National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/10937

Target Organs and Levels of Evidence for TR-019

Bioassay of Procarbazine for Possible Carcinogenicity (CASRN 366-70-1)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Procarbazine hydrochloride
366-70-1
NAAntineoplasticIntraperitoneal Injection
R: 0,15,30, M: 0,6,12 MG/KG/35 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: (LYMPHOMA OR LEUKEMIA)
  • Mammary Gland: (ADENOCARCINOMA)
  • Brain: (ADENOCARCINOMA, NEUROBLASTOMA, CARCINOMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: (LYMPHOMA)
  • Mammary Gland: (ADENOCARCINOMA)
  • Brain: (NEUROBLASTOMA)
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: (LYMPHOMA OR LEUKEMIA)
  • Brain: (NEUROBLASTOMA)
  • Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: (LYMPHOMA OR LEUKEMIA)
  • Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA)
  • Brain: (NEUROBLASTOMA)
  • Uterus/Cervix: (ADENOCARCINOMA)


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