National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/10935

Target Organs and Levels of Evidence for TR-018

Bioassay of 3,3'-Iminobis-1-propanol Dimethanesulfonate (Ester) Hydrochloride (IPD) for Possible Carcinogenicity (CASRN 3458-22-8)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
IPD (3,3'-iminobis-1-propanol dimethanesulfonate (ester) hydrochloride)
3458-22-8
11/28/1977Anticancer drugIntraperitoneal Injection
R: 0,12,24,48, M: 0,20,40 MG/KG/35 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Mesothelium (Abdominal Cavity/Tunica Vaginalis): FIBROMA OR FIBROSARCOMA OR SARCOMA
Female Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Mesothelium (Abdominal Cavity/Tunica Vaginalis): FIBROSARCOMA OR SARCOMA
Male Mice: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Subcutaneous Tissue: (SQUAMOUS CELL CARCINOMA)
  • Hematopoietic System: (LYMPHOMA)
Female Mice: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Subcutaneous Tissue: (SQUAMOUS CELL CARCINOMA)
  • Hematopoietic System: (LYMPHOMA)


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