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Target Organs and Levels of Evidence for TR-027

Bioassay of 1,1,2,2-Tetrachloroethane for Possible Carcinogenicity (CASRN 79-34-5)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1,1,2,2-Tetrachloroethane
79-34-5
09/26/1977Solvent; soil sterilization; herbicides; insecticides; paints; varnish; metal cleaners and degreasers. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
FR: 0,43,76 (AVG), MR: 0,62,108 (AVG), M: 0,142,284 (AVG) MG/KG/50 PER GROUP
Hazleton, Vienna

Levels of Evidence

Male Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
Female Rats: Negative
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)