National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13606

TDMS Study 97013-98 Pathology Tables

NTP Experiment-Test: 97013-98         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/04/03
Route: GAVAGE                                  WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 12:09:51

                                                          FINAL#1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  75-27-4

       Lock Date:  07/19/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 97013-98         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/04/03    
Route: GAVAGE                                  WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 12:09:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/KG      25 MG/KG     50 MG/KG     100                                    
                                                                                             MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      1                                                                            
    Moribund Sacrifice                                              1            1            1                                     
    Dosing Accident                                                              1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9            9            8            9                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                                                    (1)                                                 
      Perforation                                                                1                                                  
   Liver                                              (10)         (10)         (10)         (10)                                   
      Infiltration Cellular, Lymphocyte                3 [2.0]      2 [1.0]      3 [1.3]                                            
      Inflammation                                     6 [1.0]     10 [1.0]      7 [1.0]      8 [1.0]                               
      Necrosis                                                      2 [1.0]      1 [3.0]                                            
      Hepatocyte, Fatty Change                         3 [1.3]      3 [1.3]      6 [1.3]      9 [2.3]                               
      Hepatocyte, Vacuolization Cytoplasmic            9 [1.8]     10 [1.6]      9 [2.1]     10 [2.4]                               
   Mesentery                                                                    (1)                                                 
      Inflammation, Suppurative                                                  1 [2.0]                                            
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Hyperkeratosis                                                             1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Subcapsular, Hyperplasia                        10 [1.0]      9 [1.0]      9 [1.0]     10 [1.0]                               
   Parathyroid Gland                                  (1)                                                                           
      Cyst                                             1 [1.0]                                                                      
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Cyst                                                                       1 [1.0]                                            
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Inflammation                                     1 [1.0]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-98         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/04/03    
Route: GAVAGE                                  WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 12:09:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/KG      25 MG/KG     50 MG/KG     100                                    
                                                                                             MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (10)         (10)                                   
      Atrophy                                          1 [2.0]      1 [3.0]                                                         
      Cyst                                                                       3 [1.3]      1 [1.0]                               
   Oviduct                                            (2)                       (1)                                                 
      Infiltration Cellular, Lymphocyte                2 [2.0]                   1 [1.0]                                            
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Inflammation                                     2 [1.0]      2 [1.0]      1 [1.0]      1 [1.0]                               
      Endometrium, Hyperplasia, Cystic                 9 [1.7]      8 [1.6]      8 [1.9]     10 [1.7]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
      Hyperplasia                                                   1 [2.0]                                                         
   Lymph Node, Mesenteric                             (10)         (10)         (10)         (10)                                   
      Atrophy                                          1 [1.0]                                1 [2.0]                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                          1 [2.0]                                                                      
      Hematopoietic Cell Proliferation                 1 [1.0]      1 [1.0]      1 [3.0]                                            
   Thymus                                             (9)          (10)         (10)         (10)                                   
      Atrophy                                          1 [4.0]      2 [2.5]      2 [3.0]      1 [3.0]                               
      Cyst                                             6 [1.0]      8 [1.3]      8 [1.0]      8 [1.1]                               
      Necrosis                                                                   1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-98         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/04/03    
Route: GAVAGE                                  WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 12:09:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/KG      25 MG/KG     50 MG/KG     100                                    
                                                                                             MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Infiltration Cellular, Lymphocyte                1 [1.0]      2 [1.0]      1 [1.0]                                            
      Alveolar Epithelium, Hyperplasia                              1 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Accumulation, Hyaline Droplet                                              1 [3.0]                                            
      Casts Protein                                    7 [1.0]      4 [1.0]      6 [1.0]      6 [1.0]                               
      Mineralization                                   1 [1.0]                                                                      
      Nephropathy                                      2 [1.0]      3 [1.0]      1 [1.0]                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-98         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/04/03    
Route: GAVAGE                                  WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 12:09:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/KG      25 MG/KG     50 MG/KG     100                                    
                                                                                             MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                              1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                10            9           10           10                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                              1 [1.0]                                                         
      Infiltration Cellular, Lymphocyte                2 [1.5]      3 [1.0]      1 [2.0]      3 [1.3]                               
      Inflammation                                     7 [1.0]      9 [1.1]      9 [1.0]      9 [1.0]                               
      Necrosis                                                                                1 [1.0]                               
      Hepatocyte, Fatty Change                         6 [1.3]      6 [1.0]      5 [1.8]     10 [3.0]                               
      Hepatocyte, Vacuolization Cytoplasmic           10 [3.1]      9 [2.9]     10 [2.7]     10 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Hypertrophy                                      3 [1.0]      2 [1.0]      2 [1.0]      1 [1.0]                               
      Subcapsular, Hyperplasia                         2 [1.0]                   1 [1.0]      2 [1.0]                               
   Parathyroid Gland                                  (1)                                                                           
      Cyst                                             1 [2.0]                                                                      
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Cyst                                             4 [1.0]      2 [1.0]      3 [1.0]      1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-98         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/04/03    
Route: GAVAGE                                  WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 12:09:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/KG      25 MG/KG     50 MG/KG     100                                    
                                                                                             MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)         (10)         (10)         (10)                                   
      Infiltration Cellular, Lymphocyte                1 [2.0]      1 [2.0]                                                         
      Inflammation                                                               1 [2.0]                                            
   Testes                                             (10)         (10)         (10)         (10)                                   
      Mineralization                                                2 [1.0]      1 [1.0]                                            
      Germinal Epithelium, Degeneration                2 [1.0]      5 [1.4]      2 [1.5]      2 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (9)          (10)         (10)         (10)                                   
      Infiltration Cellular, Polymorphonuclear                                                1 [1.0]                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                              1 [3.0]                                                         
   Thymus                                             (9)          (10)         (9)          (10)                                   
      Cyst                                             6 [1.2]      7 [1.0]      6 [1.3]      4 [1.0]                               
      Epithelial Cell, Hyperplasia                                  1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Infiltration Cellular, Lymphocyte                1 [1.0]      1 [1.0]                                                         
      Alveolar Epithelium, Hyperplasia                                           1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-98         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/04/03    
Route: GAVAGE                                  WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 12:09:51    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/KG      25 MG/KG     50 MG/KG     100                                    
                                                                                             MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Casts Protein                                    1 [1.0]      2 [1.0]                                                         
      Cyst                                             1 [1.0]                                                                      
      Mineralization                                                                          1 [2.0]                               
      Nephropathy                                      4 [1.0]      3 [1.0]      4 [1.0]      9 [1.0]                               
      Renal Tubule, Degeneration                                    1 [3.0]                  10 [2.5]                               
      Renal Tubule, Dilatation                                      1 [1.0]                                                         
      Renal Tubule, Vacuolization Cytoplasmic          8 [1.1]      5 [1.0]      1 [1.0]                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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