National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/11790

Abstract for TR-121 - Dimethyl Terephthalate (CASRN 120-61-6)

Bioassay of Dimethyl Terephthalate for Possible Carcinogenicity (CAS No. 120-61-6)

Link to the full study report in PDF. If you have difficulty accessing the document, please send email to the NTP Webmaster [ Send Email ] and identify documents/pages for which access is required.  

 

Chemical Formula:  C10H10O4


 

Dimethyl terephthalate is one of the basic monomers used in the synthesis of polyester fibers.

A bioassay of dimethyl terephthalate for possible carcinogenicity was conducted by administering the test chemical in feed to F344 rats and B6C3F1 mice.

Groups of 50 rats of each sex and 50 mice of each sex were administered dimethyl terephthalate at one of two doses, either 2,500 or 5,000 ppm, for 103 weeks, then observed for 2 additional weeks. Matched controls consisted of 50 untreated rats of each sex and 50 untreated mice of each sex. All surviving rats were killed at 105 or 106 weeks and all surviving mice at 104 or 105 weeks.

Administration of dimethyl terephthalate had no appreciable effect on the mean body weights of the rats and mice of either sex. No clinical signs related to administration of the test chemical were noted in the rats. Survivals of the rats and mice at the end of the bioassay were not affected by thetest chemical. Both species may have been able to tolerate higher doses.

In rats and mice of each sex, no tumors occurred at incidences that clearly were related to administration of the test chemical.

Although it is recognized that both rats and mice may not have received a dose of the test chemical sufficiently high to provide maximum test sensitivity, it is concluded that under the conditions of this bioassay, dimethyl terephthalate was not carcinogenic for F344 rats or B6C3F1 mice.

 

Levels of Evidence of Carcinogenicity:
Sex Species Results
Male Rats: Negative
Female Rats: Negative
Male Mice: Equivocal
Female Mice: Negative

Report Date: 1979

Target Organs from 2-year Studies


Return to Long Term Abstracts

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.