Share This:
https://ntp.niehs.nih.gov/go/10939

Target Organs and Levels of Evidence for TR-020

Bioassay of Dapsone for Possible Carcinogenicity (CASRN 80-08-0)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
4,4'-Sulfonyldianiline (Dapsone)
80-08-0
07/25/1977Hardening agent for epoxy resins; topical antibacterial agent; treatment of gynecologic neoplasms; antibacterial/antiprotozoal in veterinary medicine, used in treatment of leprosyDosed-Feed
R: 0,600,1200, M: 0,500,1000 PPM/35 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Spleen: (FIBROMA, FIBROSARCOMA, SARCOMA)
Female Rats: Negative
Male Mice: Negative
Female Mice: Negative