National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/10929

Target Organs and Levels of Evidence for TR-015

Bioassay of Captan for Possible Carcinogenicity (CASRN 133-06-2)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Captan
133-06-2
07/25/1977Fungicide, bacteriostat in soap (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R: 0,2525,6050 (AVG), M: 0,8000,16000 PPM/50 PER GROUP
Gulf South Research Institute

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Intestines: (POLYPOID CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Intestines: (POLYPOID CARCINOMA)


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