Infiltration Cellular, Lymphocyte                3 (30%)      2 (20%)      3 (30%)                                            
      Inflammation                                     6 (60%)     10 (100%)     7 (70%)      8 (80%)                               
      Necrosis                                                      2 (20%)      1 (10%)                                            
      Hepatocyte, Fatty Change                         3 (30%)      3 (30%)      6 (60%)      9 (90%)                               
      Hepatocyte, Vacuolization Cytoplasmic            9 (90%)     10 (100%)     9 (90%)     10 (100%)                              
   Mesentery                                                                    (1)                                                 
      Inflammation, Suppurative                                                  1 (100%)                                           
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Hyperkeratosis                                                             1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Subcapsular, Hyperplasia                        10 (100%)     9 (90%)      9 (90%)     10 (100%)                              
   Parathyroid Gland                                  (1)                                                                           
      Cyst                                             1 (100%)                                                                     
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Cyst                                                                       1 (10%)                                            
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Inflammation                                     1 (10%)                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-98         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:04:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/KG      25 MG/KG     50 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (10)         (10)                                   
      Atrophy                                          1 (10%)      1 (10%)                                                         
      Cyst                                                                       3 (30%)      1 (10%)                               
   Oviduct                                            (2)                       (1)                                                 
      Infiltration Cellular, Lymphocyte                2 (100%)                  1 (100%)                                           
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Inflammation                                     2 (20%)      2 (20%)      1 (10%)      1 (10%)                               
      Endometrium, Hyperplasia, Cystic                 9 (90%)      8 (80%)      8 (80%)     10 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
      Hyperplasia                                                   1 (10%)                                                         
   Lymph Node, Mesenteric                             (10)         (10)         (10)         (10)                                   
      Atrophy                                          1 (10%)                                1 (10%)                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                          1 (10%)                                                                      
      Hematopoietic Cell Proliferation                 1 (10%)      1 (10%)      1 (10%)                                            
   Thymus                                             (9)          (10)         (10)         (10)                                   
      Atrophy                                          1 (11%)      2 (20%)      2 (20%)      1 (10%)                               
      Cyst                                             6 (67%)      8 (80%)      8 (80%)      8 (80%)                               
      Necrosis                                                                   1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-98         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:04:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/KG      25 MG/KG     50 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Infiltration Cellular, Lymphocyte                1 (10%)      2 (20%)      1 (10%)                                            
      Alveolar Epithelium, Hyperplasia                              1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Accumulation, Hyaline Droplet                                              1 (10%)                                            
      Casts Protein                                    7 (70%)      4 (40%)      6 (60%)      6 (60%)                               
      Mineralization                                   1 (10%)                                                                      
      Nephropathy                                      2 (20%)      3 (30%)      1 (10%)                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-98         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:04:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/KG      25 MG/KG     50 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                              1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                10            9           10           10                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                              1 (10%)                                                         
      Infiltration Cellular, Lymphocyte                2 (20%)      3 (30%)      1 (10%)      3 (30%)                               
      Inflammation                                     7 (70%)      9 (90%)      9 (90%)      9 (90%)                               
      Necrosis                                                                                1 (10%)                               
      Hepatocyte, Fatty Change                         6 (60%)      6 (60%)      5 (50%)     10 (100%)                              
      Hepatocyte, Vacuolization Cytoplasmic           10 (100%)     9 (90%)     10 (100%)    10 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Hypertrophy                                      3 (30%)      2 (20%)      2 (20%)      1 (10%)                               
      Subcapsular, Hyperplasia                         2 (20%)                   1 (10%)      2 (20%)                               
   Parathyroid Gland                                  (1)                                                                           
      Cyst                                             1 (100%)                                                                     
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Cyst                                             4 (40%)      2 (20%)      3 (30%)      1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-98         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:04:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/KG      25 MG/KG     50 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)         (10)         (10)         (10)                                   
      Infiltration Cellular, Lymphocyte                1 (10%)      1 (10%)                                                         
      Inflammation                                                               1 (10%)                                            
   Testes                                             (10)         (10)         (10)         (10)                                   
      Mineralization                                                2 (20%)      1 (10%)                                            
      Germinal Epithelium, Degeneration                2 (20%)      5 (50%)      2 (20%)      2 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (9)          (10)         (10)         (10)                                   
      Infiltration Cellular, Polymorphonuclear                                                1 (10%)                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                              1 (10%)                                                         
   Thymus                                             (9)          (10)         (9)          (10)                                   
      Cyst                                             6 (67%)      7 (70%)      6 (67%)      4 (40%)                               
      Epithelial Cell, Hyperplasia                                  1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Infiltration Cellular, Lymphocyte                1 (10%)      1 (10%)                                                         
      Alveolar Epithelium, Hyperplasia                                           1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-98         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:04:54    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/KG      25 MG/KG     50 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Casts Protein                                    1 (10%)      2 (20%)                                                         
      Cyst                                             1 (10%)                                                                      
      Mineralization                                                                          1 (10%)                               
      Nephropathy                                      4 (40%)      3 (30%)      4 (40%)      9 (90%)                               
      Renal Tubule, Degeneration                                    1 (10%)                  10 (100%)                              
      Renal Tubule, Dilatation                                      1 (10%)                                                         
      Renal Tubule, Vacuolization Cytoplasmic          8 (80%)      5 (50%)      1 (10%)                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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