National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/10335

Abstract for TR-109 - 4-Nitroanthranilic Acid (CASRN 619-17-0)

ABSTRACT

Bioassay of 4-Nitroanthranilic Acid for Possible Carcinogenicity (CAS No. 619-17-0)

Link to the full study report in PDF. If you have difficulty accessing the document, please send email to the NTP Webmaster [ Send Email ] and identify documents/pages for which access is required.  

 

Chemical Formula:  C7H6N2O4

4-Nitroanthranilic acid, a nitrobenzene derivative formerly used as a dye intermediate, was selected for bioassay by the National Cancer Institute along with other dye intermediates in an attempt to identify those chemicals which may be responsible for the increased incidence of bladder cancer observed among workers in the dye manufacturing industry.

A bioassay of 4-nitroanthranilic acid for possible carcinogenicity was conducted using Fischer 344 rats and B6C3F1 mice. 4-Nitroanthranilic acid was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. The high and low time-weighted average concentrations used for the chronic study were, respectively, 1.5 and 0.46 percent for rats and 1.0 and 0.46 percent for mice. After a 78-week period of chemical administration, the rats were observed for an additional period of up to 32 weeks and the mice for an additional period of up to 17 weeks. For rats 50 animals of each sex were placed on test as low dose controls and 25 animals of each sex were placed on test as high dose controls. For mice 50 animals of each sex were placed on test as controls for each dose group.

No statistically significant increases in tumor incidence were observed among rats or mice receiving diets containing 4-nitroanthranilic acid.

Under the conditions of this bioassay evidence was not provided for the carcinogenicity of 4-nitroanthranilic acid in Fischer 344 rats or B6C3F1 mice.

 

Levels of Evidence of Carcinogenicity:
Sex Species Results
Male Rats: Negative
Female Rats: Negative
Male Mice: Negative
Female Mice: Negative

Synonym: 2-amino-4-nitro-benzoic acid


Report Date: 1978

Target Organs from 2-year Studies


Return to Long Term Abstracts

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.