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Target Organs and Levels of Evidence for TR-006

Bioassays of Nitrilotriacetic Acid (NTA) and Nitrilotriacetic Acid, Trisodium Salt, Monohydrate (Na3-NTA-H2O) for Possible Carcinogenicity (CASRN 139-13-9) (NTA) (CASRN 18662-53-8) (Na3-NTA-H2O)

Chemical (Study Title)
CASRN
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Nitrilotriacetic acid (NTA)
139-13-9
03/25/1977 Chelating agent; detergents; water and textile treatment; metal plating; pulp and paper processing Dosed-Feed
R: 0,7500,15000, M: 0,2500,5000,7500,15000 PPM/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA OR ADENOCARCINOMA
  • Ureter: (ADENOMA OR PAPILLOMA)
Female Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Urinary Bladder: (TRANSITIONAL CELL CARCINOMA)
Male Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOCARCINOMA
Female Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOCARCINOMA


Chemical (Study Title)
CASRN
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Nitrilotriacetic acid trisodium monohydrate
18662-53-8
03/25/1977 Detergents Dosed-Feed
0,200,2000,20000 PPM/48 PER GROUP
SRI International

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Transitional Cell: CARCINOMA
  • Kidney Tubular Cell: ADENOCARCINOMA OR CARCINOMA
  • Ureter: (TRANSITIONAL CELL CARCINOMA)
Female Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA OR ADENOCARCINOMA
  • Ureter: (TRANSITIONAL CELL CARCINOMA)
  • Urinary Bladder: (TRANSITIONAL CELL CARCINOMA)


Chemical (Study Title)
CASRN
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Nitrilotriacetic acid trisodium monohydrate
18662-53-8
03/25/1977 Detergents Dosed-Feed
R: 0,7500,15000, M: 0,2500,5000 PPM/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Equivocal
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Transitional Cell: PAPILLOMA
  • Kidney Tubular Cell: ADENOCARCINOMA
Female Rats: Equivocal
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Urinary Bladder: (TRANSITIONAL CELL CARCINOMA)
Male Mice: Negative
Female Mice: Negative