Share This:
https://ntp.niehs.nih.gov/go/9539

Target Organs and Levels of Evidence for TR-429

Toxicology and Carcinogenesis Studies of Diethylphthalate (CASRN 84-66-2) in F344/N Rats and B6C3F1 Mice (Dermal Studies) with Dermal Initiation/Promotion Study of Diethylphthalate and Dimethylphthalate (CASRN 131-11-3) in Male Swiss (CD-1®) Mice

Chemical (Study Title)
CASRN
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Diethyl phthalate
84-66-2
11/17/1993 In manufacture of celluloid, cosmetics, varnishes, and dopes. Plasticizer for cellulose ester plastics. Insecticide sprays. Used as phthalate plasticizers, in an extensive array of products. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. Topical Application
R: 0,100,300 M: 0,7.5,15,30 UL/100 UL SOLUTION /50 PER GROUP
Hazleton Labs, Rockville, Goverment Services, Inc

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: ACANTHOSIS
Other Considerations
  • LIVER: FATTY DEGENERATION 26/50 8/50 4/51
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: ACANTHOSIS
Other Considerations
  • LIVER: FATTY DEGENERATION 23/50 11/50 3/50
  • MAMMARY GLAND: FIBROADENOMA 21/51 12/50 7/50
Male Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 6/50 11/50 9/50 12/50 OR CARCINOMA 4/50 4/50 6/50 7/50 COMBINED 9/50 14/50 14/50 18/50
Non-Neoplastic Lesions
  • LIVER: BASOPHILIC FOCI
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 4/50 12/51 14/50 10/50 OR CARCINOMA 4/50 5/51 6/50 3/50 COMBINED 7/50 16/51 19/50 12/50


Chemical (Study Title)
CASRN
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Diethyl phthalate/dimethyl phthalate
DIETH/DIMETH
11/17/1993 Diethyl: celluloid manufacture, cosmetics, varnishes, dopes, insecticidal soaps, plasticizer. Dimethyl: insecticides, plasticizer, solvent, dye carrier, rocket fuel. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. Topical Application
100 UL (PROMOTOR) NEAT CHEMICAL ON UNINITIATED AND DMBA INITIATED SKIN
Hazleton Labs, Rockville, Goverment Services, Inc

Levels of Evidence



Type Organ/Tissue (Lesion)
Note 1-YEAR DERMAL INITIATION/PROMOTION STUDY IN MALE SWISS CD-1 MICE. THERE WAS NO EVIDENCE OF INITIATING OR PROMOTING ACTIVITY. MINOR DERMAL ACANTHOSIS WAS OBSERVED FOLLOWING 1 YEAR EXPOSURE TO DIETHYLPHTHALATE OR DIMETHYLPHTHALATE.