National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/14588

Target Organs and Levels of Evidence for TR-005

Bioassay of Proflavine for Possible Carcinogenicity (CASRN 952-23-8)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Proflavin hydrochloride
952-23-8
03/25/1977Bacteriostatic, treatment of psoriasis and type - ii herpes virus infections.Dosed-Feed
R: 0,300,600, M: 0,200,400 PPM/50 PER GROUP
Dow

Levels of Evidence

Male Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Intestines: (LEIOMYOSARCOMA)
Female Rats: Negative
Male Mice: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
Female Mice: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)


NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.