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Target Organs and Levels of Evidence for TR-028

Bioassay of Dibromochloropropane for Possible Carcinogenicity (CASRN 96-12-8)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1,2-Dibromo-3-chloropropane
96-12-8
09/26/1977Soil fumigant. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R:0,15,29 MM:0,114,219 FM:0,110,209 MG/KG/50 PER GROUP
Hazleton, Vienna

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: (SQUAMOUS CELL CARCINOMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: (SQUAMOUS CELL CARCINOMA)
  • Mammary Gland: (ADENOCARCINOMA)
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: (SQUAMOUS CELL CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: (SQUAMOUS CELL CARCINOMA)