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TDMS Study 97013-99 Pathology Tables

NTP  EXP/TEST: 97013-99                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/05/03
ROUTE: SKIN APPLICATION                                                                                           TIME: 09:59:42

                                                         EIS REPORT 37


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  97013F

       CONTRACT NUMBER:  NO1-ES-65406

       CAS NUMBER:  75-27-4

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 97013-99                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 2
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/05/03
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:59:42
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 2                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: FEMALE                               TRT: 0 MG/KG            PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-99                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 3
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/05/03
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:59:42
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 4                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: FEMALE                               TRT: 64 MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

1259       1259  134 12/30/99   134 12/30/99   1/28  Irritation Site Of Application

  REMOVED  **  CID  1259 **   REASON - MSAC
                                196 03/01/00         Thin
                                196 03/01/00         Ruffled Fur

NTP  EXP/TEST: 97013-99                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 4
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/05/03
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:59:42
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 6                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: FEMALE                               TRT: 128     MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-99                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 5
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/05/03
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:59:42
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 8                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: FEMALE                               TRT: 256     MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-99                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 6
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/05/03
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:59:42
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 1                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: MALE                                 TRT: 0 MG/KG            PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-99                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 7
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/05/03
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:59:42
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 3                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: MALE                                 TRT: 64 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-99                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 8
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/05/03
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:59:42
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 5                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: MALE                                 TRT: 128     MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

1229       1229  169 02/03/00   176 02/10/00   2/39  Irritation Site Of Application
                 232 04/06/00   267 05/11/00   6/39  Papilloma Site Of Application Small 1

  REMOVED  **  CID  1229 **   REASON - TSAC
                                274 05/18/00         Papilloma Site Of Application Small 1
                                274 05/18/00         Papilloma Head Small 5

NTP  EXP/TEST: 97013-99                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 9
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 11/05/03
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:59:42
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 7                      ROOM/AREA:    235         FIRST DOSE: 08/19/99
            SEX: MALE                                 TRT: 256     MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

1240       1240  260 05/04/00   260 05/04/00   1/39  Papilloma Site Of Application Small 1
                 267 05/11/00   267 05/11/00   1/39  Papilloma Site Of Application Small 2

  REMOVED  **  CID  1240 **   REASON - TSAC
                                274 05/18/00         Papilloma Site Of Application Small 3
                                274 05/18/00         Papilloma Head Small 3
                                274 05/18/00         Papilloma Torso/Ventral Small 3



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